Výsledky vyhľadávania - "Koopman, Peter"

Building the mammalian testis: origins, differentiation, and assembly of the component cell populations Autor Svingen, Terje, Koopman, Peter

“…Development of testes in the mammalian embryo requires the formation and assembly of several cell types that allow these organs to achieve their roles in male…”
Zistit podrobnosti o prístupe

Sry: the master switch in mammalian sex determination Autor Kashimada, Kenichi, Koopman, Peter

“…SRY, the mammalian Y-chromosomal testis-determining gene, induces male sex determination. Recent studies in mice reveal that the major role of SRY is to…”
Zistit podrobnosti o prístupe

The Curious World of Gonadal Development in Mammals Autor Koopman, Peter

“…The distinct sex phenotypes of male and female hinge on the development of the fetal gonads as testes or ovaries, in turn, regulated by the molecular genetic…”
Zistit podrobnosti o prístupe

Retinoic acid, meiosis and germ cell fate in mammals Autor Bowles, Josephine, Koopman, Peter

“…Although mammalian sex is determined genetically, the sex-specific development of germ cells as sperm or oocytes is initiated by cues provided by the gonadal…”
Zistit podrobnosti o prístupe

Sex Determination in the Mammalian Germline Autor Spiller, Cassy, Koopman, Peter, Bowles, Josephine

“…Sexual reproduction crucially depends on the production of sperm in males and oocytes in females. Both types of gamete arise from the same precursor, the germ…”
Zistit podrobnosti o prístupe

Sex determination and gonadal development in mammals Autor Wilhelm, Dagmar, Palmer, Stephen, Koopman, Peter

“…Arguably the most defining moment in our lives is fertilization, the point at which we inherit either an X or a Y chromosome from our father. The profoundly…”
Zistit podrobnosti o prístupe

Female-to-male sex reversal in mice caused by transgenic overexpression of Dmrt1 Autor Zhao, Liang, Svingen, Terje, Ng, Ee Ting, Koopman, Peter

“…Genes related to Dmrt1, which encodes a DNA-binding DM domain transcription factor, act as triggers for primary sex determination in a broad range of metazoan…”
Zistit podrobnosti o prístupe

Human sex reversal is caused by duplication or deletion of core enhancers upstream of SOX9 Autor Croft, Brittany, Ohnesorg, Thomas, Hewitt, Jacqueline, Bowles, Josephine, Quinn, Alexander, Tan, Jacqueline, Corbin, Vincent, Pelosi, Emanuele, van den Bergen, Jocelyn, Sreenivasan, Rajini, Knarston, Ingrid, Robevska, Gorjana, Vu, Dung Chi, Hutson, John, Harley, Vincent, Ayers, Katie, Koopman, Peter, Sinclair, Andrew

“…Disorders of sex development (DSDs) are conditions affecting development of the gonads or genitalia. Variants in two key genes, SRY and its target SOX9 , are…”
Získať plný text

The makings of maleness: towards an integrated view of male sexual development Autor Wilhelm, Dagmar, Koopman, Peter

“…Key Points The correct development of two distinct sexes from a sexually undifferentiated, bipotential embryo is a multi-step process that is essential for…”
Získať plný text

Sex determination in mammalian germ cells: extrinsic versus intrinsic factors Autor Bowles, Josephine, Koopman, Peter

“…Mammalian germ cells do not determine their sexual fate based on their XX or XY chromosomal constitution. Instead, sexual fate is dependent on the gonadal…”
Zistit podrobnosti o prístupe

Normal Levels of Sox9 Expression in the Developing Mouse Testis Depend on the TES/TESCO Enhancer, but This Does Not Act Alone Autor Gonen, Nitzan, Quinn, Alexander, O’Neill, Helen C., Koopman, Peter, Lovell-Badge, Robin

“…During mouse sex determination, transient expression of the Y-linked gene Sry up-regulates its direct target gene Sox9, via a 3.2 kb testis specific enhancer…”
Získať plný text

