Suchergebnisse - "Lutgens, Esther"

Immunotherapy for cardiovascular disease von Lutgens, Esther, Atzler, Dorothee, Döring, Yvonne, Duchene, Johan, Steffens, Sabine, Weber, Christian

“… The outcomes of the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial have unequivocally proven that inflammation is a key driver of …”
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CD40/CD40L and Related Signaling Pathways in Cardiovascular Health and Disease—The Pros and Cons for Cardioprotection von Daub, Steffen, Lutgens, Esther, Münzel, Thomas, Daiber, Andreas

“… The CD40–CD40 ligand (CD40L) dyad represents a scientific and clinical field that has raised many controversies in the past and cannot be clearly defined as …”
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Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics von Depuydt, Marie A C, Prange, Koen H M, Slenders, Lotte, Örd, Tiit, Elbersen, Danny, Boltjes, Arjan, de Jager, Saskia C A, Asselbergs, Folkert W, de Borst, Gert J, Aavik, Einari, Lönnberg, Tapio, Lutgens, Esther, Glass, Christopher K, den Ruijter, Hester M, Kaikkonen, Minna U, Bot, Ilze, Slütter, Bram, van der Laan, Sander W, Yla-Herttuala, Seppo, Mokry, Michal, Kuiper, Johan, de Winther, Menno P J, Pasterkamp, Gerard

“… Atherosclerotic lesions are known for their cellular heterogeneity, yet the molecular complexity within the cells of human plaques has not been fully assessed …”
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Immune cell crosstalk in obesity: a key role for costimulation? von Seijkens, Tom, Kusters, Pascal, Chatzigeorgiou, Antonios, Chavakis, Triantafyllos, Lutgens, Esther

“… In the past two decades, numerous experimental and clinical studies have established the importance of inflammation and immunity in the development of obesity …”
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Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death von Silvestre-Roig, Carlos, Braster, Quinte, Wichapong, Kanin, Lee, Ernest Y., Teulon, Jean Marie, Berrebeh, Nihel, Winter, Janine, Adrover, José M., Santos, Giancarlo Santiago, Froese, Alexander, Lemnitzer, Patricia, Ortega-Gómez, Almudena, Chevre, Raphael, Marschner, Julian, Schumski, Ariane, Winter, Carla, Perez-Olivares, Laura, Pan, Chang, Paulin, Nicole, Schoufour, Tom, Hartwig, Helene, González-Ramos, Silvia, Kamp, Frits, Megens, Remco T. A., Mowen, Kerri A., Gunzer, Matthias, Maegdefessel, Lars, Hackeng, Tilman, Lutgens, Esther, Daemen, Mat, von Blume, Julia, Anders, Hans-Joachim, Nikolaev, Viacheslav O., Pellequer, Jean-Luc, Weber, Christian, Hidalgo, Andrés, Nicolaes, Gerry A. F., Wong, Gerard C. L., Soehnlein, Oliver

“… The perpetuation of inflammation is an important pathophysiological contributor to the global medical burden. Chronic inflammation is promoted by …”
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Spatial Transcriptional Mapping Reveals Site-Specific Pathways Underlying Human Atherosclerotic Plaque Rupture von Sun, Jiangming, Singh, Pratibha, Shami, Annelie, Kluza, Ewelina, Pan, Mengyu, Djordjevic, Djordje, Michaelsen, Natasha Barascuk, Kennbäck, Cecilia, van der Wel, Nicole N, Orho-Melander, Marju, Nilsson, Jan, Formentini, Ivan, Conde-Knape, Karin, Lutgens, Esther, Edsfeldt, Andreas, Gonçalves, Isabel

“… Atherosclerotic plaque ruptures, triggered by blood flow-associated biomechanical forces, cause most myocardial infarctions and strokes. This study aims to …”
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Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection von Zernecke, Alma, Bidzhekov, Kiril, Noels, Heidi, Shagdarsuren, Erdenechimeg, Gan, Lin, Denecke, Bernd, Hristov, Mihail, Köppel, Thomas, Jahantigh, Maliheh Nazari, Lutgens, Esther, Wang, Shusheng, Olson, Eric N, Schober, Andreas, Weber, Christian

“… Apoptosis is a pivotal process in embryogenesis and postnatal cell homeostasis and involves the shedding of membranous microvesicles termed apoptotic bodies …”
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Regulatory T Cell Metabolism in Atherosclerosis von Baardman, Jeroen, Lutgens, Esther

