Suchergebnisse - "Launer, Lenore J"

Cerebral microvascular complications of type 2 diabetes: stroke, cognitive dysfunction, and depression von van Sloten, Thomas T, Sedaghat, Sanaz, Carnethon, Mercedes R, Launer, Lenore J, Stehouwer, Coen D A

“… Adults with type 2 diabetes are at an increased risk of developing certain brain or mental disorders, including stroke, dementia, and depression. Although …”
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A genome-wide association study of serum proteins reveals shared loci with common diseases von Gudjonsson, Alexander, Gudmundsdottir, Valborg, Axelsson, Gisli T., Gudmundsson, Elias F., Jonsson, Brynjolfur G., Launer, Lenore J., Lamb, John R., Jennings, Lori L., Aspelund, Thor, Emilsson, Valur, Gudnason, Vilmundur

“… With the growing number of genetic association studies, the genotype-phenotype atlas has become increasingly more complex, yet the functional consequences of …”
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Cerebral small vessel disease and risk of incident stroke, dementia and depression, and all-cause mortality: A systematic review and meta-analysis von Rensma, Sytze P., van Sloten, Thomas T., Launer, Lenore J., Stehouwer, Coen D.A.

“… •Cerebral small vessel disease may lead to stroke, dementia, and depression.•We did a systematic review/meta-analysis of studies on these associations.•Strong …”
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Impact of Hypertension on Cognitive Function: A Scientific Statement From the American Heart Association von Iadecola, Costantino, Yaffe, Kristine, Biller, José, Bratzke, Lisa C, Faraci, Frank M, Gorelick, Philip B, Gulati, Martha, Kamel, Hooman, Knopman, David S, Launer, Lenore J, Saczynski, Jane S, Seshadri, Sudha, Zeki Al Hazzouri, Adina

“… Age-related dementia, most commonly caused by Alzheimer disease or cerebrovascular factors (vascular dementia), is a major public health threat. Chronic …”
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Harmonization of large MRI datasets for the analysis of brain imaging patterns throughout the lifespan von Pomponio, Raymond, Erus, Guray, Habes, Mohamad, Doshi, Jimit, Srinivasan, Dhivya, Mamourian, Elizabeth, Bashyam, Vishnu, Nasrallah, Ilya M., Satterthwaite, Theodore D., Fan, Yong, Launer, Lenore J., Masters, Colin L., Maruff, Paul, Zhuo, Chuanjun, Völzke, Henry, Johnson, Sterling C., Fripp, Jurgen, Koutsouleris, Nikolaos, Wolf, Daniel H., Gur, Raquel, Gur, Ruben, Morris, John, Albert, Marilyn S., Grabe, Hans J., Resnick, Susan M., Bryan, R. Nick, Wolk, David A., Shinohara, Russell T., Shou, Haochang, Davatzikos, Christos

“… As medical imaging enters its information era and presents rapidly increasing needs for big data analytics, robust pooling and harmonization of imaging data …”
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Co-regulatory networks of human serum proteins link genetics to disease von Emilsson, Valur, Ilkov, Marjan, Lamb, John R, Finkel, Nancy, Gudmundsson, Elias F, Pitts, Rebecca, Hoover, Heather, Gudmundsdottir, Valborg, Horman, Shane R, Aspelund, Thor, Shu, Le, Trifonov, Vladimir, Sigurdsson, Sigurdur, Manolescu, Andrei, Zhu, Jun, Olafsson, Örn, Jakobsdottir, Johanna, Lesley, Scott A, To, Jeremy, Zhang, Jia, Harris, Tamara B, Launer, Lenore J, Zhang, Bin, Eiriksdottir, Gudny, Yang, Xia, Orth, Anthony P, Jennings, Lori L, Gudnason, Vilmundur

