Suchergebnisse - "Lord, Simon"

Is it still worth pursuing the repurposing of metformin as a cancer therapeutic? von Lord, Simon R, Harris, Adrian L

“… Over the past 15 years, there has been great interest in the potential to repurpose the diabetes drug, metformin, as a cancer treatment. However, despite …”
Volltext

Implications of obesity and insulin resistance for the treatment of oestrogen receptor-positive breast cancer von Javed, Sohail Rooman, Skolariki, Aglaia, Zameer, Mohammed Zeeshan, Lord, Simon R

“… Breast cancer is the most common cancer in women, and incidence rates are rising, it is thought in part, due to increasing levels of obesity. Endocrine therapy …”
Volltext

Window of opportunity clinical trial designs to study cancer metabolism von Aroldi, Francesca, Lord, Simon R.

“… Window of opportunity trials exploit the ‘window’ of time after cancer diagnosis, typically prior to initiation of cancer therapy. In recent years this study …”
Volltext

Repressing expression of difficult‐to‐express recombinant proteins during the selection process increases productivity of CHO stable pools von Maltais, Jean‐Sébastien, Lord Dufour, Simon, Morasse, Audrey, Stuible, Matthew, Loignon, Martin, Durocher, Yves

“… NRC publication: Yes …”
Volltext

Trastuzumab duocarmazine in locally advanced and metastatic solid tumours and HER2-expressing breast cancer: a phase 1 dose-escalation and dose-expansion study von Banerji, Udai, van Herpen, Carla M L, Saura, Cristina, Thistlethwaite, Fiona, Lord, Simon, Moreno, Victor, Macpherson, Iain R, Boni, Valentina, Rolfo, Christian, de Vries, Elisabeth G E, Rottey, Sylvie, Geenen, Jill, Eskens, Ferry, Gil-Martin, Marta, Mommers, Ellen C, Koper, Norbert P, Aftimos, Philippe

“… Trastuzumab duocarmazine is a novel HER2-targeting antibody–drug conjugate comprised of trastuzumab covalently bound to a linker drug containing duocarmycin …”
Volltext

Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib von Coombes, R. C., Howell, Sacha, Lord, Simon R., Kenny, Laura, Mansi, Janine, Mitri, Zahi, Palmieri, Carlo, Chap, Linnea I., Richards, Paul, Gradishar, William, Sardesai, Sagar, Melear, Jason, O’Shaughnessy, Joyce, Ward, Patrick, Chalasani, Pavani, Arkenau, Tobias, Baird, Richard D., Jeselsohn, Rinath, Ali, Simak, Clack, Glen, Bahl, Ashwani, McIntosh, Stuart, Krebs, Matthew G.

“… Samuraciclib is a selective oral CDK7-inhibitor. A multi-modular, open-label Phase I study to evaluate safety and tolerability of samuraciclib in patients with …”
Volltext

Obesity: a perfect storm for carcinogenesis von Harris, Benjamin H. L., Macaulay, Valentine M., Harris, David A., Klenerman, Paul, Karpe, Fredrik, Lord, Simon R., Harris, Adrian L., Buffa, Francesca M.

“… Obesity-related cancers account for 40% of the cancer cases observed in the USA and obesity is overtaking smoking as the most widespread modifiable risk factor …”
Volltext

Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer von Lord, Simon R, Cheng, Wei-Chen, Liu, Dan, Gaude, Edoardo, Haider, Syed, Metcalf, Tom, Patel, Neel, Teoh, Eugene J, Gleeson, Fergus, Bradley, Kevin, Wigfield, Simon, Zois, Christos, McGowan, Daniel R, Ah-See, Mei-Lin, Thompson, Alastair M, Sharma, Anand, Bidaut, Luc, Pollak, Michael, Roy, Pankaj G, Karpe, Fredrik, James, Tim, English, Ruth, Adams, Rosie F, Campo, Leticia, Ayers, Lisa, Snell, Cameron, Roxanis, Ioannis, Frezza, Christian, Fenwick, John D, Buffa, Francesca M, Harris, Adrian L

“… Late-phase clinical trials investigating metformin as a cancer therapy are underway. However, there remains controversy as to the mode of action of metformin …”
Weitere Angaben

Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation von Bensaad, Karim, Favaro, Elena, Lewis, Caroline A., Peck, Barrie, Lord, Simon, Collins, Jennifer M., Pinnick, Katherine E., Wigfield, Simon, Buffa, Francesca M., Li, Ji-Liang, Zhang, Qifeng, Wakelam, Michael J.O., Karpe, Fredrik, Schulze, Almut, Harris, Adrian L.

“… An in vivo model of antiangiogenic therapy allowed us to identify genes upregulated by bevacizumab treatment, including Fatty Acid Binding Protein 3 (FABP3) …”
Volltext

Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer von Morotti, Matteo, Bridges, Esther, Valli, Alessandro, Choudhry, Hani, Sheldon, Helen, Wigfield, Simon, Gray, Nicki, Zois, Christos E, Grimm, Fiona, Jones, Dylan, Teoh, Eugene J, Cheng, Wei-Chen, Lord, Simon, Anastasiou, Dimitrios, Haider, Syed, McIntyre, Alan, Goberdhan, Deborah C I, Buffa, Francesca, Harris, Adrian L

“… Tumor hypoxia is associated with poor patient outcomes in estrogen receptor-α-positive (ERα ) breast cancer. Hypoxia is known to affect tumor growth by …”
Weitere Angaben

New role of fat-free mass in cancer risk linked with genetic predisposition von Harris, Benjamin H. L., Di Giovannantonio, Matteo, Zhang, Ping, Harris, David A., Lord, Simon R., Allen, Naomi E., Maughan, Tim S., Bryant, Richard J., Harris, Adrian L., Bond, Gareth L., Buffa, Francesca M.

