Suchergebnisse - "MAP Kinase Signaling System"

Erdheim-Chester disease: consensus recommendations for evaluation, diagnosis, and treatment in the molecular era von Goyal, Gaurav, Heaney, Mark L, Collin, Matthew, Cohen-Aubart, Fleur, Vaglio, Augusto, Durham, Benjamin H, Hershkovitz-Rokah, Oshrat, Girschikofsky, Michael, Jacobsen, Eric D, Toyama, Kazuhiro, Goodman, Aaron M, Hendrie, Paul, Cao, Xin-Xin, Estrada-Veras, Juvianee I, Shpilberg, Ofer, Abdo, André, Kurokawa, Mineo, Dagna, Lorenzo, McClain, Kenneth L, Mazor, Roei D, Picarsic, Jennifer, Janku, Filip, Go, Ronald S, Haroche, Julien, Diamond, Eli L

“… Erdheim-Chester disease (ECD) is a rare histiocytosis that was recently recognized as a neoplastic disorder owing to the discovery of recurrent activating MAPK …”
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MAP Kinase Cascades Regulate the Cold Response by Modulating ICE1 Protein Stability von Zhao, Chunzhao, Wang, Pengcheng, Si, Tong, Hsu, Chuan-Chih, Wang, Lu, Zayed, Omar, Yu, Zheping, Zhu, Yingfang, Dong, Juan, Tao, W Andy, Zhu, Jian-Kang

“… Mitogen-activated protein kinase cascades are important signaling modules that convert environmental stimuli into cellular responses. We show that MPK3, MPK4, …”
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Dectin-1 Activation by a Natural Product β-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype von Liu, Min, Luo, Fengling, Ding, Chuanlin, Albeituni, Sabrin, Hu, Xiaoling, Ma, Yunfeng, Cai, Yihua, McNally, Lacey, Sanders, Mary Ann, Jain, Dharamvir, Kloecker, Goetz, Bousamra, 2nd, Michael, Zhang, Huang-ge, Higashi, Richard M, Lane, Andrew N, Fan, Teresa W-M, Yan, Jun

“… Tumor-associated macrophages (TAM) with an alternatively activated phenotype have been linked to tumor-elicited inflammation, immunosuppression, and resistance …”
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Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis von Ramachandran, Prakash, Pellicoro, Antonella, Vernon, Madeleine A, Boulter, Luke, Aucott, Rebecca L, Ali, Aysha, Hartland, Stephen N, Snowdon, Victoria K, Cappon, Andrea, Gordon-Walker, Timothy T, Williams, Mike J, Dunbar, Donald R, Manning, Jonathan R, van Rooijen, Nico, Fallowfield, Jonathan A, Forbes, Stuart J, Iredale, John P

“… Although macrophages are widely recognized to have a profibrotic role in inflammation, we have used a highly tractable CCl(4)-induced model of reversible …”
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Salt generates antiinflammatory Th17 cells but amplifies pathogenicity in proinflammatory cytokine microenvironments von Matthias, Julia, Heink, Sylvia, Picard, Felix, Zeiträg, Julia, Kolz, Anna, Chao, Ying-Yin, Soll, Dominik, de Almeida, Gustavo P., Glasmacher, Elke, Jacobsen, Ilse D., Riedel, Thomas, Peters, Anneli, Floess, Stefan, Huehn, Jochen, Baumjohann, Dirk, Huber, Magdalena, Korn, Thomas, Zielinski, Christina E.

“… Th cells integrate signals from their microenvironment to acquire distinct specialization programs for efficient clearance of diverse pathogens or for …”
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BRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic Inhibition von Yao, Zhan, Torres, Neilawattie M, Tao, Anthony, Gao, Yijun, Luo, Lusong, Li, Qi, de Stanchina, Elisa, Abdel-Wahab, Omar, Solit, David B, Poulikakos, Poulikos I, Rosen, Neal

“… ERK signaling requires RAS-induced RAF dimerization and is limited by feedback. Activated BRAF mutants evade feedback inhibition of RAS by either of two …”
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p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents von Sui, Xinbing, Kong, Na, Ye, Li, Han, Weidong, Zhou, Jichun, Zhang, Qin, He, Chao, Pan, Hongming

“… The Mitogen Activated Protein Kinase (MAPK) signaling plays a critical role in the outcome and the sensitivity to anticancer therapies. Activated MAPK can …”
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Propagating Wave of ERK Activation Orients Collective Cell Migration von Aoki, Kazuhiro, Kondo, Yohei, Naoki, Honda, Hiratsuka, Toru, Itoh, Reina E, Matsuda, Michiyuki

“… The biophysical framework of collective cell migration has been extensively investigated in recent years; however, it remains elusive how chemical inputs from …”
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IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment von Karakasheva, Tatiana A, Lin, Eric W, Tang, Qiaosi, Qiao, Edmund, Waldron, Todd J, Soni, Monica, Klein-Szanto, Andres J, Sahu, Varun, Basu, Devraj, Ohashi, Shinya, Baba, Kiichiro, Giaccone, Zachary T, Walker, Sarah R, Frank, David A, Wileyto, E Paul, Long, Qi, Dunagin, Margaret C, Raj, Arjun, Diehl, J Alan, Wong, K K, Bass, Adam J, Rustgi, Anil K

