Suchergebnisse - "Lima, Marcelo A."

Unfractionated heparin inhibits live wild type SARS‐CoV‐2 cell infectivity at therapeutically relevant concentrations von Tree, Julia A., Turnbull, Jeremy E., Buttigieg, Karen R., Elmore, Michael J., Coombes, Naomi, Hogwood, John, Mycroft‐West, Courtney J., Lima, Marcelo A., Skidmore, Mark A., Karlsson, Richard, Chen, Yen‐Hsi, Yang, Zhang, Spalluto, Cosma Mirella, Staples, Karl J., Yates, Edwin A., Gray, Elaine, Singh, Dave, Wilkinson, Tom, Page, Clive P., Carroll, Miles W.

“… Background and Purpose Currently, there are no licensed vaccines and limited antivirals for the treatment of COVID‐19. Heparin (delivered systemically) is …”
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Aurora kinase genetic polymorphisms: an association study in Down syndrome and spontaneous abortion von de Castro, Carolina Monteiro Leite, Pereira, Carolina Oliveto Bastos, Aprigio, Joissy, Costa Lima, Marcelo A., Ribeiro, Márcia G., Amorim, Márcia Rodrigues

“… Aneuploidies, such as Down syndrome (DS), are the leading cause of pregnancy loss. Abnormalities in aurora kinase proteins result in genomic instability and …”
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A modular, reusable biocatalytic flow system for UDP-GlcNAc production von Roberts, Tom L, Dolan, Jonathan P, Miller, Gavin J, Lima, Marcelo A. D, Cosgrove, Sebastian C

“… We report here the continuous flow synthesis of a high-value sugar nucleotide. Immobilisation of enzymes onto solid carriers permitted transfer of the …”
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Subverting the mechanisms of cell death: flavivirus manipulation of host cell responses to infection von Vicenzi, Elisa, Pagani, Isabel, Ghezzi, Silvia, Taylor, Sarah L, Rudd, Timothy R, Lima, Marcelo A, Skidmore, Mark A, Yates, Edwin A

“… Viruses exploit host metabolic and defence machinery for their own replication. The flaviviruses, which include Dengue (DENV), Yellow Fever (YFV), Japanese …”
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Glycosaminoglycans from Litopenaeus vannamei Inhibit the Alzheimer’s Disease β Secretase, BACE1 von Mycroft-West, Courtney J., Devlin, Anthony J., Cooper, Lynsay C., Guimond, Scott E., Procter, Patricia, Guerrini, Marco, Miller, Gavin J., Fernig, David G., Yates, Edwin A., Lima, Marcelo A., Skidmore, Mark A.

“… Only palliative therapeutic options exist for the treatment of Alzheimer’s Disease; no new successful drug candidates have been developed in over 15 years. The …”
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Inhibition of BACE1, the β-secretase implicated in Alzheimer's disease, by a chondroitin sulfate extract from Sardina pilchardus von Mycroft-West, Courtney, Devlin, Anthony, Cooper, Lynsay, Procter, Patricia, Miller, Gavin, Fernig, David, Guerrini, Marco, Guimond, Scott, Lima, Marcelo, Yates, Edwin, Skidmore, Mark

“… The pharmaceutical and anticoagulant agent heparin, a member of the glycosaminoglycan family of carbohydrates, has previously been identified as a potent …”
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Crude Heparin Preparations Unveil the Presence of Structurally Diverse Oversulfated Contaminants von Mendes, Aline, Meneghetti, Maria C. Z., Palladino, Marcelly Valle, Justo, Giselle Zenker, Sassaki, Guilherme L., Fareed, Jawed, Lima, Marcelo A., Nader, Helena B.

“… Nowadays, pharmaceutical heparin is purified from porcine and bovine intestinal mucosa. In the past decade there has been an ongoing concern about the safety …”
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Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domain von Schuurs, Zachariah P., Hammond, Edward, Elli, Stefano, Rudd, Timothy R., Mycroft-West, Courtney J., Lima, Marcelo A., Skidmore, Mark A., Karlsson, Richard, Chen, Yen-Hsi, Bagdonaite, Ieva, Yang, Zhang, Ahmed, Yassir A., Richard, Derek J., Turnbull, Jeremy, Ferro, Vito, Coombe, Deirdre R., Gandhi, Neha S.

“… [Display omitted] •Co-solvent MD simulation identified a putative glycosaminoglycan binding site.•Novel binding site identified at R246 and the mutated S247R …”
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A Glycosaminoglycan Extract from Portunus pelagicus Inhibits BACE1, the β Secretase Implicated in Alzheimer’s Disease von Mycroft-West, Courtney J., Cooper, Lynsay C., Devlin, Anthony J., Procter, Patricia, Guimond, Scott E., Guerrini, Marco, Fernig, David G., Lima, Marcelo A., Yates, Edwin A., Skidmore, Mark A.

