Search Results - "Kos, Kevin"

Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response by Salvagno, Camilla, Ciampricotti, Metamia, Tuit, Sander, Hau, Cheei-Sing, van Weverwijk, Antoinette, Coffelt, Seth B., Kersten, Kelly, Vrijland, Kim, Kos, Kevin, Ulas, Thomas, Song, Ji-Ying, Ooi, Chia-Huey, Rüttinger, Dominik, Cassier, Philippe A., Jonkers, Jos, Schultze, Joachim L., Ries, Carola H., de Visser, Karin E.

“…Recent studies have revealed a role for macrophages and neutrophils in limiting chemotherapy efficacy; however, the mechanisms underlying the therapeutic…”
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Subtle Kinematic Changes During One-Arm Pulling and Their Implications on Upper Extremity and Trunk Moments by Kos, Kevin D., Mulla, Daanish M., Keir, Peter J.

“…OCCUPATIONAL APPLICATIONSSmall deviations in individual joint angles (<5°) simulated using a simple probabilistic computational model resulted in significant…”
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Tumor-educated Tregs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node niche by Kos, Kevin, Aslam, Muhammad A., van de Ven, Rieneke, Wellenstein, Max D., Pieters, Wietske, van Weverwijk, Antoinette, Duits, Danique E.M., van Pul, Kim, Hau, Cheei-Sing, Vrijland, Kim, Kaldenbach, Daphne, Raeven, Elisabeth A.M., Quezada, Sergio A., Beyaert, Rudi, Jacobs, Heinz, de Gruijl, Tanja D., de Visser, Karin E.

“…Breast cancer is accompanied by systemic immunosuppression, which facilitates metastasis formation, but how this shapes organotropism of metastasis is poorly…”
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NK cell heparanase controls tumor invasion and immune surveillance by Putz, Eva M., Mayfosh, Alyce J., Kos, Kevin, Barkauskas, Deborah S., Nakamura, Kyohei, Town, Liam, Goodall, Katharine J., Yee, Dean Y., Poon, Ivan K.H., Baschuk, Nikola, Souza-Fonseca-Guimaraes, Fernando, Hulett, Mark D., Smyth, Mark J.

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Tumor-associated macrophages promote intratumoral conversion of conventional CD4+ T cells into regulatory T cells via PD-1 signalling by Kos, Kevin, Salvagno, Camilla, Wellenstein, Max D., Aslam, Muhammad A., Meijer, Denize A., Hau, Cheei-Sing, Vrijland, Kim, Kaldenbach, Daphne, Raeven, Elisabeth A.M., Schmittnaegel, Martina, Ries, Carola H., de Visser, Karin E.

“…While regulatory T cells (T regs ) and macrophages have been recognized as key orchestrators of cancer-associated immunosuppression, their cellular crosstalk…”
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Neoadjuvant immune checkpoint blockade triggers persistent and systemic Treg activation which blunts therapeutic efficacy against metastatic spread of breast tumors by Blomberg, Olga S., Kos, Kevin, Spagnuolo, Lorenzo, Isaeva, Olga I., Garner, Hannah, Wellenstein, Max D., Bakker, Noor, Duits, Danique E.M., Kersten, Kelly, Klarenbeek, Sjoerd, Hau, Cheei-Sing, Kaldenbach, Daphne, Raeven, Elisabeth A.M., Vrijland, Kim, Kok, Marleen, de Visser, Karin E.

“…The clinical successes of immune checkpoint blockade (ICB) in advanced cancer patients have recently spurred the clinical implementation of ICB in the…”
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Targeting cytokine signaling checkpoint CIS activates NK cells to protect from tumor initiation and metastasis by Putz, Eva M., Guillerey, Camille, Kos, Kevin, Stannard, Kimberley, Miles, Kim, Delconte, Rebecca B., Takeda, Kazuyoshi, Nicholson, Sandra E., Huntington, Nicholas D., Smyth, Mark J.

“…The cytokine-induced SH2-containing protein CIS belongs to the suppressor of cytokine signaling (SOCS) protein family. Here, we show the critical role of CIS…”
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Pro-mutagenic effects of the gut microbiota in a Lynch syndrome mouse model by Pieters, Wietske, Hugenholtz, Floor, Kos, Kevin, Cammeraat, Maxime, Moliej, Teddy C., Kaldenbach, Daphne, Klarenbeek, Sjoerd, Davids, Mark, Drost, Lisa, de Konink, Charlotte, Delzenne-Goette, Elly, de Visser, Karin E., te Riele, Hein

“…The gut microbiota strongly impacts the development of sporadic colorectal cancer (CRC), but it is largely unknown how the microbiota affects the pathogenesis…”
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Neutrophils create a fertile soil for metastasis by Kos, Kevin, de Visser, Karin E

