Suchergebnisse - "Leeuwenburgh, Christiaan"

Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting von Anton, Stephen D., Moehl, Keelin, Donahoo, William T., Marosi, Krisztina, Lee, Stephanie A., Mainous, Arch G., Leeuwenburgh, Christiaan, Mattson, Mark P.

“… Objective Intermittent fasting (IF) is a term used to describe a variety of eating patterns in which no or few calories are consumed for time periods that can …”
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Mitochondrial dysfunction and sarcopenia of aging: From signaling pathways to clinical trials von Marzetti, Emanuele, Calvani, Riccardo, Cesari, Matteo, Buford, Thomas W., Lorenzi, Maria, Behnke, Bradley J., Leeuwenburgh, Christiaan

“… Sarcopenia, the age-related loss of muscle mass and function, imposes a dramatic burden on individuals and society. The development of preventive and …”
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Fasting or caloric restriction for Healthy Aging von Anton, Stephen, Leeuwenburgh, Christiaan

“… Aging is associated with a host of biological changes that contribute to a progressive decline in cognitive and physical function, ultimately leading to a loss …”
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Beneficial effects of exercise on age‐related mitochondrial dysfunction and oxidative stress in skeletal muscle von Joseph, Anna‐Maria, Adhihetty, Peter J., Leeuwenburgh, Christiaan

“… Mitochondria are negatively affected by ageing leading to their inability to adapt to higher levels of oxidative stress and this ultimately contributes to the …”
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Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics von Marzetti, Emanuele, Csiszar, Anna, Dutta, Debapriya, Balagopal, Gauthami, Calvani, Riccardo, Leeuwenburgh, Christiaan

“… Advanced age is associated with a disproportionate prevalence of cardiovascular disease (CVD). Intrinsic alterations in the heart and the vasculature occurring …”
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Fueling Inflamm-Aging through Mitochondrial Dysfunction: Mechanisms and Molecular Targets von Picca, Anna, Lezza, Angela, Leeuwenburgh, Christiaan, Pesce, Vito, Calvani, Riccardo, Landi, Francesco, Bernabei, Roberto, Marzetti, Emanuele

“… Among the complex determinants of aging, mitochondrial dysfunction has been in the spotlight for a long time. As the hub for many cellular functions, the …”
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The Effects of Time Restricted Feeding on Overweight, Older Adults: A Pilot Study von Anton, Stephen D., Lee, Stephanie A., Donahoo, William T., McLaren, Christian, Manini, Todd, Leeuwenburgh, Christiaan, Pahor, Marco

“… A growing body of evidence indicates that time restricted feeding (TRF), a popular form of intermittent fasting, can activate similar biological pathways as …”
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Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction von Someya, Shinichi, Yu, Wei, Hallows, William C, Xu, Jinze, Vann, James M, Leeuwenburgh, Christiaan, Tanokura, Masaru, Denu, John M, Prolla, Tomas A

“… Caloric restriction (CR) extends the life span and health span of a variety of species and slows the progression of age-related hearing loss (AHL), a common …”
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Skeletal muscle autophagy and apoptosis during aging: Effects of calorie restriction and life-long exercise von Wohlgemuth, Stephanie Eva, Seo, Arnold Young, Marzetti, Emanuele, Lees, Hazel Anne, Leeuwenburgh, Christiaan

“… Sarcopenia, loss of muscle mass and function, is a common feature of aging. Oxidative damage and apoptosis are likely underlying factors. Autophagy, a process …”
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The COVID-19 pandemic and physical activity von Woods, Jeffrey A., Hutchinson, Noah T., Powers, Scott K., Roberts, William O., Gomez-Cabrera, Mari Carmen, Radak, Zsolt, Berkes, Istvan, Boros, Anita, Boldogh, Istvan, Leeuwenburgh, Christiaan, Coelho-Júnior, Hélio José, Marzetti, Emanuele, Cheng, Ying, Liu, Jiankang, Durstine, J. Larry, Sun, Junzhi, Ji, Li Li

“… The SARS-CoV-2-caused COVID-19 pandemic has resulted in a devastating threat to human society in terms of health, economy, and lifestyle. Although the virus …”
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The contribution of mitochondrial DNA alterations to aging, cancer, and neurodegeneration von Picca, Anna, Guerra, Flora, Calvani, Riccardo, Coelho-Júnior, Hélio José, Leeuwenburgh, Christiaan, Bucci, Cecilia, Marzetti, Emanuele

