Výsledky vyhľadávania - "Louphrasitthiphol, Pakavarin"

Venous identity requires BMP signalling through ALK3 Autor Neal, Alice, Nornes, Svanhild, Payne, Sophie, Wallace, Marsha D., Fritzsche, Martin, Louphrasitthiphol, Pakavarin, Wilkinson, Robert N., Chouliaras, Kira M., Liu, Ke, Plant, Karen, Sholapurkar, Radhika, Ratnayaka, Indrika, Herzog, Wiebke, Bond, Gareth, Chico, Tim, Bou-Gharios, George, De Val, Sarah

“…Venous endothelial cells are molecularly and functionally distinct from their arterial counterparts. Although veins are often considered the default…”
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Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity Autor Vivas-García, Yurena, Falletta, Paola, Liebing, Jana, Louphrasitthiphol, Pakavarin, Feng, Yongmei, Chauhan, Jagat, Scott, David A, Glodde, Nicole, Chocarro-Calvo, Ana, Bonham, Sarah, Osterman, Andrei L, Fischer, Roman, Ronai, Ze'ev, García-Jiménez, Custodia, Hölzel, Michael, Goding, Colin R

“…Phenotypic and metabolic heterogeneity within tumors is a major barrier to effective cancer therapy. How metabolism is implicated in specific phenotypes and…”
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Glycan expression profile of signet ring cell gastric cancer cells and potential applicability of rBC2LCN-targeted lectin drug conjugate therapy Autor Yang, Yu, Akashi, Yoshimasa, Shimomura, Osamu, Tateno, Hiroaki, Saito, Sayoko, Hiemori, Keiko, Miyazaki, Yoshihiro, Furuta, Tomoaki, Kitaguchi, Daichi, Kuroda, Yukihito, Pakavarin, Louphrasitthiphol, Oda, Tatsuya

“…Background Signet ring cell carcinoma (SRC) is a distinct subtype of gastric cancer (GC); however, the specific characteristics of cancer cell surface glycans…”
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Novel positron emission tomography imaging targeting cell surface glycans for pancreatic cancer: 18F‐labeled rBC2LCN lectin Autor Kuroda, Yukihito, Oda, Tatsuya, Shimomura, Osamu, Louphrasitthiphol, Pakavarin, Mathis, Bryan J., Tateno, Hiroaki, Hatano, Kentaro

“…Advancement in early detection modalities will greatly improve the overall prognoses of pancreatic ductal adenocarcinoma (PDAC). For this purpose, we report a…”
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The MITF-SOX10 regulated long non-coding RNA DIRC3 is a melanoma tumour suppressor Autor Coe, Elizabeth A., Tan, Jennifer Y., Shapiro, Michael, Louphrasitthiphol, Pakavarin, Bassett, Andrew R., Marques, Ana C., Goding, Colin R., Vance, Keith W.

“…The MITF and SOX10 transcription factors regulate the expression of genes important for melanoma proliferation, invasion and metastasis. Despite growing…”
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MITF controls the TCA cycle to modulate the melanoma hypoxia response Autor Louphrasitthiphol, Pakavarin, Ledaki, Ioanna, Chauhan, Jagat, Falletta, Paola, Siddaway, Robert, Buffa, Francesca M., Mole, David R., Soga, Tomoyoshi, Goding, Colin R.

“…In response to the dynamic intra‐tumor microenvironment, melanoma cells adopt distinct phenotypic states associated with differential expression of the…”
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Lectin‐based phototherapy targeting cell surface glycans for pancreatic cancer Autor Kuroda, Yukihito, Oda, Tatsuya, Shimomura, Osamu, Hashimoto, Shinji, Akashi, Yoshimasa, Miyazaki, Yoshihiro, Furuya, Kinji, Furuta, Tomoaki, Nakahashi, Hiromitsu, Louphrasitthiphol, Pakavarin, Mathis, Bryan J, Nakajima, Takahito, Tateno, Hiroaki

“…Pancreatic ductal adenocarcinoma (PDAC) is resistant to current treatments but lectin‐based therapy targeting cell surface glycans could be a promising new…”
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TBX2 controls a proproliferative gene expression program in melanoma Autor Lu, Sizhu, Louphrasitthiphol, Pakavarin, Goradia, Nishit, Lambert, Jean-Philippe, Schmidt, Johannes, Chauhan, Jagat, Rughani, Milap G, Larue, Lionel, Wilmanns, Matthias, Goding, Colin R

“…Senescence shapes embryonic development, plays a key role in aging, and is a critical barrier to cancer initiation, yet how senescence is regulated remains…”
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Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution Autor Louphrasitthiphol, Pakavarin, Siddaway, Robert, Loffreda, Alessia, Pogenberg, Vivian, Friedrichsen, Hans, Schepsky, Alexander, Zeng, Zhiqiang, Lu, Min, Strub, Thomas, Freter, Rasmus, Lisle, Richard, Suer, Eda, Thomas, Benjamin, Schuster-Böckler, Benjamin, Filippakopoulos, Panagis, Middleton, Mark, Lu, Xin, Patton, E Elizabeth, Davidson, Irwin, Lambert, Jean-Philippe, Wilmanns, Matthias, Steingrímsson, Eiríkur, Mazza, Davide, Goding, Colin R

“…It is widely assumed that decreasing transcription factor DNA-binding affinity reduces transcription initiation by diminishing occupancy of sequence-specific…”
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Acetylation reprograms MITF target selectivity and residence time Autor Louphrasitthiphol, Pakavarin, Loffreda, Alessia, Pogenberg, Vivian, Picaud, Sarah, Schepsky, Alexander, Friedrichsen, Hans, Zeng, Zhiqiang, Lashgari, Anahita, Thomas, Benjamin, Patton, E. Elizabeth, Wilmanns, Matthias, Filippakopoulos, Panagis, Lambert, Jean-Philippe, Steingrímsson, Eiríkur, Mazza, Davide, Goding, Colin R.

