Suchergebnisse - "Kocher, Thomas"

A Tandem Duplicate of Anti-Müllerian Hormone with a Missense SNP on the Y Chromosome Is Essential for Male Sex Determination in Nile Tilapia, Oreochromis niloticus von Li, Minghui, Sun, Yunlv, Zhao, Jiue, Shi, Hongjuan, Zeng, Sheng, Ye, Kai, Jiang, Dongneng, Zhou, Linyan, Sun, Lina, Tao, Wenjing, Nagahama, Yoshitaka, Kocher, Thomas D., Wang, Deshou

“… Variation in the TGF-β signaling pathway is emerging as an important mechanism by which gonadal sex determination is controlled in teleosts. Here we show that …”
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Periodontal complications of hyperglycemia/diabetes mellitus: Epidemiologic complexity and clinical challenge von Kocher, Thomas, König, Jörgen, Borgnakke, Wenche Sylling, Pink, Christiane, Meisel, Peter

“… This report provides a comprehensive overview of the adverse effects of hyperglycemia on the periodontium. It combines data from literature reviews of original …”
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Dmrt1 is the only male pathway gene tested indispensable for sex determination and functional testis development in tilapia von Qi, Shuangshuang, Dai, Shengfei, Zhou, Xin, Wei, Xueyan, Chen, Ping, He, Yuanyuan, Kocher, Thomas D., Wang, Deshou, Li, Minghui

“… Sex is determined by multiple factors derived from somatic and germ cells in vertebrates. We have identified amhy , dmrt1 , gsdf as male and foxl2 , foxl3 , …”
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CRISPR Knockouts of pmela and pmelb Engineered a Golden Tilapia by Regulating Relative Pigment Cell Abundance von Wang, Chenxu, Xu, Jia, Kocher, Thomas D, Li, Minghui, Wang, Deshou

“… Premelanosome protein (pmel) is a key gene for melanogenesis. Mutations in this gene are responsible for white plumage in chicken, but its role in pigmentation …”
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A high quality assembly of the Nile Tilapia (Oreochromis niloticus) genome reveals the structure of two sex determination regions von Conte, Matthew A., Gammerdinger, William J., Bartie, Kerry L., Penman, David J., Kocher, Thomas D.

“… Background Tilapias are the second most farmed fishes in the world and a sustainable source of food. Like many other fish, tilapias are sexually dimorphic and …”
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Changing sex for selfish gain: B chromosomes of Lake Malawi cichlid fish von Clark, Frances E., Kocher, Thomas D.

“… B chromosomes are extra, non-essential chromosomes present in addition to the normal complement of A chromosomes. Many species of cichlid fish in Lake Malawi …”
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Adaptive evolution and explosive speciation: the cichlid fish model von Kocher, Thomas D.

“… Key Points The spectacular radiation of 2,000 species of cichlid fishes in East Africa is an ideal model system and natural laboratory for studying …”
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Identification of sex chromosome and sex-determining gene of southern catfish ( Silurus meridionalis ) based on XX, XY and YY genome sequencing von Zheng, Shuqing, Tao, Wenjing, Yang, Haowen, Kocher, Thomas D, Wang, Zhijian, Peng, Zuogang, Jin, Li, Pu, Deyong, Zhang, Yaoguang, Wang, Deshou

“… Teleosts are important models to study sex chromosomes and sex-determining (SD) genes because they present a variety of sex determination systems. Here, we …”
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Knockout of Hermansky-Pudlak syndrome 5 (hps5) leads to red tilapia with reduced melanophores and iridophores von Wang, Chenxu, Kocher, Thomas D., Liu, Hao, Wen, Zilong, Yao, Jiawen, Wang, Deshou

“… Tilapia as an economically important fish is also an excellent model for studying pigment cell biology and body color formation. In the present study, we …”
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Knockout of Hermansky-Pudlak Syndrome 4 (hps4) leads to silver-white tilapia lacking melanosomes von Wang, Chenxu, Kocher, Thomas D., Lu, Baoyue, Xu, Jia, Wang, Deshou

“… Body color is a major factor determining the economic value of farmed tilapia. In the present study, we engineered a silver-white tilapia by mutation of hps4 …”
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Unusual Diversity of Sex Chromosomes in African Cichlid Fishes von Gammerdinger, William J., Kocher, Thomas D.