“… Cancer risk is associated with the widely debated measure body mass index (BMI). Fat mass and fat-free mass measurements from bioelectrical impedance may …”
Volltext

A CHO stable pool production platform for rapid clinical development of trimeric SARS‐CoV‐2 spike subunit vaccine antigens von Joubert, Simon, Stuible, Matthew, Lord‐Dufour, Simon, Lamoureux, Linda, Vaillancourt, François, Perret, Sylvie, Ouimet, Manon, Pelletier, Alex, Bisson, Louis, Mahimkar, Rohan, Pham, Phuong Lan, L'Ecuyer-Coelho, Helene, Roy, Marjolaine, Voyer, Robert, Baardsnes, Jason, Sauvageau, Janelle, St-Michael, Frank, Robotham, Anna, Kelly, John, Acel, Andrea, Schrag, Joseph D, El Bakkouri, Majida, Durocher, Yves

“… NRC publication: Yes …”
Volltext

Author Correction: Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib von Coombes, R. C., Howell, Sacha, Lord, Simon R., Kenny, Laura, Mansi, Janine, Mitri, Zahi, Palmieri, Carlo, Chap, Linnea I., Richards, Paul, Gradishar, William, Sardesai, Sagar, Melear, Jason, O’Shaughnessy, Joyce, Ward, Patrick, Chalasani, Pavani, Arkenau, Tobias, Baird, Richard D., Jeselsohn, Rinath, Ali, Simak, Clack, Glen, Bahl, Ashwani, McIntosh, Stuart, Krebs, Matthew G.

Volltext

A First-in-Class mAb (BI-1607) Targeting FcγRIIB: Preclinical Data and First-in-Human Studies in Patients with HER2-Positive Advanced Solid Tumors von Cortés, Javier, Priego, Araceli, Garralda, Elena, Rojas, Katerin, Lord, Simon R, Goetze, Thorsten O, Kuemmel, Sherko, Crabb, Simon J, Parra-Guillen, Zinnia P, Borggren, Marie, Karlsson, Ingrid, Lindahl, Danijela, Mårtensson, Linda, Oldham, Robert, Ropenga, Anna, Teige, Ingrid, Wallin, Johan, Frendeus, Björn, McAllister, Andres

“… BI-1607 is a human mAb that specifically blocks FcγRIIB, the sole inhibitory Fc receptor and master regulator of humoral and innate immune homeostasis. These …”
Weitere Angaben

The Impact of Body Mass Index (BMI) on Clinical Outcomes for Patients Receiving Systemic Anti-Cancer Therapies for Advanced Clear Cell Renal Carcinoma von Greene, John, Wang, Zhe, Harris, Benjamin H. L., Dodwell, David, Lord, Simon R.

“… This project reviewed the impact of an individual’s weight on the treatment they received for advanced kidney cancer …”
Volltext

Transcriptomic analysis of human primary breast cancer identifies fatty acid oxidation as a target for metformin von Lord, Simon R., Collins, Jennifer M., Cheng, Wei-Chen, Haider, Syed, Wigfield, Simon, Gaude, Edoardo, Fielding, Barbara A., Pinnick, Katherine E., Harjes, Ulrike, Segaran, Ashvina, Jha, Pooja, Hoefler, Gerald, Pollak, Michael N., Thompson, Alastair M., Roy, Pankaj G., English, Ruth, Adams, Rosie F., Frezza, Christian, Buffa, Francesca M., Karpe, Fredrik, Harris, Adrian L.

“… Background Epidemiological studies suggest that metformin may reduce the incidence of cancer in patients with diabetes and multiple late phase clinical trials …”
Volltext

New soluble angiopoietin analog of Hepta‐ANG1 prevents pathological vascular leakage von Liu, Pan, Ryczko, Michael, Xie, Xinfang, Baardsnes, Jason, Lord‐Dufour, Simon, Duroche, Yves, Hicks, Emily Anne, Taiyab, Aftab, Sheardown, Heather, Quaggin, Susan E, Jin, Jing

“… Vascular leak is a key driver of organ injury in diseases, and strategies that reduce enhanced permeability and vascular inflammation are promising therapeutic …”
Volltext

Author Correction: Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib von Coombes, R. C., Howell, Sacha, Lord, Simon R., Kenny, Laura, Mansi, Janine, Mitri, Zahi, Palmieri, Carlo, Chap, Linnea I., Richards, Paul, Gradishar, William, Sardesai, Sagar, Melear, Jason, O’Shaughnessy, Joyce, Ward, Patrick, Chalasani, Pavani, Arkenau, Tobias, Baird, Richard D., Jeselsohn, Rinath, Ali, Simak, Clack, Glen, Bahl, Ashwani, McIntosh, Stuart, Krebs, Matthew G.

Volltext

Predicting 10-year breast cancer mortality risk in the general female population in England: a model development and validation study von Clift, Ash Kieran, Collins, Gary S, Lord, Simon, Petrou, Stavros, Dodwell, David, Brady, Michael, Hippisley-Cox, Julia

“… Identifying female individuals at highest risk of developing life-threatening breast cancers could inform novel stratified early detection and prevention …”
Volltext

Role of PI3K/Akt/mTOR pathway in mediating endocrine resistance: concept to clinic von Skolariki, Aglaia, D’Costa, Jamie, Little, Martin, Lord, Simon

“… The majority of breast cancers express the estrogen receptor (ER) and for this group of patients, endocrine therapy is the cornerstone of systemic treatment …”
Volltext