Search Results - "Krogsdam, Anne"

Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and novel targets for immunotherapy by Angelova, Mihaela, Charoentong, Pornpimol, Hackl, Hubert, Fischer, Maria L, Snajder, Rene, Krogsdam, Anne M, Waldner, Maximilian J, Bindea, Gabriela, Mlecnik, Bernhard, Galon, Jerome, Trajanoski, Zlatko

“…Background While large-scale cancer genomic projects are comprehensively characterizing the mutational spectrum of various cancers, so far little attention has…”
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Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution by Efremova, Mirjana, Rieder, Dietmar, Klepsch, Victoria, Charoentong, Pornpimol, Finotello, Francesca, Hackl, Hubert, Hermann-Kleiter, Natascha, Löwer, Martin, Baier, Gottfried, Krogsdam, Anne, Trajanoski, Zlatko

“…The cancer immunoediting hypothesis postulates a dual role of the immune system: protecting the host by eliminating tumor cells, and shaping the tumor by…”
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Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data by Finotello, Francesca, Mayer, Clemens, Plattner, Christina, Laschober, Gerhard, Rieder, Dietmar, Hackl, Hubert, Krogsdam, Anne, Loncova, Zuzana, Posch, Wilfried, Wilflingseder, Doris, Sopper, Sieghart, Ijsselsteijn, Marieke, Brouwer, Thomas P., Johnson, Douglas, Xu, Yaomin, Wang, Yu, Sanders, Melinda E., Estrada, Monica V., Ericsson-Gonzalez, Paula, Charoentong, Pornpimol, Balko, Justin, de Miranda, Noel Filipe da Cunha Carvalho, Trajanoski, Zlatko

“…We introduce quanTIseq, a method to quantify the fractions of ten immune cell types from bulk RNA-sequencing data. quanTIseq was extensively validated in blood…”
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Comprehensive characterization of the prostate tumor microenvironment identifies CXCR4/CXCL12 crosstalk as a novel antiangiogenic therapeutic target in prostate cancer by Heidegger, Isabel, Fotakis, Georgios, Offermann, Anne, Goveia, Jermaine, Daum, Sophia, Salcher, Stefan, Noureen, Asma, Timmer-Bosscha, Hetty, Schäfer, Georg, Walenkamp, Annemiek, Perner, Sven, Beatovic, Aleksandar, Moisse, Matthieu, Plattner, Christina, Krogsdam, Anne, Haybaeck, Johannes, Sopper, Sieghart, Thaler, Stefanie, Keller, Markus A., Klocker, Helmut, Trajanoski, Zlatko, Wolf, Dominik, Pircher, Andreas

“…Background Crosstalk between neoplastic and stromal cells fosters prostate cancer (PCa) progression and dissemination. Insight in cell-to-cell communication…”
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Nuclear receptor NR2F6 inhibition potentiates responses to PD-L1/PD-1 cancer immune checkpoint blockade by Klepsch, Victoria, Hermann-Kleiter, Natascha, Do-Dinh, Patricia, Jakic, Bojana, Offermann, Anne, Efremova, Mirjana, Sopper, Sieghart, Rieder, Dietmar, Krogsdam, Anne, Gamerith, Gabriele, Perner, Sven, Tzankov, Alexandar, Trajanoski, Zlatko, Wolf, Dominik, Baier, Gottfried

“…Analyzing mouse tumor models in vivo, human T cells ex vivo, and human lung cancer samples, we provide direct evidence that NR2F6 acts as an immune checkpoint…”
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Impact of Fusobacterium nucleatum on immune cell interactions and gene expression in colorectal cancer: a retrospective cohort study by Heregger, Ronald, Huemer, Florian, Greil, Richard, Canadas-Ortega, Marina, Posselt, Gernot, Ijsselsteijn, Marieke E, Plattner, Christina, Rieder, Dietmar, Trajanoski, Zlatko, Krogsdam, Anne, Klieser, Eckhard, Neureiter, Daniel, Wessler, Silja, Weiss, Lukas

“…Colorectal cancer (CRC) is a major global health concern. The presence of (Fn) in CRC can promote cancer progression by modulating the immune response and…”
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13C tracer analysis reveals the landscape of metabolic checkpoints in human CD8+ T cell differentiation and exhaustion by Kirchmair, Alexander, Nemati, Niloofar, Lamberti, Giorgia, Trefny, Marcel, Krogsdam, Anne, Siller, Anita, Hörtnagl, Paul, Schumacher, Petra, Sopper, Sieghart, Sandbichler, Adolf, Zippelius, Alfred, Ghesquière, Bart, Trajanoski, Zlatko

