Suchergebnisse - "Kappagantula, Rajya"

Neoantigen quality predicts immunoediting in survivors of pancreatic cancer von Łuksza, Marta, Sethna, Zachary M., Rojas, Luis A., Lihm, Jayon, Bravi, Barbara, Elhanati, Yuval, Soares, Kevin, Amisaki, Masataka, Dobrin, Anton, Hoyos, David, Guasp, Pablo, Zebboudj, Abderezak, Yu, Rebecca, Chandra, Adrienne Kaya, Waters, Theresa, Odgerel, Zagaa, Leung, Joanne, Kappagantula, Rajya, Makohon-Moore, Alvin, Johns, Amber, Gill, Anthony, Gigoux, Mathieu, Wolchok, Jedd, Merghoub, Taha, Sadelain, Michel, Patterson, Erin, Monasson, Remi, Mora, Thierry, Walczak, Aleksandra M., Cocco, Simona, Iacobuzio-Donahue, Christine, Greenbaum, Benjamin D., Balachandran, Vinod P.

“… Cancer immunoediting 1 is a hallmark of cancer 2 that predicts that lymphocytes kill more immunogenic cancer cells to cause less immunogenic clones to dominate …”
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Cancer biology as revealed by the research autopsy von Iacobuzio-Donahue, Christine A, Michael, Chelsea, Baez, Priscilla, Kappagantula, Rajya, Hooper, Jody E, Hollman, Travis J

“… A research autopsy is a post-mortem medical procedure performed on a deceased individual with the primary goal of collecting tissue to support basic and …”
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A microglia clonal inflammatory disorder in Alzheimer’s disease von Vicario, Rocio, Fragkogianni, Stamatina, Weber, Leslie, Lazarov, Tomi, Hu, Yang, Hayashi, Samantha Y, Craddock, Barbara, Socci, Nicholas D, Alberdi, Araitz, Baako, Ann, Ay, Oyku, Ogishi, Masato, Lopez-Rodrigo, Estibaliz, Kappagantula, Rajya, Viale, Agnes, Iacobuzio-Donahue, Christine A, Zhou, Ting, Ransohoff, Richard M, Chesworth, Richard, Abdel-Wahab, Omar, Boisson, Bertrand, Elemento, Olivier, Casanova, Jean-Laurent, Miller, W Todd, Geissmann, Frédéric

“… Somatic genetic heterogeneity resulting from post-zygotic DNA mutations is widespread in human tissues and can cause diseases, however, few studies have …”
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The Evolutionary Origins of Recurrent Pancreatic Cancer von Sakamoto, Hitomi, Attiyeh, Marc A, Gerold, Jeffrey M, Makohon-Moore, Alvin P, Hayashi, Akimasa, Hong, Jungeui, Kappagantula, Rajya, Zhang, Lance, Melchor, Jerry P, Reiter, Johannes G, Heyde, Alexander, Bielski, Craig M, Penson, Alexander V, Gönen, Mithat, Chakravarty, Debyani, O'Reilly, Eileen M, Wood, Laura D, Hruban, Ralph H, Nowak, Martin A, Socci, Nicholas D, Taylor, Barry S, Iacobuzio-Donahue, Christine A

“… Surgery is the only curative option for stage I/II pancreatic cancer; nonetheless, most patients will experience a recurrence after surgery and die of their …”
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Germ cell tumors and associated hematologic malignancies evolve from a common shared precursor von Taylor, Justin, Donoghue, Mark T.A., Ho, Caleb, Petrova-Drus, Kseniya, Al-Ahmadie, Hikmat A., Funt, Samuel A., Zhang, Yanming, Aypar, Umut, Rao, Pavitra, Chavan, Shweta S., Haddadin, Michael, Tamari, Roni, Giralt, Sergio, Tallman, Martin S., Rampal, Raajit K., Baez, Priscilla, Kappagantula, Rajya, Kosuri, Satyajit, Dogan, Ahmet, Tickoo, Satish K., Reuter, Victor E., Bosl, George J., Iacobuzio-Donahue, Christine A., Solit, David B., Taylor, Barry S., Feldman, Darren R., Abdel-Wahab, Omar

