Výsledky vyhľadávania - "Kuka, Janis"

Plasma acylcarnitine concentrations reflect the acylcarnitine profile in cardiac tissues Autor Makrecka-Kuka, Marina, Sevostjanovs, Eduards, Vilks, Karlis, Volska, Kristine, Antone, Unigunde, Kuka, Janis, Makarova, Elina, Pugovics, Osvalds, Dambrova, Maija, Liepinsh, Edgars

“…Increased plasma concentrations of acylcarnitines (ACs) are suggested as a marker of metabolism disorders. The aim of the present study was to clarify which…”
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Structure and Function of CutC Choline Lyase from Human Microbiota Bacterium Klebsiella pneumoniae Autor Kalnins, Gints, Kuka, Janis, Grinberga, Solveiga, Makrecka-Kuka, Marina, Liepinsh, Edgars, Dambrova, Maija, Tars, Kaspars

“…CutC choline trimethylamine-lyase is an anaerobic bacterial glycyl radical enzyme (GRE) that cleaves choline to produce trimethylamine (TMA) and acetaldehyde…”
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Metformin decreases bacterial trimethylamine production and trimethylamine N-oxide levels in db/db mice Autor Kuka, Janis, Videja, Melita, Makrecka-Kuka, Marina, Liepins, Janis, Grinberga, Solveiga, Sevostjanovs, Eduards, Vilks, Karlis, Liepinsh, Edgars, Dambrova, Maija

“…The current study aimed to explore whether metformin, the most widely prescribed oral medication for the treatment of type 2 diabetes, alters plasma levels of…”
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Pharmacological activation of PPARβ/δ preserves mitochondrial respiratory function in ischemia/reperfusion via stimulation of fatty acid oxidation-linked respiration and PGC-1α/NRF-1 signaling Autor Papatheodorou, Ioanna, Makrecka-Kuka, Marina, Kuka, Janis, Liepinsh, Edgars, Dambrova, Maija, Lazou, Antigone

“…Myocardial ischemia/reperfusion (I/R) injury leads to significant impairment of cardiac function and remains the leading cause of morbidity and mortality…”
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SBT-272 improves TDP-43 pathology in ALS upper motor neurons by modulating mitochondrial integrity, motility, and function Autor Gautam, Mukesh, Genç, Barış, Helmold, Benjamin, Ahrens, Angela, Kuka, Janis, Makrecka-Kuka, Marina, Günay, Aksu, Koçak, Nuran, Aguilar-Wickings, Izaak R., Keefe, Dennis, Zheng, Guozhu, Swaminathan, Suchitra, Redmon, Martin, Zariwala, Hatim A., Özdinler, P. Hande

“…Mitochondrial defects are one of the common underlying causes of neuronal vulnerability in neurodegenerative diseases, such as amyotrophic lateral sclerosis…”
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Empagliflozin Protects Cardiac Mitochondrial Fatty Acid Metabolism in a Mouse Model of Diet-Induced Lipid Overload Autor Makrecka-Kuka, Marina, Korzh, Stanislava, Videja, Melita, Vilks, Karlis, Cirule, Helena, Kuka, Janis, Dambrova, Maija, Liepinsh, Edgars

“…Purpose Sodium-glucose cotransporter 2 (SGLT2) inhibitors prevent heart failure and decrease cardiovascular mortality in patients with type 2 diabetes. Heart…”
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trans-Fluorine Effect in Cyclopropane: Diastereoselective Synthesis of Fluorocyclopropyl Cabozantinib Analogs Autor Veliks, Janis, Videja, Melita, Kinens, Artis, Bobrovs, Raitis, Priede, Martins, Kuka, Janis

“…Investigation of the trans-fluorine effect on the hydrolysis rate of diethyl 2-fluorocyclopropane-1,1-dicarboxylate provides synthetic access to both…”
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Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis Autor Becker, Katja, Cao, Sha, Nilsson, Anna, Erlandsson, Maria, Hotop, Sven-Kevin, Kuka, Janis, Hansen, Jon, Haldimann, Klara, Grinberga, Solveiga, Berruga-Fernández, Talia, Huseby, Douglas L., Shariatgorji, Reza, Lindmark, Evelina, Platzack, Björn, Böttger, Erik C., Crich, David, Friberg, Lena E., Vingsbo Lundberg, Carina, Hughes, Diarmaid, Brönstrup, Mark, Andrén, Per E., Liepinsh, Edgars, Hobbie, Sven N.

