Výsledky vyhľadávania - "Keaney, John F"

Reactive oxygen species in cardiovascular disease Autor Sugamura, Koichi, Keaney, John F.

“…Based on the “free radical theory” of disease, researchers have been trying to elucidate the role of oxidative stress from free radicals in cardiovascular…”
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Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications Autor Münzel, Thomas, Gori, Tommaso, Keaney, Jr, John F, Maack, Christoph, Daiber, Andreas

“…Systolic and diastolic myocardial dysfunction has been demonstrated to be associated with an activation of the circulating and local…”
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Role of oxidative modifications in atherosclerosis Autor Stocker, Roland, Keaney, Jr, John F

“…This review focuses on the role of oxidative processes in atherosclerosis and its resultant cardiovascular events. There is now a consensus that…”
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Reactive oxygen species in endothelial function - from disease to adaptation Autor Craige, Siobhan M, Kant, Shashi, Keaney, Jr, John F

“…Endothelial function is largely dictated by its ability to rapidly sense environmental cues and adapt to these stimuli through changes in vascular tone,…”
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Bempedoic Acid and the Prevention of Cardiovascular Disease Autor Keaney, John F.

“…This editorial describes the science behind a study of bempedoic acid in persons with or at increased risk for cardiovascular disease who were unable or…”
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Regulation of ROS signal transduction by NADPH oxidase 4 localization Autor Chen, Kai, Kirber, Michael T, Xiao, Hui, Yang, Yu, Keaney, Jr, John F

“…Reactive oxygen species (ROS) function as intracellular signaling molecules in a diverse range of biological processes. However, it is unclear how freely…”
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NADPH oxidase 4 promotes endothelial angiogenesis through endothelial nitric oxide synthase activation Autor Craige, Siobhan M, Chen, Kai, Pei, Yongmei, Li, Chunying, Huang, Xiaoyun, Chen, Christine, Shibata, Rei, Sato, Kaori, Walsh, Kenneth, Keaney, Jr, John F

“…BACKGROUND- Reactive oxygen species serve signaling functions in the vasculature, and hypoxia has been associated with increased reactive oxygen species…”
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Common Statistical Pitfalls in Basic Science Research Autor Sullivan, Lisa M., Weinberg, Janice, Keaney, John F.

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Volume-Outcome Relationship of Resternotomy Coronary Artery Bypass Grafting Autor Rappoport, Nadav, Shahian, David M, Galai, Noya, Aviel, Gal, Keaney, Jr, John F, Shapira, Oz M

“…We assessed volume-outcome relationships of resternotomy coronary artery bypass grafting (CABG). We studied 1,362,218 first-time CABG and 93,985 resternotomy…”
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The clinical implications of endothelial dysfunction Autor Widlansky, Michael E, Gokce, Noyan, Keaney, Jr, John F, Vita, Joseph A

“…Defining new approaches for the prevention and treatment of atherosclerosis is an important priority. Recently, measurement of endothelial function in patients…”
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Association of Thromboxane Generation With Survival in Aspirin Users and Nonusers Autor Rade, Jeffrey J, Barton, Bruce A, Vasan, Ramachandran S, Kronsberg, Shari S, Xanthakis, Vanessa, Keaney, Jr, John F, Hamburg, Naomi M, Kakouros, Nikolaos, Kickler, Thomas A

“…Persistent systemic thromboxane generation, predominantly from nonplatelet sources, in aspirin (ASA) users with cardiovascular disease (CVD) is a mortality…”
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Kynurenine is an endothelium-derived relaxing factor produced during inflammation Autor Wang, Yutang, Liu, Hanzhong, McKenzie, Gavin, Witting, Paul K, Stasch, Johannes-Peter, Hahn, Michael, Changsirivathanathamrong, Dechaboon, Wu, Ben J, Ball, Helen J, Thomas, Shane R, Kapoor, Vimal, Celermajer, David S, Mellor, Andrew L, Keaney, John F, Hunt, Nicholas H, Stocker, Roland

“…Kynurenine, a metabolite produced by the action of the enzyme indoleamine 2,3-dioxygenase on tryptophan, accumulates under inflammatory conditions and has…”
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Hdac3 regulates lymphovenous and lymphatic valve formation Autor Janardhan, Harish P., Milstone, Zachary J., Shin, Masahiro, Lawson, Nathan D., Keaney, John F., Trivedi, Chinmay M.

“…Lymphedema, the most common lymphatic anomaly, involves defective lymphatic valve development; yet the epigenetic modifiers underlying lymphatic valve…”
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Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study Autor Pou, Karla M, Massaro, Joseph M, Hoffmann, Udo, Vasan, Ramachandran S, Maurovich-Horvat, Pal, Larson, Martin G, Keaney, Jr, John F, Meigs, James B, Lipinska, Izabella, Kathiresan, Sekar, Murabito, Joanne M, O'Donnell, Christopher J, Benjamin, Emelia J, Fox, Caroline S

“…Excess adiposity is associated with greater systemic inflammation. Whether visceral adiposity is more proinflammatory than subcutaneous abdominal adiposity is…”
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Evolving Concepts of Oxidative Stress and Reactive Oxygen Species in Cardiovascular Disease Autor Chen, Kai, Keaney, John F.

“…Cardiovascular disease (CVD) continues to be a substantial health-care burden, despite recent treatment advances. Oxidative stress has long been regarded as a…”
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Extracorporeal CPR in Out-of-Hospital Cardiac Arrest — Still on Life Support? Autor Keaney, John F., Münzel, Thomas

“…Despite many advances in the treatment of heart disease over the past four decades, up to one third of all patients with acute manifestations of heart disease…”
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Proof That Lower Is Better — LDL Cholesterol and IMPROVE-IT Autor Jarcho, John A, Keaney, John F

“…The so-called LDL hypothesis is the concept that excess low-density lipoprotein (LDL) cholesterol is a causal factor in the development of atherosclerotic…”
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Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers Autor Hamburg, Naomi M, McMackin, Craig J, Huang, Alex L, Shenouda, Sherene M, Widlansky, Michael E, Schulz, Eberhard, Gokce, Noyan, Ruderman, Neil B, Keaney, Jr, John F, Vita, Joseph A

“…Sedentary lifestyle increases the risk of cardiovascular disease and diabetes. Vascular dysfunction contributes to atherogenesis and has been linked to insulin…”
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JNK and cardiometabolic dysfunction Autor Craige, Siobhan M, Chen, Kai, Blanton, Robert M, Keaney, Jr, John F, Kant, Shashi

“…Cardiometabolic syndrome (CMS) describes the cluster of metabolic and cardiovascular diseases that are generally characterized by impaired glucose tolerance,…”
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Endothelial NADPH oxidase 4 protects ApoE-/- mice from atherosclerotic lesions Autor Craige, Siobhan M., Kant, Shashi, Reif, Michaella, Chen, Kai, Pei, Yongmei, Angoff, Rebecca, Sugamura, Koichi, Fitzgibbons, Timothy, Keaney, John F.

“…Vascular reactive oxygen species (ROS) are known to be involved in atherosclerosis development and progression. NADPH oxidase 4 (Nox4) is a constitutively…”
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