“…The ability of transcription factors to discriminate between different classes of binding sites associated with specific biological functions underpins…”
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Hypoxia at 3D organoid establishment selects essential subclones within heterogenous pancreatic cancer Autor Kumano, Koichiro, Nakahashi, Hiromitsu, Louphrasitthiphol, Pakavarin, Kuroda, Yukihito, Miyazaki, Yoshihiro, Shimomura, Osamu, Hashimoto, Shinji, Akashi, Yoshimasa, Mathis, Bryan J., Kim, Jaejeong, Owada, Yohei, Goding, Colin R., Oda, Tatsuya

“…Pancreatic ductal adenocarcinoma (PDAC) is especially hypoxic and composed of heterogeneous cell populations containing hypoxia-adapted cells. Hypoxia as a…”
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ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma Autor Lu, Yuting, Travnickova, Jana, Badonyi, Mihaly, Rambow, Florian, Coates, Andrea, Khan, Zaid, Marques, Jair, Murphy, Laura C., Garcia-Martinez, Pablo, Marais, Richard, Louphrasitthiphol, Pakavarin, Chan, Alex H.Y., Schofield, Christopher J., von Kriegsheim, Alex, Marsh, Joseph A., Pavet, Valeria, Sansom, Owen J., Illingworth, Robert S., Patton, E. Elizabeth

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Aberrant Glycosylation in Pancreatic Ductal Adenocarcinoma 3D Organoids Is Mediated by KRAS Mutations Autor Nakahashi, Hiromitsu, Oda, Tatsuya, Shimomura, Osamu, Akashi, Yoshimasa, Takahashi, Kazuhiro, Miyazaki, Yoshihiro, Furuta, Tomoaki, Kuroda, Yukihito, Louphrasitthiphol, Pakavarin, Mathis, Bryan J., Tateno, Hiroaki

“…Aberrant glycosylation in tumor cells is a hallmark during carcinogenesis. KRAS gene mutations are the most well-known oncogenic abnormalities but their…”
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TFE3 promotes ferroptosis in melanoma Autor Dias, Diogo, Louphrasitthiphol, Pakavarin, Goding, Colin R.

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ABCB5 is activated by MITF and β‐catenin and is associated with melanoma differentiation Autor Louphrasitthiphol, Pakavarin, Chauhan, Jagat, Goding, Colin R.

“…Defining markers of different phenotypic states in melanoma is important for understanding disease progression, determining the response to therapy, and…”
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Isorhamnetin exerts anti-proliferative effect on cancer-associated fibroblasts by inducing cell cycle arrest Autor Ganbold, Munkhzul, Louphrasitthiphol, Pakavarin, Miyamoto, Takafumi, Miyazaki, Yoshihiro, Oda, Tatsuya, Tominaga, Kenichi, Isoda, Hiroko

“…Isorhamnetin (ISO), a dietary flavonoid, has been shown to possess antioxidant, anti-cancer, and anti-inflammatory properties. Cancer-associated fibroblasts…”
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Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition Autor Berns, H Matthew, Watkins-Chow, Dawn E, Lu, Sizhu, Louphrasitthiphol, Pakavarin, Zhang, Tongwu, Brown, Kevin M, Moura-Alves, Pedro, Goding, Colin R, Pavan, William J

“…The human Red Hair Color (RHC) trait is caused by increased pheomelanin (red-yellow) and reduced eumelanin (black-brown) pigment in skin and hair due to…”
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Novel positron emission tomography imaging targeting cell surface glycans for pancreatic cancer: 18 F ‐labeled rBC2LCN lectin Autor Kuroda, Yukihito, Oda, Tatsuya, Shimomura, Osamu, Louphrasitthiphol, Pakavarin, Mathis, Bryan J., Tateno, Hiroaki, Hatano, Kentaro

“…Advancement in early detection modalities will greatly improve the overall prognoses of pancreatic ductal adenocarcinoma (PDAC). For this purpose, we report a…”
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Macrophage Cytoplasmic Transfer in Melanoma Invasion Autor Louphrasitthiphol, Pakavarin, Goding, Colin R

“…Within tumors, macrophage infiltration can promote cancer cell invasiveness and, consequently, metastatic dissemination. In this issue of Developmental Cell,…”
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DNA damage remodels the MITF interactome to increase melanoma genomic instability Autor Binet, Romuald, Lambert, Jean-Philippe, Tomkova, Marketa, Tischfield, Samuel, Baggiolini, Arianna, Picaud, Sarah, Sarkar, Sovan, Louphrasitthiphol, Pakavarin, Dias, Diogo, Carreira, Suzanne, Humphrey, Timothy C, Fillipakopoulos, Panagis, White, Richard, Goding, Colin R

“…Since genome instability can drive cancer initiation and progression, cells have evolved highly effective and ubiquitous DNA damage response (DDR) programs…”
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