Výsledky vyhľadávania - "Linn, Sabine C"

10 year survival after breast-conserving surgery plus radiotherapy compared with mastectomy in early breast cancer in the Netherlands: a population-based study Autor van Maaren, Marissa C, de Munck, Linda, de Bock, Geertruida H, Jobsen, Jan J, van Dalen, Thijs, Linn, Sabine C, Poortmans, Philip, Strobbe, Luc J A, Siesling, Sabine

“…Investigators of registry-based studies report improved survival for breast-conserving surgery plus radiotherapy compared with mastectomy in early breast…”
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Comprehensive trends in incidence, treatment, survival and mortality of first primary invasive breast cancer stratified by age, stage and receptor subtype in the Netherlands between 1989 and 2017 Autor Meer, Daniël J., Kramer, Iris, Maaren, Marissa C., Diest, Paul J., Linn, Sabine, Maduro, John H., Strobbe, Luc, Siesling, Sabine, Schmidt, Marjanka K., Voogd, Adri C.

“…Our study aimed to provide a comprehensive overview of trends in incidence, survival, mortality and treatment of first primary invasive breast cancer (BC),…”
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Neoadjuvant chemotherapy with or without anthracyclines in the presence of dual HER2 blockade for HER2-positive breast cancer (TRAIN-2): a multicentre, open-label, randomised, phase 3 trial Autor van Ramshorst, Mette S, van der Voort, Anna, van Werkhoven, Erik D, Mandjes, Ingrid A, Kemper, Inge, Dezentjé, Vincent O, Oving, Irma M, Honkoop, Aafke H, Tick, Lidwine W, van de Wouw, Agnes J, Mandigers, Caroline M, van Warmerdam, Laurence J, Wesseling, Jelle, Vrancken Peeters, Marie-Jeanne T, Linn, Sabine C, Sonke, Gabe S

“…The optimal chemotherapy backbone for dual HER2 blockade in the neoadjuvant setting for early breast cancer is unknown. We investigated whether the addition of…”
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De-escalation of radiotherapy after primary chemotherapy in cT1–2N1 breast cancer (RAPCHEM; BOOG 2010–03): 5-year follow-up results of a Dutch, prospective, registry study Autor de Wild, Sabine R, de Munck, Linda, Simons, Janine M, Verloop, Janneke, van Dalen, Thijs, Elkhuizen, Paula H M, Houben, Ruud M A, van Leeuwen, A Elise, Linn, Sabine C, Pijnappel, Ruud M, Poortmans, Philip M P, Strobbe, Luc J A, Wesseling, Jelle, Voogd, Adri C, Boersma, Liesbeth J

“…Primary chemotherapy in breast cancer poses a dilemma with regard to adjuvant locoregional radiotherapy, as guidelines for locoregional radiotherapy were…”
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Cancer-immune interactions in ER-positive breast cancers: PI3K pathway alterations and tumor-infiltrating lymphocytes Autor Sobral-Leite, Marcelo, Salomon, Izhar, Opdam, Mark, Kruger, Dinja T., Beelen, Karin J., van der Noort, Vincent, van Vlierberghe, Ronald L. P., Blok, Erik J., Giardiello, Daniele, Sanders, Joyce, Van de Vijver, Koen, Horlings, Hugo M., Kuppen, Peter J. K., Linn, Sabine C., Schmidt, Marjanka K., Kok, Marleen

“…Introduction The presence of tumor-infiltrating lymphocytes (TILs) is correlated with good prognosis and outcome after (immuno)therapy in triple-negative and…”
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Prognosis of women with primary breast cancer diagnosed during pregnancy: results from an international collaborative study Autor Amant, Frédéric, von Minckwitz, Gunter, Han, Sileny N, Bontenbal, Marijke, Ring, Alistair E, Giermek, Jerzy, Wildiers, Hans, Fehm, Tanja, Linn, Sabine C, Schlehe, Bettina, Neven, Patrick, Westenend, Pieter J, Müller, Volkmar, Van Calsteren, Kristel, Rack, Brigitte, Nekljudova, Valentina, Harbeck, Nadia, Untch, Michael, Witteveen, Petronella O, Schwedler, Kathrin, Thomssen, Christoph, Van Calster, Ben, Loibl, Sibylle