“… The tumor microenvironment (TME) plays a major role in the pathogenesis of multiple cancer types, including upper-gastrointestinal (GI) cancers that currently …”
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Astragaloside IV confers neuroprotection against radiation-induced neuronal senescence via the ERK pathway von Ding, Yanping, Jiang, Chenxin, Chen, Lili, Liu, Xin, Shao, Baoping

“… Various factors and mechanisms, including radiation, initiate cellular senescence and are concurrent with the progression of various neurodegenerative …”
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Recent advances in RASopathies von Aoki, Yoko, Niihori, Tetsuya, Inoue, Shin-ichi, Matsubara, Yoichi

“… RASopathies or RAS/mitogen-activated protein kinase (MAPK) syndromes are a group of phenotypically overlapping syndromes caused by germline mutations that …”
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Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update von Kyriakis, John M, Avruch, Joseph

“… The mammalian stress-activated families of mitogen-activated protein kinases (MAPKs) were first elucidated in 1994, and by 2001, substantial progress had been …”
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Conservation of Chitin-Induced MAPK Signaling Pathways in Rice and Arabidopsis von Yamada, Kenta, Yamaguchi, Koji, Yoshimura, Satomi, Terauchi, Akira, Kawasaki, Tsutomu

“… Perception of microbe-associated molecular patterns (MAMPs) including chitin by pattern recognition receptors (PRRs) rapidly induces activation of …”
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MAPK Signaling Regulates Nitric Oxide and NADPH Oxidase-Dependent Oxidative Bursts in Nicotiana benthamiana von Asai, Shuta, Ohta, Kohji, Yoshioka, Hirofumi

“… Nitric oxide (NO) and reactive oxygen species (ROS) act as signals in innate immunity in plants. The radical burst is induced by INF1 elicitin, produced by the …”
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Targeting RAS–ERK signalling in cancer: promises and challenges von Samatar, Ahmed A., Poulikakos, Poulikos I.

“… Key Points ERK signalling is frequently dysregulated in human tumours, usually owing to mutations in RAS or BRAF. Therefore, components of the ERK signalling …”
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PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1 von Ebi, Hiromichi, Costa, Carlotta, Faber, Anthony C, Nishtala, Madhuri, Kotani, Hiroshi, Juric, Dejan, Della Pelle, Patricia, Song, Youngchul, Yano, Seiji, Mino-Kenudson, Mari, Benes, Cyril H, Engelman, Jeffrey A

“… The PI3K pathway is genetically altered in excess of 70% of breast cancers, largely through PIK3CA mutation and HER2 amplification. Preclinical studies have …”
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A central role for the ERK-signaling pathway in controlling Schwann cell plasticity and peripheral nerve regeneration in vivo von Napoli, Ilaria, Noon, Luke A, Ribeiro, Sara, Kerai, Ajay P, Parrinello, Simona, Rosenberg, Laura H, Collins, Melissa J, Harrisingh, Marie C, White, Ian J, Woodhoo, Ashwin, Lloyd, Alison C

“… Following damage to peripheral nerves, a remarkable process of clearance and regeneration takes place. Axons downstream of the injury degenerate, while the …”
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Photoprotective Effect of Dietary Galacto-Oligosaccharide (GOS) in Hairless Mice via Regulation of the MAPK Signaling Pathway von Suh, Min Geun, Bae, Gi Yeon, Jo, Kyungae, Kim, Jin Man, Hong, Ki-Bae, Suh, Hyung Joo

“… This study investigated the suppression of photoaging by galacto-oligosaccharide (GOS) ingestion following exposure to ultraviolet (UV) radiation. To …”
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Identification of a putative molecular subtype of adult-type diffuse astrocytoma with recurrent MAPK pathway alterations von Sievers, Philipp, Bielle, Franck, Göbel, Kirsten, Schrimpf, Daniel, Nichelli, Lucia, Mathon, Bertrand, Appay, Romain, Boldt, Henning B., Dohmen, Hildegard, Selignow, Carmen, Acker, Till, Vicha, Ales, Martinetto, Horacio, Schweizer, Leonille, Schüller, Ulrich, Brandner, Sebastian, Wesseling, Pieter, Schmid, Simone, Capper, David, Abdullaev, Zied, Aldape, Kenneth, Korshunov, Andrey, Krieg, Sandro M., Wick, Wolfgang, Pfister, Stefan M., von Deimling, Andreas, Reuss, David E., Jones, David T. W., Sahm, Felix

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Bacterial c-di-GMP is an immunostimulatory molecule von Karaolis, David K R, Means, Terry K, Yang, De, Takahashi, Munehisa, Yoshimura, Teizo, Muraille, Eric, Philpott, Dana, Schroeder, John T, Hyodo, Mamoru, Hayakawa, Yoshihiro, Talbot, Brian G, Brouillette, Eric, Malouin, François

“… Cyclic diguanylate (c-di-GMP) is a bacterial intracellular signaling molecule. We have shown that treatment with exogenous c-di-GMP inhibits Staphylococcus …”
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