Suchergebnisse - "Kok, Lianne"

The Branching Point in Erythro-Myeloid Differentiation von Perié, Leïla, Duffy, Ken R, Kok, Lianne, de Boer, Rob J, Schumacher, Ton N

“… Development of mature blood cell progenies from hematopoietic stem cells involves the transition through lineage-restricted progenitors. The first branching …”
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Replicative history marks transcriptional and functional disparity in the CD8 + T cell memory pool von Bresser, Kaspar, Kok, Lianne, Swain, Arpit C, King, Lisa A, Jacobs, Laura, Weber, Tom S, Perié, Leïla, Duffy, Ken R, de Boer, Rob J, Scheeren, Ferenc A, Schumacher, Ton N

“… Clonal expansion is a core aspect of T cell immunity. However, little is known with respect to the relationship between replicative history and the formation …”
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The precursors of CD8 + tissue resident memory T cells: from lymphoid organs to infected tissues von Kok, Lianne, Masopust, David, Schumacher, Ton N

“… CD8 tissue resident memory T cells (T cells) are essential for immune defence against pathogens and malignancies, and the molecular processes that lead to T …”
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Transcriptional state and function of CD8 + memory T cells is linked to past proliferation

“… A new genetic ‘recorder’ of long-term cell proliferation revealed substantial heterogeneity in the division history of central memory CD8+ T cells …”
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A committed tissue-resident memory T cell precursor within the circulating CD8+ effector T cell pool von Kok, Lianne, Dijkgraaf, Feline E, Urbanus, Jos, Bresser, Kaspar, Vredevoogd, David W, Cardoso, Rebeca F, Perié, Leïla, Beltman, Joost B, Schumacher, Ton N

“… An increasing body of evidence emphasizes the role of tissue-resident memory T cells (TRM) in the defense against recurring pathogens and malignant neoplasms …”
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Formation of Tissue-Resident CD8 + T-Cell Memory von Dijkgraaf, Feline E, Kok, Lianne, Schumacher, Ton N M

“… Resident memory CD8 T (Trm) cells permanently reside in nonlymphoid tissues where they act as a first line of defense against recurrent pathogens. How and when …”
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Single cell behavior in T cell differentiation von Rohr, Jan C., Gerlach, Carmen, Kok, Lianne, Schumacher, Ton N.

“… •Upon antigen encounter, proliferating T cells diversify in function and phenotype.•Lineage tracing demonstrates that the output of individual T cells is …”
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Author Correction: Replicative history marks transcriptional and functional disparity in the CD8 + T cell memory pool von Bresser, Kaspar, Kok, Lianne, Swain, Arpit C, King, Lisa A, Jacobs, Laura, Weber, Tom S, Perié, Leïla, Duffy, Ken R, de Boer, Rob J, Scheeren, Ferenc A, Schumacher, Ton N

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DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age von Urbanus, Jos, Cosgrove, Jason, Beltman, Joost B., Elhanati, Yuval, Moral, Rafael A., Conrad, Cecile, van Heijst, Jeroen W., Tubeuf, Emilie, Velds, Arno, Kok, Lianne, Merle, Candice, Magnusson, Jens P., Guyonnet, Léa, Frisén, Jonas, Fre, Silvia, Walczak, Aleksandra M., Mora, Thierry, Jacobs, Heinz, Schumacher, Ton N., Perié, Leïla

“… Ageing is associated with changes in the cellular composition of the immune system. During ageing, hematopoietic stem and progenitor cells (HSPCs) that produce …”
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346 Pre-clinical characterization of AZD0240, a CRISPR-engineered autologous TCR-T cell product targeting KRAS-G12D/HLA-A11:01 that is multi-armored to increase epitope sensitivity von Kok Lianne, Eshuis Sander, Kong Xiangjun, Ma, Jennifer, Mojadidi Michelle, Hall, Elizabeth, Grace Sun Ka Hei, Kroon, Paula, Tubb, Vanessa, Schumacher, Ton, Perez, Arianne, Linnemann Carsten, Cobbold, Mark, Heijst Jeroen van, Bendle Gavin

“… BackgroundKRAS is one of the most mutated genes in human cancer, with the G12D mutation having the highest frequency, occurring in 28% and 12% of pancreatic …”
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T Cell factor 1 represses CD8+ effector T cell formation and function von Tiemessen, Machteld M, Baert, Miranda R M, Kok, Lianne, van Eggermond, Marja C J A, van den Elsen, Peter J, Arens, Ramon, Staal, Frank J T

“… The Wnt-responsive transcription factor T cell factor 1 (Tcf1) is well known for its role in thymic T cell development and the formation of memory CD8(+) T …”
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DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age von Urbanus, Jos, Cosgrove, Jason, Beltman, Joost, Elhanati, Yuval, De Andrade Moral, Rafael, Conrad, Cecile, Jeroen Van Heijst, Tubeuf, Emilie, Velds, Arno, Kok, Lianne, Merle, Candice, Magnusson, Jens P, Frisen, Jonas, Fre, Silvia, Walczak, Aleksandra, Mora, Thierry, Jacobs, Heinz, Shumacher, Ton, Perie, Leila

“… Ageing is associated with changes in the cellular composition of the immune system. During ageing, hematopoietic stem and progenitor cells (HSPCs) that produce …”
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