Search Results - "Long non-coding RNA"

Potential of long non‐coding RNAs in cancer patients: From biomarkers to therapeutic targets by Chandra Gupta, Subash, Nandan Tripathi, Yashoda

“…Because of high specificity and easy detection in the tissues, serum, plasma, urine and saliva, interest in exploring the potential of long non‐coding RNAs…”
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Molecular mechanisms of long noncoding RNAs and their role in disease pathogenesis by Hu, Guoku, Niu, Fang, Humburg, Bree A, Liao, Ke, Bendi, Sunil, Callen, Shannon, Fox, Howard S, Buch, Shilpa

“…LncRNAs are long non-coding regulatory RNAs that are longer than 200 nucleotides. One of the major functions of lncRNAs is the regulation of specific gene…”
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Emerging roles of long non‐coding RNA in cancer by Sanchez Calle, Anna, Kawamura, Yumi, Yamamoto, Yusuke, Takeshita, Fumitaka, Ochiya, Takahiro

“…Since comprehensive analysis of the mammalian genome revealed that the majority of genomic products are transcribed in long non‐coding RNA (lncRNA), increasing…”
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Long non‐coding RNAs in development and disease: conservation to mechanisms by Tsagakis, Ioannis, Douka, Katerina, Birds, Isabel, Aspden, Julie L

“…Our genomes contain the blueprint of what makes us human and many indications as to why we develop disease. Until the last 10 years, most studies had focussed…”
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Long non‐coding RNA SNHG14 contributes to gastric cancer development through targeting miR‐145/SOX9 axis by Liu, Zhao, Yan, Yan, Cao, Sizhe, Chen, Yi

“…This study aimed to elucidate the roles of long non‐coding RNA SNHG14 in gastric cancer development. LncRNA SNHG14 was markedly up‐regulated in gastric cancer…”
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KLF7-IT1-ARPC2 axis in macrophages orchestrates caspase-4-driven hypercoagulation in sepsis by Wang, Xiangyu, Lu, Yanyan, Yuan, Chuang, Yang, Xinyu

“…Sepsis is characterized by dysregulated inflammation and coagulation leading to organ dysfunction, yet the molecular mechanisms linking these processes remain…”
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Long non-coding RNAs (lncRNAs); roles in tumorigenesis and potentials as biomarkers in cancer diagnosis by Najafi, Sajad, Khatami, Seyyed Hossein, Khorsand, Marjan, Jamali, Zeinab, Shabaninejad, Zahra, Moazamfard, Mostafa, Majidpoor, Jamal, Aghaei Zarch, Seyed Mohsen, Movahedpour, Ahmad

“…New research has indicated that long non-coding RNAs (lncRNAs) play critical roles in a broad range of biological processes, including the pathogenesis of many…”
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Long Non-Coding RNAs: The Regulatory Mechanisms, Research Strategies, and Future Directions in Cancers by Gao, Na, Li, Yueheng, Li, Jing, Gao, Zhengfan, Yang, Zhenzhen, Li, Yong, Liu, Hongtao, Fan, Tianli

“…The development and application of whole genome sequencing technology has greatly broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs)…”
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LncRNA VEAL2 regulates PRKCB2 to modulate endothelial permeability in diabetic retinopathy by Sehgal, Paras, Mathew, Samatha, Sivadas, Ambily, Ray, Arjun, Tanwar, Jyoti, Vishwakarma, Sushma, Ranjan, Gyan, Shamsudheen, K V, Bhoyar, Rahul C, Pateria, Abhishek, Leonard, Elvin, Lalwani, Mukesh, Vats, Archana, Pappuru, Rajeev R, Tyagi, Mudit, Jakati, Saumya, Sengupta, Shantanu, B K, Binukumar, Chakrabarti, Subhabrata, Kaur, Inderjeet, Motiani, Rajender K, Scaria, Vinod, Sivasubbu, Sridhar

“…Long non‐coding RNAs (lncRNAs) are emerging as key regulators of endothelial cell function. Here, we investigated the role of a novel vascular…”
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Lung cancer cells and their sensitivity/resistance to cisplatin chemotherapy: Role of microRNAs and upstream mediators by Ashrafizadeh, Milad, Zarrabi, Ali, Hushmandi, Kiavash, Hashemi, Farid, Moghadam, Ebrahim Rahmani, Owrang, Marzieh, Hashemi, Fardin, Makvandi, Pooyan, Goharrizi, Mohammad Ali Sheikh Beig, Najafi, Masoud, Khan, Haroon

