Suchergebnisse - "Lv, Dingyi"

Protective Effect of Sirtuin 3 on CLP-Induced Endothelial Dysfunction of Early Sepsis by Inhibiting NF-κB and NLRP3 Signaling Pathways von Lv, Dingyi, Luo, Minghao, Yan, Jianghong, Yang, Xiyang, Luo, Suxin

“… It has been revealed that widespread vascular endothelial dysfunction occurs in septic shock, ultimately resulting in multiple organ failure. The mitochondrial …”
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Role of the cGAS-STING Pathway in Aging-related Endothelial Dysfunction von Yu, Huilin, Liao, Ke, Hu, Yu, Lv, Dingyi, Luo, Minghao, Liu, Qian, Huang, Longxiang, Luo, Suxin

“… Endothelial dysfunction develops gradually with age, and is the foundation of many age-related diseases in the elderly. The purpose of this study was to …”
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Silencing CXCL16 alleviate neuroinflammation and M1 microglial polarization in mouse brain hemorrhage model and BV2 cell model through PI3K/AKT pathway von Dingyi, Lv, Libin, Hu, Jifeng, Piao, Ding, Zhiquan, Yulong, Li, Zhangyi, Wu, Yunong, Yin, Qinghua, Wang, Feng, Li

“… Neuroinflammation and microglia polarization play pivotal roles in brain injury induced by intracerebral hemorrhage (ICH). Despite the well-established …”
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Role of the Nucleotide-Binding Domain-Like Receptor Protein 3 Inflammasome in the Endothelial Dysfunction of Early Sepsis von Luo, Minghao, Meng, Jiayu, Yan, Jianghong, Shang, Feifei, Zhang, Ting, Lv, Dingyi, Li, Chang, Yang, Xiyang, Luo, Suxin

“… Endothelial dysfunction is responsible for multiple organ failure and the high mortality rate of sepsis. Nucleotide-binding domain-like receptor protein 3 …”
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Dapagliflozin ameliorates myocardial infarction injury through AMPKα-dependent regulation of oxidative stress and apoptosis von Peng, Yuce, Guo, Mingyu, Luo, Minghao, Lv, Dingyi, Liao, Ke, Luo, Suxin, Zhang, Bingyu

“… Dapagliflozin (DAPA) has been demonstrated to reduce cardiovascular mortality and heart failure hospitalization rates in diabetic patients. However, the …”
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Role of thioredoxin-interacting protein in mediating endothelial dysfunction in hypertension von Wang, Ruiyu, Guo, Yongzheng, Li, Lingjiao, Luo, Minghao, Peng, Linqian, Lv, Dingyi, Cheng, Zhe, Xue, Qian, Wang, Liang, Huang, Jing

“… Excessive oxidative stress is a major causative factor of endothelial dysfunction in hypertension. As an endogenous pro-oxidant, thioredoxin-interacting …”
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LncRNA GAS5 downregulates NLRP3 inflammasome activation-mediated pyroptosis in sepsis-induced myocardial injury by targeting SIRT3/AMPKα von Luo, Minghao, Peng, Yuce, Lv, Dingyi, Xue, Yuzhou, Huang, Longxiang, Hu, Yu, Zhu, Wenyan, Luo, Suxin, Shen, Jian, Li, Xiang

“… An increasing body of studies has demonstrated the significance of long non-coding RNA (lncRNA) growth arrest specific 5 (GAS5) in inflammation and myocardial …”
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Hypoglycemia Induces Diabetic Macrovascular Endothelial Dysfunction via Endothelial Cell PANoptosis, Macrophage Polarization, and VSMC Fibrosis von Zuo, Deyu, Peng, Yuce, Zhao, Guozhi, Cheng, Zhesheng, Luo, Minghao, Lv, Dingyi, Chang, Shuting, Li, Na, Huang, Yanyao, Li, Xunjia, He, An

“… Hypoglycemia is a commonly neglected complication in elderly diabetic patients, which can lead to cardiovascular events. Endothelial cell dysfunction is the …”
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The lncRNA GAS5 upregulates ANXA2 to mediate the macrophage inflammatory response during atherosclerosis development von Xue, Yuzhou, Hu, Yu, Yu, Shikai, Zhu, Wenyan, Liu, Lin, Luo, Minghao, Luo, Suxin, Shen, Jian, Huang, Longxiang, Liu, Jie, Lv, Dingyi, Zhang, Wenming, Wang, Jingyu, Li, Xiang

“… Inflammatory macrophages play a crucial role in atherosclerosis development. The long non-coding RNA growth arrest-specific 5 (GAS5) regulates THP-1 macrophage …”
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Aerobic Exercise Training Improves Renal Injury in Spontaneously Hypertensive Rats by Increasing Renalase Expression in Medulla von Luo, Minghao, Cao, Shuyuan, Lv, Dingyi, He, Longlin, He, Zhou, Li, Lingang, Li, Yongjian, Luo, Suxin, Chang, Qing

