Suchergebnisse - "Journal of translational medicine"

Eating habits and lifestyle changes during COVID-19 lockdown: an Italian survey von Di Renzo, Laura, Gualtieri, Paola, Pivari, Francesca, Soldati, Laura, Attinà, Alda, Cinelli, Giulia, Leggeri, Claudia, Caparello, Giovanna, Barrea, Luigi, Scerbo, Francesco, Esposito, Ernesto, De Lorenzo, Antonino

“… Background On December 12th 2019, a new coronavirus (SARS-Cov2) emerged in Wuhan, China, sparking a pandemic of acute respiratory syndrome in humans …”
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Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant von Pachetti, Maria, Marini, Bruna, Benedetti, Francesca, Giudici, Fabiola, Mauro, Elisabetta, Storici, Paola, Masciovecchio, Claudio, Angeletti, Silvia, Ciccozzi, Massimo, Gallo, Robert C., Zella, Davide, Ippodrino, Rudy

“… Background SARS-CoV-2 is a RNA coronavirus responsible for the pandemic of the Severe Acute Respiratory Syndrome (COVID-19). RNA viruses are characterized by a …”
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Neutrophil-to-lymphocyte ratio predicts critical illness patients with 2019 coronavirus disease in the early stage von Liu, Jingyuan, Liu, Yao, Xiang, Pan, Pu, Lin, Xiong, Haofeng, Li, Chuansheng, Zhang, Ming, Tan, Jianbo, Xu, Yanli, Song, Rui, Song, Meihua, Wang, Lin, Zhang, Wei, Han, Bing, Yang, Li, Wang, Xiaojing, Zhou, Guiqin, Zhang, Ting, Li, Ben, Wang, Yanbin, Chen, Zhihai, Wang, Xianbo

“… Background Patients with critical illness due to infection with the 2019 coronavirus disease (COVID-19) show rapid disease progression to acute respiratory …”
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TPM, FPKM, or Normalized Counts? A Comparative Study of Quantification Measures for the Analysis of RNA-seq Data from the NCI Patient-Derived Models Repository von Zhao, Yingdong, Li, Ming-Chung, Konaté, Mariam M., Chen, Li, Das, Biswajit, Karlovich, Chris, Williams, P. Mickey, Evrard, Yvonne A., Doroshow, James H., McShane, Lisa M.

“… Background In order to correctly decode phenotypic information from RNA-sequencing (RNA-seq) data, careful selection of the RNA-seq quantification measure is …”
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Predicting 30-days mortality for MIMIC-III patients with sepsis-3: a machine learning approach using XGboost von Hou, Nianzong, Li, Mingzhe, He, Lu, Xie, Bing, Wang, Lin, Zhang, Rumin, Yu, Yong, Sun, Xiaodong, Pan, Zhengsheng, Wang, Kai

“… Background Sepsis is a significant cause of mortality in-hospital, especially in ICU patients. Early prediction of sepsis is essential, as prompt and …”
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Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2/HO-1 pathway von Li, Jiucui, Lu, Kongmiao, Sun, Fenglan, Tan, Shanjuan, Zhang, Xiao, Sheng, Wei, Hao, Wanming, Liu, Min, Lv, Weihong, Han, Wei

“… Background Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) induces uncontrolled and self-amplified pulmonary inflammation, and has high …”
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The role of collagen in cancer: from bench to bedside von Xu, Shuaishuai, Xu, Huaxiang, Wang, Wenquan, Li, Shuo, Li, Hao, Li, Tianjiao, Zhang, Wuhu, Yu, Xianjun, Liu, Liang

“… Collagen is the major component of the tumor microenvironment and participates in cancer fibrosis. Collagen biosynthesis can be regulated by cancer cells …”
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Liquid biopsies: the future of cancer early detection von Connal, Siobhan, Cameron, James M., Sala, Alexandra, Brennan, Paul M., Palmer, David S., Palmer, Joshua D., Perlow, Haley, Baker, Matthew J.