“… Regulatory T cells (Tregs) are capable of suppressing excessive immune responses to prevent autoimmunity and chronic inflammation. Decreased numbers of Tregs …”
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Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis von Santovito, Donato, Egea, Virginia, Bidzhekov, Kiril, Natarelli, Lucia, Mourão, André, Blanchet, Xavier, Wichapong, Kanin, Aslani, Maria, Brunßen, Coy, Horckmans, Michael, Hristov, Michael, Geerlof, Arie, Lutgens, Esther, Daemen, Mat J A P, Hackeng, Tilman, Ries, Christian, Chavakis, Triantafyllos, Morawietz, Henning, Naumann, Ronald, von Hundelshausen, Philipp, Steffens, Sabine, Duchêne, Johan, Megens, Remco T A, Sattler, Michael, Weber, Christian

“… MicroRNAs (miRNAs) are versatile regulators of gene expression with profound implications for human disease including atherosclerosis, but whether they can …”
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Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans von Remie, Carlijn M E, Roumans, Kay H M, Moonen, Michiel P B, Connell, Niels J, Havekes, Bas, Mevenkamp, Julian, Lindeboom, Lucas, de Wit, Vera H W, van de Weijer, Tineke, Aarts, Suzanne A B M, Lutgens, Esther, Schomakers, Bauke V, Elfrink, Hyung L, Zapata-Pérez, Rubén, Houtkooper, Riekelt H, Auwerx, Johan, Hoeks, Joris, Schrauwen-Hinderling, Vera B, Phielix, Esther, Schrauwen, Patrick

“… ABSTRACT Background Nicotinamide riboside (NR) is an NAD+ precursor that boosts cellular NAD+ concentrations. Preclinical studies have shown profound metabolic …”
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Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques von Baardman, Jeroen, Verberk, Sanne G. S., van der Velden, Saskia, Gijbels, Marion J. J., van Roomen, Cindy P. P. A., Sluimer, Judith C., Broos, Jelle Y., Griffith, Guillermo R., Prange, Koen H. M., van Weeghel, Michel, Lakbir, Soufyan, Molenaar, Douwe, Meinster, Elisa, Neele, Annette E., Kooij, Gijs, de Vries, Helga E., Lutgens, Esther, Wellen, Kathryn E., de Winther, Menno P. J., Van den Bossche, Jan

“… Macrophages represent a major immune cell population in atherosclerotic plaques and play central role in the progression of this lipid-driven chronic …”
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Distribution of macrophage polarization markers in human atherosclerosis von Stöger, J. Lauran, Gijbels, Marion J.J., van der Velden, Saskia, Manca, Marco, van der Loos, Chris M., Biessen, Erik A.L., Daemen, Mat J.A.P., Lutgens, Esther, de Winther, Menno P.J.

“… Macrophages are decisive in the chronic inflammatory processes that drive atherogenesis. The purpose of this study was to explore the presence and spatial …”
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Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis von Seijkens, Tom T P, van Tiel, Claudia M, Kusters, Pascal J H, Atzler, Dorothee, Soehnlein, Oliver, Zarzycka, Barbara, Aarts, Suzanne A B M, Lameijer, Marnix, Gijbels, Marion J, Beckers, Linda, den Toom, Myrthe, Slütter, Bram, Kuiper, Johan, Duchene, Johan, Aslani, Maria, Megens, Remco T A, van 't Veer, Cornelis, Kooij, Gijs, Schrijver, Roy, Hoeksema, Marten A, Boon, Louis, Fay, Francois, Tang, Jun, Baxter, Samantha, Jongejan, Aldo, Moerland, Perry D, Vriend, Gert, Bleijlevens, Boris, Fisher, Edward A, Duivenvoorden, Raphael, Gerdes, Norbert, de Winther, Menno P J, Nicolaes, Gerry A, Mulder, Willem J M, Weber, Christian, Lutgens, Esther

“… Disrupting the costimulatory CD40-CD40L dyad reduces atherosclerosis, but can result in immune suppression. The authors recently identified small molecule …”
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Identifying the anti-inflammatory response to lipid lowering therapy: a position paper from the working group on atherosclerosis and vascular biology of the European Society of Cardiology von Tuñón, José, Badimón, Lina, Bochaton-Piallat, Marie-Luce, Cariou, Bertrand, Daemen, Mat J, Egido, Jesus, Evans, Paul C, Hoefer, Imo E, Ketelhuth, Daniel F J, Lutgens, Esther, Matter, Christian M, Monaco, Claudia, Steffens, Sabine, Stroes, Erik, Vindis, Cécile, Weber, Christian, Bäck, Magnus