“… Proteins circulating in the blood are critical for age-related disease processes; however, the serum proteome has remained largely unexplored. To this end, …”
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MRI signatures of brain age and disease over the lifespan based on a deep brain network and 14 468 individuals worldwide von Bashyam, Vishnu M, Erus, Guray, Doshi, Jimit, Habes, Mohamad, Nasrallah, Ilya, Truelove-Hill, Monica, Srinivasan, Dhivya, Mamourian, Liz, Pomponio, Raymond, Fan, Yong, Launer, Lenore J, Masters, Colin L, Maruff, Paul, Zhuo, Chuanjun, Völzke, Henry, Johnson, Sterling C, Fripp, Jurgen, Koutsouleris, Nikolaos, Satterthwaite, Theodore D, Wolf, Daniel, Gur, Raquel E, Gur, Ruben C, Morris, John, Albert, Marilyn S, Grabe, Hans J, Resnick, Susan, Bryan, R Nick, Wolk, David A, Shou, Haochang, Davatzikos, Christos

“… Deep learning has emerged as a powerful approach to constructing imaging signatures of normal brain ageing as well as of various neuropathological processes …”
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Batch effects removal for microbiome data via conditional quantile regression von Ling, Wodan, Lu, Jiuyao, Zhao, Ni, Lulla, Anju, Plantinga, Anna M., Fu, Weijia, Zhang, Angela, Liu, Hongjiao, Song, Hoseung, Li, Zhigang, Chen, Jun, Randolph, Timothy W., Koay, Wei Li A., White, James R., Launer, Lenore J., Fodor, Anthony A., Meyer, Katie A., Wu, Michael C.

“… Batch effects in microbiome data arise from differential processing of specimens and can lead to spurious findings and obscure true signals. Strategies …”
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Early adult to midlife cardiovascular risk factors and cognitive function von Yaffe, Kristine, Vittinghoff, Eric, Pletcher, Mark J, Hoang, Tina D, Launer, Lenore J, Whitmer, Rachel, Coker, Laura H, Sidney, Stephen

“… Studies have linked midlife and late-life cardiovascular risk factors (CVRFs) to cognitive function, yet little is known about CVRF exposure in early adulthood …”
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Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility--Reykjavik study von Mitchell, Gary F, van Buchem, Mark A, Sigurdsson, Sigurdur, Gotal, John D, Jonsdottir, Maria K, Kjartansson, Ólafur, Garcia, Melissa, Aspelund, Thor, Harris, Tamara B, Gudnason, Vilmundur, Launer, Lenore J

“… Aortic stiffness increases with age and vascular risk factor exposure and is associated with increased risk for structural and functional abnormalities in the …”
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Association between arterial stiffness, cerebral small vessel disease and cognitive impairment: A systematic review and meta-analysis von van Sloten, Thomas T., Protogerou, Athanase D., Henry, Ronald M.A., Schram, Miranda T., Launer, Lenore J., Stehouwer, Coen D.A.

“… Arterial stiffness may be a cause of cerebral small vessel disease and cognitive impairment. We therefore performed a systematic review and meta-analysis of …”
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Space and location of cerebral microbleeds, cognitive decline, and dementia in the community von Ding, Jie, Sigurðsson, Sigurður, Jónsson, Pálmi V, Eiriksdottir, Gudny, Meirelles, Osorio, Kjartansson, Olafur, Lopez, Oscar L, van Buchem, Mark A, Gudnason, Vilmundur, Launer, Lenore J

“… To assess the association of the number and anatomic location of cerebral microbleeds (CMBs), visible indicators of microvascular damage on MRI, with incident …”
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The Brain Chart of Aging: Machine-learning analytics reveals links between brain aging, white matter disease, amyloid burden, and cognition in the iSTAGING consortium of 10,216 harmonized MR scans von Habes, Mohamad, Pomponio, Raymond, Shou, Haochang, Doshi, Jimit, Mamourian, Elizabeth, Erus, Guray, Nasrallah, Ilya, Launer, Lenore J, Rashid, Tanweer, Bilgel, Murat, Fan, Yong, Toledo, Jon B, Yaffe, Kristine, Sotiras, Aristeidis, Srinivasan, Dhivya, Espeland, Mark, Masters, Colin, Maruff, Paul, Fripp, Jurgen, Völzk, Henry, Johnson, Sterling C, Morris, John C, Albert, Marilyn S, Miller, Michael I, Bryan, R Nick, Grabe, Hans J, Resnick, Susan M, Wolk, David A, Davatzikos, Christos

“… Relationships between brain atrophy patterns of typical aging and Alzheimer's disease (AD), white matter disease, cognition, and AD neuropathology were …”
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Microinfarcts, brain atrophy, and cognitive function: The Honolulu Asia Aging Study Autopsy Study von Launer, Lenore J., Hughes, Timothy M., White, Lon R.

