Výsledky vyhľadávania - "Larson, Martin G"

Galectin-3, a marker of cardiac fibrosis, predicts incident heart failure in the community Autor Ho, Jennifer E, Liu, Chunyu, Lyass, Asya, Courchesne, Paul, Pencina, Michael J, Vasan, Ramachandran S, Larson, Martin G, Levy, Daniel

“…The aim of this study was to examine the relation of galectin-3 (Gal-3), a marker of cardiac fibrosis, with incident heart failure (HF) in the community. Gal-3…”
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Lifetime risk of atrial fibrillation according to optimal, borderline, or elevated levels of risk factors: cohort study based on longitudinal data from the Framingham Heart Study Autor Staerk, Laila, Wang, Biqi, Preis, Sarah R, Larson, Martin G, Lubitz, Steven A, Ellinor, Patrick T, McManus, David D, Ko, Darae, Weng, Lu-Chen, Lunetta, Kathryn L, Frost, Lars, Benjamin, Emelia J, Trinquart, Ludovic

“…AbstractObjectiveTo examine the association between risk factor burdens—categorized as optimal, borderline, or elevated—and the lifetime risk of atrial…”
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50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study Autor Schnabel, Renate B, Yin, Xiaoyan, Gona, Philimon, Larson, Martin G, Beiser, Alexa S, McManus, David D, Newton-Cheh, Christopher, Lubitz, Steven A, Magnani, Jared W, Ellinor, Patrick T, Seshadri, Sudha, Wolf, Philip A, Vasan, Ramachandran S, Benjamin, Emelia J, Levy, Daniel

“…Comprehensive long-term data on atrial fibrillation trends in men and women are scant. We aimed to provide such data through analysis of the Framingham cohort…”
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Genetic Predisposition, Clinical Risk Factor Burden, and Lifetime Risk of Atrial Fibrillation Autor Weng, Lu-Chen, Preis, Sarah R, Hulme, Olivia L, Larson, Martin G, Choi, Seung Hoan, Wang, Biqi, Trinquart, Ludovic, McManus, David D, Staerk, Laila, Lin, Honghuang, Lunetta, Kathryn L, Ellinor, Patrick T, Benjamin, Emelia J, Lubitz, Steven A

“…The long-term probability of developing atrial fibrillation (AF) considering genetic predisposition and clinical risk factor burden is unknown. We estimated…”
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Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease Autor Yao, Chen, Chen, George, Song, Ci, Keefe, Joshua, Mendelson, Michael, Huan, Tianxiao, Sun, Benjamin B., Laser, Annika, Maranville, Joseph C., Wu, Hongsheng, Ho, Jennifer E., Courchesne, Paul, Lyass, Asya, Larson, Martin G., Gieger, Christian, Graumann, Johannes, Johnson, Andrew D., Danesh, John, Runz, Heiko, Hwang, Shih-Jen, Liu, Chunyu, Butterworth, Adam S., Suhre, Karsten, Levy, Daniel

“…Identifying genetic variants associated with circulating protein concentrations (protein quantitative trait loci; pQTLs) and integrating them with variants…”
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Aortic stiffness, blood pressure progression, and incident hypertension Autor Kaess, Bernhard M, Rong, Jian, Larson, Martin G, Hamburg, Naomi M, Vita, Joseph A, Levy, Daniel, Benjamin, Emelia J, Vasan, Ramachandran S, Mitchell, Gary F

“…Vascular stiffness increases with advancing age and is a major risk factor for age-related morbidity and mortality. Vascular stiffness and blood pressure…”
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A formal validation of a deep learning-based automated workflow for the interpretation of the echocardiogram Autor Tromp, Jasper, Bauer, David, Claggett, Brian L., Frost, Matthew, Iversen, Mathias Bøtcher, Prasad, Narayana, Petrie, Mark C., Larson, Martin G., Ezekowitz, Justin A., Solomon, Scott D.

“…This study compares a deep learning interpretation of 23 echocardiographic parameters—including cardiac volumes, ejection fraction, and Doppler…”
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Protein Biomarkers of Cardiovascular Disease and Mortality in the Community Autor Ho, Jennifer E., Lyass, Asya, Courchesne, Paul, Chen, George, Liu, Chunyu, Yin, Xiaoyan, Hwang, Shih‐Jen, Massaro, Joseph M., Larson, Martin G., Levy, Daniel

“…The discovery of novel and highly predictive biomarkers of cardiovascular disease (CVD) has the potential to improve risk-stratification methods and may be…”
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Two-stage multiple imputation with a longitudinal composite variable Autor Wang, Xuzhi, Larson, Martin G., Liu, Chunyu

“…Background Missing data are common in longitudinal studies. Multiple imputation (MI) is widely used to handle missing data. However, most of the MI methods…”
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Metabolomic Profiles of Body Mass Index in the Framingham Heart Study Reveal Distinct Cardiometabolic Phenotypes Autor Ho, Jennifer E., Larson, Martin G., Ghorbani, Anahita, Cheng, Susan, Chen, Ming-Huei, Keyes, Michelle, Rhee, Eugene P., Clish, Clary B., Vasan, Ramachandran S., Gerszten, Robert E., Wang, Thomas J.

