Suchergebnisse - "Lamb, Alastair D."

Feasibility and safety of radical prostatectomy for oligo‐metastatic prostate cancer: the Testing Radical prostatectomy in men with prostate cancer and oligo‐Metastases to the bone (TRoMbone) trial von Sooriakumaran, Prasanna, Wilson, Caroline, Rombach, Ines, Hassanali, Neelam, Aning, Jonathan, D. Lamb, Alastair, Cathcart, Paul, Eden, Christopher, Ahmad, Imran, Rajan, Prabhakar, Sridhar, Ashwin, Bryant, Richard J., Elhage, Oussama, Cook, Jonathan, Leung, Hing, Soomro, Naeem, Kelly, John, Nathan, Senthil, Donovan, Jenny L., Hamdy, Freddie C.

“… Objectives To test the feasibility of randomisation to radical prostatectomy (RP) plus pelvic lymphadenectomy in addition to standard‐of‐care (SOC) systemic …”
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The androgen receptor induces a distinct transcriptional program in castration-resistant prostate cancer in man von Sharma, Naomi L, Massie, Charlie E, Ramos-Montoya, Antonio, Zecchini, Vincent, Scott, Helen E, Lamb, Alastair D, MacArthur, Stewart, Stark, Rory, Warren, Anne Y, Mills, Ian G, Neal, David E

“… The androgen receptor (AR) regulates prostate cell growth in man, and prostate cancer is the commonest cancer in men in the UK. We present a comprehensive …”
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Neuroendocrine differentiation of prostate cancer leads to PSMA suppression von Bakht, Martin K, Derecichei, Iulian, Li, Yinan, Ferraiuolo, Rosa-Maria, Dunning, Mark, Oh, So Won, Hussein, Abdulkadir, Youn, Hyewon, Stringer, Keith F, Jeong, Chang Wook, Cheon, Gi Jeong, Kwak, Cheol, Kang, Keon Wook, Lamb, Alastair D, Wang, Yuzhuo, Dong, Xuesen, Porter, Lisa A

“… Prostate-specific membrane antigen (PSMA) is overexpressed in most prostate adenocarcinoma (AdPC) cells and acts as a target for molecular imaging. However, …”
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Protocol for the TRANSLATE prospective, multicentre, randomised clinical trial of prostate biopsy technique von Bryant, Richard J., Yamamoto, Hide, Eddy, Ben, Kommu, Sashi, Narahari, Krishna, Omer, Altan, Leslie, Tom, Catto, James W. F., Rosario, Derek J., Good, Daniel W., Gray, Rob, Liew, Matthew P. C., Lopez, J. Francisco, Campbell, Teresa, Reynard, John M., Tuck, Steve, Barber, Vicki S., Medeghri, Nadjat, Davies, Lucy, Parkes, Matthew, Hewitt, Aimi, Landeiro, Filipa, Wolstenholme, Jane, Macpherson, Ruth, Verrill, Clare, Marian, Ioana R., Williams, Roxanne, Hamdy, Freddie C., Lamb, Alastair D.

“… Objectives Primary objectives: to determine whether local anaesthetic transperineal prostate (LATP) biopsy improves the detection of clinically significant …”
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Gene regulatory mechanisms underpinning prostate cancer susceptibility von Whitington, Thomas, Gao, Ping, Song, Wei, Ross-Adams, Helen, Lamb, Alastair D, Yang, Yuehong, Svezia, Ilaria, Klevebring, Daniel, Mills, Ian G, Karlsson, Robert, Halim, Silvia, Dunning, Mark J, Egevad, Lars, Warren, Anne Y, Neal, David E, Grönberg, Henrik, Lindberg, Johan, Wei, Gong-Hong, Wiklund, Fredrik

“… Thomas Whitington and colleagues present a detailed characterization of gene regulatory mechanisms underlying prostate cancer susceptibility. Their analysis …”
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Spatio-temporal analysis of prostate tumors in situ suggests pre-existence of treatment-resistant clones von Marklund, Maja, Schultz, Niklas, Friedrich, Stefanie, Berglund, Emelie, Tarish, Firas, Tanoglidi, Anna, Liu, Yao, Bergenstråhle, Ludvig, Erickson, Andrew, Helleday, Thomas, Lamb, Alastair D., Sonnhammer, Erik, Lundeberg, Joakim

“… The molecular mechanisms underlying lethal castration-resistant prostate cancer remain poorly understood, with intratumoral heterogeneity a likely contributing …”
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Clonal phylogenies inferred from bulk, single cell, and spatial transcriptomic analysis of epithelial cancers von Erickson, Andrew, Figiel, Sandy, Rajakumar, Timothy, Rao, Srinivasa, Yin, Wencheng, Doultsinos, Dimitrios, Magnussen, Anette, Singh, Reema, Poulose, Ninu, Bryant, Richard J., Cussenot, Olivier, Hamdy, Freddie C., Woodcock, Dan, Mills, Ian G., Lamb, Alastair D.

