Suchergebnisse - "Leitsalu, Liis"

Cohort Profile: Estonian Biobank of the Estonian Genome Center, University of Tartu von Leitsalu, Liis, Haller, Toomas, Esko, Tõnu, Tammesoo, Mari-Liis, Alavere, Helene, Snieder, Harold, Perola, Markus, Ng, Pauline C, Mägi, Reedik, Milani, Lili, Fischer, Krista, Metspalu, Andres

“… The Estonian Biobank cohort is a volunteer-based sample of the Estonian resident adult population (aged ≥18 years). The current number of participants-close to …”
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Genotype-first approach to the detection of hereditary breast and ovarian cancer risk, and effects of risk disclosure to biobank participants von Leitsalu, Liis, Palover, Marili, Sikka, Timo Tõnis, Reigo, Anu, Kals, Mart, Pärn, Kalle, Nikopensius, Tiit, Esko, Tõnu, Metspalu, Andres, Padrik, Peeter, Tõnisson, Neeme

“… Genotype-first approach allows to systematically identify carriers of pathogenic variants in BRCA1/2 genes conferring a high risk of familial breast and …”
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Copy number variations and cognitive phenotypes in unselected populations von Männik, Katrin, Mägi, Reedik, Macé, Aurélien, Cole, Ben, Guyatt, Anna L, Shihab, Hashem A, Maillard, Anne M, Alavere, Helene, Kolk, Anneli, Reigo, Anu, Mihailov, Evelin, Leitsalu, Liis, Ferreira, Anne-Maud, Nõukas, Margit, Teumer, Alexander, Salvi, Erika, Cusi, Daniele, McGue, Matt, Iacono, William G, Gaunt, Tom R, Beckmann, Jacques S, Jacquemont, Sébastien, Kutalik, Zoltán, Pankratz, Nathan, Timpson, Nicholas, Metspalu, Andres, Reymond, Alexandre

“… The association of copy number variations (CNVs), differing numbers of copies of genetic sequence at locations in the genome, with phenotypes such as …”
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Data in question: A survey of European biobank professionals on ethical, legal and societal challenges of biobank research von Goisauf, Melanie, Martin, Gillian, Bentzen, Heidi Beate, Budin-Ljøsne, Isabelle, Ursin, Lars, Durnová, Anna, Leitsalu, Liis, Smith, Katharine, Casati, Sara, Lavitrano, Marialuisa, Mascalzoni, Deborah, Boeckhout, Martin, Mayrhofer, Michaela Th

“… Biobanks have evolved, and their governance procedures have undergone important transformations. Our paper examines this issue by focusing on the perspective …”
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Do Biobank Recall Studies Matter? Long-Term Follow-Up of Research Participants With Familial Hypercholesterolemia von Nurm, Miriam, Reigo, Anu, Nõukas, Margit, Leitsalu, Liis, Nikopensius, Tiit, Palover, Marili, Annilo, Tarmo, Alver, Maris, Saar, Aet, Marandi, Toomas, Ainla, Tiia, Metspalu, Andres, Esko, Tõnu, Tõnisson, Neeme

“… Recall-by-genotype (RbG) studies conducted with population-based biobank data remain urgently needed, and follow-up RbG studies, which add substance to this …”
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Correction: Data in question: A survey of European biobank professionals on ethical, legal and societal challenges of biobank research von Goisauf, Melanie, Martin, Gillian, Bentzen, Heidi Beate, Budin-Ljøsne, Isabelle, Ursin, Lars, Durnová, Anna, Leitsalu, Liis, Smith, Katharine, Casati, Sara, Lavitrano, Marialuisa, Mascalzoni, Deborah, Boeckhout, Martin, Mayrhofer, Michaela Th

“… [This corrects the article DOI: 10.1371/journal.pone.0221496.] …”
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Precise, Genotype-First Breast Cancer Prevention: Experience With Transferring Monogenic Findings From a Population Biobank to the Clinical Setting von Jürgens, Hannes, Roht, Laura, Leitsalu, Liis, Nõukas, Margit, Palover, Marili, Nikopensius, Tiit, Reigo, Anu, Kals, Mart, Kallak, Kersti, Kütner, Riina, Budrikas, Kai, Kuusk, Saskia, Valvere, Vahur, Laidre, Piret, Toome, Kadri, Rekker, Kadri, Tooming, Mikk, Ülle Murumets, Kahre, Tiina, Kruuv-Käo, Krista, Õunap, Katrin, Padrik, Peeter, Metspalu, Andres, Esko, Tõnu, Fischer, Krista, Tõnisson, Neeme