“… Objective: This study was untaken to investigate the association of micro brain infarcts (MBIs) with antemortem global cognitive function (CF), and whether …”
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Vascular Factors and Multiple Measures of Early Brain Health: CARDIA Brain MRI Study von Launer, Lenore J., Lewis, Cora E., Schreiner, Pamela J., Sidney, Steve, Battapady, Harsha, Jacobs, David R., Lim, Kelvin O., D’Esposito, Mark, Zhang, Qian, Reis, Jared, Davatzikos, Christos, Bryan, R. Nick

“… To identify early changes in brain structure and function that are associated with cardiovascular risk factors (CVRF). Cross-sectional brain Magnetic Resonance …”
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Smoking mediates the relationship between SES and brain volume: The CARDIA study von Dougherty, Ryan J., Moonen, Justine, Yaffe, Kristine, Sidney, Stephen, Davatzikos, Christos, Habes, Mohamad, Launer, Lenore J.

“… Investigate whether socioeconomic status (SES) was related to brain volume in aging related regions, and if so, determine whether this relationship was …”
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Prevalence and prognosis of ischaemic and non-ischaemic myocardial fibrosis in older adults von Shanbhag, Sujata M, Greve, Anders M, Aspelund, Thor, Schelbert, Erik B, Cao, J Jane, Danielsen, Ragnar, Þorgeirsson, Guðmundur, Sigurðsson, Sigurður, Eiríksdóttir, Guðný, Harris, Tamara B, Launer, Lenore J, Guðnason, Vilmundur, Arai, Andrew E

“… Non-ischaemic cardiomyopathies (NICM) can cause heart failure and death. Cardiac magnetic resonance (CMR) detects myocardial scar/fibrosis associated with …”
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Fasting blood glucose as a predictor of mortality: Lost in translation von Palliyaguru, Dushani L, Shiroma, Eric J, Nam, John K, Duregon, Eleonora, Vieira Ligo Teixeira, Camila, Price, Nathan L, Bernier, Michel, Camandola, Simonetta, Vaughan, Kelli L, Colman, Ricki J, Deighan, Andrew, Korstanje, Ron, Peters, Luanne L, Dickinson, Stephanie L, Ejima, Keisuke, Simonsick, Eleanor M, Launer, Lenore J, Chia, Chee W, Egan, Josephine, Allison, David B, Churchill, Gary A, Anderson, Rozalyn M, Ferrucci, Luigi, Mattison, Julie A, de Cabo, Rafael

“… Aging leads to profound changes in glucose homeostasis, weight, and adiposity, which are considered good predictors of health and survival in humans. Direct …”
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Cerebral microbleeds: a guide to detection and interpretation von Greenberg, Steven M, Vernooij, Meike W, Cordonnier, Charlotte, Viswanathan, Anand, Al-Shahi Salman, Rustam, Warach, Steven, Launer, Lenore J, Van Buchem, Mark A, Breteler, Monique MB

“… Cerebral microbleeds (CMBs) are increasingly recognised neuroimaging findings in individuals with cerebrovascular disease and dementia, and in normal ageing …”
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Multi-dimensional sleep health and dementia risk: a prospective study in the UK Biobank von Huang, Tianyi, Beydoun, May A., Kianersi, Sina, Redline, Susan, Launer, Lenore J.

“… Background The intricate interplay of various sleep characteristics may influence dementia risk through different pathogenic pathways. However, few studies …”
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