Výsledky vyhľadávania - "Liptay, Martin"

H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours Autor Dibitetto, Diego, Liptay, Martin, Vivalda, Francesca, Dogan, Hülya, Gogola, Ewa, González Fernández, Martín, Duarte, Alexandra, Schmid, Jonas A., Decollogny, Morgane, Francica, Paola, Przetocka, Sara, Durant, Stephen T., Forment, Josep V., Klebic, Ismar, Siffert, Myriam, de Bruijn, Roebi, Kousholt, Arne N., Marti, Nicole A., Dettwiler, Martina, Sørensen, Claus S., Tille, Jean-Christophe, Undurraga, Manuela, Labidi-Galy, Intidhar, Lopes, Massimo, Sartori, Alessandro A., Jonkers, Jos, Rottenberg, Sven

“…Histone H2AX plays a key role in DNA damage signalling in the surrounding regions of DNA double-strand breaks (DSBs). In response to DNA damage, H2AX becomes…”
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Replication Fork Remodeling and Therapy Escape in DNA Damage Response-Deficient Cancers Autor Liptay, Martin, Barbosa, Joana S., Rottenberg, Sven

“…Most cancers have lost a critical DNA damage response (DDR) pathway during tumor evolution. These alterations provide a useful explanation for the initial…”
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MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells Autor Zelceski, Anabel, Francica, Paola, Lingg, Lea, Mutlu, Merve, Stok, Colin, Liptay, Martin, Alexander, John, Baxter, Joseph S., Brough, Rachel, Gulati, Aditi, Haider, Syed, Raghunandan, Maya, Song, Feifei, Sridhar, Sandhya, Forment, Josep V., O’Connor, Mark J., Davies, Barry R., van Vugt, Marcel A.T.M., Krastev, Dragomir B., Pettitt, Stephen J., Tutt, Andrew N.J., Rottenberg, Sven, Lord, Christopher J.

“…The PSMC3IP-MND1 heterodimer promotes meiotic D loop formation before DNA strand exchange. In genome-scale CRISPR-Cas9 mutagenesis and interference screens in…”
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DNA-PKcs promotes fork reversal and chemoresistance Autor Dibitetto, Diego, Marshall, Shannon, Sanchi, Andrea, Liptay, Martin, Badar, Jumana, Lopes, Massimo, Rottenberg, Sven, Smolka, Marcus B

“…The DNA-PKcs kinase mediates the repair of DNA double-strand breaks via classical non-homologous end joining (NHEJ). DNA-PKcs is also recruited to active…”
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Overview of the biomedical research in the newly established Laboratory of Genome Integrity at the Palacky University, Olomouc Autor Loubalová, Zuzana, Jahodíková, Kamila, Liptay, Martin

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H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours Autor Dibitetto, Diego, Liptay, Martin, Vivalda, Francesca, Gogola, Ewa, Dogan, Hulya, Fernández, Martín G., Duarte, Alexandra, Schmid, Jonas A., Durant, Stephen T., Forment, Josep V., Klebic, Ismar, Siffert, Myriam, de Bruijn, Roebi, Kousholt, Arne N., Marti, Nicole A., Dettwiler, Martina, Sørensen, Claus S., Lopes, Massimo, Sartori, Alessandro A., Jonkers, Jos, Rottenberg, Sven

“…Histone H2AX plays a key role in DNA damage signalling in the surrounding regions of DNA double-strand breaks (DSBs)1,2. In response to DNA damage, H2AX…”
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MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells Autor Zelceski, Anabel, Francica, Paola, Lingg, Lea, Mutlu, Merve, Stok, Colin, Liptay, Martin, Alexander, John, Baxter, Joseph S., Brough, Rachel, Gulati, Aditi, Haider, Syed, Raghunandan, Maya, Song, Feifei, Sridhar, Sandhya, Forment, Josep V., O’Connor, Mark J., Davies, Barry R., van Vugt, Marcel A.T.M., Krastev, Dragomir B., Pettitt, Stephen J., Tutt, Andrew N. J., Rottenberg, Sven, Lord, Christopher J.

“…The PSMC3IP-MND1 heterodimer promotes RAD51 and DMC1-dependent D-loop formation during meiosis in yeast and mammalian organisms. For this purpose, it catalyzes…”
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MDC1 counteracts restrained replication fork restart and its loss causes chemoresistance in BRCA1/2-deficient mammary tumors Autor Liptay, Martin, Barbosa, Joana S., Gogola, Ewa, Duarte, Alexandra A., Dibitetto, Diego, Schmid, Jonas A., Klebic, Ismar, Mutlu, Merve, Siffert, Myriam, Francica, Paola, Salguero, Israel, van de Ven, Marieke, Korte-Grimmerink, Renske de, Jackson, Stephen P., Jonkers, Jos, Lopes, Massimo, Rottenberg, Sven

“…MDC1 is a key protein in DNA damage signaling. When DNA double-strand breaks (DSBs) occur, MDC1 localizes to sites of damage to promote the recruitment of…”
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