Suchergebnisse - "Lehman, Susan"

Bacteriophage-mediated control of a two-species biofilm formed by microorganisms causing catheter-associated urinary tract infections in an in vitro urinary catheter model von Lehman, Susan M, Donlan, Rodney M

“… Microorganisms from a patient or their environment may colonize indwelling urinary catheters, forming biofilm communities on catheter surfaces and increasing …”
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Novel bacteriophage therapy for treatment of left ventricular assist device infection von Aslam, Saima, Pretorius, Victor, Lehman, Susan M, Morales, Sandra, Schooley, Robert T

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Successful adjunctive use of bacteriophage therapy for treatment of multidrug-resistant Pseudomonas aeruginosa infection in a cystic fibrosis patient von Law, Nancy, Logan, Cathy, Yung, Gordon, Furr, Carrie-Lynn Langlais, Lehman, Susan M., Morales, Sandra, Rosas, Francisco, Gaidamaka, Alexander, Bilinsky, Igor, Grint, Paul, Schooley, Robert T., Aslam, Saima

“… Introduction We describe the use of bacteriophage therapy in a 26-year-old cystic fibrosis (CF) patient awaiting lung transplantation. Hospital Course The …”
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Early clinical experience of bacteriophage therapy in 3 lung transplant recipients von Aslam, Saima, Courtwright, Andrew M., Koval, Christine, Lehman, Susan M., Morales, Sandra, Furr, Carrie‐Lynn Langlais, Rosas, Francisco, Brownstein, Michael J., Fackler, Joseph R., Sisson, Brittany M., Biswas, Biswajit, Henry, Matthew, Luu, Truong, Bivens, Brittany N., Hamilton, Theron, Duplessis, Christopher, Logan, Cathy, Law, Nancy, Yung, Gordon, Turowski, Jason, Anesi, Judith, Strathdee, Steffanie A., Schooley, Robert T.

“… Bacteriophage therapy (BT) uses bacteriophages to treat pathogenic bacteria and is an emerging strategy against multidrug‐resistant (MDR) infections …”
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Bacteriophage cocktail for the prevention of biofilm formation by Pseudomonas aeruginosa on catheters in an in vitro model system von Fu, Weiling, Forster, Terri, Mayer, Oren, Curtin, John J, Lehman, Susan M, Donlan, Rodney M

“… Microorganisms develop biofilms on indwelling medical devices and are associated with device-related infections, resulting in substantial morbidity and …”
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Design and Preclinical Development of a Phage Product for the Treatment of Antibiotic-Resistant Staphylococcus aureus Infections von Lehman, Susan M., Mearns, Gillian, Rankin, Deborah, Cole, Robert A., Smrekar, Frenk, Branston, Steven D., Morales, Sandra

“… Bacteriophages, viruses that only kill specific bacteria, are receiving substantial attention as nontraditional antibacterial agents that may help alleviate …”
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Bacteriophage-Antibiotic Combination Strategy: an Alternative against Methicillin-Resistant Phenotypes of Staphylococcus aureus von Kebriaei, Razieh, Lev, Katherine, Morrisette, Taylor, Stamper, Kyle C, Abdul-Mutakabbir, Jacinda C, Lehman, Susan M, Morales, Sandra, Rybak, Michael J

“… Comparative time-kill experiments with bacteriophage (phage) Sb-1 alone and phage-antibiotic combinations (PACs) against two methicillin-resistant (MRSA) …”
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Development of Host Immune Response to Bacteriophage in a Lung Transplant Recipient on Adjunctive Phage Therapy for a Multidrug-Resistant Pneumonia von Dan, Jennifer M, Lehman, Susan M, Al-Kolla, Rita, Penziner, Samuel, Afshar, Kamyar, Yung, Gordon, Golts, Eugene, Law, Nancy, Logan, Cathy, Kovach, Zsuzsanna, Mearns, Gill, Schooley, Robert T, Aslam, Saima, Crotty, Shane

“… Bacteriophage therapy is the use of viruses to kill bacteria for the treatment of antibiotic-resistant infections. Little is known about the human immune …”
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Bacteriophage‐antibiotic combination therapy for multidrug‐resistant Pseudomonas aeruginosa: In vitro synergy testing von Holger, Dana J., Lev, Katherine L., Kebriaei, Razieh, Morrisette, Taylor, Shah, Rahi, Alexander, Jose, Lehman, Susan M., Rybak, Michael J.

“… Aims Here, we investigate the impact of phage‐antibiotic combinations (PAC) on bacterial killing, resistance development and outer membrane vesicle (OMV) …”
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Optimizing phage-antibiotic combinations: impact of administration order against daptomycin non-susceptible (DNS) MRSA clinical isolates von Bleick, Callan R, Van Helden, Sean R, Berti, Andrew D, Richa, Rita, Lehman, Susan M, Bayer, Arnold S, Rybak, Michael J

“… The rise of bacterial resistance has driven the exploration of novel therapies, such as bacteriophage-antibiotic cocktails (PACs), which have shown promise …”
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Optimization of Phage-Antibiotic Combinations against Staphylococcus aureus Biofilms von Kebriaei, Razieh, Lehman, Susan M., Shah, Rahi M., Stamper, Kyle C., Kunz Coyne, Ashlan J., Holger, Dana, El Ghali, Amer, Rybak, Michael J.

