Suchergebnisse - "LC/MS/MS"

A multiplexed LC–MS/MS method to reveal changes in inflammatory and coagulation cascades induced by host infection von Pinto, Gabriella, Illiano, Anna, Serpico, Stefania, Maurelli, Fabio, Scaglione, Elena, Colicchio, Roberta, Vitiello, Mariateresa, Varelli, Marco, Salvatore, Paola, Amoresano, Angela

“… Above the immune system, abnormalities in coagulation parameters have been observed in COVID-19-affected subjects displaying an increased risk of a blood clot causing thromboembolic events …”
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Triple Negative Breast Cancer Detection Using LC-MS/MS Lipidomic Profiling von Eghlimi, Ryan, Shi, Xiaojian, Hrovat, Jonathan, Xi, Bowei, Gu, Haiwei

“… Breast cancer (BC) is a heterogeneous malignancy that is responsible for a great portion of female cancer cases and cancer-related deaths in the United States …”
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Optimized and Robust Workflow for Quantifying the Canonical Histone Ubiquitination Marks H2AK119ub and H2BK120ub by LC-MS/MS von Lopes, Mariana, Lund, Peder J, Garcia, Benjamin A

“… Although robust LC-MS/MS methods are available to analyze modifications on the histone N-terminal tails, routine methods for characterizing ubiquitin marks on histone C-terminal regions, especially …”
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A Simultaneous Extraction/Derivatization Strategy for Quantitation of Vitamin D in Dried Blood Spots Using LC–MS/MS: Application to Biomarker Study in Subjects Tested for SARS-CoV-2 von Chhonker, Yashpal S., Ahmed, Nusrat, Johnston, Christine M., Barnabas, Ruanne V., Murry, Daryl J.

“… In this context, we have developed and validated a robust LC–MS/MS method for simultaneous quantitation of vitamin D and its metabolites in human dried blood spot (DBS …”
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LC–MS/MS-QTOF analysis of Anodendron parviflorum (Roxb.) leaves extract and exploring its antioxidant, antimicrobial, and cytotoxic potential von Sharmila, Arunagiri, Selvaraj, Chinnadurai Immanuel

“… The present study seeks to understand better the phytochemical and LC–MS/MS-QTOF profiling of A. parviflorum 's ethanolic extract and to investigate the properties of the different solvents …”
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Identification and quantification of the molecular species of bilirubin BDG, BMG and UCB by LC‒MS/MS in hyperbilirubinemic human serum von Castillo-Castañeda, Stephany M., Rivera-Espinosa, Liliana, Gómez-Garduño, Josefina, Cordova-Gallardo, Jacqueline, Chávez-Pacheco, Juan Luis, Méndez-Sánchez, Nahum

“… The aim of this study was to standardize and validate a method for the identification and simultaneous quantification of BMG, BDG and UCB by LC‒MS/MS. Liquid …”
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Simultaneous quantitation of urine aldosterone and tetrahydroaldosterone in healthy Chinese subjects using a validated LC–MS/MS method von Cheng, Jenny Yeuk Ki, Lo, Clara Wai Shan, Chan, Alan Shek Lun, Luk, Yue Kin, Tsui, Teresa Kam Chi, Ho, Chung Shun

“… We report a validated LC–MS/MS method to measure both analytes simultaneously. Urine samples underwent enzymatic hydrolysis to release the analytes from their glucuronide conjugates followed by organic solvent extraction and LC–MS/MS …”
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Sex- and age-specific reference intervals of 16 steroid metabolites quantified simultaneously by LC-MS/MS in sera from 2458 healthy subjects aged 0 to 77 years von Frederiksen, Hanne, Johannsen, Trine Holm, Andersen, Stine Ehlern, Petersen, Jørgen Holm, Busch, Alexander Siegfried, Ljubicic, Marie Lindhardt, Fischer, Margit Bistrup, Upners, Emmie N., Hagen, Casper P., Main, Katharina M., Aksglaede, Lise, Jørgensen, Niels, Lund Kårhus, Line, Linneberg, Allan, Andersson, Anna-Maria, Flück, Christa E., Juul, Anders

“… •A novel, specific, and sensitive isotope diluted LC-MS/MS method was developed for simultaneous quantitation of 16 steroid hormone metabolites …”
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Development of LC‐MS/MS determination method and backpropagation artificial neural networks pharmacokinetic model of febuxostat in healthy subjects von Xu, Yichao, Chen, Jinliang, Yang, Dandan, Hu, Yin, Hu, Xinhua, Jiang, Bo, Ruan, Zourong, Lou, Honggang

“… What is known and objective Febuxostat is a well‐known drug for treating hyperuricemia and gout. The published methods for determination of febuxostat in human …”
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Sex-specific Estrogen Levels and Reference Intervals from Infancy to Late Adulthood Determined by LC-MS/MS von Frederiksen, Hanne, Johannsen, Trine Holm, Andersen, Stine Ehlern, Albrethsen, Jakob, Landersoe, Selma Kløve, Petersen, Jørgen Holm, Andersen, Anders Nyboe, Vestergaard, Esben Thyssen, Schorring, Mia Elbek, Linneberg, Allan, Main, Katharina M, Andersson, Anna-Maria, Juul, Anders

