Suchergebnisse - "Leucine - metabolism"

Blunting of insulin inhibition of proteolysis in legs of older subjects may contribute to age-related sarcopenia von Wilkes, Emilie A, Selby, Anna L, Atherton, Philip J, Patel, Rekha, Rankin, Debbie, Smith, Ken, Rennie, Michael J

“… We tested the hypothesis that suppression of leg protein breakdown (LPB) by insulin is blunted in older subjects, together with blunted activation of Akt-protein kinase …”
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Combined ingestion of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo in male subjects von Koopman, René, Wagenmakers, Anton J M, Manders, Ralph J F, Zorenc, Antoine H G, Senden, Joan M G, Gorselink, Marchel, Keizer, Hans A, van Loon, Luc J C

“… Eight male subjects were randomly assigned to three trials in which they consumed drinks containing either carbohydrate (CHO …”
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Quantifying protein kinetics in vivo: influence of precursor dynamics on product labeling von Yao, Huifang, Kelley, Seamus, Zhou, Dan, VanSickle, Sophie, Wang, Sheng-Ping, Piesvaux, Jennifer, Zhou, Haihong, Chen, Hao, McKenney, David, McLaren, David G, Ballard, Jeanine E, Previs, Stephen F

“… Protein kinetics can be quantified by coupling stable isotope tracer methods with mass spectrometry readouts; however, interconnected decision points in the …”
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Amadori and Heyns rearrangement products of bioactive peptides as potential new ligands of galectin-3 von Jakas, Andreja, Ayyalasomayajula, Ramya, Cudic, Mare

“… (Heyns compounds), was the subject of our study. The binding interactions between galectin-3 and the Amadori and Heyns compounds of leucine-enkephalin (YGGFL …”
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Leucine requirement determined in healthy young adult males using the indicator amino acid oxidation method von Szwiega, Sylwia, Pencharz, Paul B, Xu, Libai, Kong, Dehan, Tomlinson, Christopher, Elango, Rajavel, Courtney-Martin, Glenda

“… ), subjects received experimental diets containing the randomly assigned test leucine intake …”
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Branched-Chain Amino Acids as New Biomarkers of Major Depression - A Novel Neurobiology of Mood Disorder von Baranyi, Andreas, Amouzadeh-Ghadikolai, Omid, von Lewinski, Dirk, Rothenhäusler, Hans-Bernd, Theokas, Simon, Robier, Christoph, Mangge, Harald, Reicht, Gerhard, Hlade, Peter, Meinitzer, Andreas

“… The proteinogenic branched-chain amino acids (BCAAs) valine, leucine and isoleucine might play an unrecognised crucial role in the development of depression …”
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Molecular breath analysis supports altered amino acid metabolism in idiopathic pulmonary fibrosis von Gaugg, Martin Thomas, Engler, Anna, Bregy, Lukas, Nussbaumer‐Ochsner, Yvonne, Eiffert, Lara, Bruderer, Tobias, Zenobi, Renato, Sinues, Pablo, Kohler, Malcolm

“… ABSTRACT Background and objective Diagnosis of idiopathic pulmonary fibrosis (IPF) is complex and its pathogenesis is poorly understood. Recent findings …”
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Role of hyperglucagonemia in catabolism associated with type 1 diabetes: effects on leucine metabolism and the resting metabolic rate von Charlton, M R, Nair, K S

“… Role of hyperglucagonemia in catabolism associated with type 1 diabetes: effects on leucine metabolism and the resting metabolic rate …”
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PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase von D’Hulst, Gommaar, Soro-Arnaiz, Inés, Masschelein, Evi, Veys, Koen, Fitzgerald, Gillian, Smeuninx, Benoit, Kim, Sunghoon, Deldicque, Louise, Blaauw, Bert, Carmeliet, Peter, Breen, Leigh, Koivunen, Peppi, Zhao, Shi-Min, De Bock, Katrien

“… mTORC1 is an important regulator of muscle mass but how it is modulated by oxygen and nutrients is not completely understood. We show that loss of the prolyl …”
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Decreased rates of cerebral protein synthesis in conscious young adults with fragile X syndrome demonstrated by L-[1- 11 C]leucine PET von Schmidt, Kathleen C, Loutaev, Inna, Burlin, Thomas V, Thurm, Audrey, Sheeler, Carrie, Smith, Carolyn Beebe