“… Epithelial cancers are typically heterogeneous with primary prostate cancer being a typical example of histological and genomic variation. Prior studies of …”
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Spatial transcriptomic analysis of virtual prostate biopsy reveals confounding effect of tissue heterogeneity on genomic signatures von Figiel, Sandy, Yin, Wencheng, Doultsinos, Dimitrios, Erickson, Andrew, Poulose, Ninu, Singh, Reema, Magnussen, Anette, Anbarasan, Thineskrishna, Teague, Renuka, He, Mengxiao, Lundeberg, Joakim, Loda, Massimo, Verrill, Clare, Colling, Richard, Gill, Pelvender S., Bryant, Richard J., Hamdy, Freddie C., Woodcock, Dan J., Mills, Ian G., Cussenot, Olivier, Lamb, Alastair D.

“… Genetic signatures have added a molecular dimension to prognostics and therapeutic decision-making. However, tumour heterogeneity in prostate cancer and …”
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Single-cell analysis uncovers preserved prostate cancer lineages and universally altered pathways in Matrigel-free patient-derived organoids von Dolgos, Robin, Parmentier, Romuald, Wang, Jing, Servant, Raphaëlle, Templeton, Arnoud J., Zellweger, Tobias, Lamb, Alastair D., Mertz, Kirsten D., Subotic, Svetozar, Vlajnic, Tatjana, Seifert, Helge, Mortezavi, Ashkan, Rentsch, Cyrill A., Bubendorf, Lukas, Le Magnen, Clémentine

“… The application of patient-derived organoids (PDOs) in prostate cancer (PCa) research has been hampered by poor take rates and benign overgrowth. We highlight …”
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Statistical analysis plan for the TRANSLATE (TRANSrectal biopsy versus Local Anaesthetic Transperineal biopsy Evaluation of potentially clinically significant prostate cancer) multicentre randomised controlled trial von Marian, Ioana R., Ooms, Alexander, Holmes, Jane, Parkes, Matthew J., Lamb, Alastair D., Bryant, Richard J.

“… Background The TRANSLATE (TRANSrectal biopsy versus Local Anaesthetic Transperineal biopsy Evaluation) trial assesses the clinical and cost-effectiveness of …”
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Protocol for a randomised phase 3 trial evaluating the role of Finasteride in Active Surveillance for men with low and intermediate-risk prostate cancer: the FINESSE Study von Cumberbatch, Marcus, North, Bernard, Kealy, Roseann, Smith, Samuel, Hubbard, Rachel, Kennish, Steven, Bhattrai, Selina, Cross, William, Chahal, Rohit, Bryant, Richard, Lamb, Alastair D, Dooldeniya, Mohantha, Faulkner, Simon, Sasieni, Peter, Catto, James

“… BackgroundProstate cancer (PCa) is the most common male malignancy in the western world. Many men (40%) are diagnosed with localised low or intermediate-risk …”
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Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer von Yang, Lingjian, Roberts, Darren, Takhar, Mandeep, Erho, Nicholas, Bibby, Becky A.S., Thiruthaneeswaran, Niluja, Bhandari, Vinayak, Cheng, Wei-Chen, Haider, Syed, McCorry, Amy M.B., McArt, Darragh, Jain, Suneil, Alshalalfa, Mohammed, Ross, Ashley, Schaffer, Edward, Den, Robert B., Jeffrey Karnes, R., Klein, Eric, Hoskin, Peter J., Freedland, Stephen J., Lamb, Alastair D., Neal, David E., Buffa, Francesca M., Bristow, Robert G., Boutros, Paul C., Davicioni, Elai, Choudhury, Ananya, West, Catharine M.L.