“… African cichlids display a remarkable assortment of jaw morphologies, pigmentation patterns, and mating behaviors. In addition to this previously documented …”
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Sexual conflict resolved by invasion of a novel sex determiner in Lake Malawi cichlid fishes von Roberts, Reade B, Ser, Jennifer R, Kocher, Thomas D

“… Sex determination mechanisms differ among animal species, but it is not clear how these differences evolve. New sex determiners may arise in response to sexual …”
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Mutation of mpv17 results in loss of iridophores due to mitochondrial dysfunction in tilapia von Xu, Jia, Li, Peng, Xu, Mengmeng, Wang, Chenxu, Kocher, Thomas D, Wang, Deshou

“… Mpv17 (mitochondrial inner membrane protein MPV17) deficiency causes severe mitochondrial DNA depletion syndrome in mammals and loss of pigmentation of …”
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Genome sequencing and identification of candidate variants for a red/black color polymorphism in tilapia (Oreochromis spp.) von Behrens, Kristen A., Danley, Aimee H., Jailwala, Soumya, Kocher, Thomas D.

“… Red tilapia are favored by consumers, but the molecular genetic basis for this color pattern is unknown. Here we report on the genetic and physical mapping of …”
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Entwicklung der Zahn- und Mundgesundheit in Deutschland von 1997 bis 2014 von Kocher, Thomas, Holtfreter, Birte, Pitchika, Vinay, Kuhr, Kathrin, Jordan, Rainer A.

“… Zusammenfassung Hintergrund Zur Veränderung der oralen Krankheitslast in der deutschen Allgemeinbevölkerung über die letzten 20 Jahre gibt es bisher keine …”
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Periodontitis and systemic inflammation as independent and interacting risk factors for mortality: evidence from a prospective cohort study von Pink, Christiane, Holtfreter, Birte, Völzke, Henry, Nauck, Matthias, Dörr, Marcus, Kocher, Thomas

“… Background Recent studies have highlighted the role of low-grade systemic inflammation in linking periodontitis to cardiovascular disease (CVD) outcomes, but …”
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Nile Tilapia: A Model for Studying Teleost Color Patterns von Wang, Chenxu, Lu, Baoyue, Li, Tao, Liang, Guangyuan, Xu, Mengmeng, Liu, Xingyong, Tao, Wenjing, Zhou, Linyan, Kocher, Thomas D, Wang, Deshou

“… The diverse color patterns of cichlid fishes play an important role in mate choice and speciation. Here we develop the Nile tilapia (Oreochromis niloticus) as …”
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Loss of Cyp11c1 causes delayed spermatogenesis due to the absence of 11-ketotestosterone von Zheng, Qiaoyuan, Xiao, Hesheng, Shi, Hongjuan, Wang, Tingru, Sun, Lina, Tao, Wenjing, Kocher, Thomas D, Li, Minghui, Wang, Deshou

“… The impacts of androgens and glucocorticoids on spermatogenesis have intrigued scientists for decades. 11β-hydroxylase, encoded by cyp11c1, is the key enzyme …”
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Homozygous mutation of foxh1 arrests oogenesis causing infertility in female Nile tilapia von Tao, Wenjing, Shi, Hongjuan, Yang, Jing, Diakite, Hamidou, Kocher, Thomas D., Wang, Deshou

“… Foxh1, a member of fox gene family, was first characterized as a transcriptional partner in the formation of the Smad protein complex. Recent studies have …”
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Sex chromosome turnover and biodiversity in fishes von Wang, Jingrong, Tao, Wenjing, Kocher, Thomas D., Wang, Deshou

“… The impact of sex chromosomes and their turnover in speciation remains a subject of ongoing debate in the field of evolutionary biology. Fishes are the largest …”
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