Výsledky vyhľadávania - "Lyashkov, Alexey"

Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria Autor Ubaida-Mohien, Ceereena, Lyashkov, Alexey, Gonzalez-Freire, Marta, Tharakan, Ravi, Shardell, Michelle, Moaddel, Ruin, Semba, Richard D, Chia, Chee W, Gorospe, Myriam, Sen, Ranjan, Ferrucci, Luigi

“…A decline of skeletal muscle strength with aging is a primary cause of mobility loss and frailty in older persons, but the molecular mechanisms of such decline…”
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Skeletal muscle transcriptome in healthy aging Autor Tumasian, Robert A., Harish, Abhinav, Kundu, Gautam, Yang, Jen-Hao, Ubaida-Mohien, Ceereena, Gonzalez-Freire, Marta, Kaileh, Mary, Zukley, Linda M., Chia, Chee W., Lyashkov, Alexey, Wood, William H., Piao, Yulan, Coletta, Christopher, Ding, Jun, Gorospe, Myriam, Sen, Ranjan, De, Supriyo, Ferrucci, Luigi

“…Age-associated changes in gene expression in skeletal muscle of healthy individuals reflect accumulation of damage and compensatory adaptations to preserve…”
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Biophysical characterization of the underappreciated and important relationship between heart rate variability and heart rate Autor Monfredi, Oliver, Lyashkov, Alexey E, Johnsen, Anne-Berit, Inada, Shin, Schneider, Heiko, Wang, Ruoxi, Nirmalan, Mahesh, Wisloff, Ulrik, Maltsev, Victor A, Lakatta, Edward G, Zhang, Henggui, Boyett, Mark R

“…Heart rate (HR) variability (HRV; beat-to-beat changes in the R-wave to R-wave interval) has attracted considerable attention during the past 30+ years (PubMed…”
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Positive Feedback Mechanisms among Local Ca Releases, NCX, and ICaL Ignite Pacemaker Action Potentials Autor Lyashkov, Alexey E, Behar, Joachim, Lakatta, Edward G, Yaniv, Yael, Maltsev, Victor A

“…Recent data suggest that cardiac pacemaker cell function is determined by numerous time-, voltage-, and Ca-dependent interactions of cell membrane electrogenic…”
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Positive Feedback Mechanisms among Local Ca Releases, NCX, and I CaL Ignite Pacemaker Action Potentials Autor Lyashkov, Alexey E, Behar, Joachim, Lakatta, Edward G, Yaniv, Yael, Maltsev, Victor A

“…Recent data suggest that cardiac pacemaker cell function is determined by numerous time-, voltage-, and Ca-dependent interactions of cell membrane electrogenic…”
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Unbiased proteomics, histochemistry, and mitochondrial DNA copy number reveal better mitochondrial health in muscle of high-functioning octogenarians Autor Ubaida-Mohien, Ceereena, Spendiff, Sally, Lyashkov, Alexey, Moaddel, Ruin, MacMillan, Norah J, Filion, Marie-Eve, Morais, Jose A, Taivassalo, Tanja, Ferrucci, Luigi, Hepple, Russell T

“…Master athletes (MAs) prove that preserving a high level of physical function up to very late in life is possible, but the mechanisms responsible for their…”
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Synchronization of sinoatrial node pacemaker cell clocks and its autonomic modulation impart complexity to heart beating intervals Autor Yaniv, Yael, Ahmet, Ismayil, Liu, Jie, Lyashkov, Alexey E, Guiriba, Toni-Rose, Okamoto, Yosuke, Ziman, Bruce D, Lakatta, Edward G

“…A reduction of complexity of heart beating interval variability that is associated with an increased morbidity and mortality in cardiovascular disease states…”
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Physical Activity Associated Proteomics of Skeletal Muscle: Being Physically Active in Daily Life May Protect Skeletal Muscle From Aging Autor Ubaida-Mohien, Ceereena, Gonzalez-Freire, Marta, Lyashkov, Alexey, Moaddel, Ruin, Chia, Chee W., Simonsick, Eleanor M., Sen, Ranjan, Ferrucci, Luigi

“…Muscle strength declines with aging and increasing physical activity is the only intervention known to attenuate this decline. In order to adequately…”
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Crosstalk between Mitochondrial and Sarcoplasmic Reticulum Ca2+ Cycling Modulates Cardiac Pacemaker Cell Automaticity Autor Yaniv, Yael, Spurgeon, Harold A., Lyashkov, Alexey E., Yang, Dongmei, Ziman, Bruce D., Maltsev, Victor A., Lakatta, Edward G.

“…Mitochondria dynamically buffer cytosolic Ca(2+) in cardiac ventricular cells and this affects the Ca(2+) load of the sarcoplasmic reticulum (SR). In…”
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Real-time relationship between PKA biochemical signal network dynamics and increased action potential firing rate in heart pacemaker cells: Kinetics of PKA activation in heart pacemaker cells Autor Yaniv, Yael, Ganesan, Ambhighainath, Yang, Dongmei, Ziman, Bruce D, Lyashkov, Alexey E, Levchenko, Andre, Zhang, Jin, Lakatta, Edward G

“…cAMP-PKA protein kinase is a key nodal signaling pathway that regulates a wide range of heart pacemaker cell functions. These functions are predicted to be…”
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Positive Feedback Mechanisms among Local Ca Releases, NCX, and I CaL Ignite Pacemaker Action Potentials Autor Lyashkov, Alexey E, Behar, Joachim, Lakatta, Edward G, Yaniv, Yael, Maltsev, Victor A