“… Hypoxia is associated with a poor prognosis in prostate cancer. This work aimed to derive and validate a hypoxia-related mRNA signature for localized prostate …”
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Identification of potential therapeutic targets in prostate cancer through a cross‐species approach von Jurmeister, Sarah, Ramos‐Montoya, Antonio, Sandi, Chiranjeevi, Pértega‐Gomes, Nelma, Wadhwa, Karan, Lamb, Alastair D, Dunning, Mark J, Attig, Jan, Carroll, Jason S, Fryer, Lee GD, Felisbino, Sérgio L, Neal, David E

“… Genetically engineered mouse models of cancer can be used to filter genome‐wide expression datasets generated from human tumours and to identify gene …”
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Intra-prostatic tumour evolution, steps in metastatic spread and histogenomic associations revealed by integration of multi-region whole-genome sequencing with histopathological features von Rao, Srinivasa, Verrill, Clare, Cerundolo, Lucia, Alham, Nasullah Khalid, Kaya, Zeynep, O’Hanlon, Miriam, Hayes, Alicia, Lambert, Adam, James, Martha, Tullis, Iain D. C., Niederer, Jane, Lovell, Shelagh, Omer, Altan, Lopez, Francisco, Leslie, Tom, Buffa, Francesca, Bryant, Richard J., Lamb, Alastair D., Vojnovic, Boris, Wedge, David C., Mills, Ian G., Woodcock, Dan J., Tomlinson, Ian, Hamdy, Freddie C.

“… Background Extension of prostate cancer beyond the primary site by local invasion or nodal metastasis is associated with poor prognosis. Despite significant …”
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HES6 drives a critical AR transcriptional programme to induce castration‐resistant prostate cancer through activation of an E2F1‐mediated cell cycle network von Ramos‐Montoya, Antonio, Lamb, Alastair D, Russell, Roslin, Carroll, Thomas, Jurmeister, Sarah, Galeano‐Dalmau, Nuria, Massie, Charlie E, Boren, Joan, Bon, Helene, Theodorou, Vasiliki, Vias, Maria, Shaw, Greg L, Sharma, Naomi L, Ross‐Adams, Helen, Scott, Helen E, Vowler, Sarah L, Howat, William J, Warren, Anne Y, Wooster, Richard F, Mills, Ian G, Neal, David E

“… Castrate‐resistant prostate cancer (CRPC) is poorly characterized and heterogeneous and while the androgen receptor (AR) is of singular importance, other …”
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Prostate cancer detection after atypical small acinar proliferation (ASAP): A 10‐year single‐centre cohort von Anbarasan, Thineskrishna, Raslan, Mutie, Ghosh, Kanchan, Macklin, Philip, Mercader, Claudia, Leslie, Tom, Hamdy, Freddie C., Colling, Richard, Browning, Lisa, Roberts, Ian, Verrill, Clare, Bryant, Richard J., Lopez, Francisco, Lamb, Alastair D.

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The Use of Digital Pathology and Artificial Intelligence in Histopathological Diagnostic Assessment of Prostate Cancer: A Survey of Prostate Cancer UK Supporters von Rakovic, Kai, Colling, Richard, Browning, Lisa, Dolton, Monica, Horton, Margaret R., Protheroe, Andrew, Lamb, Alastair D., Bryant, Richard J., Scheffer, Richard, Crofts, James, Stanislaus, Ewart, Verrill, Clare

“… There has been particular interest in the deployment of digital pathology (DP) and artificial intelligence (AI) in the diagnosis of prostate cancer, but little …”
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Changing face of robot‐assisted radical prostatectomy in Melbourne over 12 years von Sathianathen, Niranjan J., Lamb, Alastair D., Lawrentschuk, Nathan L., Goad, Jeremy R., Peters, Justin, Costello, Anthony J., Murphy, Declan G., Moon, Daniel A.

“… Background This study aims to characterize the trends in disease presentation for robot‐assisted radical prostatectomy (RARP) over a 12‐year period in …”
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Ductal adenocarcinoma of the prostate: A systematic review and meta‐analysis of incidence, presentation, prognosis, and management von Ranasinha, Nithesh, Omer, Altan, Philippou, Yiannis, Harriss, Eli, Davies, Lucy, Chow, Ken, Chetta, Paolo M., Erickson, Andrew, Rajakumar, Timothy, Mills, Ian G., Bryant, Richard J., Hamdy, Freddie C., Murphy, Declan G., Loda, Massimo, Hovens, Christopher M., Corcoran, Niall M., Verrill, Clare, Lamb, Alastair D.

“… Context Ductal adenocarcinoma (DAC) is relatively rare, but is nonetheless the second most common subtype of prostate cancer. First described in 1967, opinion …”
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Editorial Comment to White blood cell count is positively associated with benign prostatic hyperplasia von Lamb, Alastair D

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