Search Results - "Klco, Jeffery M"

TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation by Malireddi, R K Subbarao, Gurung, Prajwal, Mavuluri, Jayadev, Dasari, Tejasvi Krishna, Klco, Jeffery M, Chi, Hongbo, Kanneganti, Thirumala-Devi

“…The NOD-like receptor (NLR)-P3 inflammasome is a global sensor of infection and stress. Elevated NLRP3 activation levels are associated with human diseases,…”
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The genomic landscape of pediatric myelodysplastic syndromes by Schwartz, Jason R., Ma, Jing, Lamprecht, Tamara, Walsh, Michael, Wang, Shuoguo, Bryant, Victoria, Song, Guangchun, Wu, Gang, Easton, John, Kesserwan, Chimene, Nichols, Kim E., Mullighan, Charles G., Ribeiro, Raul C., Klco, Jeffery M.

“…Myelodysplastic syndromes (MDS) are uncommon in children and have a poor prognosis. In contrast to adult MDS, little is known about the genomic landscape of…”
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Venetoclax in combination with cytarabine with or without idarubicin in children with relapsed or refractory acute myeloid leukaemia: a phase 1, dose-escalation study by Karol, Seth E, Alexander, Thomas B, Budhraja, Amit, Pounds, Stanley B, Canavera, Kristin, Wang, Lei, Wolf, Joshua, Klco, Jeffery M, Mead, Paul E, Das Gupta, Soumyasri, Kim, Su Y, Salem, Ahmed Hamed, Palenski, Tammy, Lacayo, Norman J, Pui, Ching-Hon, Opferman, Joseph T, Rubnitz, Jeffrey E

“…Outcomes for children with relapsed or refractory acute myeloid leukaemia remain poor. The BCL-2 inhibitor, venetoclax, has shown promising activity in…”
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Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome by Rusch, Michael, Nakitandwe, Joy, Shurtleff, Sheila, Newman, Scott, Zhang, Zhaojie, Edmonson, Michael N., Parker, Matthew, Jiao, Yuannian, Ma, Xiaotu, Liu, Yanling, Gu, Jiali, Walsh, Michael F., Becksfort, Jared, Thrasher, Andrew, Li, Yongjin, McMurry, James, Hedlund, Erin, Patel, Aman, Easton, John, Yergeau, Donald, Vadodaria, Bhavin, Tatevossian, Ruth G., Raimondi, Susana, Hedges, Dale, Chen, Xiang, Hagiwara, Kohei, McGee, Rose, Robinson, Giles W., Klco, Jeffery M., Gruber, Tanja A., Ellison, David W., Downing, James R, Zhang, Jinghui

“…To evaluate the potential of an integrated clinical test to detect diverse classes of somatic and germline mutations relevant to pediatric oncology, we…”
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CAR T cells redirected to cell surface GRP78 display robust anti-acute myeloid leukemia activity and do not target hematopoietic progenitor cells by Hebbar, Nikhil, Epperly, Rebecca, Vaidya, Abishek, Thanekar, Unmesha, Moore, Sarah E., Umeda, Masayuki, Ma, Jing, Patil, Sagar L., Langfitt, Deanna, Huang, Sujuan, Cheng, Cheng, Klco, Jeffery M., Gottschalk, Stephen, Velasquez, M. Paulina

“…Developing CAR T cells for acute myeloid leukemia (AML) has been hampered by a paucity of targets that are expressed on AML blasts and not on hematopoietic…”
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Pediatric MDS and bone marrow failure-associated germline mutations in SAMD9 and SAMD9L impair multiple pathways in primary hematopoietic cells by Thomas, Melvin E., Abdelhamed, Sherif, Hiltenbrand, Ryan, Schwartz, Jason R., Sakurada, Sadie Miki, Walsh, Michael, Song, Guangchun, Ma, Jing, Pruett-Miller, Shondra M., Klco, Jeffery M.

“…Pediatric myelodysplastic syndromes (MDS) are a heterogeneous disease group associated with impaired hematopoiesis, bone marrow hypocellularity, and frequently…”
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Novel classification system and high-risk categories of pediatric acute myeloid leukemia by Umeda, Masayuki, Liu, Yen-Chun, Karol, Seth E., Klco, Jeffery M.