“… Therapeutic options for Alzheimer’s disease, the most common form of dementia, are currently restricted to palliative treatments. The glycosaminoglycan …”
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Association of interleukin 4 and MTHFR gene polymorphisms with distal symmetrical polyneuropathy in young diabetics von Silva, Raquel Garcia Rocco da, Lima, Marcelo A. Costa, Moura, Claudia de Melo, Luescher, Jorge Luiz, Campos, Ludmila Nascimento Rodrigues, Silva, Daniel de Souza e, Ribeiro, Márcia Gonçalves

“… Background It is believed that genetic factors play a role in the development and severity of neural injury among people with distal symmetrical polyneuropathy …”
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History and Prospects for the Sustainability and Circularity of the Windowpane Oyster Placuna placenta Fishery in the Philippines von Rustia, Jessica M., Antonino, Judith P., Velasco, Ravelina R., Lima, Marcelo A., Yates, Edwin A., Fernig, David G.

“… The windowpane oyster Placuna placenta lives in brackish coastal waters and has long been economically important to the Philippines because of its durable and …”
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SULF2 overexpression positively regulates tumorigenicity of human prostate cancer cells von Vicente, Carolina M, Lima, Marcelo A, Nader, Helena B, Toma, Leny

“… Background SULF2 is a 6-O-endosulfatase which removes 6-O sulfate residues from N-glucosamine present on heparan sulfate (HS). The sulfation pattern of HS …”
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A new heparin fragment decreases liver ischemia-reperfusion injury von Vasques, Enio R, Figueira, Estela RR, Rocha-Filho, Joel A, Lanchotte, Cinthia, Ximenes, Jorge LS, Nader, Helena B, Tersariol, Ivarne LS, Lima, Marcelo A, Rodrigues, Tiago, Cunha, José EM, Chaib, Eleazar, D'Albuquerque, Luiz AC, Galvão, Flávio HF

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Insights into the N-Sulfation Mechanism: Molecular Dynamics Simulations of the N-Sulfotransferase Domain of Ndst1 and Mutants von Gesteira, Tarsis F., Pol-Fachin, Laércio, Coulson-Thomas, Vivien Jane, Lima, Marcelo A., Verli, Hugo, Nader, Helena B.

“… Sulfation patterns along glycosaminoglycan (GAG) chains dictate their functional role. The N-deacetylase N-sulfotransferase family (NDST) catalyzes the initial …”
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Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin von Mycroft-West, Courtney J., Su, Dunhao, Pagani, Isabel, Rudd, Timothy R., Elli, Stefano, Gandhi, Neha S., Guimond, Scott E., Miller, Gavin J., Meneghetti, Maria C. Z., Nader, Helena B., Li, Yong, Nunes, Quentin M., Procter, Patricia, Mancini, Nicasio, Clementi, Massimo, Bisio, Antonella, Forsyth, Nicholas R., Ferro, Vito, Turnbull, Jeremy E., Guerrini, Marco, Fernig, David G., Vicenzi, Elisa, Yates, Edwin A., Lima, Marcelo A., Skidmore, Mark A.

“… Abstract The dependence of development and homeostasis in animals on the interaction of hundreds of extracellular regulatory proteins with the peri- and …”
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Synthesis of 4-thio-d-glucopyranose and interconversion to 4-thio-d-glucofuranose von Porter, Jack, Lima, Marcelo A., Pongener, Imlirenla, Miller, Gavin J.

“… Sulfur containing glycosides offer an exciting prospect for inclusion within noncanonical glycan sequences, particularly as enabling probes for chemical …”
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Development of a nano-luciferase based assay to measure the binding of SARS-CoV-2 spike receptor binding domain to ACE-2 von Lima, Marcelo A., Skidmore, Mark, Khanim, Farhat, Richardson, Alan

“… To identify drugs that could potentially be used to treat infection with SARS-CoV-2, a high throughput 384-well assay was developed to measure the binding of …”
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High Accuracy Power Quality Evaluation under a Colored Noisy Condition by Filter Bank ESPRIT von Santos, Elaine, Khosravy, Mahdi, Lima, Marcelo A. A., Cerqueira, Augusto S., Duque, Carlos A., Yona, Atsushi

“… Due to the highly increasing integration of renewable energy sources with the power grid and their fluctuations, besides the recent growth of new power …”
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Heparan sulfate and heparin interactions with proteins von Meneghetti, Maria C Z, Hughes, Ashley J, Rudd, Timothy R, Nader, Helena B, Powell, Andrew K, Yates, Edwin A, Lima, Marcelo A

“… Heparan sulfate (HS) polysaccharides are ubiquitous components of the cell surface and extracellular matrix of all multicellular animals, whereas heparin is …”
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A novel method for power quality multiple disturbance decomposition based on Independent Component Analysis von Lima, Marcelo A.A., Cerqueira, Augusto S., Coury, Denis V., Duque, Carlos A.

“… ► We propose a method to decompose a power system signal into its isolated disturbances. ► We use Independent Component Analysis to separate disturbances …”
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