“… Mitochondrial DNA (mtDNA) is as a double-stranded molecule existing in hundreds to thousands copies in cells depending on cell metabolism and exposure to …”
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Apoptosis in Skeletal Myocytes: A Potential Target for Interventions against Sarcopenia and Physical Frailty – A Mini-Review von Marzetti, Emanuele, Calvani, Riccardo, Bernabei, Roberto, Leeuwenburgh, Christiaan

“… Background: Sarcopenia, the age-related loss of muscle mass and function, represents a relevant public health issue due to its high prevalence and detrimental …”
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Editorial for the special issue on “microbiomes in extremes of aging” von Yadav, Hariom, Badal, Varsha D., Masternak, Michal M., Leeuwenburgh, Christiaan

“… This special issue of the Journal of Experimental Gerontology explores the dynamic interplay between microbiomes and aging-related conditions. The four …”
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Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy von Calvani, Riccardo, Joseph, Anna-Maria, Adhihetty, Peter J, Miccheli, Alfredo, Bossola, Maurizio, Leeuwenburgh, Christiaan, Bernabei, Roberto, Marzetti, Emanuele

“… Muscle loss during aging and disuse is a highly prevalent and disabling condition, but knowledge about cellular pathways mediating muscle atrophy is still …”
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Cardiac mitochondrial bioenergetics, oxidative stress, and aging von Judge, Sharon, Leeuwenburgh, Christiaan

“… Mitochondria have been a central focus of several theories of aging as a result of their critical role in bioenergetics, oxidant production, and regulation of …”
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Circulating Mitochondrial DNA at the Crossroads of Mitochondrial Dysfunction and Inflammation During Aging and Muscle Wasting Disorders von Picca, Anna, Lezza, Angela Maria Serena, Leeuwenburgh, Christiaan, Pesce, Vito, Calvani, Riccardo, Bossola, Maurizio, Manes-Gravina, Ester, Landi, Francesco, Bernabei, Roberto, Marzetti, Emanuele

“… Mitochondrial structural and functional integrity is maintained through the coordination of several processes (e.g., biogenesis, dynamics, mitophagy), …”
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Microbiome interactions with different risk factors in development of myocardial infarction von Bijla, Manisha, Saini, Sunil Kumar, Pathak, Ajai Kumar, Bharadwaj, Kamal Prakash, Sukhavasi, Katyayani, Patil, Ayurshi, Saini, Diksha, Yadav, Rakesh, Singh, Shalini, Leeuwenburgh, Christiaan, Kumar, Pramod

“… Among all non-communicable diseases, Cardiovascular Diseases (CVDs) stand as the leading global cause of mortality. Within this spectrum, Myocardial Infarction …”
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Older Sepsis Survivors Suffer Persistent Disability Burden and Poor Long‐Term Survival von Mankowski, Robert T., Anton, Stephen D., Ghita, Gabriela L., Brumback, Babette, Cox, Michael C., Mohr, Alicia M., Leeuwenburgh, Christiaan, Moldawer, Lyle L., Efron, Philip A., Brakenridge, Scott C., Moore, Frederick A.

“… Objectives Sepsis has been called a “disease of the elderly,” and as in‐hospital mortality has decreased, more sepsis survivors are progressing into poorly …”
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Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases von Knutson, Mitchell D, Leeuwenburgh, Christiaan

“… Studies show that the plant polyphenol resveratrol can extend the life span of yeast, worms, flies, and fish. It also mitigates the metabolic dysfunction of …”
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Iron homeostasis in older adults: balancing nutritional requirements and health risks von Zeidan, Rola S., Martenson, Matthew, Tamargo, Javier A., McLaren, Christian, Ezzati, Armin, Lin, Yi, Yang, Jae Jeong, Yoon, Hyung-Suk, McElroy, Taylor, Collins, James F., Leeuwenburgh, Christiaan, Mankowski, Robert T., Anton, Stephen

“… Iron plays a crucial role in many physiological processes, including oxygen transport, bioenergetics, and immune function. Iron is assimilated from food and …”
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