ALDH1A1 provides a source of meiosis-inducing retinoic acid in mouse fetal ovaries Autor Bowles, Josephine, Feng, Chun-Wei, Miles, Kim, Ineson, Jessica, Spiller, Cassy, Koopman, Peter

“…Substantial evidence exists that during fetal ovarian development in mammals, retinoic acid (RA) induces germ cells to express the pre-meiotic marker Stra8 and…”
Získať plný text

Of sex and determination: marking 25 years of Randy, the sex-reversed mouse Autor Koopman, Peter, Sinclair, Andrew, Lovell-Badge, Robin

“…On Thursday 9 May 1991, the world awoke to front-page news of a breakthrough in biological research. From Washington to Wollongong, newspapers, radio and TV…”
Zistit podrobnosti o prístupe

Identification of regulatory elements required for Stra8 expression in fetal ovarian germ cells of the mouse Autor Feng, Chun-Wei, Burnet, Guillaume, Spiller, Cassy M, Cheung, Fiona Ka Man, Chawengsaksophak, Kallayanee, Koopman, Peter, Bowles, Josephine

“…In mice, the entry of germ cells into meiosis crucially depends on the expression of stimulated by retinoic acid gene 8 ( ). is expressed specifically in…”
Zistit podrobnosti o prístupe

Sox10 gain-of-function causes XX sex reversal in mice: implications for human 22q-linked disorders of sex development Autor Polanco, Juan Carlos, Wilhelm, Dagmar, Davidson, Tara-Lynne, Knight, Deon, Koopman, Peter

“…Male development in mammals is normally initiated by the Y-linked gene Sry, which activates expression of Sox9, leading to a cascade of gene activity required…”
Zistit podrobnosti o prístupe

SOX30 is required for male fertility in mice Autor Feng, Chun-Wei Allen, Spiller, Cassy, Merriner, Donna J., O’Bryan, Moira K., Bowles, Josephine, Koopman, Peter

“…Male infertility is a major and growing problem and, in most cases, the specific root cause is unknown. Here we show that the transcription factor SOX30 plays…”
Získať plný text

Sry and the hesitant beginnings of male development Autor Polanco, Juan Carlos, Koopman, Peter

“…In mammals, Sry (sex-determining region Y gene) is the master regulator of male sex determination. The discovery of Sry in 1990 was expected to provide the key…”
Získať plný text

Gene editing of the multi-copy H2A.B gene and its importance for fertility Autor Anuar, Nur Diana, Kurscheid, Sebastian, Field, Matt, Zhang, Lei, Rebar, Edward, Gregory, Philip, Buchou, Thierry, Bowles, Josephine, Koopman, Peter, Tremethick, David J., Soboleva, Tatiana A.

“…Background Altering the biochemical makeup of chromatin by the incorporation of histone variants during development represents a key mechanism in regulating…”
Získať plný text

Retinoid signaling determines germ cell fate in mice Autor Bowles, Josephine, Knight, Deon, Smith, Christopher, Wilhelm, Dagmar, Richman, Joy, Mamiya, Satoru, Yashiro, Kenta, Chawengsaksophak, Kallayanee, Wilson, Megan J, Rossant, Janet, Hamada, Hiroshi, Koopman, Peter

“…Germ cells in the mouse embryo can develop as oocytes or spermatogonia, depending on molecular cues that have not been identified. We found that retinoic acid,…”
Zistit podrobnosti o prístupe

Transcriptomic analysis of mRNA expression and alternative splicing during mouse sex determination Autor Zhao, Liang, Wang, Chenwei, Lehman, Melanie L., He, Mingyu, An, Jiyuan, Svingen, Terje, Spiller, Cassy M., Ng, Ee Ting, Nelson, Colleen C., Koopman, Peter

“…Mammalian sex determination hinges on sexually dimorphic transcriptional programs in developing fetal gonads. A comprehensive view of these programs is crucial…”
Získať plný text