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Single‐extracellular vesicle (EV) analyses validate the use of L1 Cell Adhesion Molecule (L1CAM) as a reliable biomarker of neuron‐derived EVs Autor Nogueras‐Ortiz, Carlos J, Eren, Erden, Yao, Pamela, Calzada, Elizabeth, Dunn, Christopher, Volpert, Olga, Delgado‐Peraza, Francheska, Mustapic, Maja, Lyashkov, Alexey, Rubio, F Javier, Vreones, Michael, Cheng, Lesley, You, Yang, Hill, Andrew F, Ikezu, Tsuneya, Eitan, Erez, Goetzl, Edward J, Kapogiannis, Dimitrios

“…Isolation of neuron‐derived extracellular vesicles (NDEVs) with L1 Cell Adhesion Molecule (L1CAM)‐specific antibodies has been widely used to identify blood…”
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Ca2+ and Membrane Potential Transitions During Action Potentials Are Self-Similar to Each Other and to Variability of AP Firing Intervals Across the Broad Physiologic Range of AP Intervals During Autonomic Receptor Stimulation Autor Yang, Dongmei, Morrell, Christopher H., Lyashkov, Alexey E., Tagirova Sirenko, Syevda, Zahanich, Ihor, Yaniv, Yael, Vinogradova, Tatiana M., Ziman, Bruce D., Maltsev, Victor A., Lakatta, Edward G.

“…Ca 2+ and V m transitions occurring throughout action potential (AP) cycles in sinoatrial nodal (SAN) cells are cues that (1) not only regulate activation…”
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A remarkable adaptive paradigm of heart performance and protection emerges in response to the constitutive challenge of marked cardiac-specific overexpression of adenylyl cyclase type 8 Autor Tarasov, Kirill V, Chakir, Khalid, Riordon, Daniel R, Lyashkov, Alexey E, Ahmet, Ismayil, Perino, Maria G, Silvester, Allwin J, Wang, Mingyi, Lukyanenko, Yevgeniya O, Qu, Jia-Hua, Barrera, Miguel C-R, Tarasova, Yelena S, Pacak, Karel, Field, Loren, Lakatta, Edward G

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Stochasticity intrinsic to coupled-clock mechanisms underlies beat-to-beat variability of spontaneous action potential firing in sinoatrial node pacemaker cells Autor Yaniv, Yael, Lyashkov, Alexey E., Sirenko, Syevda, Okamoto, Yosuke, Guiriba, Toni-Rose, Ziman, Bruce D., Morrell, Christopher H., Lakatta, Edward G.

“…Recent evidence indicates that the spontaneous action potential (AP) of isolated sinoatrial node cells (SANCs) is regulated by a system of stochastic…”
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Positive Feedback Mechanisms among Local Ca Releases, NCX, and ICaL Ignite Pacemaker Action Potentials Autor Lyashkov, Alexey E, Behar, Joachim, Lakatta, Edward G, Yaniv, Yael, Maltsev, Victor A

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High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells Autor Vinogradova, Tatiana M, Lyashkov, Alexey E, Zhu, Weizhong, Ruknudin, Abdul M, Sirenko, Syevda, Yang, Dongmei, Deo, Shekhar, Barlow, Matthew, Johnson, Shavsha, Caffrey, James L, Zhou, Ying-Ying, Xiao, Rui-Ping, Cheng, Heping, Stern, Michael D, Maltsev, Victor A, Lakatta, Edward G

“…Local, rhythmic, subsarcolemmal Ca2+ releases (LCRs) from the sarcoplasmic reticulum (SR) during diastolic depolarization in sinoatrial nodal cells (SANC)…”
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Ca(2+)/calmodulin-activated phosphodiesterase 1A is highly expressed in rabbit cardiac sinoatrial nodal cells and regulates pacemaker function Autor Lukyanenko, Yevgeniya O, Younes, Antoine, Lyashkov, Alexey E, Tarasov, Kirill V, Riordon, Daniel R, Lee, Joonho, Sirenko, Syevda G, Kobrinsky, Evgeny, Ziman, Bruce, Tarasova, Yelena S, Juhaszova, Magdalena, Sollott, Steven J, Graham, David R, Lakatta, Edward G

“…Constitutive Ca(2+)/calmodulin (CaM)-activation of adenylyl cyclases (ACs) types 1 and 8 in sinoatrial nodal cells (SANC) generates cAMP within lipid-raft-rich…”
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Mechanisms that match ATP supply to demand in cardiac pacemaker cells during high ATP demand Autor Yaniv, Yael, Spurgeon, Harold A, Ziman, Bruce D, Lyashkov, Alexey E, Lakatta, Edward G

“…The spontaneous action potential (AP) firing rate of sinoatrial node cells (SANCs) involves high-throughput signaling via Ca(2+)-calmodulin activated adenylyl…”
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Constitutive phosphodiesterase activity restricts spontaneous beating rate of cardiac pacemaker cells by suppressing local Ca2+ releases Autor Vinogradova, Tatiana M, Sirenko, Syevda, Lyashkov, Alexey E, Younes, Antoine, Li, Yue, Zhu, Weizhong, Yang, Dongmei, Ruknudin, Abdul M, Spurgeon, Harold, Lakatta, Edward G

“…Spontaneous beating of rabbit sinoatrial node cells (SANCs) is controlled by cAMP-mediated, protein kinase A-dependent local subsarcolemmal ryanodine receptor…”
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