Suchergebnisse - "Lamb, Robert A."

Structure of a paramyxovirus polymerase complex reveals a unique methyltransferase-CTD conformation von Abdella, Ryan, Aggarwal, Megha, Okura, Takashi, Lamb, Robert A, He, Yuan

“… Paramyxoviruses are enveloped, nonsegmented, negative-strand RNA viruses that cause a wide spectrum of human and animal diseases. The viral genome, packaged by …”
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The Structure, Function, and Pathobiology of the Influenza A and B Virus Ion Channels von Lamb, Robert A

“… Influenza A virus AM2 protein is an integral membrane protein that is an ion channel (also known as a viroporin). The channel has 24 extracellular residues, 19 …”
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The innate immune sensor LGP2 activates antiviral signaling by regulating MDA5-RNA interaction and filament assembly von Bruns, Annie M, Leser, George P, Lamb, Robert A, Horvath, Curt M

“… Cytoplasmic pattern recognition receptors detect non-self RNAs during virus infections and initiate antiviral signaling. One receptor, MDA5, possesses …”
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Influenza A virus uses intercellular connections to spread to neighboring cells von Roberts, Kari L, Manicassamy, Balaji, Lamb, Robert A

“… In the extracellular environment, cell-free virions seek out naive host cells over long distances and between organisms. This is the primary mechanism of …”
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Lateral Organization of Influenza Virus Proteins in the Budozone Region of the Plasma Membrane von Leser, George P, Lamb, Robert A

“… Influenza virus assembles and buds at the plasma membrane of virus-infected cells. The viral proteins assemble at the same site on the plasma membrane for …”
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Activation of paramyxovirus membrane fusion and virus entry von Jardetzky, Theodore S, Lamb, Robert A

“… •Most paramyxoviruses require attachment and fusion (F) proteins for cell entry.•Competing ‘clamp’ and ‘provocateur’ models have been proposed as entry …”
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Filamentous influenza virus enters cells via macropinocytosis von Rossman, Jeremy S, Leser, George P, Lamb, Robert A

“… Influenza virus is pleiomorphic, producing both spherical (100-nm-diameter) and filamentous (100-nm by 20-μm) virions. While the spherical virions are known to …”
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Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus von Wang, Jun, Wu, Yibing, Ma, Chunlong, Fiorin, Giacomo, Wang, Jizhou, Pinto, Lawrence H, Lamb, Robert A, Klein, Michael L, Degrado, William F

“… The influenza A virus M2 proton channel (A/M2) is the target of the antiviral drugs amantadine and rimantadine, whose use has been discontinued due to …”
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Structure of the paramyxovirus parainfluenza virus 5 nucleoprotein-RNA complex von Alayyoubi, Maher, Leser, George P, Kors, Christopher A, Lamb, Robert A

“… Parainfluenza virus 5 (PIV5) is a member of the Paramyxoviridae family of membrane-enveloped viruses with a negative-sense RNA genome that is packaged and …”
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Structural basis of viral invasion: lessons from paramyxovirus F von Lamb, Robert A, Jardetzky, Theodore S

“… The structures of glycoproteins that mediate enveloped virus entry into cells have revealed dramatic structural changes that accompany membrane fusion and …”
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A new influenza virus virulence determinant: the NS1 protein four C-terminal residues modulate pathogenicity von Jackson, David, Hossain, Md Jaber, Hickman, Danielle, Perez, Daniel R, Lamb, Robert A

“… The virulence of influenza virus is a multigenic trait. One determinant of virulence is the multifunctional NS1 protein that functions in several ways to …”
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Robust and Guided Bayesian Reconstruction of Single-Photon 3D Lidar Data: Application to Multispectral and Underwater Imaging von Halimi, Abderrahim, Maccarone, Aurora, Lamb, Robert A., Buller, Gerald S., McLaughlin, Stephen

“… 3D Lidar imaging can be a challenging modality when using multiple wavelengths, or when imaging in high noise environments (e.g., imaging through obscurants) …”
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Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus von Acharya, Rudresh, Carnevale, Vincenzo, Fiorin, Giacomo, Levine, Benjamin G, Polishchuk, Alexei L, Balannik, Victoria, Samish, Ilan, Lamb, Robert A, Pinto, Lawrence H, DeGrado, William F, Klein, Michael L

“… The M2 proton channel from influenza A virus is an essential protein that mediates transport of protons across the viral envelope. This protein has a single …”
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The influenza virus M2 protein cytoplasmic tail interacts with the M1 protein and influences virus assembly at the site of virus budding von Chen, Benjamin J, Leser, George P, Jackson, David, Lamb, Robert A

“… The cytoplasmic tail of the influenza A virus M2 proton-selective ion channel has been shown to be important for virus replication. Previous analysis of M2 …”
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Structure of the Newcastle disease virus hemagglutinin-neuraminidase (HN) ectodomain reveals a four-helix bundle stalk von Yuan, Ping, Swanson, Kurt A, Leser, George P, Paterson, Reay G, Lamb, Robert A, Jardetzky, Theodore S

“… The paramyxovirus hemagglutinin-neuraminidase (HN) protein plays multiple roles in viral entry and egress, including binding to sialic acid receptors, …”
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Structure of the Parainfluenza Virus 5 (PIV5) Hemagglutinin-Neuraminidase (HN) Ectodomain von Welch, Brett D., Yuan, Ping, Bose, Sayantan, Kors, Christopher A., Lamb, Robert A., Jardetzky, Theodore S.

“… Paramyxoviruses cause a wide variety of human and animal diseases. They infect host cells using the coordinated action of two surface glycoproteins, the …”
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Influenza virus hemagglutinin and neuraminidase, but not the matrix protein, are required for assembly and budding of plasmid-derived virus-like particles von Chen, Benjamin J, Leser, George P, Morita, Eiji, Lamb, Robert A

“… For influenza virus, we developed an efficient, noncytotoxic, plasmid-based virus-like particle (VLP) system to reflect authentic virus particles. This system …”
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Structure and stabilization of the Hendra virus F glycoprotein in its prefusion form von Wong, Joyce J W, Paterson, Reay G, Lamb, Robert A, Jardetzky, Theodore S

“… Hendra virus (HeV) is one of the two prototypical members of the Henipavirus genus of paramyxoviruses, which are designated biosafety level 4 (BSL-4) organisms …”
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The amphipathic helix of influenza A virus M2 protein is required for filamentous bud formation and scission of filamentous and spherical particles von Roberts, Kari L, Leser, George P, Ma, Chunlong, Lamb, Robert A

“… Influenza virus assembles and buds at the infected-cell plasma membrane. This involves extrusion of the plasma membrane followed by scission of the bud, …”
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Influenza virus m2 ion channel protein is necessary for filamentous virion formation von Rossman, Jeremy S, Jing, Xianghong, Leser, George P, Balannik, Victoria, Pinto, Lawrence H, Lamb, Robert A

“… Influenza A virus buds from cells as spherical (approximately 100-nm diameter) and filamentous (approximately 100 nm x 2 to 20 microm) virions. Previous work …”
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