Suchergebnisse - "Lubitz, Steven A."

Detection of Atrial Fibrillation in a Large Population Using Wearable Devices: The Fitbit Heart Study von Lubitz, Steven A, Faranesh, Anthony Z, Selvaggi, Caitlin, Atlas, Steven J, McManus, David D, Singer, Daniel E, Pagoto, Sherry, McConnell, Michael V, Pantelopoulos, Alexandros, Foulkes, Andrea S

“… Morbidity from undiagnosed atrial fibrillation (AF) may be preventable with early detection. Many consumer wearables contain optical photoplethysmography (PPG) …”
Weitere Angaben

ECG-Based Deep Learning and Clinical Risk Factors to Predict Atrial Fibrillation von Khurshid, Shaan, Friedman, Samuel, Reeder, Christopher, Di Achille, Paolo, Diamant, Nathaniel, Singh, Pulkit, Harrington, Lia X, Wang, Xin, Al-Alusi, Mostafa A, Sarma, Gopal, Foulkes, Andrea S, Ellinor, Patrick T, Anderson, Christopher D, Ho, Jennifer E, Philippakis, Anthony A, Batra, Puneet, Lubitz, Steven A

“… Artificial intelligence (AI)-enabled analysis of 12-lead ECGs may facilitate efficient estimation of incident atrial fibrillation (AF) risk. However, it …”
Weitere Angaben

Population-Based Screening for Atrial Fibrillation von Khurshid, Shaan, Healey, Jeffrey S, McIntyre, William F, Lubitz, Steven A

“… Atrial fibrillation (AF) is a common and morbid arrhythmia. Stroke is a major hazard of AF and may be preventable with oral anticoagulation. Yet since AF is …”
Weitere Angaben

Lifetime risk of atrial fibrillation according to optimal, borderline, or elevated levels of risk factors: cohort study based on longitudinal data from the Framingham Heart Study von Staerk, Laila, Wang, Biqi, Preis, Sarah R, Larson, Martin G, Lubitz, Steven A, Ellinor, Patrick T, McManus, David D, Ko, Darae, Weng, Lu-Chen, Lunetta, Kathryn L, Frost, Lars, Benjamin, Emelia J, Trinquart, Ludovic

“… AbstractObjectiveTo examine the association between risk factor burdens—categorized as optimal, borderline, or elevated—and the lifetime risk of atrial …”
Volltext

Frequency of Cardiac Rhythm Abnormalities in a Half Million Adults von Khurshid, Shaan, Choi, Seung Hoan, Weng, Lu-Chen, Wang, Elizabeth Y, Trinquart, Ludovic, Benjamin, Emelia J, Ellinor, Patrick T, Lubitz, Steven A

“… The frequency of cardiac rhythm abnormalities and their risk factors in community-dwelling adults are not well characterized. We determined the frequency of …”
Weitere Angaben

50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study von Schnabel, Renate B, Yin, Xiaoyan, Gona, Philimon, Larson, Martin G, Beiser, Alexa S, McManus, David D, Newton-Cheh, Christopher, Lubitz, Steven A, Magnani, Jared W, Ellinor, Patrick T, Seshadri, Sudha, Wolf, Philip A, Vasan, Ramachandran S, Benjamin, Emelia J, Levy, Daniel

“… Comprehensive long-term data on atrial fibrillation trends in men and women are scant. We aimed to provide such data through analysis of the Framingham cohort …”
Volltext

Rationale and design of a large population study to validate software for the assessment of atrial fibrillation from data acquired by a consumer tracker or smartwatch: The Fitbit heart study von Lubitz, Steven A., Faranesh, Anthony Z., Atlas, Steven J., McManus, David D., Singer, Daniel E., Pagoto, Sherry, Pantelopoulos, Alexandros, Foulkes, Andrea S.