“… We aimed to examine the effects of aerobic exercise training on renal function in spontaneously hypertensive rats (SHR) and elucidate their possible …”
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SIRT3-AMPK signaling pathway as a protective target in endothelial dysfunction of early sepsis von Yu, Huilin, Liu, Qian, Chen, Guodong, Huang, Longxiang, Luo, Minghao, Lv, Dingyi, Luo, Suxin

“… •We demonstrated that p-AMPK expression in the aorta increased in the early stage of sepsis.•Activation of AMPK protected the vascular endothelial function and …”
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P2Y6 Receptor Activation Aggravates NLRP3-dependent Microglial Pyroptosis via Downregulation of the PI3K/AKT Pathway in a Mouse Model of Intracerebral Hemorrhage von Li, Yulong, Tu, Huiru, Zhang, Shengfan, Ding, Zhiquan, Wu, Guiwei, Piao, Jifeng, Lv, Dingyi, Hu, Libin, Li, Feng, Wang, Qinghua

“… Pro-inflammatory signals generated after intracerebral hemorrhage (ICH) trigger a form of regulated cell death known as pyroptosis in microglia. White matter …”
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Bone marrow-mesenchymal stem cells alleviate microglial Pyroptosis after intracerebral hemorrhage in rat by secreting C1q/tumor necrosis factor-related protein 3 von Wang, Qinghua, Piao, Jifeng, Li, Yulong, Tu, Huiru, Lv, Dingyi, Hu, Libin, Zhang, Run, Zhong, Zhenzhong

“… There are no specific treatment methods for intracerebral hemorrhage (ICH). Neuroinflammation triggered by microglial pyroptosis plays an important role in ICH …”
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Nucleotide-binding domain-like receptor protein 3 inflammasome contributes to vascular endothelial barrier dysfunction and shock after burn injury von Yu, Huilin, Lyu, Fengjie, Cheng, Zhe, Luo, Minghao, Sasmita, Bryan Richard, Lan, Yuan, Lv, Dingyi

“… Burn injury-induced systemic inflammation significantly contributes to vascular endothelial dysfunction and hypotension. This study aimed to investigate the …”
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Bifunctional Peptide‐Engineered Mitochondria Alleviate Myocarditis and Cardiac Fibrosis by Site‐Specifically Inhibiting NETosis von Hu, Xiankang, Pan, Lina, Chen, Haiyan, Chen, Liyuan, Tang, Yige, Lv, Dingyi, Li, Chenwen, Zhang, Jianxiang, Luo, Suxin

“… Myocarditis is a leading cause of sudden cardiac death and dilated cardiomyopathy in young adults, and effective therapies are urgently needed. Here, it is …”
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Diacerein attenuates sepsis shock mortality through combined suppression of vascular inflammation, stiffness, and permeability von Luo, Minghao, Jiang, Yi, Peng, Yuce, Lv, Dingyi, He, An, Huang, Longxiang, Xia, Yong, Luo, Suxin, Li, Yuanjing

“… Sepsis shock mortality remains critically high due to dysregulated vascular inflammation and permeability. Diacerein (DIA), an anthraquinone derivative with …”
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Hypoglycaemia aggravates impaired endothelial-dependent vasodilation in diabetes by suppressing endothelial nitric oxide synthase activity and stimulating inducible nitric oxide synthase expression von He, An, Guo, Yongzheng, Xu, Zhixin, Yan, Jianghong, Xie, Lingyun, Li, Yuanjing, Lv, Dingyi, Luo, Minghao

“… Diabetes exacerbates vascular injury by triggering endothelial dysfunction. Endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS) …”
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Diacerein attenuates vascular dysfunction by reducing inflammatory response and insulin resistance in type 2 diabetic rats von He, An, Shen, Jian, Xue, Yuzhou, Xiang li, Li, Yuanjing, Huang, Longxiang, Lv, Dingyi, Luo, Minghao

“… To examine the effect of diacerein on vascular dysfunction in type 2 diabetic rats and elucidate the mechanism of diacerein. In a rat model, type 2 diabetes …”
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NLRP3 inflammasome contributes to endothelial dysfunction in angiotensin II-induced hypertension in mice von Li, Xingbing, Zhang, Ziyue, Luo, Minghao, Cheng, Zhe, Wang, Ruiyu, Liu, Qian, Lv, Dingyi, Yan, Jianghong, Shang, Feifei, Luo, Suxin, Xia, Yong

“… Inflammation is a key feature of endothelial dysfunction induced by angiotensin (Ang) II. The purpose of this study was to explore the role of …”
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Leonurine Attenuates Myocardial Fibrosis Through Upregulation of miR-29a-3p in Mice Post-myocardial Infarction von Wang, Ruiyu, Peng, Linqian, Lv, Dingyi, Shang, Feifei, Yan, Jianghong, Li, Guoxing, Li, Dan, Ouyang, Jing, Yang, Jiadan

“… Myocardial fibrosis (MF) is a pathological process that accelerates cardiac remodeling in myocardial infarction (MI), and miR-29 has become one of the foci of …”
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