Výsledky vyhľadávania - "Kalniņš, Gints"

Potent SARS-CoV-2 mRNA Cap Methyltransferase Inhibitors by Bioisosteric Replacement of Methionine in SAM Cosubstrate Autor Bobileva, Olga, Bobrovs, Raitis, Kanepe, Iveta, Patetko, Liene, Kalnins, Gints, Sisovs, Mihails, Bula, Anna L., Grinberga, Solveiga, Boroduskis, Martins, Ramata-Stunda, Anna, Rostoks, Nils, Jirgensons, Aigars, Tars, Kaspars, Jaudzems, Kristaps

“…Viral mRNA cap methyltransferases (MTases) are emerging targets for the development of broad-spectrum antiviral agents. In this work, we designed potential…”
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Modulation of Hybrid GRM2-type Bacterial Microcompartment Shells through BMC-H Shell Protein Fusion and Incorporation of Non-native BMC-T Shell Proteins Autor Česle, Eva Emi Lija, Ta Rs, Kaspars, Jansons, Juris, Kalniņš, Gints

“…Bacterial microcompartments (BMCs) are organelle-like structures in bacteria that facilitate a wide range of enzymatic reactions. The microcompartment shell…”
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Encapsulation mechanisms and structural studies of GRM2 bacterial microcompartment particles Autor Kalnins, Gints, Cesle, Eva-Emilija, Jansons, Juris, Liepins, Janis, Filimonenko, Anatolij, Tars, Kaspars

“…Bacterial microcompartments (BMCs) are prokaryotic organelles consisting of a protein shell and an encapsulated enzymatic core. BMCs are involved in several…”
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Structure and Function of CutC Choline Lyase from Human Microbiota Bacterium Klebsiella pneumoniae Autor Kalnins, Gints, Kuka, Janis, Grinberga, Solveiga, Makrecka-Kuka, Marina, Liepinsh, Edgars, Dambrova, Maija, Tars, Kaspars

“…CutC choline trimethylamine-lyase is an anaerobic bacterial glycyl radical enzyme (GRE) that cleaves choline to produce trimethylamine (TMA) and acetaldehyde…”
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Discovery of SARS-CoV-2 Nsp14 and Nsp16 Methyltransferase Inhibitors by High-Throughput Virtual Screening Autor Bobrovs, Raitis, Kanepe, Iveta, Narvaiss, Nauris, Patetko, Liene, Kalnins, Gints, Sisovs, Mihails, Bula, Anna L., Grinberga, Solveiga, Boroduskis, Martins, Ramata-Stunda, Anna, Rostoks, Nils, Jirgensons, Aigars, Tars, Kaspars, Jaudzems, Kristaps

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses mRNA capping to evade the human immune system. The cap formation is performed by the…”
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Production and characterization of novel ssRNA bacteriophage virus-like particles from metagenomic sequencing data Autor Liekniņa, Ilva, Kalniņš, Gints, Akopjana, Ināra, Bogans, Jānis, Šišovs, Mihails, Jansons, Juris, Rūmnieks, Jānis, Tārs, Kaspars

“…Background Protein shells assembled from viral coat proteins are an attractive platform for development of new vaccines and other tools such as targeted…”
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N‐Terminal Modification of Gly‐His‐Tagged Proteins with Azidogluconolactone Autor Brune, Karl D., Liekniņa, Ilva, Sutov, Grigorij, Morris, Alexander R., Jovicevic, Dejana, Kalniņš, Gints, Kazāks, Andris, Kluga, Rihards, Kastaljana, Sabine, Zajakina, Anna, Jansons, Juris, Skrastiņa, Dace, Spunde, Karīna, Cohen, Alexander A., Bjorkman, Pamela J., Morris, Howard R., Suna, Edgars, Tārs, Kaspars

“…Site‐specific protein modifications are vital for biopharmaceutical drug development. Gluconoylation is a non‐enzymatic, post‐translational modification of…”
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Antimicrobial Activity of Zymomonas mobilis Is Related to Its Aerobic Catabolism and Acid Resistance Autor Rutkis, Reinis, Ļaša, Zane, Rubina, Marta, Ščerbaka, Rita, Kalniņš, Gints, Bogans, Jānis, Kalnenieks, Uldis

“…Zymomonas mobilis is an ethanologenic, facultatively anaerobic alpha-proteobacterium, known for its inhibitory effect on the growth of a wide variety of…”
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Three-dimensional structure of 22 uncultured ssRNA bacteriophages: Flexibility of the coat protein fold and variations in particle shapes Autor Rūmnieks, Jānis, Liekniņa, Ilva, Kalniņš, Gints, Šišovs, Mihails, Akopjana, Ināra, Bogans, Jānis, Tārs, Kaspars

