Suchergebnisse - "Kuehnemann, Chisaka"

A proteomic atlas of senescence-associated secretomes for aging biomarker development von Basisty, Nathan, Kale, Abhijit, Jeon, Ok Hee, Kuehnemann, Chisaka, Payne, Therese, Rao, Chirag, Holtz, Anja, Shah, Samah, Sharma, Vagisha, Ferrucci, Luigi, Campisi, Judith, Schilling, Birgit

“… The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of and promising therapeutic target for multiple age-related conditions, …”
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Senescent cells at the crossroads of aging, disease, and tissue homeostasis von Kuehnemann, Chisaka, Wiley, Christopher D.

“… Originally identified as an outcome of continuous culture of primary cells, cellular senescence has moved beyond the culture dish and is now a bona fide driver …”
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Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice von Asadi Shahmirzadi, Azar, Edgar, Daniel, Liao, Chen-Yu, Hsu, Yueh-Mei, Lucanic, Mark, Asadi Shahmirzadi, Arash, Wiley, Christopher D, Gan, Garbo, Kim, Dong Eun, Kasler, Herbert G, Kuehnemann, Chisaka, Kaplowitz, Brian, Bhaumik, Dipa, Riley, Rebeccah R, Kennedy, Brian K, Lithgow, Gordon J

“… Metabolism and aging are tightly connected. Alpha-ketoglutarate is a key metabolite in the tricarboxylic acid (TCA) cycle, and its levels change upon fasting, …”
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Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis von Wiley, Christopher D, Sharma, Rishi, Davis, Sonnet S, Lopez-Dominguez, Jose Alberto, Mitchell, Kylie P, Wiley, Samantha, Alimirah, Fatouma, Kim, Dong Eun, Payne, Therese, Rosko, Andrew, Aimontche, Eliezer, Deshpande, Sharvari M, Neri, Francesco, Kuehnemann, Chisaka, Demaria, Marco, Ramanathan, Arvind, Campisi, Judith

“… Cellular senescence is a stress or damage response that causes a permanent proliferative arrest and secretion of numerous factors with potent biological …”
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SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells von Wiley, Christopher D., Liu, Su, Limbad, Chandani, Zawadzka, Anna M., Beck, Jennifer, Demaria, Marco, Artwood, Robert, Alimirah, Fatouma, Lopez-Dominguez, Jose-Alberto, Kuehnemann, Chisaka, Danielson, Steven R., Basisty, Natan, Kasler, Herbert G., Oron, Tal Ronnen, Desprez, Pierre-Yves, Mooney, Sean D., Gibson, Bradford W., Schilling, Birgit, Campisi, Judith, Kapahi, Pankaj

“… Cellular senescence irreversibly arrests cell proliferation, accompanied by a multi-component senescence-associated secretory phenotype (SASP) that …”
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Extracellular Nicotinamide Phosphoribosyltransferase Is a Component of the Senescence-Associated Secretory Phenotype von Kuehnemann, Chisaka, Hu, Kang-Quan, Butera, Kayla, Patel, Sandip K., Bons, Joanna, Schilling, Birgit, Aguayo-Mazzucato, Cristina, Wiley, Christopher D.

“… Cellular senescence is a stress or damage response by which a cell adopts of state of essentially permanent proliferative arrest, coupled to the secretion of a …”
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Nicotinamide Mononucleotide Administration Prevents Doxorubicin-Induced Cardiotoxicity and Loss in Physical Activity in Mice von Margier, Marielle, Kuehnemann, Chisaka, Hulo, Nicolas, Morales, Jazmin, Ashok Kumaar, Prasanna Vadhana, Cros, Cecile, Cannelle, Helene, Charmetant, Julie, Verdin, Eric, Canault, Matthias, Grozio, Alessia

“… Doxorubicin (Doxo) is a widely used antineoplastic drug with limited clinical application due to its deleterious dose-related side effects. We investigated …”
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Mitochondrial peptides modulate mitochondrial function during cellular senescence von Kim, Su-Jeong, Mehta, Hemal H, Wan, Junxiang, Kuehnemann, Chisaka, Chen, Jingcheng, Hu, Ji-Fan, Hoffman, Andrew R, Cohen, Pinchas

“… Cellular senescence is a complex cell fate response that is thought to underlie several age-related pathologies. Despite a loss of proliferative potential, …”
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Cholesterol drives inflammatory senescence von Kuehnemann, Chisaka, Wiley, Christopher D.

“… Both cell cycle arrest and secretions of senescent cells are subject to metabolic control. In this issue of Nature Metabolism , Roh et al. show that lysosomal …”
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Antiretroviral protease inhibitors induce features of cellular senescence that are reversible upon drug removal von Kuehnemann, Chisaka, Hughes, Jun‐Wei B., Desprez, Pierre‐Yves, Melov, Simon, Wiley, Christopher D., Campisi, Judith

“… Antiretroviral drugs have dramatically improved the prognosis of HIV‐infected patients, with strikingly reduced morbidity and mortality. However, long‐term use …”
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Fatty acid desaturation guides cellular decisions between ferroptosis and cellular senescence von Kuehnemann, Chisaka, Jezak, Samantha, Mogck, Bronwyn, Kura, Niharika, Che, Yuheng, Vaittinen, Maija, Siokas, Ioannis, Tariq, Rushmeen, Deshpande, Sharvari, Guthrie, Carlyn, Tan, Xuejuan, Aimontche, Eliezer, Zheng, Tong, Greenberg, Andrew S., Wang, Xiang-Dong, Kitazawa, Koji, Dolnikowsi, Gregory, Cheng, Yong, Matthan, Nirupa R., Ramanthan, Arvind, Pihlajamaki, Jussi, Korstanje, Ron, Wiley, Christopher D.

“… When subject to damage or stress, cells develop responses in order to maintain tissue homeostasis. Two such decisions are ferroptosis and cellular senescence, …”
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A Proteomic Atlas of Senescence-Associated Secretomes for Aging Biomarker Development von Basisty, Nathan, Kale, Abhijit, Jeon, Okhee, Kuehnemann, Chisaka, Payne, Therese, Rao, Chirag, Holtz, Anja, Shah, Samah, Sharma, Vagisha, Ferrucci, Luigi, Campisi, Judith, Schilling, Birgit

“… The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of, and promising therapeutic target for, multiple age-related …”
Volltext

Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice von Azar Asadi Shahmirzadi, Edgar, Daniel, Chen-Yu, Liao, Yueh-Mei Hsu, Lucanic, Mark, Arash Asadi Shahmirzadi, Wiley, Christopher, Riley, Rebeccah, Gan, Garbo, Kuehnemann, Chisaka, Bhaumik, Dipa, Lithgow, Gordon J, Kennedy, Brian K

“… The decline in early life mortality since the 1950s has resulted in dramatic demographic shift towards aged population. Aging manifests as a decline in health, …”
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