Výsledky vyhľadávania - "Kaileh, Mary"

Molecular insight in the multifunctional activities of Withaferin A Autor Vanden Berghe, Wim, Sabbe, Linde, Kaileh, Mary, Haegeman, Guy, Heyninck, Karen

“…Herbal medicine which involves the use of plants for their medicinal value, dates as far back as the origin of mankind and demonstrates an array of…”
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Skeletal muscle transcriptome in healthy aging Autor Tumasian, Robert A., Harish, Abhinav, Kundu, Gautam, Yang, Jen-Hao, Ubaida-Mohien, Ceereena, Gonzalez-Freire, Marta, Kaileh, Mary, Zukley, Linda M., Chia, Chee W., Lyashkov, Alexey, Wood, William H., Piao, Yulan, Coletta, Christopher, Ding, Jun, Gorospe, Myriam, Sen, Ranjan, De, Supriyo, Ferrucci, Luigi

“…Age-associated changes in gene expression in skeletal muscle of healthy individuals reflect accumulation of damage and compensatory adaptations to preserve…”
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HiIDDD: a high-throughput imaging pipeline for the quantitative detection of DNA damage in primary human immune cells Autor Gallant, Kelsey, Bektas, Arsun, Kaileh, Mary, Lustig, Ana, Ferrucci, Luigi, Pegoraro, Gianluca, Misteli, Tom

“…DNA damage is a prominent biomarker for numerous diseases, including cancer, as well as for the aging process. Detection of DNA damage routinely relies on…”
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Transcription factor TFII-I fine tunes innate properties of B lymphocytes Autor Singh, Amit, Kaileh, Mary, De, Supriyo, Mazan-Mamczarz, Krystyna, Bayarsaihan, Dashzeveg, Sen, Ranjan, Roy, Ananda L.

“…The ubiquitously expressed transcription factor TFII-I is a multifunctional protein with pleiotropic roles in gene regulation. TFII-I associated polymorphisms…”
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Epigenetic signature of human immune aging in the GESTALT study Autor Roy, Roshni, Kuo, Pei-Lun, Candia, Julián, Sarantopoulou, Dimitra, Ubaida-Mohien, Ceereena, Hernandez, Dena, Kaileh, Mary, Arepalli, Sampath, Singh, Amit, Bektas, Arsun, Kim, Jaekwan, Moore, Ann Z, Tanaka, Toshiko, McKelvey, Julia, Zukley, Linda, Nguyen, Cuong, Wallace, Tonya, Dunn, Christopher, Wood, William, Piao, Yulan, Coletta, Christopher, De, Supriyo, Sen, Jyoti, Weng, Nan-ping, Sen, Ranjan, Ferrucci, Luigi

“…Age-associated DNA methylation in blood cells convey information on health status. However, the mechanisms that drive these changes in circulating cells and…”
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Skeletal Muscle mRNA Splicing Variants Association With Four Different Fitness and Energetic Measures in the GESTALT Study Autor Donega, Stefano, Banskota, Nirad, Gupta, Esha, Gonzalez‐Freire, Marta, Moore, Ann Zenobia, Ubaida‐Mohien, Ceereena, Munk, Rachel, Zukley, Linda, Piao, Yulan, Bergeron, Chris, Bergeron, Jan, Bektas, Arsun, Zampino, Marta, Stagg, Carole, Indig, Fred, Hartnell, Lisa M., Kaileh, Mary, Fishbein, Kenneth, Spencer, Richard G., Gorospe, Myriam, De, Supriyo, Egan, Josephine M., Sen, Ranjan, Ferrucci, Luigi

“…ABSTRACT Background Physical activity is essential for maintaining muscle mitochondrial function and aerobic capacity. The molecular mechanisms underlying such…”
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Human Metabolome Reference Database in a Biracial Cohort across the Adult Lifespan Autor Tian, Qu, Adam, M. Gordian, Ozcariz, Enrique, Fantoni, Giovanna, Shehadeh, Nader M., Turek, Lisa M., Collingham, Victoria L., Kaileh, Mary, Moaddel, Ruin, Ferrucci, Luigi

“…As one of the OMICS in systems biology, metabolomics defines the metabolome and simultaneously quantifies numerous metabolites that are final or intermediate…”
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Assaying Homodimers of NF-κB in Live Single Cells Autor Martin, Erik W., Chakraborty, Sayantan, Presman, Diego M., Tomassoni Ardori, Francesco, Oh, Kyu-Seon, Kaileh, Mary, Tessarollo, Lino, Sung, Myong-Hee

“…NF-κB is a family of heterodimers and homodimers which are generated from subunits encoded by five genes. The predominant classical dimer RelA:p50 is presumed…”
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mTOR-Dependent and Independent Survival Signaling by PI3K in B Lymphocytes Autor Kaileh, Mary, Vazquez, Estefania, MacFarlane, Alexander W., Campbell, Kerry, Kurosaki, Tomohiro, Siebenlist, Ulrich, Sen, Ranjan

“…Peripheral B lymphocyte survival requires the B cell receptor (BCR) and B cell activating factor (BAFF) binding to its receptor (BAFF-R). Deletion of the BCR,…”
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NF-κB function in B lymphocytes Autor Kaileh, Mary, Sen, Ranjan

