Suchergebnisse - "Lihm, Jayon"

Neoantigen quality predicts immunoediting in survivors of pancreatic cancer von Łuksza, Marta, Sethna, Zachary M., Rojas, Luis A., Lihm, Jayon, Bravi, Barbara, Elhanati, Yuval, Soares, Kevin, Amisaki, Masataka, Dobrin, Anton, Hoyos, David, Guasp, Pablo, Zebboudj, Abderezak, Yu, Rebecca, Chandra, Adrienne Kaya, Waters, Theresa, Odgerel, Zagaa, Leung, Joanne, Kappagantula, Rajya, Makohon-Moore, Alvin, Johns, Amber, Gill, Anthony, Gigoux, Mathieu, Wolchok, Jedd, Merghoub, Taha, Sadelain, Michel, Patterson, Erin, Monasson, Remi, Mora, Thierry, Walczak, Aleksandra M., Cocco, Simona, Iacobuzio-Donahue, Christine, Greenbaum, Benjamin D., Balachandran, Vinod P.

“… Cancer immunoediting 1 is a hallmark of cancer 2 that predicts that lymphocytes kill more immunogenic cancer cells to cause less immunogenic clones to dominate …”
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Systemic and Oligo-Acquired Resistance to PD-(L)1 Blockade in Lung Cancer von Schoenfeld, Adam J, Rizvi, Hira A, Memon, Danish, Shaverdian, Narek, Bott, Matthew J, Sauter, Jennifer L, Tsai, C Jillian, Lihm, Jayon, Hoyos, David, Plodkowski, Andrew J, Perez-Johnston, Rocio, Sawan, Peter, Egger, Jacklynn V, Greenbaum, Benjamin D, Rimner, Andreas, Riely, Gregory J, Rudin, Charles M, Rusch, Valerie W, Gomez, Daniel R, Hellmann, Matthew D

“… Clinical patterns and the associated optimal management of acquired resistance to PD-(L)1 blockade are poorly understood. All cases of metastatic lung cancer …”
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Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer von Rojas, Luis A., Sethna, Zachary, Soares, Kevin C., Olcese, Cristina, Pang, Nan, Patterson, Erin, Lihm, Jayon, Ceglia, Nicholas, Guasp, Pablo, Chu, Alexander, Yu, Rebecca, Chandra, Adrienne Kaya, Waters, Theresa, Ruan, Jennifer, Amisaki, Masataka, Zebboudj, Abderezak, Odgerel, Zagaa, Payne, George, Derhovanessian, Evelyna, Müller, Felicitas, Rhee, Ina, Yadav, Mahesh, Dobrin, Anton, Sadelain, Michel, Łuksza, Marta, Cohen, Noah, Tang, Laura, Basturk, Olca, Gönen, Mithat, Katz, Seth, Do, Richard Kinh, Epstein, Andrew S., Momtaz, Parisa, Park, Wungki, Sugarman, Ryan, Varghese, Anna M., Won, Elizabeth, Desai, Avni, Wei, Alice C., D’Angelica, Michael I., Kingham, T. Peter, Mellman, Ira, Merghoub, Taha, Wolchok, Jedd D., Sahin, Ugur, Türeci, Özlem, Greenbaum, Benjamin D., Jarnagin, William R., Drebin, Jeffrey, O’Reilly, Eileen M., Balachandran, Vinod P.

“… Pancreatic ductal adenocarcinoma (PDAC) is lethal in 88% of patients 1 , yet harbours mutation-derived T cell neoantigens that are suitable for vaccines 2 , 3 …”
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Clinical and molecular features of acquired resistance to immunotherapy in non-small cell lung cancer von Memon, Danish, Schoenfeld, Adam J, Ye, Darwin, Fromm, George, Rizvi, Hira, Zhang, Xiang, Keddar, Mohamed Reda, Mathew, Divij, Yoo, Kyung Jin, Qiu, Jingya, Lihm, Jayon, Miriyala, Jayalaksmi, Sauter, Jennifer L, Luo, Jia, Chow, Andrew, Bhanot, Umesh K, McCarthy, Caroline, Vanderbilt, Chad M, Liu, Cailian, Abu-Akeel, Mohsen, Plodkowski, Andrew J, McGranahan, Nicholas, Łuksza, Marta, Greenbaum, Benjamin D, Merghoub, Taha, Achour, Ikbel, Barrett, J Carl, Stewart, Ross, Beltrao, Pedro, Schreiber, Taylor H, Minn, Andy J, Miller, Martin L, Hellmann, Matthew D

“… Although immunotherapy with PD-(L)1 blockade is routine for lung cancer, little is known about acquired resistance. Among 1,201 patients with non-small cell …”
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RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer von Sethna, Zachary, Guasp, Pablo, Reiche, Charlotte, Milighetti, Martina, Ceglia, Nicholas, Patterson, Erin, Lihm, Jayon, Payne, George, Lyudovyk, Olga, Rojas, Luis A., Pang, Nan, Ohmoto, Akihiro, Amisaki, Masataka, Zebboudj, Abderezak, Odgerel, Zagaa, Bruno, Emmanuel M., Zhang, Siqi Linsey, Cheng, Charlotte, Elhanati, Yuval, Derhovanessian, Evelyna, Manning, Luisa, Müller, Felicitas, Rhee, Ina, Yadav, Mahesh, Merghoub, Taha, Wolchok, Jedd D., Basturk, Olca, Gönen, Mithat, Epstein, Andrew S., Momtaz, Parisa, Park, Wungki, Sugarman, Ryan, Varghese, Anna M., Won, Elizabeth, Desai, Avni, Wei, Alice C., D’Angelica, Michael I., Kingham, T. Peter, Soares, Kevin C., Jarnagin, William R., Drebin, Jeffrey, O’Reilly, Eileen M., Mellman, Ira, Sahin, Ugur, Türeci, Özlem, Greenbaum, Benjamin D., Balachandran, Vinod P.