“… Germ cell tumors (GCTs) are the most common cancer in men between the ages of 15 and 40. Although most patients are cured, those with disease arising in the …”
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A unifying paradigm for transcriptional heterogeneity and squamous features in pancreatic ductal adenocarcinoma von Hayashi, Akimasa, Fan, Jun, Chen, Ruoyao, Ho, Yu-jui, Makohon-Moore, Alvin P., Lecomte, Nicolas, Zhong, Yi, Hong, Jungeui, Huang, Jinlong, Sakamoto, Hitomi, Attiyeh, Marc A., Kohutek, Zachary A., Zhang, Lance, Boumiza, Aida, Kappagantula, Rajya, Baez, Priscilla, Bai, Jessica, Lisi, Marta, Chadalavada, Kalyani, Melchor, Jerry P., Wong, Winston, Nanjangud, Gouri J., Basturk, Olca, O’Reilly, Eileen M., Klimstra, David S., Hruban, Ralph H., Wood, Laura D., Overholtzer, Michael, Iacobuzio-Donahue, Christine A.

“… Pancreatic cancer expression profiles largely reflect a classical or basal-like phenotype. The extent to which these profiles vary within a patient is unknown …”
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Syndecan-1 is a Key Mediator of Entosis and Cellular Competition in Pancreatic Cancer von Li, Kara, Li, Chenyang, Umeda, Shigeaki, Kappagantula, Rajya L, Paku, Masakatsu, Zeng, Yue, Iacobuzio-Donahue, Christine, Yao, Wantong

“… Entosis, a form of cell-in-cell (CIC) structure formation where one cell invades and becomes internalized by another, has long been observed in various …”
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The Genetic Evolution of Treatment-Resistant Cutaneous, Acral, and Uveal Melanomas von Makohon-Moore, Alvin P, Lipson, Evan J, Hooper, Jody E, Zucker, Amanda, Hong, Jungeui, Bielski, Craig M, Hayashi, Akimasa, Tokheim, Collin, Baez, Priscilla, Kappagantula, Rajya, Kohutek, Zachary, Makarov, Vladimir, Riaz, Nadeem, Postow, Michael A, Chapman, Paul B, Karchin, Rachel, Socci, Nicholas D, Solit, David B, Chan, Timothy A, Taylor, Barry S, Topalian, Suzanne L, Iacobuzio-Donahue, Christine A

“… Melanoma is a biologically heterogeneous disease composed of distinct clinicopathologic subtypes that frequently resist treatment. To explore the evolution of …”
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Convergent evolution of BRCA2 reversion mutations under therapeutic pressure by PARP inhibition and platinum chemotherapy von Walmsley, Charlotte S., Jonsson, Philip, Cheng, Michael L., McBride, Sean, Kaeser, Christopher, Vargas, Herbert Alberto, Laudone, Vincent, Taylor, Barry S., Kappagantula, Rajya, Baez, Priscilla, Richards, Allison L., Noronha, Anne Marie, Perera, Dilmi, Berger, Michael, Solit, David B., Iacobuzio-Donahue, Christine A., Scher, Howard I., Donoghue, Mark T. A., Abida, Wassim, Schram, Alison M.

“… Reversion mutations that restore wild-type function of the BRCA gene have been described as a key mechanism of resistance to Poly(ADP-ribose) polymerase (PARP) …”
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A microglia clonal inflammatory disorder in Alzheimer’s disease von Vicario, Rocio, Fragkogianni, Stamatina, Weber, Leslie, Lazarov, Tomi, Hu, Yang, Hayashi, Samantha Y, Craddock, Barbara, Socci, Nicholas D, Alberdi, Araitz, Baako, Ann, Ay, Oyku, Ogishi, Masato, Lopez-Rodrigo, Estibaliz, Kappagantula, Rajya, Viale, Agnes, Iacobuzio-Donahue, Christine A, Zhou, Ting, Ransohoff, Richard M, Chesworth, Richard, Abdel-Wahab, Omar, Boisson, Bertrand, Elemento, Olivier, Casanova, Jean-Laurent, Miller, W Todd, Geissmann, Frédéric

