Suchergebnisse - "Loftus, Brendan J."

Methicillin Resistance Alters the Biofilm Phenotype and Attenuates Virulence in Staphylococcus aureus Device-Associated Infections von Pozzi, Clarissa, Waters, Elaine M., Rudkin, Justine K., Schaeffer, Carolyn R., Lohan, Amanda J., Tong, Pin, Loftus, Brendan J., Pier, Gerald B., Fey, Paul D., Massey, Ruth C., O'Gara, James P.

“… Clinical isolates of Staphylococcus aureus can express biofilm phenotypes promoted by the major cell wall autolysin and the fibronectin-binding proteins or the …”
Volltext

Genome sequencing of the extinct Eurasian wild aurochs, Bos primigenius, illuminates the phylogeography and evolution of cattle von Park, Stephen D E, Magee, David A., McGettigan, Paul A., Teasdale, Matthew D., Edwards, Ceiridwen J., Lohan, Amanda J., Murphy, Alison, Braud, Martin, Donoghue, Mark T., Liu, Yuan, Chamberlain, Andrew T., Rue-Albrecht, Kévin, Schroeder, Steven, Spillane, Charles, Tai, Shuaishuai, Bradley, Daniel G., Sonstegard, Tad S., Loftus, Brendan J., MacHugh, David E.

“… Background Domestication of the now-extinct wild aurochs, Bos primigenius , gave rise to the two major domestic extant cattle taxa, B. taurus and B. indicus  …”
Volltext

Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation von Brien, Gerard L, Gambero, Guillermo, O'Connell, David J, Jerman, Emilia, Turner, Siobhán A, Egan, Chris M, Dunne, Eiseart J, Jurgens, Maike C, Wynne, Kieran, Piao, Lianhua, Lohan, Amanda J, Ferguson, Neil, Shi, Xiaobing, Sinha, Krishna M, Loftus, Brendan J, Cagney, Gerard, Bracken, Adrian P

“… How Polycomb repressive complex 2 (PRC2) is recruited to active chromatin to mediate transcriptional silencing during lineage specification in metazoans has …”
Volltext

BINDER: computationally inferring a gene regulatory network for Mycobacterium abscessus von Staunton, Patrick M., Miranda-CasoLuengo, Aleksandra A., Loftus, Brendan J., Gormley, Isobel Claire

“… Background Although many of the genic features in Mycobacterium abscessus have been fully validated, a comprehensive understanding of the regulatory elements …”
Volltext

Sequencing Illustrates the Transcriptional Response of Legionella pneumophila during Infection and Identifies Seventy Novel Small Non-Coding RNAs von Weissenmayer, Barbara A., Prendergast, James G. D., Lohan, Amanda J., Loftus, Brendan J.

“… Second generation sequencing has prompted a number of groups to re-interrogate the transcriptomes of several bacterial and archaeal species. One of the central …”
Volltext

Characterization of the equine skeletal muscle transcriptome identifies novel functional responses to exercise training von McGivney, Beatrice A, McGettigan, Paul A, Browne, John A, Evans, Alexander CO, Fonseca, Rita G, Loftus, Brendan J, Lohan, Amanda, MacHugh, David E, Murphy, Barbara A, Katz, Lisa M, Hill, Emmeline W

“… Background Digital gene expression profiling was used to characterize the assembly of genes expressed in equine skeletal muscle and to identify the subset of …”
Volltext

A Complete Mitochondrial Genome Sequence from a Mesolithic Wild Aurochs (Bos primigenius) von Edwards, Ceiridwen J., Magee, David A., Park, Stephen D. E., McGettigan, Paul A., Lohan, Amanda J., Murphy, Alison, Finlay, Emma K., Shapiro, Beth, Chamberlain, Andrew T., Richards, Martin B., Bradley, Daniel G., Loftus, Brendan J., MacHugh, David E.

“… The derivation of domestic cattle from the extinct wild aurochs (Bos primigenius) has been well-documented by archaeological and genetic studies. Genetic …”
Volltext

Molecular aspects of mucin biosynthesis and mucus formation in the bovine cervix during the periestrous period von Pluta, Katarzyna, McGettigan, Paul A, Reid, Colm J, Browne, John A, Irwin, Jane A, Tharmalingam, Tharmala, Corfield, Anthony, Baird, Alan, Loftus, Brendan J, Evans, Alexander C O, Carrington, Stephen D

“… Mucus within the cervical canal represents a hormonally regulated barrier that reconciles the need to exclude the vaginal microflora from the uterus during …”
Weitere Angaben

The intestinal protozoan parasite Entamoeba histolytica contains 20 cysteine protease genes, of which only a small subset is expressed during in vitro cultivation von Bruchhaus, Iris, Loftus, Brendan J, Hall, Neil, Tannich, Egbert

“… Cysteine proteases are known to be important pathogenicity factors of the protozoan parasite Entamoeba histolytica. So far, a total of eight genes coding for …”
Weitere Angaben

Relaxed Selection Drives a Noisy Noncoding Transcriptome in Members of the Mycobacterium tuberculosis Complex von Dinan, Adam M., Tong, Pin, Lohan, Amanda J., Conlon, Kevin M., Miranda-CasoLuengo, Aleksandra A., Malone, Kerri M., Gordon, Stephen V., Loftus, Brendan J.