“…Naïve T cells remain in an actively maintained state of quiescence until activation by antigenic signals, upon which they start to proliferate and generate…”
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Comparative analysis of 10X Chromium vs. BD Rhapsody whole transcriptome single-cell sequencing technologies in complex human tissues by Salcher, Stefan, Heidegger, Isabel, Untergasser, Gerold, Fotakis, Georgios, Scheiber, Alexandra, Martowicz, Agnieszka, Noureen, Asma, Krogsdam, Anne, Schatz, Christoph, Schäfer, Georg, Trajanoski, Zlatko, Wolf, Dominik, Sopper, Sieghart, Pircher, Andreas

“…The development of single-cell omics tools has enabled scientists to study the tumor microenvironment (TME) in unprecedented detail. However, each of the…”
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Exosomal mitochondrial tRNAs and miRNAs as potential predictors of inflammation in renal proximal tubular epithelial cells by Ranches, Glory, Zeidler, Maximilian, Kessler, Roman, Hoelzl, Martina, Hess, Michael W., Vosper, Jonathan, Perco, Paul, Schramek, Herbert, Kummer, Kai K., Kress, Michaela, Krogsdam, Anne, Rudnicki, Michael, Mayer, Gert, Huettenhofer, Alexander

“…Exosomes have emerged as a valuable repository of novel biomarkers for human diseases such as chronic kidney disease (CKD). From a healthy control group, we…”
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Nr4a1 is required for fasting-induced down-regulation of Pparγ2 in white adipose tissue by Duszka, Kalina, Bogner-Strauss, Juliane G, Hackl, Hubert, Rieder, Dietmar, Neuhold, Claudia, Prokesch, Andreas, Trajanoski, Zlatko, Krogsdam, Anne-M

“…Expression of the nuclear receptor gene, Nur77 (Nr4a1), is induced in white adipose tissue (WAT) in response to β-adrenergic stimulation and fasting. Recently,…”
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Spatial transcriptomics in embryonic mouse diaphragm muscle reveals regional gradients and subdomains of developmental gene expression by Kaplan, Mehmet Mahsum, Zeidler, Maximilian, Knapp, Annabella, Hölzl, Martina, Kress, Michaela, Fritsch, Helga, Krogsdam, Anne, Flucher, Bernhard E.

“…The murine embryonic diaphragm is a primary model for studying myogenesis and neuro-muscular synaptogenesis, both representing processes regulated by spatially…”
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NR4A3 Suppresses Lymphomagenesis through Induction of Proapoptotic Genes by Deutsch, Alexander J A, Rinner, Beate, Pichler, Martin, Prochazka, Katharina, Pansy, Katrin, Bischof, Marco, Fechter, Karoline, Hatzl, Stefan, Feichtinger, Julia, Wenzl, Kerstin, Frisch, Marie-Therese, Stiegelbauer, Verena, Prokesch, Andreas, Krogsdam, Anne, Sill, Heinz, Thallinger, Gerhard G, Greinix, Hildegard T, Wang, Chenguang, Beham-Schmid, Christine, Neumeister, Peter

“…Nuclear orphan receptor NR4A1 exerts an essential tumor suppressor function in aggressive lymphomas. In this study, we investigated the hypothesized…”
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SARS-CoV-2 activates the TLR4/MyD88 pathway in human macrophages: A possible correlation with strong pro-inflammatory responses in severe COVID-19 by Sahanic, Sabina, Hilbe, Richard, Dünser, Christina, Tymoszuk, Piotr, Löffler-Ragg, Judith, Rieder, Dietmar, Trajanoski, Zlatko, Krogsdam, Anne, Demetz, Egon, Yurchenko, Maria, Fischer, Christine, Schirmer, Michael, Theurl, Markus, Lener, Daniela, Hirsch, Jakob, Holfeld, Johannes, Gollmann-Tepeköylü, Can, Zinner, Carl P., Tzankov, Alexandar, Zhang, Shen-Ying, Casanova, Jean-Laurent, Posch, Wilfried, Wilflingseder, Doris, Weiss, Guenter, Tancevski, Ivan

