Výsledky vyhľadávania - "Kuiken, Hendrik J."

Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages Autor Rosenbluth, Jennifer M., Schackmann, Ron C. J., Gray, G. Kenneth, Selfors, Laura M., Li, Carman Man-Chung, Boedicker, Mackenzie, Kuiken, Hendrik J., Richardson, Andrea, Brock, Jane, Garber, Judy, Dillon, Deborah, Sachs, Norman, Clevers, Hans, Brugge, Joan S.

“…Recently, organoid technology has been used to generate a large repository of breast cancer organoids. Here we present an extensive evaluation of the ability…”
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Single-cell and spatial analyses reveal a tradeoff between murine mammary proliferation and lineage programs associated with endocrine cues Autor Gray, G. Kenneth, Girnius, Nomeda, Kuiken, Hendrik J., Henstridge, Aylin Z., Brugge, Joan S.

“…Although distinct epithelial cell types have been distinguished in glandular tissues such as the mammary gland, the extent of heterogeneity within each cell…”
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Cholesterol biosynthesis as a drug-induced vulnerability in diffuse large B cell lymphoma insensitive to EZH2 inhibition Autor Niccolai, Rachele, Göbel, Camiel, Ndoj, Klevis, Kreft, Maaike, Kuiken, Hendrik J., Lieftink, Cor, Morris, Ben, Yska, Sietse D., Hendrix, Sebastian, van den Broek, Bram, Pappalardo, Vincent, Kersten, Marie José, Beijersbergen, Roderick L., Zelcer, Noam, van Leeuwen, Fred, Jacobs, Heinz

“…•GCB-DLBCL insensitive to EZH2 inhibition become dependent on cholesterol synthesis.•This dependency relates to altered LDLR subcellular localization and LDL…”
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Transient commensal clonal interactions can drive tumor metastasis Autor Naffar-Abu Amara, Suha, Kuiken, Hendrik J., Selfors, Laura M., Butler, Timothy, Leung, Marco L., Leung, Cheuk T., Kuhn, Elaine P., Kolarova, Teodora, Hage, Carina, Ganesh, Kripa, Panayiotou, Richard, Foster, Rosemary, Rueda, Bo R., Aktipis, Athena, Spellman, Paul, Ince, Tan A., Xiu, Joanne, Oberley, Matthew, Gatalica, Zoran, Navin, Nicholas, Mills, Gordon B., Bronson, Rodrick T., Brugge, Joan S.

“…The extent and importance of functional heterogeneity and crosstalk between tumor cells is poorly understood. Here, we describe the generation of clonal…”
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Systematic screening identifies ABCG2 as critical factor underlying synergy of kinase inhibitors with transcriptional CDK inhibitors Autor van der Noord, Vera E., van der Stel, Wanda, Louwerens, Gijs, Verhoeven, Danielle, Kuiken, Hendrik J., Lieftink, Cor, Grandits, Melanie, Ecker, Gerhard F., Beijersbergen, Roderick L., Bouwman, Peter, Le Dévédec, Sylvia E., van de Water, Bob

“…Background Triple-negative breast cancer (TNBC) is a subtype of breast cancer with limited treatment options and poor clinical prognosis. Inhibitors of…”
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Deubiquitination of FANCD2 is required for DNA crosslink repair Autor Oestergaard, Vibe H, Langevin, Frederic, Kuiken, Hendrik J, Pace, Paul, Niedzwiedz, Wojciech, Simpson, Laura J, Ohzeki, Mioko, Takata, Minoru, Sale, Julian E, Patel, Ketan J

“…Monoubiquitination of FANCD2 and PCNA promotes DNA repair. It causes chromatin accumulation of FANCD2 and facilitates PCNA's recruitment of translesion…”
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3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis Autor Takahashi, Nobuaki, Cho, Patricia, Selfors, Laura M, Kuiken, Hendrik J, Kaul, Roma, Fujiwara, Takuro, Harris, Isaac S, Zhang, Tian, Gygi, Steven P, Brugge, Joan S

“…Cancer-associated mutations that stabilize NRF2, an oxidant defense transcription factor, are predicted to promote tumor development. Here, utilizing 3D cancer…”
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Screening for modulators of cisplatin sensitivity: Unbiased screens reveal common themes Autor Nijwening, Jeroen H., Kuiken, Hendrik J., Beijersbergen, Roderick L.

“…Cisplatin is a widely used chemotherapeutic agent to treat a variety of solid tumors. The cytotoxic mode of action of cisplatin is mediated by inducing…”
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Inducible CRISPR-Cas9 screening platform to interrogate non-proliferative cellular states Autor Casagrande Raffi, Gabriele, Kuiken, Hendrik J, Lieftink, Cor, Bernards, Rene, Beijersbergen, Roderick L, Wang, Liqin

“…CRISPR screens have revolutionized the study of diverse biological processes, particularly in cancer research. Both pooled and arrayed CRISPR screens have…”
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PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair Autor Andronikou, Christina, Burdova, Kamila, Dibitetto, Diego, Lieftink, Cor, Malzer, Elke, Kuiken, Hendrik J, Gogola, Ewa, Ray Chaudhuri, Arnab, Beijersbergen, Roderick L, Hanzlikova, Hana, Jonkers, Jos, Rottenberg, Sven