“… [Display omitted] Early detection of atrial fibrillation or flutter (AF) may enable prevention of downstream morbidity. Consumer wrist-worn wearable technology …”
Volltext

Genetic Predisposition, Clinical Risk Factor Burden, and Lifetime Risk of Atrial Fibrillation von Weng, Lu-Chen, Preis, Sarah R, Hulme, Olivia L, Larson, Martin G, Choi, Seung Hoan, Wang, Biqi, Trinquart, Ludovic, McManus, David D, Staerk, Laila, Lin, Honghuang, Lunetta, Kathryn L, Ellinor, Patrick T, Benjamin, Emelia J, Lubitz, Steven A

“… The long-term probability of developing atrial fibrillation (AF) considering genetic predisposition and clinical risk factor burden is unknown. We estimated …”
Weitere Angaben

Sudden Cardiac Arrest Survivorship: A Scientific Statement From the American Heart Association von Sawyer, Kelly N, Camp-Rogers, Teresa R, Kotini-Shah, Pavitra, Del Rios, Marina, Gossip, Michelle R, Moitra, Vivek K, Haywood, Kirstie L, Dougherty, Cynthia M, Lubitz, Steven A, Rabinstein, Alejandro A, Rittenberger, Jon C, Callaway, Clifton W, Abella, Benjamin S, Geocadin, Romergryko G, Kurz, Michael C

“… Cardiac arrest systems of care are successfully coordinating community, emergency medical services, and hospital efforts to improve the process of care for …”
Weitere Angaben

Cross-modal autoencoder framework learns holistic representations of cardiovascular state von Radhakrishnan, Adityanarayanan, Friedman, Sam F., Khurshid, Shaan, Ng, Kenney, Batra, Puneet, Lubitz, Steven A., Philippakis, Anthony A., Uhler, Caroline

“… A fundamental challenge in diagnostics is integrating multiple modalities to develop a joint characterization of physiological state. Using the heart as a …”
Volltext

Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy von Pirruccello, James P., Bick, Alexander, Wang, Minxian, Chaffin, Mark, Friedman, Samuel, Yao, Jie, Guo, Xiuqing, Venkatesh, Bharath Ambale, Taylor, Kent D., Post, Wendy S., Rich, Stephen, Lima, Joao A. C., Rotter, Jerome I., Philippakis, Anthony, Lubitz, Steven A., Ellinor, Patrick T., Khera, Amit V., Kathiresan, Sekar, Aragam, Krishna G.

“… Dilated cardiomyopathy (DCM) is an important cause of heart failure and the leading indication for heart transplantation. Many rare genetic variants have been …”
Volltext

Genetics of myocardial interstitial fibrosis in the human heart and association with disease von Nauffal, Victor, Di Achille, Paolo, Klarqvist, Marcus D. R., Cunningham, Jonathan W., Hill, Matthew C., Pirruccello, James P., Weng, Lu-Chen, Morrill, Valerie N., Choi, Seung Hoan, Khurshid, Shaan, Friedman, Samuel F., Nekoui, Mahan, Roselli, Carolina, Ng, Kenney, Philippakis, Anthony A., Batra, Puneet, Ellinor, Patrick T., Lubitz, Steven A.

“… Myocardial interstitial fibrosis is associated with cardiovascular disease and adverse prognosis. Here, to investigate the biological pathways that underlie …”
Volltext

Development of a clinical polygenic risk score assay and reporting workflow von Hao, Limin, Kraft, Peter, Berriz, Gabriel F., Hynes, Elizabeth D., Koch, Christopher, Korategere V Kumar, Prathik, Parpattedar, Shruti S., Steeves, Marcie, Yu, Wanfeng, Antwi, Ashley A., Brunette, Charles A., Danowski, Morgan, Gala, Manish K., Green, Robert C., Jones, Natalie E., Lewis, Anna C. F., Lubitz, Steven A., Natarajan, Pradeep, Vassy, Jason L., Lebo, Matthew S.

“… Implementation of polygenic risk scores (PRS) may improve disease prevention and management but poses several challenges: the construction of clinically valid …”
Volltext

Adjusting for common variant polygenic scores improves yield in rare variant association analyses von Jurgens, Sean J., Pirruccello, James P., Choi, Seung Hoan, Morrill, Valerie N., Chaffin, Mark, Lubitz, Steven A., Lunetta, Kathryn L., Ellinor, Patrick T.