“… Related species are often used to understand the molecular underpinning of virulence through examination of a shared set of biological features attributable to …”
Volltext

The diversity of Rab GTPases in Entamoeba histolytica von Saito-Nakano, Yumiko, Loftus, Brendan J., Hall, Neil, Nozaki, Tomoyoshi

“… Rab proteins are ubiquitous small GTP-binding proteins that form a highly conserved family and regulate vesicular trafficking. Recent completion of the genome …”
Volltext

Functional characterization of the Mycobacterium abscessus genome coupled with condition specific transcriptomics reveals conserved molecular strategies for host adaptation and persistence von Miranda-CasoLuengo, Aleksandra A., Staunton, Patrick M., Dinan, Adam M., Lohan, Amanda J., Loftus, Brendan J.

“… Background Mycobacterium abscessus subsp. abscessus (MAB) is a highly drug resistant mycobacterium and the most common respiratory pathogen among the rapidly …”
Volltext

Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling von Clarke, Michael, Lohan, Amanda J, Liu, Bernard, Lagkouvardos, Ilias, Roy, Scott, Zafar, Nikhat, Bertelli, Claire, Schilde, Christina, Kianianmomeni, Arash, Bürglin, Thomas R, Frech, Christian, Turcotte, Bernard, Kopec, Klaus O, Synnott, John M, Choo, Caleb, Paponov, Ivan, Finkler, Aliza, Heng Tan, Chris Soon, Hutchins, Andrew P, Weinmeier, Thomas, Rattei, Thomas, Chu, Jeffery SC, Gimenez, Gregory, Irimia, Manuel, Rigden, Daniel J, Fitzpatrick, David A, Lorenzo-Morales, Jacob, Bateman, Alex, Chiu, Cheng-Hsun, Tang, Petrus, Hegemann, Peter, Fromm, Hillel, Raoult, Didier, Greub, Gilbert, Miranda-Saavedra, Diego, Chen, Nansheng, Nash, Piers, Ginger, Michael L, Horn, Matthias, Schaap, Pauline, Caler, Lis, Loftus, Brendan J

“… Background The Amoebozoa constitute one of the primary divisions of eukaryotes, encompassing taxa of both biomedical and evolutionary importance, yet its …”
Volltext

Evidence for lateral transfer of genes encoding ferredoxins, nitroreductases, NADH oxidase, and alcohol dehydrogenase 3 from anaerobic prokaryotes to Giardia lamblia and Entamoeba histolytica von Nixon, Julie E J, Wang, Amy, Field, Jessica, Morrison, Hilary G, McArthur, Andrew G, Sogin, Mitchell L, Loftus, Brendan J, Samuelson, John

“… Giardia lamblia and Entamoeba histolytica are amitochondriate, microaerophilic protists which use fermentation enzymes like those of bacteria to survive …”
Weitere Angaben

Entamoeba histolytica: Observations on metabolism based on the genome sequence von Anderson, Iain J., Loftus, Brendan J.

“… The sequencing of the genome of Entamoeba histolytica has allowed a reconstruction of its metabolic pathways, many of which are unusual for a eukaryote. Based …”
Volltext

High-throughput transcriptomics reveals common and strain-specific responses of human macrophages to infection with Mycobacterium abscessus Smooth and Rough variants von Aulicino, Anna, Dinan, Adam M., Miranda-CasoLuengo, Aleksandra A., Browne, John A., Rue-Albrecht, Kévin, MacHugh, David E., Loftus, Brendan J.

“… Background Mycobacterium abscessus (MAB) is an emerging pathogen causing pulmonary infections in those with inflammatory lung disorders, such as Cystic …”
Volltext

Whole-transcriptome, high-throughput RNA sequence analysis of the bovine macrophage response to Mycobacterium bovis infection in vitro von Nalpas, Nicolas C, Park, Stephen DE, Magee, David A, Taraktsoglou, Maria, Browne, John A, Conlon, Kevin M, Rue-Albrecht, Kévin, Killick, Kate E, Hokamp, Karsten, Lohan, Amanda J, Loftus, Brendan J, Gormley, Eamonn, Gordon, Stephen V, MacHugh, David E

“… Background Mycobacterium bovis , the causative agent of bovine tuberculosis, is an intracellular pathogen that can persist inside host macrophages during …”
Volltext

The Aedes aegypti glutathione transferase family von Lumjuan, Nongkran, Stevenson, Bradley J., Prapanthadara, La-aied, Somboon, Pradya, Brophy, Peter M., Loftus, Brendan J., Severson, David W., Ranson, Hilary

“… In this report, we describe the glutathione transferase (GST) gene family in the dengue vector Aedes aegypti and suggest a novel role for a new class of …”
Volltext

TIGRFAMs: a protein family resource for the functional identification of proteins von Haft, D. H.

“… TIGRFAMs is a collection of protein families featuring curated multiple sequence alignments, hidden Markov models and associated information designed to …”
Volltext

(Non-)translational medicine: targeting bacterial RNA von Dinan, Adam M., Loftus, Brendan J.

“… The rise and spread of antibiotic resistance is among the most severe challenges facing modern medicine. Despite this fact, attempts to develop novel classes …”
Volltext