“… Although hereditary breast cancer screening and management are well accepted and established in clinical settings, these efforts result in the detection of …”
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MixFit: Methodology for Computing Ancestry-Related Genetic Scores at the Individual Level and Its Application to the Estonian and Finnish Population Studies von Haller, Toomas, Leitsalu, Liis, Fischer, Krista, Nuotio, Marja-Liisa, Esko, Tõnu, Boomsma, Dorothea Irene, Kyvik, Kirsten Ohm, Spector, Tim D., Perola, Markus, Metspalu, Andres

“… Ancestry information at the individual level can be a valuable resource for personalized medicine, medical, demographical and history research, as well as for …”
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Country Reports von Zawati, Ma'N, Chalmers, Don, Dallari, Sueli, de Neiva Borba, Marina, Pinkesz, Miriam, Joly, Yann, Chen, Haidan, Hartlev, Mette, Leitsalu, Liis, Soini, Sirpa, Rial-Sebbag, Emmanuelle, Hoppe, Nils, Garani-Papadatos, Tina, Vidalis, Panagiotis, Srinivas, Krishna Ravi, Siegal, Gil, Negri, Stefania, Hatanaka, Ryoko, Al-Hussaini, Maysa, Al-Tabba, Amal, Motta-Murgía, Lourdes, Moran, Laura Estela Torres, Hendriks, Aart, Nnamuchi, Obiajulu, Isasi, Rosario, Krekora-Zajac, Dorota, Sadoun, Eman, Ho, Calvin, Andanda, Pamela, Lee, Won Bok, Nicolás, Pilar, Mattsson, Titti, Talanova, Vladislava, Dosch, Alexandre, Sprumont, Dominique, Fan, Chien-Te, Hung, Tzu-Hsun, Kaye, Jane, Phillips, Andelka, Gowans, Heather, Shah, Nisha, Hazel, James

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Lessons learned during the process of reporting individual genomic results to participants of a population-based biobank von Leitsalu, Liis, Reigo, Anu, Palover, Marili, Nikopensius, Tiit, Läll, Kristi, Krebs, Kristi, Reisberg, Sulev, Mägi, Reedik, Kals, Mart, Alavere, Helene, Nõukas, Margit, Kolk, Anneli, Normet, Ivi, Tammesoo, Mari-Liis, Käärik, Ene, Puusepp, Mairo, Metsalu, Kristjan, Allik, Annely, Milani, Lili, Fischer, Krista, Tõnisson, Neeme, Metspalu, Andres

“… The return of individual genomic results (ROR) to research participants is still in its early phase, and insight on how individuals respond to ROR is scarce …”
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Recall by genotype and cascade screening for familial hypercholesterolemia in a population-based biobank from Estonia von Alver, Maris, Palover, Marili, Saar, Aet, Läll, Kristi, Zekavat, Seyedeh Maryam, Tõnisson, Neeme, Leitsalu, Liis, Reigo, Anu, Nikopensius, Tiit, Ainla, Tiia, Kals, Mart, Mägi, Reedik, Gabriel, Stacey B., Eha, Jaan, Lander, Eric S., Irs, Alar, Philippakis, Anthony, Marandi, Toomas, Natarajan, Pradeep, Metspalu, Andres, Kathiresan, Sekar, Esko, Tõnu

“… Purpose Large-scale, population-based biobanks integrating health records and genomic profiles may provide a platform to identify individuals with …”
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Clinical Implementation Study of Genetic Risk-Based Breast Cancer Screening von Tamm, Madli, Padrik, Peeter, Ojamaa, Kristiina, Paas, Anette, Lepland, Anni, Kruuv-Käo, Krista, Leitsalu, Liis, Sõber, Siim, Roht, Laura, Pajusalu, Sander, Kahre, Tiina, Padrik, Anna, Pindmaa, Jagnar, Luga, Kadri, Rootslane, Ly, Ilves, Anne, Ulp, Sulev, Kallak, Kersti, Tihamäe, Ave-Triin, Feldman, Inna, Sampaio, Filipa, Costa, Luís, Nogueira-Costa, Gonçalo, Österman, Tiina, Rosenmöller, Magda, Tõnisson, Neeme

“… •Evaluated a genetic risk-based personalized breast cancer screening service model.•Utilized telemedicine, home-based testing, and questionnaire-based …”
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Advances in Genomic Discovery and Implications for Personalized Prevention and Medicine: Estonia as Example von Prins, Bram Peter, Leitsalu, Liis, Pärna, Katri, Fischer, Krista, Metspalu, Andres, Haller, Toomas, Snieder, Harold