“… Cancer is a worldwide pandemic. The burden it imposes grows steadily on a global scale causing emotional, physical, and financial strains on individuals, …”
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Mesenchymal stem cell derived-exosomes: a modern approach in translational medicine von Nikfarjam, Sepideh, Rezaie, Jafar, Zolbanin, Naime Majidi, Jafari, Reza

“… Mesenchymal stem cells (MSCs) have captured great attention in regenerative medicine for over a few decades by virtue of their differentiation capacity, potent …”
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Influence of diet on the gut microbiome and implications for human health von Singh, Rasnik K., Chang, Hsin-Wen, Yan, Di, Lee, Kristina M., Ucmak, Derya, Wong, Kirsten, Abrouk, Michael, Farahnik, Benjamin, Nakamura, Mio, Zhu, Tian Hao, Bhutani, Tina, Liao, Wilson

“… Recent studies have suggested that the intestinal microbiome plays an important role in modulating risk of several chronic diseases, including inflammatory …”
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Patient-derived xenograft (PDX) models, applications and challenges in cancer research von Abdolahi, Shahrokh, Ghazvinian, Zeinab, Muhammadnejad, Samad, Saleh, Mahshid, Asadzadeh Aghdaei, Hamid, Baghaei, Kaveh

“… The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies …”
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Mitochondrial dysfunction: roles in skeletal muscle atrophy von Chen, Xin, Ji, Yanan, Liu, Ruiqi, Zhu, Xucheng, Wang, Kexin, Yang, Xiaoming, Liu, Boya, Gao, Zihui, Huang, Yan, Shen, Yuntian, Liu, Hua, Sun, Hualin

“… Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle health, and damage to mitochondria can lead to a series of …”
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Why tocilizumab could be an effective treatment for severe COVID-19? von Fu, Binqing, Xu, Xiaoling, Wei, Haiming

“… A severe pneumonia-associated respiratory syndrome caused by a new coronavirus was identified in December 2019 (COVID-19), spread rapidly and has become a …”
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Machine learning for the prediction of acute kidney injury in patients with sepsis von Yue, Suru, Li, Shasha, Huang, Xueying, Liu, Jie, Hou, Xuefei, Zhao, Yumei, Niu, Dongdong, Wang, Yufeng, Tan, Wenkai, Wu, Jiayuan

“… Background Acute kidney injury (AKI) is the most common and serious complication of sepsis, accompanied by high mortality and disease burden. The early …”
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Endothelial dysfunction and altered endothelial biomarkers in patients with post-COVID-19 syndrome and chronic fatigue syndrome (ME/CFS) von Haffke, Milan, Freitag, Helma, Rudolf, Gordon, Seifert, Martina, Doehner, Wolfram, Scherbakov, Nadja, Hanitsch, Leif, Wittke, Kirsten, Bauer, Sandra, Konietschke, Frank, Paul, Friedemann, Bellmann-Strobl, Judith, Kedor, Claudia, Scheibenbogen, Carmen, Sotzny, Franziska

“… Background Fatigue, exertion intolerance and post-exertional malaise are among the most frequent symptoms of Post-COVID Syndrome (PCS), with a subset of …”
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Systematic review and meta-analysis of the prevalence of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) von Lim, Eun-Jin, Ahn, Yo-Chan, Jang, Eun-Su, Lee, Si-Woo, Lee, Su-Hwa, Son, Chang-Gue

“… Background Chronic fatigue syndrome / myalgic encephalomyelitis (CFS/ME) has been emerging as a significant health issue worldwide. This study aimed to …”
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Microbiota medicine: towards clinical revolution von Gebrayel, Prisca, Nicco, Carole, Al Khodor, Souhaila, Bilinski, Jaroslaw, Caselli, Elisabetta, Comelli, Elena M., Egert, Markus, Giaroni, Cristina, Karpinski, Tomasz M., Loniewski, Igor, Mulak, Agata, Reygner, Julie, Samczuk, Paulina, Serino, Matteo, Sikora, Mariusz, Terranegra, Annalisa, Ufnal, Marcin, Villeger, Romain, Pichon, Chantal, Konturek, Peter, Edeas, Marvin

“… The human gastrointestinal tract is inhabited by the largest microbial community within the human body consisting of trillions of microbes called gut …”
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Causal relationship between physical activity, leisure sedentary behaviors and COVID-19 risk: a Mendelian randomization study von Chen, Xiong, Hong, Xiaosi, Gao, Wenjing, Luo, Shulu, Cai, Jiahao, Liu, Guochang, Huang, Yinong

“… Background The 2019 coronavirus disease pandemic (COVID-19) poses an enormous threat to public health worldwide, and the ensuing management of social isolation …”
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SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis von Feng, Lei, Zhao, Kaikai, Sun, Liangchao, Yin, Xiaoyang, Zhang, Junpeng, Liu, Conghe, Li, Baosheng

“… Background Solute carrier family 7 member 11(SLC7A11) is a component of cysteine/glutamate transporter, which plays a key role in tumor growth; however, its …”
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Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing von Hua, Yu, Zheng, Yue, Yao, Yiran, Jia, Renbing, Ge, Shengfang, Zhuang, Ai

“… Metformin is a well-known anti-diabetic drug that has been repurposed for several emerging applications, including as an anti-cancer agent. It boasts the …”
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