“…The prognosis of pediatric acute myeloid leukemia (AML) remains poor compared with pediatric acute lymphoblastic leukemia (ALL); accurate diagnosis and…”
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SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data by Davis, Eric M., Sun, Yu, Liu, Yanling, Kolekar, Pandurang, Shao, Ying, Szlachta, Karol, Mulder, Heather L., Ren, Dongren, Rice, Stephen V., Wang, Zhaoming, Nakitandwe, Joy, Gout, Alexander M., Shaner, Bridget, Hall, Salina, Robison, Leslie L., Pounds, Stanley, Klco, Jeffery M., Easton, John, Ma, Xiaotu

“…Background There is currently no method to precisely measure the errors that occur in the sequencing instrument/sequencer, which is critical for…”
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Pediatric Erythroid Sarcoma Diagnostically Confirmed by Identification of a Recurrent NFIA::CBFA2T3 Fusion by Anelo, Obianuju Mercy, Ma, Jing, Neary, Jennifer L., Koo, Selene C., Inaba, Hiroto, Pinto, Soniya N., Nguyen, Nga Thi, Hoang, Thach Ngoc, Bui, Lan Ngoc, Klco, Jeffery M., Gheorghe, Gabriela, Blackburn, Patrick R.

“…ABSTRACT Erythroid sarcoma (ES) is exceedingly rare in the pediatric population with only a handful of reports of de novo cases, mostly occurring in the…”
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Molecular basis of ETV6-mediated predisposition to childhood acute lymphoblastic leukemia by Nishii, Rina, Baskin-Doerfler, Rebekah, Yang, Wentao, Oak, Ninad, Zhao, Xujie, Yang, Wenjian, Hoshitsuki, Keito, Bloom, Mackenzie, Verbist, Katherine, Burns, Melissa, Li, Zhenhua, Lin, Ting-Nien, Qian, Maoxiang, Moriyama, Takaya, Gastier-Foster, Julie M, Rabin, Karen R, Raetz, Elizabeth, Mullighan, Charles, Pui, Ching-Hon, Yeoh, Allen Eng-Juh, Zhang, Jinghui, Metzger, Monika L, Klco, Jeffery M, Hunger, Stephen P, Newman, Scott, Wu, Gang, Loh, Mignon L, Nichols, Kim E, Yang, Jun J

“…There is growing evidence supporting an inherited basis for susceptibility to acute lymphoblastic leukemia (ALL) in children. In particular, we and others…”
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Mutant Samd9l expression impairs hematopoiesis and induces bone marrow failure in mice by Abdelhamed, Sherif, Thomas, Melvin E., Westover, Tamara, Umeda, Masayuki, Xiong, Emily, Rolle, Chandra, Walsh, Michael P., Wu, Huiyun, Schwartz, Jason R., Valentine, Virginia, Valentine, Marcus, Pounds, Stanley, Ma, Jing, Janke, Laura J., Klco, Jeffery M.

“…SAMD9 and SAMD9L germline mutations have recently emerged as a new class of predispositions to pediatric myeloid neoplasms. Patients commonly have impaired…”
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Integrated stem cell signature and cytomolecular risk determination in pediatric acute myeloid leukemia by Huang, Benjamin J., Smith, Jenny L., Farrar, Jason E., Wang, Yi-Cheng, Umeda, Masayuki, Ries, Rhonda E., Leonti, Amanda R., Crowgey, Erin, Furlan, Scott N., Tarlock, Katherine, Armendariz, Marcos, Liu, Yanling, Shaw, Timothy I., Wei, Lisa, Gerbing, Robert B., Cooper, Todd M., Gamis, Alan S., Aplenc, Richard, Kolb, E. Anders, Rubnitz, Jeffrey, Ma, Jing, Klco, Jeffery M., Ma, Xiaotu, Alonzo, Todd A., Triche, Timothy, Meshinchi, Soheil

“…Relapsed or refractory pediatric acute myeloid leukemia (AML) is associated with poor outcomes and relapse risk prediction approaches have not changed…”
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Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies by Cole, Christopher B., Russler-Germain, David A., Ketkar, Shamika, Verdoni, Angela M., Smith, Amanda M., Bangert, Celia V., Helton, Nichole M., Guo, Mindy, Klco, Jeffery M., O’Laughlin, Shelly, Fronick, Catrina, Fulton, Robert, Chang, Gue Su, Petti, Allegra A., Miller, Christopher A., Ley, Timothy J.