“… Dysregulated lipid metabolism induces an inflammatory and immune response leading to atherosclerosis. Conversely, inflammation may alter lipid metabolism …”
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Auto-antigenic protein-DNA complexes stimulate plasmacytoid dendritic cells to promote atherosclerosis von Döring, Yvonne, Manthey, Helga D, Drechsler, Maik, Lievens, Dirk, Megens, Remco T A, Soehnlein, Oliver, Busch, Martin, Manca, Marco, Koenen, Rory R, Pelisek, Jaroslav, Daemen, Mat J, Lutgens, Esther, Zenke, Martin, Binder, Christoph J, Weber, Christian, Zernecke, Alma

“… Inflammation has been closely linked to auto-immunogenic processes in atherosclerosis. Plasmacytoid dendritic cells (pDCs) are specialized to produce type-I …”
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Cardiovascular toxicities of immune therapies for cancer – a scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Council of Cardio‐Oncology von Tocchetti, Carlo Gabriele, Farmakis, Dimitrios, Koop, Yvonne, Andres, Maria Sol, Couch, Liam S., Formisano, Luigi, Ciardiello, Fortunato, Pane, Fabrizio, Au, Lewis, Emmerich, Max, Plummer, Chris, Gulati, Geeta, Ramalingam, Sivatharshini, Cardinale, Daniela, Brezden‐Masley, Christine, Iakobishvili, Zaza, Thavendiranathan, Paaladinesh, Santoro, Ciro, Bergler‐Klein, Jutta, Keramida, Kalliopi, Boer, Rudolf A., Maack, Christoph, Lutgens, Esther, Rassaf, Tienush, Fradley, Michael G., Moslehi, Javid, Yang, Eric H., De Keulenaer, Gilles, Ameri, Pietro, Bax, Jeroen, Neilan, Tomas G., Herrmann, Joerg, Mbakwem, Amam C., Mirabel, Mariana, Skouri, Hadi, Hirsch, Emilio, Cohen‐Solal, Alain, Sverdlov, Aaron L., Meer, Peter, Asteggiano, Riccardo, Barac, Ana, Ky, Bonnie, Lenihan, Daniel, Dent, Susan, Seferovic, Petar, Coats, Andrew J.S., Metra, Marco, Rosano, Giuseppe, Suter, Thomas, Lopez‐Fernandez, Teresa, Lyon, Alexander R.

“… ABSTRACT The advent of immunological therapies has revolutionized the treatment of solid and haematological cancers over the last decade. Licensed therapies …”
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Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease von Lacy, Michael, Bürger, Christina, Shami, Annelie, Ahmadsei, Maiwand, Winkels, Holger, Nitz, Katrin, van Tiel, Claudia M., Seijkens, Tom T. P., Kusters, Pascal J. H., Karshovka, Ela, Prange, Koen H. M., Wu, Yuting, Brouns, Sanne L. N., Unterlugauer, Sigrid, Kuijpers, Marijke J. E., Reiche, Myrthe E., Steffens, Sabine, Edsfeldt, Andreas, Megens, Remco T. A., Heemskerk, Johan W. M., Goncalves, Isabel, Weber, Christian, Gerdes, Norbert, Atzler, Dorothee, Lutgens, Esther

“… Atherosclerosis is a major underlying cause of cardiovascular disease. Previous studies showed that inhibition of the co-stimulatory CD40 ligand (CD40L)-CD40 …”
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A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia von Baardman, Jeroen, Verberk, Sanne G.S., Prange, Koen H.M., van Weeghel, Michel, van der Velden, Saskia, Ryan, Dylan G., Wüst, Rob C.I., Neele, Annette E., Speijer, Dave, Denis, Simone W., Witte, Maarten E., Houtkooper, Riekelt H., O’neill, Luke A., Knatko, Elena V., Dinkova-Kostova, Albena T., Lutgens, Esther, de Winther, Menno P.J., Van den Bossche, Jan

“… Metabolic reprogramming has emerged as a crucial regulator of immune cell activation, but how systemic metabolism influences immune cell metabolism and …”
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Cancer patients receiving immune checkpoint inhibitor therapy are at an increased risk for atherosclerotic cardiovascular disease von Lutgens, Esther, Seijkens, Tom T.P.

“… The widespread clinical use of immune checkpoint inhibitors (ICI) has increased our knowledge on their adverse effects on chronic inflammatory diseases …”
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The Link between Hematopoiesis and Atherosclerosis von de Winther, Menno P.J, Lutgens, Esther

“… Clinical evidence supporting a link between inflammation and atherosclerosis includes the results of the Canakinumab Antiinflammatory Thrombosis Outcomes Study …”
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