“… With the emergence of large-scale sequencing data, methods for improving power in rare variant association tests are needed. Here we show that adjusting for …”
Volltext

Clonal haematopoiesis of indeterminate potential predicts incident cardiac arrhythmias von Schuermans, Art, Vlasschaert, Caitlyn, Nauffal, Victor, Cho, So Mi Jemma, Uddin, Md Mesbah, Nakao, Tetsushi, Niroula, Abhishek, Klarqvist, Marcus D R, Weeks, Lachelle D, Lin, Amy E, Saadatagah, Seyedmohammad, Lannery, Kim, Wong, Megan, Hornsby, Whitney, Lubitz, Steven A, Ballantyne, Christie, Jaiswal, Siddhartha, Libby, Peter, Ebert, Benjamin L, Bick, Alexander G, Ellinor, Patrick T, Natarajan, Pradeep, Honigberg, Michael C

“… Clonal haematopoiesis of indeterminate potential (CHIP), the age-related expansion of blood cells with preleukemic mutations, is associated with …”
Weitere Angaben

Clinical and genetic evaluation after sudden cardiac arrest von Harris, Stephanie L., Lubitz, Steven A.

“… Sudden cardiac arrest (SCA) and sudden cardiac death (SCD) can be attributed to cardiac, respiratory, metabolic, and toxicologic etiologies. Most cases of SCD …”
Volltext

Phenotypic Refinement of Heart Failure in a National Biobank Facilitates Genetic Discovery von Aragam, Krishna G, Chaffin, Mark, Levinson, Rebecca T, McDermott, Gregory, Choi, Seung Hoan, Shoemaker, M Benjamin, Haas, Mary E, Weng, Lu-Chen, Lindsay, Mark E, Smith, J Gustav, Newton-Cheh, Christopher, Roden, Dan M, London, Barry, Wells, Quinn S, Ellinor, Patrick T, Kathiresan, Sekar, Lubitz, Steven A

“… Heart failure (HF) is a morbid and heritable disorder for which the biological mechanisms are incompletely understood. We therefore examined genetic …”
Weitere Angaben

The Effect of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Inhibition on the Risk of Venous Thromboembolism von Marston, Nicholas A, Gurmu, Yared, Melloni, Giorgio E M, Bonaca, Marc, Gencer, Baris, Sever, Peter S, Pedersen, Terje R, Keech, Anthony C, Roselli, Carolina, Lubitz, Steven A, Ellinor, Patrick T, O'Donoghue, Michelle L, Giugliano, Robert P, Ruff, Christian T, Sabatine, Marc S

“… The relationship between cholesterol levels and risk of venous thromboembolism (VTE) is uncertain. We set out to determine the effect of PCSK9 (proprotein …”
Weitere Angaben

A Functional Variant Associated with Atrial Fibrillation Regulates PITX2c Expression through TFAP2a von Ye, Jiangchuan, Tucker, Nathan R, Weng, Lu-Chen, Clauss, Sebastian, Lubitz, Steven A, Ellinor, Patrick T

“… The most significantly associated genetic locus for atrial fibrillation (AF) is in chromosomal region 4q25, where four independent association signals have …”
Weitere Angaben

Deep Learning-Enabled Assessment of Left Heart Structure and Function Predicts Cardiovascular Outcomes von Lau, Emily S, Di Achille, Paolo, Kopparapu, Kavya, Andrews, Carl T, Singh, Pulkit, Reeder, Christopher, Al-Alusi, Mostafa, Khurshid, Shaan, Haimovich, Julian S, Ellinor, Patrick T, Picard, Michael H, Batra, Puneet, Lubitz, Steven A, Ho, Jennifer E

“… Deep learning interpretation of echocardiographic images may facilitate automated assessment of cardiac structure and function. We developed a deep learning …”
Weitere Angaben