“…Neutrophils can facilitate the metastatic spread of cancer; however, how neutrophils are activated at metastatic sites remains poorly understood. In this…”
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The Multifaceted Role of Regulatory T Cells in Breast Cancer by Kos, Kevin, de Visser, Karin E

“…The microenvironment of breast cancer hosts a dynamic cross talk between diverse players of the immune system. While cytotoxic immune cells are equipped to…”
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IL-5-producing CD4 + T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer by Blomberg, Olga S, Spagnuolo, Lorenzo, Garner, Hannah, Voorwerk, Leonie, Isaeva, Olga I, van Dyk, Ewald, Bakker, Noor, Chalabi, Myriam, Klaver, Chris, Duijst, Maxime, Kersten, Kelly, Brüggemann, Marieke, Pastoors, Dorien, Hau, Cheei-Sing, Vrijland, Kim, Raeven, Elisabeth A M, Kaldenbach, Daphne, Kos, Kevin, Afonina, Inna S, Kaptein, Paulien, Hoes, Louisa, Theelen, Willemijn S M E, Baas, Paul, Voest, Emile E, Beyaert, Rudi, Thommen, Daniela S, Wessels, Lodewyk F A, de Visser, Karin E, Kok, Marleen

“…Immune checkpoint blockade (ICB) has heralded a new era in cancer therapy. Research into the mechanisms underlying response to ICB has predominantly focused on…”
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Candida albicans in oral biofilms could prevent caries by Willems, Hubertine Marjoleine, Kos, Kevin, Jabra-Rizk, Mary Ann, Krom, Bastiaan P.

“…Streptococcus mutans is a Gram-positive bacterium involved in development to caries, the most common infectious disease of our time. Streptococcus mutans…”
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Retraction: NK cell heparanase controls tumor invasion and immune surveillance by Putz, Eva M, Mayfosh, Alyce J, Kos, Kevin, Barkauskas, Deborah S, Nakamura, Kyohei, Town, Liam, Goodall, Katharine J, Yee, Dean Y, Poon, Ivan K.H, Baschuk, Nikola, Souza-Fonseca-Guimaraes, Fernando, Hulett, Mark D, Smyth, Mark J

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NK cell heparanase controls tumor invasion and immune surveillance by Putz, Eva M., Mayfosh, Alyce J., Kos, Kevin, Barkauskas, Deborah S., Nakamura, Kyohei, Town, Liam, Goodall, Katharine J., Yee, Dean Y., Poon, Ivan K.H., Baschuk, Nikola, Souza-Fonseca-Guimaraes, Fernando, Hulett, Mark D., Smyth, Mark J.

“…NK cells are highly efficient at preventing cancer metastasis but are infrequently found in the core of primary tumors. Here, have we demonstrated that freshly…”
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Tumor-educated T regs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node niche by Kos, Kevin, Aslam, Muhammad A, van de Ven, Rieneke, Wellenstein, Max D, Pieters, Wietske, van Weverwijk, Antoinette, Duits, Danique E M, van Pul, Kim, Hau, Cheei-Sing, Vrijland, Kim, Kaldenbach, Daphne, Raeven, Elisabeth A M, Quezada, Sergio A, Beyaert, Rudi, Jacobs, Heinz, de Gruijl, Tanja D, de Visser, Karin E

“…Breast cancer is accompanied by systemic immunosuppression, which facilitates metastasis formation, but how this shapes organotropism of metastasis is poorly…”
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Neoadjuvant immune checkpoint blockade triggers persistent and systemic T reg activation which blunts therapeutic efficacy against metastatic spread of breast tumors by Blomberg, Olga S., Kos, Kevin, Spagnuolo, Lorenzo, Isaeva, Olga I., Garner, Hannah, Wellenstein, Max D., Bakker, Noor, Duits, Danique E.M., Kersten, Kelly, Klarenbeek, Sjoerd, Hau, Cheei-Sing, Kaldenbach, Daphne, Raeven, Elisabeth A.M., Vrijland, Kim, Kok, Marleen, de Visser, Karin E.

“…The clinical successes of immune checkpoint blockade (ICB) in advanced cancer patients have recently spurred the clinical implementation of ICB in the…”
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Flow cytometry-based isolation of tumor-associated regulatory T cells and assessment of their suppressive potential by Kos, Kevin, van Baalen, Martijn, Meijer, Denize A, de Visser, Karin E

“…Regulatory T cells (Tregs) play a major role in establishing an immunosuppressive tumor microenvironment. In order to fully uncover their role and molecular…”
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