“… The current paradigm of personalized medicine envisages the use of genomic data to provide predictive information on the health course of an individual with …”
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Genetic counselling legislation and practice in cancer in EU Member States von McCrary, J Matt, Van Valckenborgh, Els, Poirel, Hélène A, de Putter, Robin, van Rooij, Jeroen, Horgan, Denis, Dierks, Marie-Luise, Antonova, Olga, Brunet, Joan, Chirita-Emandi, Adela, Colas, Chrystelle, Dalmas, Miriam, Ehrencrona, Hans, Grima, Claire, Janavičius, Ramūnas, Klink, Barbara, Koczok, Katalin, Krajc, Mateja, Lace, Baiba, Leitsalu, Liis, Mistrik, Martin, Paneque, Milena, Primorac, Dragan, Roetzer, Katharina M, Ronez, Joelle, Slámová, Lucie, Spanou, Elena, Stamatopoulos, Kostas, Stoklosa, Tomasz, Strang-Karlsson, Sonja, Szakszon, Katalin, Szczałuba, Krzysztof, Turner, Jacqueline, van Dooren, Marieke F, van Zelst-Stams, Wendy A G, Vassallo, Loredana-Maria, Wadt, Karin A W, Žigman, Tamara, Ripperger, Tim, Genuardi, Maurizio, Van den Bulcke, Marc, Bergmann, Anke Katharina

“… Background Somatic and germline genetic alterations are significant drivers of cancer. Increasing integration of new technologies which profile these …”
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A Cluster-Randomized Trial on Personalized Feedback on Genetic Risks: Effects on Treatment Compliance of Patients with Hypertension von Mändul, Merli, Fischer, Krista, Läll, Kristi, Leitsalu, Liis, Alavere, Helene, Tammaru, Marika, Metspalu, Andres

“… There is controversial evidence on the potential effects of personalized risk prediction in general practice. To study various aspects of applicability of the …”
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The role of a bioresource research impact factor as an incentive to share human bioresources von Cambon-Thomsen, Anne, Thorisson, Gudmundur A, Mabile, Laurence

“… Bioresources need to be easily accessible to facilitate advancement of research. Besides technical and ethical aspects, a major obstacle for sharing them is …”
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Giving and Withholding of Information following Genomic Screening: Challenges Identified in a Study of Primary Care Physicians in Estonia von Leitsalu, Liis, Hercher, Laura, Metspalu, Andres

“… The use of predictive genomic information to improve medical care remains a contentious topic. However, it is generally agreed that the potential of genomics …”
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Country Reports von Zawati, Ma'n H., Chalmers, Don, Dallari, Sueli G., de Neiva Borba, Marina, Pinkesz, Miriam, Joly, Yann, Chen, Haidan, Hartlev, Mette, Leitsalu, Liis, Soini, Sirpa, Rial-Sebbag, Emmanuelle, Hoppe, Nils, Garani-Papadatos, Tina, Vidalis, Panagiotis, Srinivas, Krishna Ravi, Siegal, Gil, Negri, Stefania, Hatanaka, Ryoko, Al-Hussaini, Maysa, Al-Tabba', Amal, Motta-Murgía, Lourdes, Moran, Laura Estela Torres, Hendriks, Aart, Nnamuchi, Obiajulu, Isasi, Rosario, Krekora-Zajac, Dorota, Sadoun, Eman, Ho, Calvin, Andanda, Pamela, Lee, Won Bok, Nicolás, Pilar, Mattsson, Titti, Talanova, Vladislava, Dosch, Alexandre, Sprumont, Dominique, Fan, Chien-Te, Hung, Tzu-Hsun, Kaye, Jane, Phillips, Andelka, Gowans, Heather, Shah, Nisha, Hazel, James W.

“… Any proposed DTP genomic research would need to comply with the specific requirements of Chapter 3.3 to be satisfactorily addressed for ethical approval. 1.2 …”
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Reporting incidental findings of genomic disorder-associated copy number variants to unselected biobank participants von Leitsalu, Liis, Alavere, Helene, Jacquemont, Sébastien, Kolk, Anneli, Maillard, Anne M, Reigo, Anu, Nõukas, Margit, Reymond, Alexandre, Männik, Katrin, Ng, Pauline C, Metspalu, Andres

“… Procedural guidelines for disclosure of incidental genomic information are lacking. We introduce a method and evaluated the impact of returning results to …”
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Counseling for complex disease: Incorporating predictive genetic testing into the national health care system of Estonia von Leitsalu, Liis

“… Education of health care providers is crucial for effective translation of genomic information into health care practice. The project aims to facilitate the …”
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