“…Although obesity and cardiometabolic traits commonly overlap, underlying pathways remain incompletely defined. The association of metabolite profiles across…”
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Sex Differences in Circulating Biomarkers of Cardiovascular Disease Autor Lau, Emily S, Paniagua, Samantha M, Guseh, James Sawalla, Bhambhani, Vijeta, Zanni, Markella V, Courchesne, Paul, Lyass, Asya, Larson, Martin G, Levy, Daniel, Ho, Jennifer E

“…Differences in proteomic profiles between men and women may provide insights into the biological pathways that contribute to known sex differences in…”
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Longitudinal Change in Galectin-3 and Incident Cardiovascular Outcomes Autor Ghorbani, Anahita, Bhambhani, Vijeta, Christenson, Robert H, Meijers, Wouter C, de Boer, Rudolf A, Levy, Daniel, Larson, Martin G, Ho, Jennifer E

“…Galectin-3 (Gal-3) has been associated with heart failure (HF) and poor cardiovascular outcomes. However, the effect of longitudinal changes in Gal-3 on…”
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Metabolite profiles and the risk of developing diabetes Autor Wang, Thomas J, Larson, Martin G, Vasan, Ramachandran S, Cheng, Susan, Rhee, Eugene P, McCabe, Elizabeth, Lewis, Gregory D, Fox, Caroline S, Jacques, Paul F, Fernandez, Céline, O'Donnell, Christopher J, Carr, Stephen A, Mootha, Vamsi K, Florez, Jose C, Souza, Amanda, Melander, Olle, Clish, Clary B, Gerszten, Robert E

“…Amino acid profiles could aid in diabetes risk assessment, as a five-amino-acid signature had highly significant associations with the development of future…”
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A genome-wide association study of the human metabolome in a community-based cohort Autor Rhee, Eugene P, Ho, Jennifer E, Chen, Ming-Huei, Shen, Dongxiao, Cheng, Susan, Larson, Martin G, Ghorbani, Anahita, Shi, Xu, Helenius, Iiro T, O'Donnell, Christopher J, Souza, Amanda L, Deik, Amy, Pierce, Kerry A, Bullock, Kevin, Walford, Geoffrey A, Vasan, Ramachandran S, Florez, Jose C, Clish, Clary, Yeh, J-R Joanna, Wang, Thomas J, Gerszten, Robert E

“…Because metabolites are hypothesized to play key roles as markers and effectors of cardiometabolic diseases, recent studies have sought to annotate the genetic…”
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Physical activity and fitness in the community: the Framingham Heart Study Autor Nayor, Matthew, Chernofsky, Ariel, Spartano, Nicole L, Tanguay, Melissa, Blodgett, Jasmine B, Murthy, Venkatesh L, Malhotra, Rajeev, Houstis, Nicholas E, Velagaleti, Raghava S, Murabito, Joanne M, Larson, Martin G, Vasan, Ramachandran S, Shah, Ravi V, Lewis, Gregory D

“…While greater physical activity (PA) is associated with improved health outcomes, the direct links between distinct components of PA, their changes over time,…”
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Metabolic Architecture of Acute Exercise Response in Middle-Aged Adults in the Community Autor Nayor, Matthew, Shah, Ravi V, Miller, Patricia E, Blodgett, Jasmine B, Tanguay, Melissa, Pico, Alexander R, Murthy, Venkatesh L, Malhotra, Rajeev, Houstis, Nicholas E, Deik, Amy, Pierce, Kerry A, Bullock, Kevin, Dailey, Lucas, Velagaleti, Raghava S, Moore, Stephanie A, Ho, Jennifer E, Baggish, Aaron L, Clish, Clary B, Larson, Martin G, Vasan, Ramachandran S, Lewis, Gregory D

“…Whereas regular exercise is associated with lower risk of cardiovascular disease and mortality, mechanisms of exercise-mediated health benefits remain less…”
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β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors Autor Roberts, Lee D, Boström, Pontus, O'Sullivan, John F, Schinzel, Robert T, Lewis, Gregory D, Dejam, Andre, Lee, Youn-Kyoung, Palma, Melinda J, Calhoun, Sondra, Georgiadi, Anastasia, Chen, Ming-Huei, Ramachandran, Vasan S, Larson, Martin G, Bouchard, Claude, Rankinen, Tuomo, Souza, Amanda L, Clish, Clary B, Wang, Thomas J, Estall, Jennifer L, Soukas, Alexander A, Cowan, Chad A, Spiegelman, Bruce M, Gerszten, Robert E

“…The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) regulates metabolic genes in skeletal muscle and…”
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A comparison of the CHARGE–AF and the CHA2DS2-VASc risk scores for prediction of atrial fibrillation in the Framingham Heart Study Autor Christophersen, Ingrid E., Yin, Xiaoyan, Larson, Martin G., Lubitz, Steven A., Magnani, Jared W., McManus, David D., Ellinor, Patrick T., Benjamin, Emelia J.

“…Atrial fibrillation (AF) affects more than 33 million individuals worldwide and increases risks of stroke, heart failure, and death. The CHARGE-AF risk score…”
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Objective physical activity and physical performance in middle-aged and older adults Autor Spartano, Nicole L., Lyass, Asya, Larson, Martin G., Tran, Tuyen, Andersson, Charlotte, Blease, Susan J., Esliger, Dale W., Vasan, Ramachandran S., Murabito, Joanne M.

“…Older adults may have difficulty meeting the Physical Activity (PA) Guidelines. A favorable balance between PA and sedentary time (SED) is an important…”
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Relations of arterial stiffness and endothelial function to brain aging in the community Autor Tsao, Connie W, Seshadri, Sudha, Beiser, Alexa S, Westwood, Andrew J, Decarli, Charles, Au, Rhoda, Himali, Jayandra J, Hamburg, Naomi M, Vita, Joseph A, Levy, Daniel, Larson, Martin G, Benjamin, Emelia J, Wolf, Philip A, Vasan, Ramachandran S, Mitchell, Gary F

“…To determine the association of arterial stiffness and pressure pulsatility, which can damage small vessels in the brain, with vascular and Alzheimer-type…”
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