“…The gene that encodes de novo DNA methyltransferase 3A (DNMT3A) is frequently mutated in acute myeloid leukemia genomes. Point mutations at position R882 have…”
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UBTF tandem duplications in pediatric myelodysplastic syndrome and acute myeloid leukemia: implications for clinical screening and diagnosis by Barajas, Juan M., Umeda, Masayuki, Contreras, Lisett, Khanlari, Mahsa, Westover, Tamara, Walsh, Michael P., Xiong, Emily, Yang, Chenchen, Otero, Brittney, Arribas-Layton, Marc, Abdelhamed, Sherif, Song, Guangchun, Ma, Xiaotu, Thomas 3rd, Melvin E., Ma, Jing, Klco, Jeffery M.

“…Recent genomic studies in adult and pediatric acute myeloid leukemia (AML) demonstrated recurrent in-frame tandem duplications (TD) in exon 13 of upstream…”
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Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML by Wong, Terrence N, Miller, Christopher A, Klco, Jeffery M, Petti, Allegra, Demeter, Ryan, Helton, Nichole M, Li, Tiandao, Fulton, Robert S, Heath, Sharon E, Mardis, Elaine R, Westervelt, Peter, DiPersio, John F, Walter, Matthew J, Welch, John S, Graubert, Timothy A, Wilson, Richard K, Ley, Timothy J, Link, Daniel C

“…There is interest in using leukemia-gene panels and next-generation sequencing to assess acute myelogenous leukemia (AML) response to induction chemotherapy…”
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Concurrent peripheral T-cell lymphoma and T-cell lymphoblastic leukemia/lymphoma with identical STIL::TAL1 fusion events by Khanlari, Mahsa, Wang, Wei, Liu, Yen-Chun, Wang, Lu, Rubnitz, Jeffrey E., Dixon, Stephanie, Orr, Brent A., Anelo, Obianuju M., Cheng, Zhongshan, Balagopal, Vidya, Klco, Jeffery M.

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Genomic impact of transient low-dose decitabine treatment on primary AML cells by Klco, Jeffery M, Spencer, David H, Lamprecht, Tamara L, Sarkaria, Shawn M, Wylie, Todd, Magrini, Vincent, Hundal, Jasreet, Walker, Jason, Varghese, Nobish, Erdmann-Gilmore, Petra, Lichti, Cheryl F, Meyer, Matthew R, Townsend, R Reid, Wilson, Richard K, Mardis, Elaine R, Ley, Timothy J

“…Acute myeloid leukemia (AML) is characterized by dysregulated gene expression and abnormal patterns of DNA methylation; the relationship between these events…”
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Advances in germline predisposition to acute leukaemias and myeloid neoplasms by Klco, Jeffery M, Mullighan, Charles G

“…Although much work has focused on the elucidation of somatic alterations that drive the development of acute leukaemias and other haematopoietic diseases, it…”
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Chemotherapy and mismatch repair deficiency cooperate to fuel TP53 mutagenesis and ALL relapse by Yang, Fan, Brady, Samuel W., Tang, Chao, Sun, Huiying, Du, Lijuan, Barz, Malwine J., Ma, Xiaotu, Chen, Yao, Fang, Houshun, Li, Xiaomeng, Kolekar, Pandurang, Pathak, Omkar, Cai, Jiaoyang, Ding, Lixia, Wang, Tianyi, von Stackelberg, Arend, Shen, Shuhong, Eckert, Cornelia, Klco, Jeffery M., Chen, Hongzhuan, Duan, Caiwen, Liu, Yu, Li, Hui, Li, Benshang, Kirschner-Schwabe, Renate, Zhang, Jinghui, Zhou, Bin-Bing S.

“…Chemotherapy is a standard treatment for pediatric acute lymphoblastic leukemia (ALL), which sometimes relapses with chemoresistant features. However, whether…”
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Mechanistic insights and potential therapeutic approaches for NUP98-rearranged hematologic malignancies by Michmerhuizen, Nicole L, Klco, Jeffery M, Mullighan, Charles G

“…Nucleoporin 98 (NUP98) fusion oncoproteins are observed in a spectrum of hematologic malignancies, particularly pediatric leukemias with poor patient outcomes…”
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