“…Cisplatin (CP) is a well-known chemotherapeutic agent with excellent clinical effects. The anti-tumor activity of CP has been demonstrated in different cancers…”
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New insights into the interplay between long non‐coding RNAs and RNA‐binding proteins in cancer by Yao, Zi‐Ting, Yang, Yan‐Ming, Sun, Miao‐Miao, He, Yan, Liao, Long, Chen, Kui‐Sheng, Li, Bin

“…With the development of proteomics and epigenetics, a large number of RNA‐binding proteins (RBPs) have been discovered in recent years, and the interaction…”
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Research Progress on the Pathogenesis of Knee Osteoarthritis by Du, Xin, Liu, Zi‐yu, Tao, Xing‐xing, Mei, Yong‐liang, Zhou, Da‐qian, Cheng, Kang, Gao, Si‐long, Shi, Hou‐yin, Song, Chao, Zhang, Xiao‐min

“…Knee osteoarthritis (KOA) is a chronic joint bone disease characterized by inflammatory destruction and hyperplasia of bone. Its main clinical symptoms are…”
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The complex role of MEG3: An emerging long non-coding RNA in breast cancer by Hussain, Md Sadique, Majami, Abdullah A., Ali, Haider, Gupta, Gaurav, Almalki, Waleed Hassan, Alzarea, Sami I., Kazmi, Imran, Syed, Rahamat Unissa, Khalifa, Nasrin E., Bin Break, Mohammed Khaled, Khan, Ruqaiyah, Altwaijry, Najla, Sharma, Rahul

“…MEG3, a significant long non-coding RNA (lncRNA), substantially functions in diverse biological processes, particularly breast cancer (BC) development. Within…”
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LncRNA XIST functions as a molecular sponge of miR‐194‐5p to regulate MAPK1 expression in hepatocellular carcinoma cell by Kong, Qinglei, Zhang, Shaoquan, Liang, Caiqian, Zhang, Ying, Kong, Qingcong, Chen, Shuxian, Qin, Jie, Jin, Yi

“…Increasing evidence highlights the important role of XIST, a long non‐coding RNA (lncRNA), in the regulation of multiple cancers. However, the underlying…”
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CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA by Conigliaro, Alice, Costa, Viviana, Lo Dico, Alessia, Saieva, Laura, Buccheri, Simona, Dieli, Francesco, Manno, Mauro, Raccosta, Samuele, Mancone, Carmine, Tripodi, Marco, De Leo, Giacomo, Alessandro, Riccardo

“…Background CD90+ liver cancer cells have been described as cancer stem-cell-like (CSC), displaying aggressive and metastatic phenotype. Using two different in…”
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Recent advances on the roles of LncRNAs in cardiovascular disease by Fang, Yexian, Xu, Yuerong, Wang, Runze, Hu, Lang, Guo, Dong, Xue, Feng, Guo, Wangang, Zhang, Dongwei, Hu, Jianqiang, Li, Yan, Zhang, Wei, Zhang, Mingming

“…Cardiovascular diseases are a main cause of mortality whose prevalence continues to increase worldwide. Long non‐coding RNAs (lncRNAs) regulate a variety of…”
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Long non‐coding RNAs and prostate cancer by Misawa, Aya, Takayama, Ken‐ichi, Inoue, Satoshi

“…Long non‐coding RNAs (lncRNAs) are RNA transcripts larger than 200 nucleotides that do not code for proteins the aberrant expression of which has been…”
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A novel autophagy‐related lncRNA survival model for lung adenocarcinoma by Wu, Liwei, Wen, Zilu, Song, Yanzheng, Wang, Lin

“…Long non‐coding RNA (lncRNA) is an important regulatory factor in the development of lung adenocarcinoma, which is related to the control of autophagy. LncRNA…”
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Long noncoding RNA MALAT-1 is a new potential therapeutic target for castration resistant prostate cancer by Ren, Shancheng, Liu, Yawei, Xu, Weidong, Sun, Yi, Lu, Ji, Wang, Fubo, Wei, Min, Shen, Jian, Hou, Jianguo, Gao, Xu, Xu, Chuanliang, Huang, Jiaoti, Zhao, Yi, Sun, Yinghao

“…To understand the role of MALAT-1 in prostate cancer we evaluated its expression in prostate cancer tissues and cell lines. We also studied the therapeutic…”
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Evaluation of serum exosomal LncRNA‐based biomarker panel for diagnosis and recurrence prediction of bladder cancer by Zhang, Shujun, Du, Lutao, Wang, Lishui, Jiang, Xiumei, Zhan, Yao, Li, Juan, Yan, Keqiang, Duan, Weili, Zhao, Yinghui, Wang, Lili, Wang, Yunshan, Shi, Yuliang, Wang, Chuanxin

“…Exosomes are small membrane vesicles released by many cells. These vesicles can mediate cellular communications by transmitting active molecules including long…”
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