Suchergebnisse - "Krause, Karl Heinz"

The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology von Bedard, Karen, Krause, Karl-Heinz

“… For a long time, superoxide generation by an NADPH oxidase was considered as an oddity only found in professional phagocytes. Over the last years, six homologs …”
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Periodontitis and peri‐implantitis in elderly people experiencing institutional and hospital confinement von Müller, Frauke, Srinivasan, Murali, Krause, Karl‐Heinz, Schimmel, Martin

“… An increasing number of elderly people retain their natural teeth into old age and further, the prevalence of endosseous implants for supporting oral …”
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Phagocyte NADPH oxidase, chronic granulomatous disease and mycobacterial infections von Deffert, Christine, Cachat, Julien, Krause, Karl‐Heinz

“… Summary Infection of humans with Mycobacterium tuberculosis remains frequent and may still lead to death. After primary infection, the immune system is often …”
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NOX enzymes in the central nervous system: from signaling to disease von Sorce, Silvia, Krause, Karl-Heinz

“… Oxidative stress has been implicated in the pathogenesis of neurologic and psychiatric diseases. The brain is particularly vulnerable to oxidative damage due …”
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Cancer Spheroids and Organoids as Novel Tools for Research and Therapy: State of the Art and Challenges to Guide Precision Medicine von El Harane, Sanae, Zidi, Bochra, El Harane, Nadia, Krause, Karl-Heinz, Matthes, Thomas, Preynat-Seauve, Olivier

“… Spheroids and organoids are important novel players in medical and life science research. They are gradually replacing two-dimensional (2D) cell cultures …”
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NOX family NADPH oxidases in mammals: Evolutionary conservation and isoform-defining sequences von Nazari, Bahareh, Jaquet, Vincent, Krause, Karl-Heinz

“… NADPH oxidases are superoxide-producing enzymes that play a role in host defense, biosynthetic pathways, as well as cellular signaling. Humans have 7 NOX …”
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Reactive oxygen species: from health to disease von Brieger, Katharine, Schiavone, Stefania, Miller Jr, Francis J., Krause, Karl-Heinz

“… Upon reaction with electrons, oxygen is transformed into reactive oxygen species (ROS). It has long been known that ROS can destroy bacteria and destroy human …”
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Aging: A revisited theory based on free radicals generated by NOX family NADPH oxidases von Krause, Karl-Heinz

“… Reactive oxygen species (ROS), often also referred to as free radicals, play an important role in aging. It is widely assumed that mitochondria are the …”
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Pharmacological characterization of the seven human NOX isoforms and their inhibitors von Augsburger, Fiona, Filippova, Aleksandra, Rasti, Delphine, Seredenina, Tamara, Lam, Magdalena, Maghzal, Ghassan, Mahiout, Zahia, Jansen-Dürr, Pidder, Knaus, Ulla G., Doroshow, James, Stocker, Roland, Krause, Karl-Heinz, Jaquet, Vincent

“… NADPH oxidases (NOX) are a family of flavoenzymes that catalyze the formation of superoxide anion radical (O ) and/or hydrogen peroxide (H O ). As major …”
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Concurrent mutations in RNA-dependent RNA polymerase and spike protein emerged as the epidemiologically most successful SARS-CoV-2 variant von Ilmjärv, Sten, Abdul, Fabien, Acosta-Gutiérrez, Silvia, Estarellas, Carolina, Galdadas, Ioannis, Casimir, Marina, Alessandrini, Marco, Gervasio, Francesco Luigi, Krause, Karl-Heinz

“… The D614G mutation in the Spike protein of the SARS-CoV-2 has effectively replaced the early pandemic-causing variant. Using pseudotyped lentivectors, we …”
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A 3D printed microfluidic device for production of functionalized hydrogel microcapsules for culture and differentiation of human Neuronal Stem Cells (hNSC) von Alessandri, Kevin, Feyeux, Maxime, Gurchenkov, Basile, Delgado, Christophe, Trushko, Anastasiya, Krause, Karl-Heinz, Vignjević, Daniela, Nassoy, Pierre, Roux, Aurélien