“… Somatic genetic heterogeneity resulting from post-zygotic DNA mutations is widespread in human tissues and can cause diseases, however, few studies have …”
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Tissue-specific features of the T cell repertoire after allogeneic hematopoietic cell transplantation in human and mouse von DeWolf, Susan, Elhanati, Yuval, Nichols, Katherine, Waters, Nicholas R, Nguyen, Chi L, Slingerland, John B, Rodriguez, Natasia, Lyudovyk, Olga, Giardina, Paul A, Kousa, Anastasia I, Andrlová, Hana, Ceglia, Nick, Fei, Teng, Kappagantula, Rajya, Li, Yanyun, Aleynick, Nathan, Baez, Priscilla, Murali, Rajmohan, Hayashi, Akimasa, Lee, Nicole, Gipson, Brianna, Rangesa, Madhumitha, Katsamakis, Zoe, Dai, Anqi, Blouin, Amanda G, Arcila, Maria, Masilionis, Ignas, Chaligne, Ronan, Ponce, Doris M, Landau, Heather J, Politikos, Ioannis, Tamari, Roni, Hanash, Alan M, Jenq, Robert R, Giralt, Sergio A, Markey, Kate A, Zhang, Yanming, Perales, Miguel-Angel, Socci, Nicholas D, Greenbaum, Benjamin D, Iacobuzio-Donahue, Christine A, Hollmann, Travis J, van den Brink, Marcel R M, Peled, Jonathan U

“… T cells are the central drivers of many inflammatory diseases, but the repertoire of tissue-resident T cells at sites of pathology in human organs remains …”
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CT radiomics associations with genotype and stromal content in pancreatic ductal adenocarcinoma von Attiyeh, Marc A., Chakraborty, Jayasree, McIntyre, Caitlin A., Kappagantula, Rajya, Chou, Yuting, Askan, Gokce, Seier, Kenneth, Gonen, Mithat, Basturk, Olca, Balachandran, Vinod P., Kingham, T. Peter, D’Angelica, Michael I., Drebin, Jeffrey A., Jarnagin, William R., Allen, Peter J., Iacobuzio-Donahue, Christine A., Simpson, Amber L., Do, Richard K.

“… Purpose The aim of this study was to investigate the relationship between CT imaging phenotypes and genetic and biological characteristics in pancreatic ductal …”
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The Non-Coding Mutational Landscape of Pancreatic Cancer Reveals Recurrent Somatic Mutations in Enhancer Regions von Hayashi, Akimasa, Ho, Yu-Jui, Makohon-Moore, Alvin P, Zucker, Amanda, Hong, Jungeui, Umeda, Shigeaki, Karnoub, Elias-Ramzey, Huang, Jinlong, Baez, Priscilla, Kappagantula, Rajya, Melchor, Jerry P, Park, Wungki, O'Reilly, Eileen M, Socci, Nicholas D, Oki, Shinya, Iacobuzio-Donahue, Christine A

“… While the coding genome of pancreatic cancer has been characterized in detail, features of the noncoding genome remain relatively unexplored. We used whole …”
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The Noncoding Mutational Landscape of Pancreatic Cancer Reveals Recurrent Somatic Mutations in Enhancer Regions von Hayashi, Akimasa, Ho, Yu-Jui, Makohon-Moore, Alvin P., Zucker, Amanda, Hong, Jungeui, Umeda, Shigeaki, Karnoub, Elias-Ramzey, Huang, Jinlong, Baez, Priscilla, Kappagantula, Rajya, Melchor, Jerry P., Park, Wungki, O’Reilly, Eileen M., Socci, Nicholas D., Oki, Shinya, Iacobuzio-Donahue, Christine A.

“… While the coding genome of pancreatic cancer has been characterized in detail, features of the noncoding genome remain relatively unexplored. We used …”
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Evolutionary Dynamics of Non-Coding Regions in Pancreatic Ductal Adenocarcinoma von Hayashi, Akimasa, Yu-Jui, Ho, Makohon-Moore, Alvin P, Zucker, Amanda, Hong, Jungeui, Reiter, Johannes G, Huang, Jinlong, Zhang, Lance, Attiyeh, Marc A, Baez, Priscilla, Kappagantula, Rajya, Melchor, Jerry P, Eileen M O’reilly, Socci, Nicholas D, Oki, Shinya, Lowe, Scott W, Iacobuzio-Donahue, Christine A

