Suchergebnisse - "Kullo, Iftikhar J"

The eMERGE Network: A consortium of biorepositories linked to electronic medical records data for conducting genomic studies von McCarty, Catherine A, Chisholm, Rex L, Chute, Christopher G, Kullo, Iftikhar J, Jarvik, Gail P, Larson, Eric B, Li, Rongling, Masys, Daniel R, Ritchie, Marylyn D, Roden, Dan M, Struewing, Jeffery P, Wolf, Wendy A

“… Introduction The eMERGE (electronic MEdical Records and GEnomics) Network is an NHGRI-supported consortium of five institutions to explore the utility of DNA …”
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Sex differences in arterial stiffness and ventricular-arterial interactions von Coutinho, Thais, Borlaug, Barry A, Pellikka, Patricia A, Turner, Stephen T, Kullo, Iftikhar J

“… This study sought to assess sex differences in ventricular-arterial interactions. Heart failure with preserved ejection fraction is more prevalent in women …”
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Associations of Self-Reported Race, Social Determinants of Health, and Polygenic Risk With Coronary Heart Disease von Norland, Kristjan, Schaid, Daniel J, Naderian, Mohammadreza, Na, Jie, Kullo, Iftikhar J

“… Social determinants of health (SDOH) influence the risk of common diseases such as coronary heart disease (CHD). This study sought to test the associations of …”
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The phenotypic legacy of admixture between modern humans and Neandertals von Simonti, Corinne N, Vernot, Benjamin, Bastarache, Lisa, Bottinger, Erwin, Carrell, David S, Chisholm, Rex L, Crosslin, David R, Hebbring, Scott J, Jarvik, Gail P, Kullo, Iftikhar J, Li, Rongling, Pathak, Jyotishman, Ritchie, Marylyn D, Roden, Dan M, Verma, Shefali S, Tromp, Gerard, Prato, Jeffrey D, Bush, William S, Akey, Joshua M, Denny, Joshua C, Capra, John A

“… Many modern human genomes retain DNA inherited from interbreeding with archaic hominins, such as Neandertals, yet the influence of this admixture on human …”
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Antibody-Based Protein Multiplex Platforms: Technical and Operational Challenges von Ellington, Allison A, Kullo, Iftikhar J, Bailey, Kent R, Klee, George G

“… Background: The measurement of multiple protein biomarkers may refine risk stratification in clinical settings. This concept has stimulated development of …”
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Predictive Utility of Polygenic Risk Scores for Coronary Heart Disease in Three Major Racial and Ethnic Groups von Dikilitas, Ozan, Schaid, Daniel J, Kosel, Matthew L, Carroll, Robert J, Chute, Christopher G, Denny, Joshua A, Fedotov, Alex, Feng, QiPing, Hakonarson, Hakon, Jarvik, Gail P, Lee, Ming Ta Michael, Pacheco, Jennifer A, Rowley, Robb, Sleiman, Patrick M, Stein, C Michael, Sturm, Amy C, Wei, Wei-Qi, Wiesner, Georgia L, Williams, Marc S, Zhang, Yanfei, Manolio, Teri A, Kullo, Iftikhar J

“… Because polygenic risk scores (PRSs) for coronary heart disease (CHD) are derived from mainly European ancestry (EA) cohorts, their validity in African …”
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The association between cigarette smoking and inflammation: The Genetic Epidemiology Network of Arteriopathy (GENOA) study von Tibuakuu, Martin, Kamimura, Daisuke, Kianoush, Sina, DeFilippis, Andrew P., Al Rifai, Mahmoud, Reynolds, Lindsay M., White, Wendy B., Butler, Kenneth R., Mosley, Thomas H., Turner, Stephen T., Kullo, Iftikhar J., Hall, Michael E., Blaha, Michael J.

“… To inform the study and regulation of emerging tobacco products, we sought to identify sensitive biomarkers of tobacco-induced subclinical cardiovascular …”
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Deep Generative Models of LDLR Protein Structure to Predict Variant Pathogenicity von James, Jose K., Norland, Kristjan, Johar, Angad S., Kullo, Iftikhar J.

“… The complex structure and function of low-density lipoprotein receptor (LDLR) makes classification of protein-coding missense variants challenging. Deep …”
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Precision Cardiovascular Medicine: State of Genetic Testing von Giudicessi, John R., Kullo, Iftikhar J., Ackerman, Michael J.

“… In the 15 years following the release of the first complete human genome sequences, our understanding of rare and common genetic variation as determinants of …”
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Usefulness of Red Cell Distribution Width to Predict Mortality in Patients With Peripheral Artery Disease von Ye, Zi, Smith, Carin, Kullo, Iftikhar J.