“… We present here a microfluidic device that generates sub-millimetric hollow hydrogel spheres, encapsulating cells and coated internally with a layer of …”
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NOX5: from basic biology to signaling and disease von Bedard, Karen, Jaquet, Vincent, Krause, Karl-Heinz

“… In mammals, the NADPH oxidase family of enzymes comprises seven members: NOXs 1–5, DUOX1, and DUOX2. All of these enzymes function to move an electron across …”
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Glut3 Addiction Is a Druggable Vulnerability for a Molecularly Defined Subpopulation of Glioblastoma von Cosset, Érika, Ilmjärv, Sten, Dutoit, Valérie, Elliott, Kathryn, von Schalscha, Tami, Camargo, Maria F, Reiss, Alexander, Moroishi, Toshiro, Seguin, Laetitia, Gomez, German, Moo, Jung-Soon, Preynat-Seauve, Olivier, Krause, Karl-Heinz, Chneiweiss, Hervé, Sarkaria, Jann N, Guan, Kun-Liang, Dietrich, Pierre-Yves, Weis, Sara M, Mischel, Paul S, Cheresh, David A

“… While molecular subtypes of glioblastoma (GBM) are defined using gene expression and mutation profiles, we identify a unique subpopulation based on addiction …”
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Detection of reactive oxygen species derived from the family of NOX NADPH oxidases von Maghzal, Ghassan J., Krause, Karl-Heinz, Stocker, Roland, Jaquet, Vincent

“… NADPH oxidases (NOX) are superoxide anion radical (O2−•)-generating enzymes. They form a family of seven members, each with a specific tissue distribution …”
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Fate of systemically and locally administered adipose‐derived mesenchymal stromal cells and their effect on wound healing von Kallmeyer, Karlien, André‐Lévigne, Dominik, Baquié, Mathurin, Krause, Karl‐Heinz, Pepper, Michael S., Pittet‐Cuénod, Brigitte, Modarressi, Ali

“… There is increasing interest in the use of adipose‐derived mesenchymal stromal cells (ASCs) for wound repair. As the fate of administered cells is still poorly …”
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Phagocyte NADPH oxidase and specific immunity von Cachat, Julien, Deffert, Christine, Hugues, Stephanie, Krause, Karl-Heinz

“… The phagocyte NADPH oxidase NOX2 produces reactive oxygen species (ROS) and is a well-known player in host defence. However, there is also increasing evidence …”
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HIV‐1 Tat C modulates NOX2 and NOX4 expressions through miR‐17 in a human microglial cell line von Jadhav, Vaishnavi Sunil, Krause, Karl‐Heinz, Singh, Sunit K.

“… HIV‐1 invades CNS in the early course of infection, which can lead to the cascade of neuroinflammation. NADPH oxidases (NOXs) are the major producers of …”
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A key role for NOX4 in epithelial cell death during development of lung fibrosis von Carnesecchi, Stephanie, Deffert, Christine, Donati, Yves, Basset, Olivier, Hinz, Boris, Preynat-Seauve, Olivier, Guichard, Cecile, Arbiser, Jack L, Banfi, Botond, Pache, Jean-Claude, Barazzone-Argiroffo, Constance, Krause, Karl-Heinz

“… The pathogenesis of pulmonary fibrosis is linked to oxidative stress, possibly generated by the reactive oxygen species (ROS) generating NADPH oxidase NOX4 …”
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Adipose‐derived stem cell spheroids are superior to single‐cell suspensions to improve fat autograft long‐term survival von El Harane, Sanae, Durual, Stéphane, Braschler, Thomas, André‐Lévigne, Dominik, Brembilla, Nicolo, Krause, Karl‐Heinz, Modarressi, Ali, Preynat‐Seauve, Olivier

“… Autologous fat transplantation is a widely used procedure for surgical reconstruction of tissues. The resorption rate of this transplantation remains high and …”
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Targeting NOX enzymes in the central nervous system: therapeutic opportunities von Sorce, Silvia, Krause, Karl-Heinz, Jaquet, Vincent

“… Among the pathogenic mechanisms underlying central nervous system (CNS) diseases, oxidative stress is almost invariably described. For this reason, numerous …”
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