“… Abstract While the non-coding genome appears to play a role, the dynamic nature of noncoding alterations with respect to clonal progression of solid tumors …”
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Accelerated single cell seeding in relapsed multiple myeloma von Landau, Heather J, Yellapantula, Venkata, Diamond, Benjamin J, Rustad, Even H, Maclachlan, Kylee, Gunes Gundem, Medina-Martinez, Juan, Arango Ossa, Juan E, Levine, Max, Zhou, Yangyu, Rajya, Kappagantula L, Baez, Priscilla, Attiyeh, Marc, Makohon-Moore, Alvin, Zhang, Lance, Boyle, Eileen E, Ashby, Cody, Blaney, Patrick, Patel, Minal, Zhang, Yanming, Dogan, Ahmet, Chung, David, Giralt, Sergio, Lahoud, Oscar B, Peled, Jonathan, Scordo, Michael, Shah, Gunjan, Hassoun, Hani, Korde, Neha S, Lesokhin, Alexander M, Lu, Sydney, Sham Mailankody, Shah, Urvi A, Smith, Eric, Hultcrantz, Malin L, Ulaner, Gary, Frits Van Rhee, Morgan, Gareth, Landgren, Ola, Papaemmanuil, Elli, Iacobuzio-Donahue, Christine A, Francesco, Maura

“… The malignant progression of multiple myeloma is characterized by the seeding of cancer cells in different anatomic sites followed by their clonal expansion …”
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A microglia clonal inflammatory disorder in Alzheimer's Disease von Vicario, Rocio, Fragkogianni, Stamatina, Weber, Leslie, Lazarov, Tomi, Hu, Yang, Hayashi, Samantha Y, Craddock, Barbara P, Socci, Nicholas D, Alberdi, Araitz, Baako, Ann, Ay, Oyku, Ogishi, Masato, Lopez-Rodrigo, Estibaliz, Kappagantula, Rajya, Viale, Agnes, Iacobuzio-Donahue, Christine A, Zhou, Ting, Ransohoff, Richard M, Chesworth, Richard, Abdel-Wahab, Omar, Boisson, Bertrand, Elemento, Olivier, Casanova, Jean-Laurent, Miller, W Todd, Geissmann, Frederic

“… Somatic genetic heterogeneity resulting from post-zygotic DNA mutations is widespread in human tissues and can cause diseases, however few studies have …”
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The Genetic Basis of Transcriptional Heterogeneity for Basal-Like Features in Pancreatic Ductal Adenocarcinoma von Hayashi, Akimasa, Fan, Jun, Chen, Ruoyao, Ho, Yu-jui, Makohon-Moore, Alvin P., Zhong, Yi, Hong, Jungeui, Sakamoto, Hitomi, Attiyeh, Marc A., Kohutek, Zachary A., Zhang, Lance, Huang, Jinlong, Boumiza, Aida, Kappagantula, Rajya, Baez, Priscilla, Wood, Laura D., Hruban, Ralph H., Marta, Lisi, Chadalavada, Kalyani, Nanjangud, Gouri J., Basturk, Olca, Klimstra, David S., Overholtzer, Michael, Iacobuzio-Donahue, Christine A.

“… Pancreatic cancer expression profiles largely reflect a classical or basal-like phenotype. The extent to which these profiles vary within a patient is unknown …”
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The Genetic Basis of Transcriptional and Spatial Heterogeneity of Basal-Like Features in Pancreatic Ductal Adenocarcinoma von Hayashi, Akimasa, Fan, Jun, Chen, Ruoyao, Yu-Jui, Ho, Makohon-Moore, Alvin P, Zhong, Yi, Hong, Jungeui, Sakamoto, Hitomi, Attiyeh, Marc A, Kohutek, Zachary A, Zhang, Lance, Huang, Jinlong, Boumiza, Aida, Kappagantula, Rajya, Baez, Priscilla, Wood, Laura D, Hruban, Ralph H, Lisi, Marta, Chadalavada, Kalyani, Nanjangud, Gouri J, Basturk, Olca, Klimstra, David S, Overholtzer, Michael, Iacobuzio-Donahue, Christine A

“… Pancreatic cancer expression profiles largely reflect a classical or basal-like phenotype. The extent to which these profiles vary within a patient is unknown …”
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Evolutionary Origins of Recurrent Pancreatic Cancer von Sakamoto, Hitomi, Attiyeh, Marc, Gerold, Jeff, Makohon-Moore, Alvin P, Hayashi, Akimasa, Hong, Jungeui, Kappagantula, Rajya, Zhang, Lance, Melchor, Jerry, Reiter, Johannes, Heyde, Alex, Bielski, Craig, Penson, Alex, Chakravarty, Debyani, O'reilly, Eileen, Wood, Laura, Hruban, Ralph H, Nowak, Martin A, Socci, Nicholas, Taylor, Barry S, Iacobuzio-Donahue, Christine A

“… Surgery is the only curative option for Stage I/II pancreatic cancer, nonetheless most patients will recur after surgery and die of their disease. To identify …”
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