“…We aimed to determine the prognosis of patients with breast cancer diagnosed during pregnancy (BCP). In this cohort study, a multicentric registry of patients…”
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Late effects of high-dose adjuvant chemotherapy on white and gray matter in breast cancer survivors: Converging results from multimodal magnetic resonance imaging Autor de Ruiter, Michiel B., Reneman, Liesbeth, Boogerd, Willem, Veltman, Dick J., Caan, Matthan, Douaud, Gwenaëlle, Lavini, Cristina, Linn, Sabine C., Boven, Epie, van Dam, Frits S.A.M., Schagen, Sanne B.

“…The neural substrate underlying cognitive impairments after chemotherapy is largely unknown. Here, we investigated very late (>9 years) effects of adjuvant…”
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Cognitive effects of endocrine therapy for breast cancer: keep calm and carry on? Autor Zwart, Wilbert, Terra, Huub, Linn, Sabine C., Schagen, Sanne B.

“…Key Points Preclinical and clinical data indicate that endocrine treatment for breast cancer might have an adverse effect on cognition Many studies exploring…”
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A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer Autor Berns, Katrien, Horlings, Hugo M, Hennessy, Bryan T, Madiredjo, Mandy, Hijmans, E Marielle, Beelen, Karin, Linn, Sabine C, Gonzalez-Angulo, Ana Maria, Stemke-Hale, Katherine, Hauptmann, Michael, Beijersbergen, Roderick L, Mills, Gordon B, van de Vijver, Marc J, Bernards, René

“…A large-scale RNA interference screen to discover genes involved in trastuzumab resistance in breast cancer identified only PTEN as a modulator of drug…”
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Can predictive biomarkers in breast cancer guide adjuvant endocrine therapy? Autor Beelen, Karin, Zwart, Wilbert, Linn, Sabine C.

“…Most studies for identifying biomarkers for oestrogen receptor-α (ERα)-positive breast cancer have been performed using material from consecutive series of…”
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Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer Autor Severson, Tesa M., Kim, Yongsoo, Joosten, Stacey E. P., Schuurman, Karianne, van der Groep, Petra, Moelans, Cathy B., ter Hoeve, Natalie D., Manson, Quirine F., Martens, John W., van Deurzen, Carolien H. M., Barbe, Ellis, Hedenfalk, Ingrid, Bult, Peter, Smit, Vincent T. H. B. M., Linn, Sabine C., van Diest, Paul J., Wessels, Lodewyk, Zwart, Wilbert

“…Male breast cancer (MBC) is rare and poorly characterized. Like the female counterpart, most MBCs are hormonally driven, but relapse after hormonal treatment…”
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Immune landscape of breast tumors with low and intermediate estrogen receptor expression Autor Voorwerk, Leonie, Sanders, Joyce, Keusters, Milou S., Balduzzi, Sara, Cornelissen, Sten, Duijst, Maxime, Lips, Esther H., Sonke, Gabe S., Linn, Sabine C., Horlings, Hugo M., Kok, Marleen

“…Immune checkpoint blockade (ICB) is currently approved for patients with triple-negative breast cancer (TNBC), whereas responses to ICB are also observed in a…”
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Effects of tamoxifen and exemestane on cognitive functioning of postmenopausal patients with breast cancer: results from the neuropsychological side study of the tamoxifen and exemestane adjuvant multinational trial Autor Schilder, Christina M, Seynaeve, Caroline, Beex, Louk V, Boogerd, Willem, Linn, Sabine C, Gundy, Chad M, Huizenga, Hilde M, Nortier, Johan W, van de Velde, Cornelis J, van Dam, Frits S, Schagen, Sanne B

