Výsledky vyhledávání - "Loria, J Patrick"

Eigenvector centrality for characterization of protein allosteric pathways Autor Negre, Christian F A, Morzan, Uriel N, Hendrickson, Heidi P, Pal, Rhitankar, Lisi, George P, Loria, J Patrick, Rivalta, Ivan, Ho, Junming, Batista, Victor S

“…Determining the principal energy-transfer pathways responsible for allosteric communication in biomolecules remains challenging, partially due to the intrinsic…”
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Solution NMR Spectroscopy for the Study of Enzyme Allostery Autor Lisi, George P, Loria, J Patrick

“…Allostery is a ubiquitous biological regulatory process in which distant binding sites within a protein or enzyme are functionally and thermodynamically…”
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Conformational motions regulate phosphoryl transfer in related protein tyrosine phosphatases Autor Whittier, Sean K, Hengge, Alvan C, Loria, J Patrick

“…Many studies have implicated a role for conformational motions during the catalytic cycle, acting to optimize the binding pocket or facilitate product release,…”
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Phosphorylation of a Human Microprotein Promotes Dissociation of Biomolecular Condensates Autor Na, Zhenkun, Luo, Yang, Cui, Danica S, Khitun, Alexandra, Smelyansky, Stephanie, Loria, J Patrick, Slavoff, Sarah A

“…Proteogenomic identification of translated small open reading frames in humans has revealed thousands of microproteins, or polypeptides of fewer than 100 amino…”
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A deubiquitylase with an unusually high-affinity ubiquitin-binding domain from the scrub typhus pathogen Orientia tsutsugamushi Autor Berk, Jason M., Lim, Christopher, Ronau, Judith A., Chaudhuri, Apala, Chen, Hongli, Beckmann, John F., Loria, J. Patrick, Xiong, Yong, Hochstrasser, Mark

“…Ubiquitin mediated signaling contributes critically to host cell defenses during pathogen infection. Many pathogens manipulate the ubiquitin system to evade…”
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Using NMR spectroscopy to elucidate the role of molecular motions in enzyme function Autor Lisi, George P., Patrick Loria, J.

“…Conformational motions play an essential role in enzyme function, often facilitating the formation of enzyme-substrate complexes and/or product release…”
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A simple method to determine changes in the affinity between HisF and HisH in the Imidazole Glycerol Phosphate Synthase heterodimer Autor Almeida, Vitor M., Loria, J. Patrick, Marana, Sandro R.

“…The bi-enzyme HisF-HisH heterodimer is part of the pathway that produces histidine and purines in bacteria and lower eukaryotes, but it is absent in mammals…”
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Allosteric Control of Enzyme Activity: From Ancient Origins to Recent Gene-Editing Technologies Autor Reiss, Krystle, Batista, Victor S, Loria, J Patrick

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Allosteric pathways in imidazole glycerol phosphate synthase Autor Rivalta, Ivan, Sultan, Mohammad M, Lee, Ning-Shiuan, Manley, Gregory A, Loria, J Patrick, Batista, Victor S

“…Protein allosteric pathways are investigated in the imidazole glycerol phosphate synthase heterodimer in an effort to elucidate how the effector (PRFAR,…”
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Altering the allosteric pathway in IGPS suppresses millisecond motions and catalytic activity Autor Lisi, George P, East, Kyle W, Batista, Victor S, Loria, J Patrick

“…Imidazole glycerol phosphate synthase (IGPS) is a V-type allosteric enzyme, meaning that its catalytic rate is critically dependent on activation by its…”
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Turning up the heat mimics allosteric signaling in imidazole-glycerol phosphate synthase Autor Maschietto, Federica, Morzan, Uriel N., Tofoleanu, Florentina, Gheeraert, Aria, Chaudhuri, Apala, Kyro, Gregory W., Nekrasov, Peter, Brooks, Bernard, Loria, J. Patrick, Rivalta, Ivan, Batista, Victor S.

“…Allosteric drugs have the potential to revolutionize biomedicine due to their enhanced selectivity and protection against overdosage. However, we need to…”
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Dissecting Dynamic Allosteric Pathways Using Chemically Related Small-Molecule Activators Autor Lisi, George P, Manley, Gregory A, Hendrickson, Heidi, Rivalta, Ivan, Batista, Victor S, Loria, J Patrick

“…The allosteric mechanism of the heterodimeric enzyme imidazole glycerol phosphate synthase was studied in detail with solution nuclear magnetic resonance…”
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Author Correction: Turning up the heat mimics allosteric signaling in imidazole-glycerol phosphate synthase Autor Maschietto, Federica, Morzan, Uriel N., Tofoleanu, Florentina, Gheeraert, Aria, Chaudhuri, Apala, Kyro, Gregory W., Nekrasov, Peter, Brooks, Bernard, Loria, J. Patrick, Rivalta, Ivan, Batista, Victor S.

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Characterization of enzyme motions by solution NMR relaxation dispersion Autor Loria, J Patrick, Berlow, Rebecca B, Watt, Eric D

“…In many enzymes, conformational changes that occur along the reaction coordinate can pose a bottleneck to the rate of conversion of substrates to products…”
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Allosteric Communication Disrupted by a Small Molecule Binding to the Imidazole Glycerol Phosphate Synthase Protein-Protein Interface Autor Rivalta, Ivan, Lisi, George P, Snoeberger, Ning-Shiuan, Manley, Gregory, Loria, J Patrick, Batista, Victor S

“…Allosteric enzymes regulate a wide range of catalytic transformations, including biosynthetic mechanisms of important human pathogens, upon binding of…”
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What's in your buffer? Solute altered millisecond motions detected by solution NMR Autor Wong, Madeline, Khirich, Gennady, Loria, J Patrick

“…To date, little work has been conducted on the relationship between solute and buffer molecules and conformational exchange motion in enzymes. This study uses…”
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I260Q DNA polymerase β highlights precatalytic conformational rearrangements critical for fidelity Autor Liptak, Cary, Mahmoud, Mariam M, Eckenroth, Brian E, Moreno, Marcus V, East, Kyle, Alnajjar, Khadijeh S, Huang, Ji, Towle-Weicksel, Jamie B, Doublié, Sylvie, Loria, J Patrick, Sweasy, Joann B

“…Abstract DNA polymerase β (pol β) fills single nucleotide gaps in DNA during base excision repair and non-homologous end-joining. Pol β must select the correct…”
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Nanometer propagation of millisecond motions in V-type allostery Autor Lipchock, James M, Loria, J Patrick

“…Imidazole glycerol phosphate synthase (IGPS) is a V-type allosteric enzyme, which is catalytically inactive for glutamine hydrolysis until the allosteric…”
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The mechanism of rate-limiting motions in enzyme function Autor Watt, Eric D, Shimada, Hiroko, Kovrigin, Evgenii L, Loria, J Patrick

“…The ability to use conformational flexibility is a hallmark of enzyme function. Here we show that protein motions and catalytic activity in a RNase are coupled…”
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Movement and specificity in a modular DNA binding protein Autor Liptak, Cary, Loria, J Patrick

“…The single-stranded DNA (ssDNA) binding protein RPA binds to and protects ssDNA while simultaneously recruiting numerous replication and repair proteins…”
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