“… A fundamental challenge for cancer vaccines is to generate long-lived functional T cells that are specific for tumour antigens. Here we find that mRNA–lipoplex …”
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De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability von McCarthy, S E, Gillis, J, Kramer, M, Lihm, J, Yoon, S, Berstein, Y, Mistry, M, Pavlidis, P, Solomon, R, Ghiban, E, Antoniou, E, Kelleher, E, O'Brien, C, Donohoe, G, Gill, M, Morris, D W, McCombie, W R, Corvin, A

“… Schizophrenia is a serious psychiatric disorder with a broadly undiscovered genetic etiology. Recent studies of de novo mutations (DNMs) in schizophrenia and …”
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AnnTools: a comprehensive and versatile annotation toolkit for genomic variants von Makarov, Vladimir, O'Grady, Tina, Cai, Guiqing, Lihm, Jayon, Buxbaum, Joseph D., Yoon, Seungtai

“… AnnTools is a versatile bioinformatics application designed for comprehensive annotation of a full spectrum of human genome variation: novel and known …”
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DNA sequence-level analyses reveal potential phenotypic modifiers in a large family with psychiatric disorders von Ryan, Niamh M, Lihm, Jayon, Kramer, Melissa, McCarthy, Shane, Morris, Stewart W, Arnau-Soler, Aleix, Davies, Gail, Duff, Barbara, Ghiban, Elena, Hayward, Caroline, Deary, Ian J, Blackwood, Douglas H R, Lawrie, Stephen M, McIntosh, Andrew M, Evans, Kathryn L, Porteous, David J, McCombie, W Richard, Thomson, Pippa A

“… Psychiatric disorders are a group of genetically related diseases with highly polygenic architectures. Genome-wide association analyses have made substantial …”
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BEYOND THE TRANSLOCATION: WHOLE GENOME SEQUENCING ANALYSIS OF THE SCOTTISH T(1;11) FAMILY von Ryan, Niamh, Lihm, Jayon, Kramer, Melissa, McCarthy, Shane, Evans, Kathryn, Ghiban, Elena, Millar, J. Kirsty, Scotland, Generation, McIntosh, Andrew, Blackwood, Douglas, Lawrie, Stephen, Porteous, David, McCombie, W. Richard, Thomson, Pippa

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SU7 - BEYOND THE TRANSLOCATION: WHOLE GENOME SEQUENCING ANALYSIS OF THE SCOTTISH T(1;11) FAMILY von Ryan, Niamh, Lihm, Jayon, Kramer, Melissa, McCarthy, Shane, Evans, Kathryn, Ghiban, Elena, Millar, J. Kirsty, Scotland, Generation, McIntosh, Andrew, Blackwood, Douglas, Lawrie, Stephen, Porteous, David, McCombie, W. Richard, Thomson, Pippa

“… Psychiatric illnesses are a group of genetically-related disorders with highly polygenic architecture and a significant environmental component. Even within …”
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Mixture modeling of next generation sequencing data and its applications to genotyping and estimating genotype frequencies von Lihm, Jayon

“… Estimating the probability that an individual has a base pair nucleodite different from the reference nucleotide is important in next generation sequencing …”
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Clinical and molecular features of acquired resistance to immunotherapy in non-small cell lung cancer von Memon, Danish, Rizvi, Hira, Fromm, George, Lihm, Jayon, Schoenfeld, Adam J, Sauter, Jennifer L, Luo, Jia, Chow, Andrew, Bhanot, Umesh K, Mccarthy, Caroline, Ye, Darwin, Vanderbilt, Chad M, Liu, Cailian, Abu-Akeel, Mohsen, Plodkowski, Andrew J, Mcgranahan, Nicholas, Luksza, Marta, Greenbaum, Benjamin D, Taha Merghoub, Minn, Andy J, Beltrao, Pedro, Schreiber, Taylor H, Miller, Martin L, Hellmann, Matthew D

“… Although cancer immunotherapy with PD-(L)1 blockade is now routine treatment for patients with lung cancer, remarkably little is known about acquired …”
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Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia von Teng, Shaolei, Thomson, Pippa, Mccarthy, Shane, Kramer, Melissa, Muller, Stephanie, Lihm, Jayon, Morris, Stewart, Soares, Dinesh, Hennah, William, Harris, Sarah, Luiz Miguel Camargo, Malkov, Vladislav, Mcintosh, Andrew, Millar, J Kirsty, Blackwood, Douglas, Evans, Kathryn, Deary, Ian, Porteous, David, Mccombie, W Richard

“… Schizophrenia (SCZ), bipolar disorder (BD) and recurrent major depressive disorder (rMDD) are common psychiatric illnesses. All have been associated with lower …”
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