“…NF‐κB proteins were identified in the search for mechanisms that regulate B‐lymphocyte‐specific transcription of immunoglobulin κ light chain genes…”
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Xanthohumol activates the proapoptotic arm of the unfolded protein response in chronic lymphocytic leukemia Autor Lust, Sofie, Vanhoecke, Barbara, VAN Gele, Mireille, Boelens, Jerina, VAN Melckebeke, Heleen, Kaileh, Mary, Vanden Berghe, Wim, Haegeman, Guy, Philippé, Jan, Bracke, Marc, Offner, Fritz

“…Chronic lymphocytic leukemia (CLL) is an incurable disease with a natural history of increasing resistance to chemotherapy. A novel approach to overcome…”
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Aging and Inflammation Autor Singh, Amit, Schurman, Shepherd H, Bektas, Arsun, Kaileh, Mary, Roy, Roshni, Wilson, 3rd, David M, Sen, Ranjan, Ferrucci, Luigi

“…Aging can be conceptualized as the progressive disequilibrium between stochastic damage accumulation and resilience mechanisms that continuously repair that…”
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NF-κB subunits direct kinetically distinct transcriptional cascades in antigen receptor-activated B cells Autor Zhao, Mingming, Chauhan, Prashant, Sherman, Cheryl A., Singh, Amit, Kaileh, Mary, Mazan-Mamczarz, Krystyna, Ji, Hongkai, Joy, Jaimy, Nandi, Satabdi, De, Supriyo, Zhang, Yongqing, Fan, Jinshui, Becker, Kevin G., Loke, Png, Zhou, Weiqiang, Sen, Ranjan

“…The nuclear factor kappa B (NF-κB) family of transcription factors orchestrates signal-induced gene expression in diverse cell types. Cellular responses to…”
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Transcriptomic and Proteomic of Gastrocnemius Muscle in Peripheral Artery Disease Autor Ferrucci, Luigi, Candia, Julián, Ubaida-Mohien, Ceereena, Lyashkov, Alexey, Banskota, Nirad, Leeuwenburgh, Christiaan, Wohlgemuth, Stephanie, Guralnik, Jack M, Kaileh, Mary, Zhang, Dongxue, Sufit, Robert, De, Supriyo, Gorospe, Myriam, Munk, Rachel, Peterson, Charlotte A, McDermott, Mary M

“…Few effective therapies exist to improve lower extremity muscle pathology and mobility loss due to peripheral artery disease (PAD), in part because mechanisms…”
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Postmitotic G1 phase survivin drives mitogen-independent cell division of B lymphocytes Autor Singh, Amit, Spitzer, Matthew H, Joy, Jaimy P, Kaileh, Mary, Qiu, Xiang, Nolan, Garry P, Sen, Ranjan

“…B and T lymphocytes of the adaptive immune system undergo proliferative bursts to generate pools of antigen-specific cells for effective immunity. Here we show…”
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Evidence of association between higher cardiorespiratory fitness and higher cerebral myelination in aging Autor Faulkner, Mary E, Gong, Zhaoyuan, Bilgel, Murat, Laporte, John P, Guo, Alex, Bae, Jonghyun, Palchamy, Elango, Kaileh, Mary, Bergeron, Christopher M, Bergeron, Jan, Church, Sarah, D'Agostino, Jarod, Ferrucci, Luigi, Bouhrara, Mustapha

“…Emerging evidence suggests that altered myelination is an important pathophysiologic correlate of several neurodegenerative diseases, including Alzheimer and…”
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DNA methylation signatures reveal that distinct combinations of transcription factors specify human immune cell epigenetic identity Autor Roy, Roshni, Ramamoorthy, Senthilkumar, Shapiro, Benjamin D, Kaileh, Mary, Hernandez, Dena, Sarantopoulou, Dimitra, Arepalli, Sampath, Boller, Sören, Singh, Amit, Bektas, Arsun, Kim, Jaekwan, Moore, Ann Zenobia, Tanaka, Toshiko, McKelvey, Julia, Zukley, Linda, Nguyen, Cuong, Wallace, Tonya, Dunn, Christopher, Wersto, Robert, Wood, William, Piao, Yulan, Becker, Kevin G, Coletta, Christopher, De, Supriyo, Sen, Jyoti Misra, Battle, Alexis, Weng, Nan-Ping, Grosschedl, Rudolf, Ferrucci, Luigi, Sen, Ranjan

“…Epigenetic reprogramming underlies specification of immune cell lineages, but patterns that uniquely define immune cell types and the mechanisms by which they…”
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NF-κB function in B lymphocytes: NF-ĸB Autor KAILEH, Mary, SEN, Ranjan

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Whole‐genome methylation analysis of aging human tissues identifies age‐related changes in developmental and neurological pathways Autor Tharakan, Ravi, Ubaida‐Mohien, Ceereena, Dunn, Christopher, Kaileh, Mary, Tryggvadottir, Rakel, Zukley, Linda, Chia, Chee W., Sen, Ranjan, Ferrucci, Luigi

“…Age‐associated changes in the DNA methylation state can be used to assess the pace of aging. However, it is not understood what mechanisms drive these changes…”
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Cross‐sectional analysis of healthy individuals across decades: Aging signatures across multiple physiological compartments Autor Moaddel, Ruin, Ubaida‐Mohien, Ceereena, Tanaka, Toshiko, Tian, Qu, Candia, Julián, Moore, Ann Zenobia, Lovett, Jacqueline, Fantoni, Giovanna, Shehadeh, Nader, Turek, Lisa, Collingham, Victoria, Kaileh, Mary, Chia, Chee W., Sen, Ranjan, Egan, Josephine M., Ferrucci, Luigi

“…The study of age‐related biomarkers from different biofluids and tissues within the same individual might provide a more comprehensive understanding of…”
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