“…Toll-like receptors (TLRs) play a pivotal role in the immunologic response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection…”
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Co-expressed genes prepositioned in spatial neighborhoods stochastically associate with SC35 speckles and RNA polymerase II factories by Rieder, Dietmar, Ploner, Christian, Krogsdam, Anne M, Stocker, Gernot, Fischer, Maria, Scheideler, Marcel, Dani, Christian, Amri, Ez-Zoubir, Müller, Waltraud G, McNally, James G, Trajanoski, Zlatko

“…Chromosomally separated, co-expressed genes can be in spatial proximity, but there is still debate about how this nuclear organization is achieved. Proposed…”
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Changes in the miRNA-mRNA Regulatory Network Precede Motor Symptoms in a Mouse Model of Multiple System Atrophy: Clinical Implications by Schafferer, Simon, Khurana, Rimpi, Refolo, Violetta, Venezia, Serena, Sturm, Edith, Piatti, Paolo, Hechenberger, Clara, Hackl, Hubert, Kessler, Roman, Willi, Michaela, Gstir, Ronald, Krogsdam, Anne, Lusser, Alexandra, Poewe, Werner, Wenning, Gregor K., Hüttenhofer, Alexander, Stefanova, Nadia

“…Multiple system atrophy (MSA) is a fatal rapidly progressive α-synucleinopathy, characterized by α-synuclein accumulation in oligodendrocytes. It is accepted…”
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Impact of the Chromatin Remodeling Factor CHD1 on Gut Microbiome Composition of Drosophila melanogaster by Sebald, Johanna, Willi, Michaela, Schoberleitner, Ines, Krogsdam, Anne, Orth-Höller, Dorothea, Trajanoski, Zlatko, Lusser, Alexandra

“…The composition of the intestinal microbiota of Drosophila has been studied in some detail in recent years. Environmental, developmental and host-specific…”
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Correction to: Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data by Finotello, Francesca, Mayer, Clemens, Plattner, Christina, Laschober, Gerhard, Rieder, Dietmar, Hackl, Hubert, Krogsdam, Anne, Loncova, Zuzana, Posch, Wilfried, Wilflingseder, Doris, Sopper, Sieghart, Ijsselsteijn, Marieke, Brouwer, Thomas P., Johnson, Douglas, Xu, Yaomin, Wang, Yu, Sanders, Melinda E., Estrada, Monica V., Ericsson-Gonzalez, Paula, Charoentong, Pornpimol, Balko, Justin, da Cunha Carvalho de Miranda, Noel Filipe, Trajanoski, Zlatko

“…It was highlighted that the original article [1] contained a typesetting mistake in the name of Noel Filipe da Cunha Carvalho de Miranda. This was incorrectly…”
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Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation by Krogsdam, Anne-M, Nielsen, Curt A F, Neve, Søren, Holst, Dorte, Helledie, Torben, Thomsen, Bo, Bendixen, Christian, Mandrup, Susanne, Kristiansen, Karsten

“…The nuclear receptor corepressor (NCoR) was isolated as a peroxisome-proliferator-activated receptor (PPAR) delta interacting protein using the yeast…”
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Transcriptional regulatory program in wild-type and retinoblastoma gene-deficient mouse embryonic fibroblasts during adipocyte differentiation by Hakim-Weber, Robab, Krogsdam, Anne-M, Jørgensen, Claus, Fischer, Maria, Prokesch, Andreas, Bogner-Strauss, Juliane G, Bornstein, Stefan R, Hansen, Jacob B, Madsen, Lise, Kristiansen, Karsten, Trajanoski, Zlatko, Hackl, Hubert

“…Background Although many molecular regulators of adipogenesis have been identified a comprehensive catalogue of components is still missing. Recent studies…”
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Opposing Effects of Fatty Acids and Acyl-CoA Esters on Conformation and Cofactor Recruitment of Peroxisome Proliferator-Activated Receptors by JØRGENSEN, CLAUS, KROGSDAM, ANNE-M., KRATCHMAROVA, IRINA, WILLSON, TIMOTHY M., KNUDSEN, JENS, MANDRUP, SUSANNE, KRISTIANSEN, KARSTEN

“…: The peroxisome proliferator‐activated receptors (PPARs) bind and are activated by a variety of fatty acids and derivatives thereof. Agonist binding enhances…”
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