“…Capsid structures reveal a remarkable structural diversity among small bacterial RNA viruses. The single-stranded RNA (ssRNA) bacteriophages are among the…”
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Comparative Evaluation of Existing and Rationally Designed Novel Antimicrobial Peptides for Treatment of Skin and Soft Tissue Infections Autor Ramata-Stunda, Anna, Boroduskis, Martins, Kaktina, Elza, Patetko, Liene, Kalnenieks, Uldis, Lasa, Zane, Rubina, Marta, Strazdina, Inese, Kalnins, Gints, Rutkis, Reinis

“…Skin and soft tissue infections (SSTIs) and acne are among the most common skin conditions in primary care. SSTIs caused by ESKAPE pathogens (Enterococcus…”
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Functionalization of bacterial microcompartment shell interior with cysteine containing peptides enhances the iron and cobalt loading capacity Autor Kalnins, Gints, Bertins, Maris, Viksna, Arturs, Tars, Kaspars

“…Bacterial microcompartments (BMCs) are prokaryotic organelles involved in several biochemical processes in bacterial cells. These cellular substructures…”
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Variety of size and form of GRM2 bacterial microcompartment particles Autor Cesle, Eva Emilija, Filimonenko, Anatolij, Tars, Kaspars, Kalnins, Gints

“…Bacterial microcompartments (BMCs) are bacterial organelles involved in enzymatic processes, such as carbon fixation, choline, ethanolamine and propanediol…”
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Vaccination against IL-31 for the treatment of atopic dermatitis in dogs Autor Bachmann, Martin F., Zeltins, Andris, Kalnins, Gints, Balke, Ina, Fischer, Nina, Rostaher, Ana, Tars, Kaspars, Favrot, Claude

“…[...]the here-presented breakthrough therapy of vaccination against IL-31 is not only a promising mode to treat AD in dogs but may also facilitate the…”
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VPg Impact on Ryegrass Mottle Virus Serine-like 3C Protease Proteolysis and Structure Autor Kalnins, Gints, Ludviga, Rebeka, Kalnciema, Ieva, Resevica, Gunta, Zeltina, Vilija, Bogans, Janis, Tars, Kaspars, Zeltins, Andris, Balke, Ina

“…Sobemoviruses encode serine-like 3C proteases (Pro) that participate in the processing and maturation of other virus-encoded proteins. Its cis and trans…”
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Structural Basis for Inhibition of the SARS‐CoV‐2 nsp16 by Substrate‐Based Dual Site Inhibitors Autor Kalnins, Gints, Rudusa, Laura, Bula, Anna L., Zelencova‐Gopejenko, Diana, Bobileva, Olga, Sisovs, Mihails, Tars, Kaspars, Jirgensons, Aigars, Jaudzems, Kristaps, Bobrovs, Raitis

“…Coronaviruses, including SARS‐CoV‐2, possess an mRNA 5′ capping apparatus capable of mimicking the natural eukaryotic capping signature. Two SAM‐dependent…”
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Preparation by alkaline treatment and detailed characterisation of empty hepatitis B virus core particles for vaccine and gene therapy applications Autor Strods, Arnis, Ose, Velta, Bogans, Janis, Cielens, Indulis, Kalnins, Gints, Radovica, Ilze, Kazaks, Andris, Pumpens, Paul, Renhofa, Regina

“…Hepatitis B virus (HBV) core (HBc) virus-like particles (VLPs) are one of the most powerful protein engineering tools utilised to expose immunological epitopes…”
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CntA oxygenase substrate profile comparison and oxygen dependency of TMA production in Providencia rettgeri Autor Kalnins, Gints, Sevostjanovs, Eduards, Hartmane, Dace, Grinberga, Solveiga, Tars, Kaspars

“…CntA oxygenase is a Rieske 2S‐2Fe cluster‐containing protein that has been previously described as able to produce trimethylamine (TMA) from carnitine,…”
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VPg impact on Ryegrass mottle virus serine-like 3C protease proteolysis and structure Autor Kalnins, Gints, Ludviga, Rebeka, Kalnciema, Ieva, Resevica, Gunta, Zeltina, Vilija, Bogans, Janis, Tars, Kaspars, Zeltins, Andris, Balke, Ina

“…Sobemoviruses encode serine-like 3C proteases (Pro) that participate in the processing and maturation of other virus-encoded proteins. Its cis and trans…”
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