“…Targeting poly(ADP-ribose) glycohydrolase (PARG) is currently explored as a therapeutic approach to treat various cancer types, but we have a poor…”
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Paradoxical Activation of Oncogenic Signaling as a Cancer Treatment Strategy Autor Dias, Matheus Henrique, Friskes, Anoek, Wang, Siying, Fernandes Neto, Joao M, van Gemert, Frank, Mourragui, Soufiane, Papagianni, Chrysa, Kuiken, Hendrik J, Mainardi, Sara, Alvarez-Villanueva, Daniel, Lieftink, Cor, Morris, Ben, Dekker, Anna, van Dijk, Emma, Wilms, Lieke H S, da Silva, Marcelo S, Jansen, Robin A, Mulero-Sánchez, Antonio, Malzer, Elke, Vidal, August, Santos, Cristina, Salazar, Ramón, Wailemann, Rosangela A M, Torres, Thompson E P, De Conti, Giulia, Raaijmakers, Jonne A, Snaebjornsson, Petur, Yuan, Shengxian, Qin, Wenxin, Kovach, John S, Armelin, Hugo A, Te Riele, Hein, van Oudenaarden, Alexander, Jin, Haojie, Beijersbergen, Roderick L, Villanueva, Alberto, Medema, Rene H, Bernards, Rene

“…Cancer homeostasis depends on a balance between activated oncogenic pathways driving tumorigenesis and engagement of stress response programs that counteract…”
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Clonal populations of a human TNBC model display significant functional heterogeneity and divergent growth dynamics in distinct contexts Autor Kuiken, Hendrik J., Dhakal, Sabin, Selfors, Laura M., Friend, Chandler M., Zhang, Tian, Callari, Maurizio, Schackmann, Ron C. J., Gray, G. Kenneth, Crowdis, Jett, Bhang, Hyo-eun C., Baslan, Timour, Stegmeier, Frank, Gygi, Steven P., Caldas, Carlos, Brugge, Joan S.

“…Intratumoral heterogeneity has been described for various tumor types and models of human cancer, and can have profound effects on tumor progression and drug…”
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Targeting of vulnerabilities of drug-tolerant persisters identified through functional genetics delays tumor relapse Autor Chen, Mengnuo, Mainardi, Sara, Lieftink, Cor, Velds, Arno, de Rink, Iris, Yang, Chen, Kuiken, Hendrik J., Morris, Ben, Edwards, Finn, Jochems, Fleur, van Tellingen, Olaf, Boeije, Manon, Proost, Natalie, Jansen, Robin A., Qin, Shifan, Jin, Haojie, Koen van der Mijn, J.C., Schepers, Arnout, Venkatesan, Subramanian, Qin, Wenxin, Beijersbergen, Roderick L., Wang, Liqin, Bernards, René

“…Drug-tolerant persisters (DTPs) are a rare subpopulation of cells within a tumor that can survive therapy through nongenetic adaptive mechanisms to develop…”
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Identification of F‐box only protein 7 as a negative regulator of NF‐kappaB signalling Autor Kuiken, Hendrik J., Egan, David A., Laman, Heike, Bernards, Rene, Beijersbergen, Roderick L., Dirac, Annette M.

“…The nuclear factor κB (NF‐κB) signalling pathway controls important cellular events such as cell proliferation, differentiation, apoptosis and immune…”
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Ubc13 and COOH terminus of Hsp70-interacting protein (CHIP) are required for growth hormone receptor endocytosis Autor Slotman, Johan A, da Silva Almeida, Ana C, Hassink, Gerco C, van de Ven, Robert H A, van Kerkhof, Peter, Kuiken, Hendrik J, Strous, Ger J

“…Growth hormone receptor (GHR) endocytosis is a highly regulated process that depends on the binding and activity of the multimeric ubiquitin ligase, SCF(βTrCP)…”
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Exploration of synthetic lethal interactions as cancer drug targets Autor Kuiken, Hendrik J, Beijersbergen, Roderick L

“…In cancer research the quest continues to identify the Achilles heel of cancer. The ideal cancer drug targets are those that are essential in tumor cells but…”
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Interleukin-1R-associated kinase 2 is a novel modulator of the transforming growth factor beta signaling cascade Autor Mullenders, Jasper, Fabius, Armida W M, van Dongen, Miranda M W, Kuiken, Hendrik J, Beijersbergen, Roderick L, Bernards, René

“…The transforming growth factor beta (TGFbeta) pathway orchestrates an extensive transcriptional program that is important for many processes in the cell. For…”
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Condensate screening identifies YM155 as β-catenin condensate inhibitor in colorectal cancer Autor Manzato, Caterina, Sirati, Nafiseh, Knol, Bronwen A, Kuiken, Hendrik J, Morris, Ben, Fleming, Cassio, Beijersbergen, Roderick L, Schuijers, Jurian

“…β-catenin is a transcriptional cofactor crucial in forming biomolecular condensates that drive WNT target gene transcription. Its pathological accumulation in…”
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Transient Commensal Clonal Interactions Can Drive Tumor Metastasis Autor Suha Naffar-Abu Amara, Kuiken, Hendrik J, Selfors, Laura M, Butler, Timothy, Leung, Marco L, Leung, Cheuk T, Kuhn, Elaine P, Kolarova, Teodora R, Hage, Carina, Ganesh, Kripa, Foster, Rosemary, Rueda, Bo R, Aktipis, Athena, Spellman, Paul T, Ince, Tan, Navin, Nicholas, Mills, Gordon B, Bronson, Rodrick T, Brugge, Joan S S

“…To interrogate functional heterogeneity and crosstalk between tumor cells, we generated clonal populations from a patient-derived ovarian clear cell carcinoma…”
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Identification of F ‐box only protein 7 as a negative regulator of NF ‐kappa B signalling Autor Kuiken, Hendrik J., Egan, David A., Laman, Heike, Bernards, Rene, Beijersbergen, Roderick L., Dirac, Annette M.

“…The nuclear factor κB ( NF ‐ κB ) signalling pathway controls important cellular events such as cell proliferation, differentiation, apoptosis and immune…”
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