Suchergebnisse - "Kalkhoven, E"

SP0045 Lipids and NKT Cells in Fat von Kalkhoven, E.

“… Obesity-induced adipose tissue (AT) dysfunction results in a chronic low-grade inflammation that predisposes to the development of insulin resistance and type …”
Volltext

Gene-gene and gene-environment interactions in lipodystrophy: Lessons learned from natural PPARγ mutants von Broekema, M.F., Savage, D.B., Monajemi, H., Kalkhoven, E.

“… Monogenic lipodystrophies are a heterogeneous group of rare disorders characterized by a lack of adipose tissue (AT), all of which predispose patients to the …”
Volltext

Systemic inflammation in childhood obesity: circulating inflammatory mediators and activated CD14++ monocytes von Schipper, H. S., Nuboer, R., Prop, S., van den Ham, H. J., de Boer, F. K., Kesmir, Ç., Mombers, I. M. H., van Bekkum, K. A., Woudstra, J., Kieft, J. H., Hoefer, I. E., de Jager, W., Prakken, B., van Summeren, M., Kalkhoven, E.

“… Aims/hypothesis In adults, circulating inflammatory mediators and activated CD14 ++ monocytes link obesity to its metabolic and cardiovascular complications …”
Volltext

Adipose tissue dysfunction and hypertriglyceridemia: mechanisms and management von van de Woestijne, A. P, Monajemi, H, Kalkhoven, E, Visseren, F. L. J

“… Elevated plasma triglyceride levels, as often seen in obese subjects, are independently associated with an increased risk of cardiovascular diseases. By …”
Volltext

Invariant natural killer T cells in adipose tissue: novel regulators of immune-mediated metabolic disease von Rakhshandehroo, M, Kalkhoven, E, Boes, M

“… Adipose tissue (AT) represents a microenvironment where intersection takes place between immune processes and metabolic pathways. A variety of immune cells …”
Volltext

Vitamin D deficiency in childhood obesity is associated with high levels of circulating inflammatory mediators, and low insulin sensitivity von Reyman, M, Verrijn Stuart, A A, van Summeren, M, Rakhshandehroo, M, Nuboer, R, de Boer, F K, van den Ham, H J, Kalkhoven, E, Prakken, B, Schipper, H S

“… Hypothesis: Childhood obesity is accompanied by low-grade systemic inflammation, which contributes to the development of insulin resistance and cardiovascular …”
Volltext

Monocyte gene expression in childhood obesity is associated with obesity and complexity of atherosclerosis in adults von Keustermans, G. C., Kofink, D., Eikendal, A., de Jager, W., Meerding, J., Nuboer, R., Waltenberger, J., Kraaijeveld, A. O., Jukema, J. W., Sels, J. W., Garssen, J., Prakken, B. J., Asselbergs, F. W., Kalkhoven, E., Hoefer, I. E., Pasterkamp, G., Schipper, H. S.

“… Childhood obesity coincides with increased numbers of circulating classical CD14 ++ CD16 - and intermediate CD14 ++ CD16 + monocytes. Monocytes are key players …”
Volltext

Altered plasma adipokine levels and in vitro adipocyte differentiation in pediatric type 1 diabetes von Verrijn Stuart, A A, Schipper, H S, Tasdelen, I, Egan, D A, Prakken, B J, Kalkhoven, E, de Jager, W

“… Type 1 diabetes (T1D) is considered a proinflammatory condition. Adipose tissue involvement seems evident because adiponectin levels correlate with disease …”
Weitere Angaben

Characterisation of non-obese diabetic patients with marked insulin resistance identifies a novel familial partial lipodystrophy-associated PPARγ mutation (Y151C) von Visser, M. E., Kropman, E., Kranendonk, M. E., Koppen, A., Hamers, N., Stroes, E. S., Kalkhoven, E., Monajemi, H.

“… Aims/hypothesis Familial partial lipodystrophy (FPLD) is a rare metabolic disorder with clinical features that may not be readily recognised. As FPLD patients …”
Volltext

Steroid receptor coactivator-1 splice variants differentially affect corticosteroid receptor signaling von Meijer, O C, Kalkhoven, E, van der Laan, S, Steenbergen, P J, Houtman, S H, Dijkmans, T F, Pearce, D, de Kloet, E R

“… The mechanisms of receptor- and cell-specific effects of the adrenal corticosteroid hormones via mineralo- (MRs) and glucocorticoid receptors (GRs) are still …”
Weitere Angaben

Adipose tissue quantity and composition contribute to adipokine concentrations in the subclavian vein and the inferior mesenteric vein von Faber, D R, Moll, F L, Vink, A, van der Waal, C, Kalkhoven, E, Schipper, H S, Hajer, G R, Monajemi, H, Visseren, F L J