“… Objective To establish sex-specific reference ranges for estrone (E1) and estradiol (E2) throughout life and to evaluate sex-differences using the state-of-the-art liquid chromatography tandem mass spectrometry (LC-MS/MS …”
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Direct sequencing of total Saccharomyces cerevisiae tRNAs by LC-MS/MS von Jones, Joshua D, Simcox, Kaley M, Kennedy, Robert T, Koutmou, Kristin S

“… Among RNAs, transfer RNAs (tRNAs) contain the widest variety of abundant posttranscriptional chemical modifications. These modifications are crucial for tRNAs …”
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Promazine Detection in Human Hair: Presentation of an LC-MS-MS Method and Pattern of Drug Discontinuation von Kintz, Pascal, Ameline, Alice, Raul, Jean-Sébastien

“… The drug is available as tablets, as syrups and in injectable forms. Despite its prescription to millions of subjects, its detection in human hair has seldom been reported …”
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Serum 25-hydroxyvitamin D status of a large Chinese population from 30 provinces by LC–MS/MS measurement for consecutive 3 years: differences by age, sex, season and province von Bai, Kai, Dong, Heng, Liu, Ling, She, Xuhui, Liu, Chang, Yu, Mujun, Liang, Zhihui, Lin, Haibiao, Ke, Peifeng, Huang, Xianzhang, Wu, Xinzhong, Zhang, Qiaoxuan, Zhao, Beibei

“… –119 years old in 30 provinces of China. Serum 25(OH)D was measured by an accurate commercial liquid chromatography-tandem mass spectrometry (LC–MS/MS …”
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Inception and development of a LC-MS/MS assay for the multiplexed quantitation of nine human drug transporter biomarkers von Kadar, Eugene P, Holliman, Christopher L, Vourvahis, Manoli, Rodrigues, A David

“… The multiplex assays were applied to a first in human study. Placebo/reference subject biomarker data were consistent with single assay in-house and published data …”
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Multiplexed LC‐MS / MS quantification of salivary RNA modifications in periodontitis von Vignon, Margaux, Bastide, Amandine, Attina, Aurore, David, Alexandre, Bousquet, Philippe, Orti, Valérie, Vialaret, Jérôme, Lehmann, Sylvain, Periere, Dominique DevilleDe, Hirtz, Christophe

“… ) and from control subjects (n = 8). Periodontitis patients were stratified according to stage and grade …”
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LC–MS/MS analysis of metformin, saxagliptin and 5‐hydroxy saxagliptin in human plasma and its pharmacokinetic study with a fixed‐dose formulation in healthy Indian subjects von Shah, Priyanka A., Shah, Jaivik V., Sanyal, Mallika, Shrivastav, Pranav S.

“… A specific and rapid liquid chromatography–tandem mass spectrometry method is proposed for the simultaneous determination of metformin (MET), saxagliptin …”
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Testing for protonitazene in human hair using LC-MS-MS von Kintz, Pascal, Ameline, Alice, Gheddar, Laurie, Pichini, Simona, Mazoyer, Cédric, Teston, Katy, Aknouche, Frédéric, Maruejouls, Christophe

“… Protonitazene is a synthetic benzimidazole opioid of the nitazenes class, developed in the 1950s as an effective analgesic, but never released on the market …”
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Quantitation of melatonin and n-acetylserotonin in human plasma by nanoflow LC-MS/MS and electrospray LC-MS/MS von Carter, Melissa D., Wade Calcutt, M., Malow, Beth A., Rose, Kristie L., Hachey, David L.

“… In support of our ongoing study to determine the safety, tolerability and PK dosing strategies for MEL in treating insomnia in children with autism spectrum disorder, two highly sensitive LC …”
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LC–MS/MS–Based Serum Lipidomic Profile to Reveal Cancer‐Specific Biomarkers for Renal Cell Carcinoma von Lin, Lin, Zheng, Jiaxin, Hu, Sixia

“… Here, a liquid chromatography–tandem mass spectrometry (LC–MS/MS) based serum lipidomic profile was carried out to reveal the lipid expression differences in RCC patients and healthy controls …”
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Simultaneous determination of tramadol and paracetamol in human plasma using LC-MS/MS and application in bioequivalence study of ­fixed-dose combination von Loh, Gabriel Onn Kit, Wong, Emily Yii Ling, Goh, Chen Zhu, Tan, Yvonne Tze Fung, Lee, Yi Lin, Pang, Lai Hui, Shahridzo, Siti Halimah, Damenthi, Nair, Hermansyah, Andi, Long, Chiau Ming, Peh, Kok Khiang

“… The study aimed to develop a sensitive and high-throughput liquid chromatography coupled with tandem mass spectrometry method to quantify concentrations of …”
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