“…The clinical-stage drug candidate EBL-1003 (apramycin) represents a distinct new subclass of aminoglycoside antibiotics for the treatment of drug-resistant…”
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Excretion of the Polymyxin Derivative NAB739 in Murine Urine Autor Vaara, Martti, Vaara, Timo, Kuka, Janis, Sevostjanovs, Eduards, Grinberga, Solveiga, Dambrova, Maija, Liepinsh, Edgars

“…Extremely multiresistant strains of Enterobacteriaceae are emerging and spreading at a worrisome pace. Polymyxins are used as the last-resort therapy against…”
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Mildronate decreases carnitine availability and up-regulates glucose uptake and related gene expression in the mouse heart Autor Liepinsh, Edgars, Vilskersts, Reinis, Skapare, Elina, Svalbe, Baiba, Kuka, Janis, Cirule, Helena, Pugovics, Osvalds, Kalvinsh, Ivars, Dambrova, Maija

“…l-carnitine has been shown to play a central role in both fat and carbohydrate metabolisms. This study investigated whether acute and long-term treatments with…”
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Expression and purification of active, stabilized trimethyllysine hydroxylase Autor Kazaks, Andris, Makrecka-Kuka, Marina, Kuka, Janis, Voronkova, Tatyana, Akopjana, Inara, Grinberga, Solveiga, Pugovics, Osvalds, Tars, Kaspars

“…•TMLH expressed in E. coli either alone, or as MBP fusion is mainly insoluble.•Co-expression of MBP–TMLH with chaperonins GroES/EL markedly improves…”
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Crystal structure of human gamma-butyrobetaine hydroxylase Autor Tars, Kaspars, Rumnieks, Janis, Zeltins, Andris, Kazaks, Andris, Kotelovica, Svetlana, Leonciks, Ainars, Sharipo, Jelena, Viksna, Arturs, Kuka, Janis, Liepinsh, Edgars, Dambrova, Maija

“…► Crystal structure of gamma-butyrobetaine hydroxylase solved at 2 Å resoluttion. ► Novel dimerization interface among 2-ketoglutarate oxygenases. ► Unique…”
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Acylcarnitines: Nomenclature, Biomarkers, Therapeutic Potential, Drug Targets, and Clinical Trials Autor Dambrova, Maija, Makrecka-Kuka, Marina, Kuka, Janis, Vilskersts, Reinis, Nordberg, Didi, Attwood, Misty M, Smesny, Stefan, Sen, Zumrut Duygu, Guo, An Chi, Oler, Eponine, Tian, Siyang, Zheng, Jiamin, Wishart, David S, Liepinsh, Edgars, Schiöth, Helgi B

“…Acylcarnitines are fatty acid metabolites that play important roles in many cellular energy metabolism pathways. They have historically been used as important…”
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Synthetic Access to Fluorocyclopropylidenes Autor Melngaile, Renate, Videja, Melita, Kuka, Janis, Kinens, Artis, Zacs, Dzintars, Veliks, Janis

“…Herein we report an approach for the straightforward preparation of fluorocyclopropylidene group from aldehydes and ketones via Julia- Kocienski olefination…”
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Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity Autor Dambrova, Maija, Makrecka-Kuka, Marina, Vilskersts, Reinis, Makarova, Elina, Kuka, Janis, Liepinsh, Edgars

“…[Display omitted] Meldonium (mildronate; 3-(2,2,2-trimethylhydrazinium)propionate; THP; MET-88) is a clinically used cardioprotective drug, which mechanism of…”
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Long-chain acylcarnitines determine ischaemia/reperfusion-induced damage in heart mitochondria Autor Liepinsh, Edgars, Makrecka-Kuka, Marina, Volska, Kristine, Kuka, Janis, Makarova, Elina, Antone, Unigunde, Sevostjanovs, Eduards, Vilskersts, Reinis, Strods, Arnis, Tars, Kaspars, Dambrova, Maija

“…The accumulation of long-chain fatty acids (FAs) and their CoA and carnitine esters is observed in the ischaemic myocardium after acute ischaemia/reperfusion…”
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Rodent Heart and Brain Tissue Preparation for Digital Macro Photography after Ischemia-reperfusion Autor Liepinsh, Edgars, Kuka, Janis, Zvejniece, Liga, Vilskersts, Reinis, Dambrova, Maija

“…Macro photography is applicable for imaging various tissue samples at high magnification to perform qualitative and quantitative analyses. Tissue preparation…”
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Low cardiac content of long-chain acylcarnitines in TMLHE knockout mice prevents ischaemia-reperfusion-induced mitochondrial and cardiac damage Autor Liepinsh, Edgars, Kuka, Janis, Vilks, Karlis, Svalbe, Baiba, Stelfa, Gundega, Vilskersts, Reinis, Sevostjanovs, Eduards, Goldins, Niks Ricards, Groma, Valerija, Grinberga, Solveiga, Plaas, Mario, Makrecka-Kuka, Marina, Dambrova, Maija

“…Increased tissue content of long-chain acylcarnitines may induce mitochondrial and cardiac damage by stimulating ROS production. N6-trimethyllysine dioxygenase…”
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Rodent Heart and Brain Tissue Preparation for Digital Macro Photography after Ischemia-reperfusion Autor Liepinsh, Edgars, Kuka, Janis, Zvejniece, Liga, Vilskersts, Reinis, Dambrova, Maija

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EPA and DHA acylcarnitines are less cardiotoxic than are saturated and monounsaturated long‐chain acylcarnitines Autor Liepinsh, Edgars, Gukalova, Baiba, Krims‐Davis, Kristaps, Kuka, Janis, Leduskrasta, Aiga, Korzh, Stanislava, Vilskersts, Reinis, Makrecka‐Kuka, Marina, Konrade, Ilze, Dambrova, Maija

“…Elevated levels of fatty acid‐derived long‐chain acylcarnitines are detrimental to cardiac health, primarily because of their adverse effects on mitochondrial…”
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