“… The extracellular polymeric matrix of biofilms presents an impediment to antibiotic diffusion, facilitating the emergence of multidrug-resistant populations …”
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Ciprofloxacin in combination with bacteriophage cocktails against multi-drug resistant Pseudomonas aeruginosa in ex vivo simulated endocardial vegetation models von El Ghali, Amer, Stamper, Kyle, Kunz Coyne, Ashlan J, Holger, Dana, Kebriaei, Razieh, Alexander, Jose, Lehman, Susan M, Rybak, Michael J

“… -associated infective endocarditis represents difficult-to-treat, deep-seated infections. Phage-antibiotic combinations have shown to eradicate multi-drug …”
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Bacteriophage AB-SA01 Cocktail in Combination with Antibiotics against MRSA-VISA Strain in an In Vitro Pharmacokinetic/Pharmacodynamic Model von Kebriaei, Razieh, Lev, Katherine L, Stamper, Kyle C, Lehman, Susan M, Morales, Sandra, Rybak, Michael J

“… This study aimed to test the efficacy of bacteriophage-antibiotic combinations (BACs) in 24-h time-kill settings and in simulated endocardial vegetation (SEV) …”
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Phage-antibiotic synergy against daptomycin-nonsusceptible MRSA in an ex vivo simulated endocardial pharmacokinetic/pharmacodynamic model von Kunz Coyne, Ashlan J, Bleick, Callan, Stamper, Kyle, Kebriaei, Razieh, Bayer, Arnold S, Lehman, Susan M, Rybak, Michael J

“… Phage-antibiotic combinations (PAC) offer a potential solution for treating refractory daptomycin-nonsusceptible (DNS) methicillin-resistant (MRSA) infections …”
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Phage-antibiotic combinations against multidrug-resistant Pseudomonas aeruginosa in in vitro static and dynamic biofilm models von Holger, Dana J, El Ghali, Amer, Bhutani, Natasha, Lev, Katherine L, Stamper, Kyle, Kebriaei, Razieh, Kunz Coyne, Ashlan J, Morrisette, Taylor, Shah, Rahi, Alexander, Jose, Lehman, Susan M, Rojas, Laura J, Marshall, Steven H, Bonomo, Robert A, Rybak, Michael J

“… Biofilm-producing infections pose a severe threat to public health and are responsible for high morbidity and mortality. Phage-antibiotic combinations (PACs) …”
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Bacteriophage-Antibiotic Combinations for Enterococcus faecium with Varying Bacteriophage and Daptomycin Susceptibilities von Morrisette, Taylor, Lev, Katherine L, Kebriaei, Razieh, Abdul-Mutakabbir, Jacinda C, Stamper, Kyle C, Morales, Sandra, Lehman, Susan M, Canfield, Gregory S, Duerkop, Breck A, Arias, Cesar A, Rybak, Michael J

“… Concerns regarding increased prevalence of daptomycin (DAP)-resistant strains necessitate novel therapies for infections. Obligately lytic bacteriophages are …”
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Bacterial Viruses Subcommittee and Archaeal Viruses Subcommittee of the ICTV: update of taxonomy changes in 2021 von Krupovic, Mart, Turner, Dann, Morozova, Vera, Dyall-Smith, Mike, Oksanen, Hanna M., Edwards, Rob, Dutilh, Bas E., Lehman, Susan M., Reyes, Alejandro, Baquero, Diana P., Sullivan, Matthew B., Uchiyama, Jumpei, Nakavuma, Jesca, Barylski, Jakub, Young, Mark J., Du, Shishen, Alfenas-Zerbini, Poliane, Kushkina, Alla, Kropinski, Andrew M., Kurtböke, Ipek, Brister, J. Rodney, Lood, Cédric, Sarkar, B. L., Yigang, Tong, Liu, Ying, Huang, Li, Wittmann, Johannes, Chanishvili, Nina, van Zyl, Leonardo J., Rumnieks, Janis, Mochizuki, Tomohiro, Jalasvuori, Matti, Aziz, Ramy K., Łobocka, Małgorzata, Stedman, Kenneth M., Shkoporov, Andrey N., Gillis, Annika, Peng, Xu, Enault, François, Knezevic, Petar, Lavigne, Rob, Rhee, Sung-Keun, Cvirkaite-Krupovic, Virginija, Moraru, Cristina, Moreno Switt, Andrea I., Poranen, Minna M., Millard, Andrew, Prangishvili, David, Adriaenssens, Evelien M.

“… In this article, we – the Bacterial Viruses Subcommittee and the Archaeal Viruses Subcommittee of the International Committee on Taxonomy of Viruses (ICTV) – …”
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Exploring synergistic and antagonistic interactions in phage-antibiotic combinations against ESKAPE pathogens von Kunz Coyne, Ashlan J., Eshaya, Mirna, Bleick, Callan, Vader, Samantha, Biswas, Biswajit, Wilson, Melanie, Deschenes, Michael V., Alexander, Jose, Lehman, Susan M., Rybak, Michael J.

“… In the face of escalating antimicrobial resistance, combining phages with antibiotics offers a promising avenue for treating infections unresponsive to …”
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The Transcriptional Program of Staphylococcus aureus Phage K Is Affected by a Host rpoC Mutation That Confers Phage K Resistance von Kongari, Rohit, Ray, Melissa D., Lehman, Susan M., Plaut, Roger D., Hinton, Deborah M., Stibitz, Scott

“… To better understand host–phage interactions and the genetic bases of phage resistance in a model system relevant to potential phage therapy, we isolated …”
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Eradication of Biofilm-Mediated Methicillin-Resistant Staphylococcus aureus Infections In Vitro : Bacteriophage-Antibiotic Combination von Kebriaei, Razieh, Lev, Katherine L., Shah, Rahi M., Stamper, Kyle C., Holger, Dana J., Morrisette, Taylor, Kunz Coyne, Ashlan J., Lehman, Susan M., Rybak, Michael J.

“… Biofilm-associated multidrug-resistant infections pose significant challenges for antibiotic therapy. The extracellular polymeric matrix of biofilms presents …”
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