“… BACKGROUND: Adipose tissue dysfunction is associated with inflammation, type 2 diabetes mellitus and vascular diseases. Visceral adipose tissue (VAT)-derived …”
Volltext

Loss of CBP acetyltransferase activity by PHD finger mutations in Rubinstein-Taybi syndrome von Kalkhoven, Eric, Roelfsema, Jeroen H, Teunissen, Hans, den Boer, Annemieke, Ariyurek, Yavuz, Zantema, Alt, Breuning, Martijn H, Hennekam, Raoul C M, Peters, Dorien J M

“… Disruption of one copy of the human CREB binding protein (CBP or CREBBP) gene leads to the Rubinstein-Taybi syndrome (RTS), a developmental disorder …”
Weitere Angaben

CBP and p300: HATs for different occasions von Kalkhoven, Eric

“… The transcriptional coactivators CREB binding protein (CBP) and p300 are key regulators of RNA polymerase II-mediated transcription. Genetic alterations in the …”
Volltext

AF-2 activity and recruitment of steroid receptor coactivator 1 to the estrogen receptor depend on a lysine residue conserved in nuclear receptors von Henttu, P M, Kalkhoven, E, Parker, M G

“… Hormone-dependent transcriptional activation by nuclear receptors depends on the presence of a conserved C-terminal amphipathic alpha-helix (helix 12) in the …”
Weitere Angaben

Conditioned media from (pre)adipocytes stimulate fibrinogen and PAI-1 production by HepG2 hepatoma cells von Faber, D R, Kalkhoven, E, Westerink, J, Bouwman, J J, Monajemi, H M, Visseren, F L J

“… Background: Obesity is associated with a prothrombotic state, which may contribute to the increased risk of thrombotic events. Objective: To assess the effects …”
Volltext

Mutations in the estrogen receptor ligand binding domain discriminate between hormone-dependent transactivation and transrepression von Valentine, J E, Kalkhoven, E, White, R, Hoare, S, Parker, M G

“… The estrogen receptor (ER) suppresses transcriptional activity of the RelA subunit of nuclear factor-kappaB in a hormone-dependent manner by a mechanism …”
Weitere Angaben

A natural transactivation mutation in the thyroid hormone beta receptor: impaired interaction with putative transcriptional mediators von Collingwood, T N, Rajanayagam, O, Adams, M, Wagner, R, Cavaillès, V, Kalkhoven, E, Matthews, C, Nystrom, E, Stenlof, K, Lindstedt, G, Tisell, L, Fletterick, R J, Parker, M G, Chatterjee, V K

“… The syndrome of resistance to thyroid hormone is characterized by elevated serum free thyroid hormones, failure to suppress pituitary thyrotropin secretion, …”
Weitere Angaben

Natural killer T cells in adipose tissue prevent insulin resistance von Schipper, Henk S., Rakhshandehroo, Maryam, van de Graaf, Stan F.J., Venken, Koen, Koppen, Arjen, Stienstra, Rinke, Prop, Serge, Meerding, Jenny, Hamers, Nicole, Besra, Gurdyal, Boon, Louis, Nieuwenhuis, Edward E.S., Elewaut, Dirk, Prakken, Berent, Kersten, Sander, Boes, Marianne, Kalkhoven, Eric

“… Lipid overload and adipocyte dysfunction are key to the development of insulin resistance and can be induced by a high-fat diet. CD1d-restricted invariant …”
Volltext

Quantitative profiling of oxylipins through comprehensive LC-MS/MS analysis: application in cardiac surgery von Strassburg, Katrin, Huijbrechts, Annemarie M. L., Kortekaas, Kirsten A., Lindeman, Jan H., Pedersen, Theresa L., Dane, Adrie, Berger, Ruud, Brenkman, Arjan, Hankemeier, Thomas, van Duynhoven, John, Kalkhoven, Eric, Newman, John W., Vreeken, Rob J.

“… Oxylipins, including eicosanoids, affect a broad range of biological processes, such as the initiation and resolution of inflammation. These compounds, also …”
Volltext

Peroxisome proliferator-activated receptor gamma regulates expression of the anti-lipolytic G-protein-coupled receptor 81 (GPR81/Gpr81) von Jeninga, Ellen H, Bugge, Anne, Nielsen, Ronni, Kersten, Sander, Hamers, Nicole, Dani, Christian, Wabitsch, Martin, Berger, Ruud, Stunnenberg, Hendrik G, Mandrup, Susanne, Kalkhoven, Eric

“… The ligand-inducible nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) plays a key role in the differentiation, maintenance, and …”
Weitere Angaben