“…To evaluate the influence of adjuvant tamoxifen and exemestane on cognitive functioning in postmenopausal patients with breast cancer (BC). Neuropsychological…”
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High-dose chemotherapy for patients with stage III breast cancer with homologous recombination deficiency: a discrete choice experiment among healthcare providers Autor Verbeek, Joost G.E., Azarang, Leyla, Pilli, Luis E., De Jong, Vincent M.T., Jager, Agnes, Linn, Sabine C., Retèl, Valesca P., Van Harten, Wim H.

“…Background and purpose: High-dose chemotherapy with autologous stem cell rescue (HDCT) is currently under investigation as a potential therapy for patients…”
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Effects of Pharmacogenetics on the Pharmacokinetics and Pharmacodynamics of Tamoxifen Autor de Vries Schultink, Aurelia H. M., Zwart, Wilbert, Linn, Sabine C., Beijnen, Jos H., Huitema, Alwin D. R.

“…The antiestrogenic drug tamoxifen is widely used in the treatment of estrogen receptor-α-positive breast cancer and substantially decreases recurrence and…”
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Prognostication and treatment predictions for estrogen receptor positive early-stage breast cancer: incorporating the 70-gene signature into the PREDICT prognostication model Autor Engelhardt, Ellen G., Binuya, Mary Ann E., Pharoah, Paul D.P., Poncet, Coralie, Rutgers, Emiel J.T., Piccart, Martine, Cardoso, Fatima, van ‘t Veer, Laura J., Steyerberg, Ewout W., Linn, Sabine C., Schmidt, Marjanka K.

“…The 70-gene signature (70-GS) has been shown to identify women at low-risk of distant recurrence who can safely forgo adjuvant chemotherapy. Incorporating this…”
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predictive value of the 70-gene signature for adjuvant chemotherapy in early breast cancer Autor Knauer, Michael, Mook, Stella, Rutgers, Emiel J. T, Bender, Richard A, Hauptmann, Michael, van de Vijver, Marc J, Koornstra, Rutger H. T, Bueno-de-Mesquita, Jolien M, Linn, Sabine C, van 't Veer, Laura J

“…Multigene assays have been developed and validated to determine the prognosis of breast cancer. In this study, we assessed the additional predictive value of…”
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Genomic patterns resembling BRCA1- and BRCA2-mutated breast cancers predict benefit of intensified carboplatin-based chemotherapy Autor Vollebergh, Marieke A, Lips, Esther H, Nederlof, Petra M, Wessels, Lodewyk FA, Wesseling, Jelle, vd Vijver, Marc J, de Vries, Elisabeth GE, van Tinteren, Harm, Jonkers, Jos, Hauptmann, Michael, Rodenhuis, Sjoerd, Linn, Sabine C

“…Introduction BRCA -mutated breast cancer cells lack the DNA-repair mechanism homologous recombination that is required for error-free DNA double-strand break…”
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Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model Autor Meuwissen, Ralph, Linn, Sabine C, Linnoila, R Ilona, Zevenhoven, John, Mooi, Wolter J, Berns, Anton

“…Small cell lung cancer (SCLC) is a highly aggressive human tumor with a more than 95% mortality rate. Its ontogeny and molecular pathogenesis remains poorly…”
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BRCAness digitalMLPA profiling predicts benefit of intensified platinum-based chemotherapy in triple-negative and luminal-type breast cancer Autor Lips, Esther H., Benard-Slagter, Anne, Opdam, Mark, Scheerman, Caroline E., Wesseling, Jelle, Hogervorst, Frans B. L., Linn, Sabine C., Savola, Suvi, Nederlof, Petra M.

“…Background We previously showed that BRCA-like profiles can be used to preselect individuals with the highest risk of carrying BRCA mutations but could also…”
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