“… Increased red blood cell distribution width (RDW), a marker of anisocytosis, has been associated with adverse outcomes in multiple settings. Whether RDW is …”
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Bempedoic Acid Falls in Line von Safarova, Maya S, Moriarty, Patrick M, Kullo, Iftikhar J, Ballantyne, Christie M, Gianos, Eugenia

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My Approach to the Patient With Familial Hypercholesterolemia von Safarova, Maya S., Kullo, Iftikhar J.

“… Familial hypercholesterolemia (FH), a relatively common Mendelian genetic disorder, is associated with a dramatically increased lifetime risk of premature …”
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Rapid identification of familial hypercholesterolemia from electronic health records: The SEARCH study von Safarova, Maya S., Liu, Hongfang, Kullo, Iftikhar J.

“… Little is known about prevalence, awareness, and control of familial hypercholesterolemia (FH) in the United States. To address these knowledge gaps, we …”
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Risk Factors for Polyvascular Involvement in Patients With Peripheral Artery Disease: A Mendelian Randomization Study von Dikilitas, Ozan, Satterfield, Benjamin A., Kullo, Iftikhar J.

“… Background Atherosclerosis in >1 vascular bed (ie, polyvascular disease), often a feature of peripheral artery disease (PAD), is associated with high morbidity …”
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Mining peripheral arterial disease cases from narrative clinical notes using natural language processing von Afzal, Naveed, Sohn, Sunghwan, Abram, Sara, Scott, Christopher G, Chaudhry, Rajeev, Liu, Hongfang, Kullo, Iftikhar J, Arruda-Olson, Adelaide M

“… Lower extremity peripheral arterial disease (PAD) is highly prevalent and affects millions of individuals worldwide. We developed a natural language processing …”
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Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms von Pividori, Milton, Lu, Sumei, Li, Binglan, Su, Chun, Johnson, Matthew E., Wei, Wei-Qi, Feng, Qiping, Namjou, Bahram, Kiryluk, Krzysztof, Kullo, Iftikhar J., Luo, Yuan, Sullivan, Blair D., Voight, Benjamin F., Skarke, Carsten, Ritchie, Marylyn D., Grant, Struan F. A., Greene, Casey S.

“… Genes act in concert with each other in specific contexts to perform their functions. Determining how these genes influence complex traits requires a …”
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Identification of Four Novel Loci in Asthma in European American and African American Populations von Almoguera, Berta, Vazquez, Lyam, Mentch, Frank, Connolly, John, Pacheco, Jennifer A., Sundaresan, Agnes S., Peissig, Peggy L., Linneman, James G., McCarty, Catherine A., Crosslin, David, Carrell, David S., Lingren, Todd, Namjou-Khales, Bahram, Harley, John B., Larson, Eric, Jarvik, Gail P., Brilliant, Murray, Williams, Marc S., Kullo, Iftikhar J., Hysinger, Erik B., Sleiman, Patrick M. A., Hakonarson, Hakon

“… Despite significant advances in knowledge of the genetic architecture of asthma, specific contributors to the variability in the burden between populations …”
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Electronic medical records for genetic research: results of the eMERGE consortium von Kho, Abel N, Pacheco, Jennifer A, Peissig, Peggy L, Rasmussen, Luke, Newton, Katherine M, Weston, Noah, Crane, Paul K, Pathak, Jyotishman, Chute, Christopher G, Bielinski, Suzette J, Kullo, Iftikhar J, Li, Rongling, Manolio, Teri A, Chisholm, Rex L, Denny, Joshua C

“… Clinical data in electronic medical records (EMRs) are a potential source of longitudinal clinical data for research. The Electronic Medical Records and …”
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Plasma Osteopontin Levels and Adverse Cardiovascular Outcomes in the PEACE Trial von Abdalrhim, Ahmed D., Marroush, Tariq S., Austin, Erin E., Gersh, Bernard J., Solak, Nusret, Rizvi, Syed A., Bailey, Kent R., Kullo, Iftikhar J.

“… Osteopontin (OPN) is a secreted glycophosphoprotein that has a role in inflammation, immune response and calcification. We hypothesized that plasma OPN levels …”
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Transgelin: a new gene involved in LDL endocytosis identified by a genome-wide CRISPR-Cas9 screen von Lucero, Diego, Dikilitas, Ozan, Mendelson, Michael M., Aligabi, Zahra, Islam, Promotto, Neufeld, Edward B., Bansal, Aruna T., Freeman, Lita A., Vaisman, Boris, Tang, Jingrong, Combs, Christian A., Li, Yuesheng, Voros, Szilard, Kullo, Iftikhar J., Remaley, Alan T.

“… A significant proportion of patients with elevated LDL and a clinical presentation of familial hypercholesterolemia do not carry known genetic mutations …”
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