“… We have previously reported increased rCPS in the knockout mouse model of FXS. To address the hypothesis in human subjects, we measured rCPS in young men with FXS with L-[1- C]leucine PET …”
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Ingestion of a protein hydrolysate is accompanied by an accelerated in vivo digestion and absorption rate when compared with its intact protein von Koopman, René, Crombach, Nico, Gijsen, Annemie P, Walrand, Stéphane, Fauquant, Jacques, Kies, Arie K, Lemosquet, Sophie, Saris, Wim H M, Boirie, Yves, van Loon, Luc J C

“… with its intact protein in vivo in humans. Ten elderly men (mean +/- SEM age: 64 +/- 1 y) were randomly assigned to a crossover experiment that involved 2 treatments in which the subjects consumed a 35-g bolus of specifically produced L-[1-(13)C …”
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Changes in basal and insulin and amino acid response of whole body and skeletal muscle proteins in obese men von Guillet, Christelle, Delcourt, Ingrid, Rance, Melanie, Giraudet, Christophe, Walrand, Stephane, Bedu, Mario, Duche, Pascale, Boirie, Yves

“… )C-leucine in six obese and eight nonobese subjects. Responses of WB glucose disposal rate and protein breakdown to insulin and amino acid infusion were significantly lower in obese than in nonobese subjects (P < 0.05 …”
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Phenylbutyrate-induced glutamine depletion in humans: effect on leucine metabolism von Darmaun, Dominique, Welch, Susan, Rini, Annie, Sager, Brenda K, Altomare, Astride, Haymond, Morey W

“… In a first group of three healthy subjects, graded doses (0, 0.18, and 0.36 g ⋅ kg ⋅ day ) of Φ …”
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Effect of glutamine on leucine metabolism in humans von Hankard, R G, Haymond, M W, Darmaun, D

“… h-1, equivalent to 0.11 g N/kg) on the other day. Seven additional subjects were studied using the same protocol except they received isonitrogenous infusion of glycine …”
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Analysis of L-leucine amino acid transporter species activity and gene expression by human blood brain barrier hCMEC/D3 model reveal potential LAT1, LAT4, B 0 AT2 and y + LAT1 functional cooperation von Taslimifar, Mehdi, Faltys, Martin, Kurtcuoglu, Vartan, Verrey, François, Makrides, Victoria

“… In the CNS, amino acid (AA) neurotransmitters and neurotransmitter precursors are subject to tight homeostatic control mediated by blood-brain barrier (BBB …”
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Distinct metabolism of apolipoproteins (a) and B-100 within plasma lipoprotein(a) von Diffenderfer, Margaret R., Lamon-Fava, Stefania, Marcovina, Santica M., Barrett, P. Hugh R., Lel, Julian, Dolnikowski, Gregory G., Berglund, Lars, Schaefer, Ernst J.

“… ]. All subjects received a primed constant infusion of [5,5,5-2H3] L-leucine while in the constantly fed state. Lp …”
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Fast-digestive protein supplement for ten days overcomes muscle anabolic resistance in healthy elderly men von Walrand, Stéphane, Gryson, Céline, Salles, Jérôme, Giraudet, Christophe, Migné, Carole, Bonhomme, Cécile, Le Ruyet, Pascale, Boirie, Yves

“… Adequate protein intake is crucial to maintain muscle protein content in elderly subjects, but quality of dietary proteins should be considered …”
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Glucose and Leucine Metabolism in Lung Tranplanted Patients on Low Dose of Steroids for Immunosuppressive Therapy von Benedini, S., Ruffini, E., Terruzzi, I., Mancuso, M., Luzi, L.

“… ± 0.29 mg/kg/d, and prednisone 8.25 mg/d for comparison with 6 healthy subjects, who were selected to be comparable to the recipients in terms of anthropometric features and age …”
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Substitution of venous for arterial blood sampling in the determination of regional rates of cerebral protein synthesis with L-[1- 11 C]leucine PET: A validation study von Tomasi, Giampaolo, Veronese, Mattia, Bertoldo, Alessandra, Smith, Carolyn B, Schmidt, Kathleen C

“… ]leucine PET scans with both arterial and venous blood sampling: 13 awake healthy volunteers, 10 sedated healthy volunteers, and 5 sedated subjects with fragile X syndrome …”
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Leucine metabolism in IDDM. Role of insulin and substrate availability von Luzi, L, Castellino, P, Simonson, D C, Petrides, A S, DeFronzo, R A

“… The effect of insulin on plasma amino acid concentrations and leucine metabolism was examined in 18 healthy nondiabetic young volunteers and in 7 subjects with insulin-dependent diabetes mellitus (IDDM …”
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