Suchergebnisse - "Journal of investigative dermatology"

Research Techniques Made Simple: Cutaneous Colorimetry: A Reliable Technique for Objective Skin Color Measurement von Ly, Bao Chau K, Dyer, Ethan B, Feig, Jessica L, Chien, Anna L, Del Bino, Sandra

“… Skin color evaluation contributes to assessment of an individual's cutaneous phenotype. Skin color changes provide important clues to disease progression or …”
Weitere Angaben

Treatment of Advanced Melanoma in 2020 and Beyond von Jenkins, Russell W, Fisher, David E

“… The melanoma field has seen an unprecedented set of clinical advances over the past decade. Therapeutic efficacy for advanced or metastatic melanoma went from …”
Weitere Angaben

Classification of the Clinical Images for Benign and Malignant Cutaneous Tumors Using a Deep Learning Algorithm von Han, Seung Seog, Kim, Myoung Shin, Lim, Woohyung, Park, Gyeong Hun, Park, Ilwoo, Chang, Sung Eun

“… We tested the use of a deep learning algorithm to classify the clinical images of 12 skin diseases-basal cell carcinoma, squamous cell carcinoma, …”
Weitere Angaben

Atopic Dermatitis Is an IL-13-Dominant Disease with Greater Molecular Heterogeneity Compared to Psoriasis von Tsoi, Lam C, Rodriguez, Elke, Degenhardt, Frauke, Baurecht, Hansjörg, Wehkamp, Ulrike, Volks, Natalie, Szymczak, Silke, Swindell, William R, Sarkar, Mrinal K, Raja, Kalpana, Shao, Shuai, Patrick, Matthew, Gao, Yilin, Uppala, Ranjitha, Perez White, Bethany E, Getsios, Spiro, Harms, Paul W, Maverakis, Emanual, Elder, James T, Franke, Andre, Gudjonsson, Johann E, Weidinger, Stephan

“… Atopic dermatitis (AD) affects up to 20% of children and adults worldwide. To gain a deeper understanding of the pathophysiology of AD, we conducted a …”
Weitere Angaben

Atopic Dermatitis in America Study: A Cross-Sectional Study Examining the Prevalence and Disease Burden of Atopic Dermatitis in the US Adult Population von Chiesa Fuxench, Zelma C, Block, Julie K, Boguniewicz, Mark, Boyle, John, Fonacier, Luz, Gelfand, Joel M, Grayson, Mitchell H, Margolis, David J, Mitchell, Lynda, Silverberg, Jonathan I, Schwartz, Lawrence, Simpson, Eric L, Ong, Peck Y

“… Population-based estimates on the prevalence of atopic dermatitis in adults vary widely. The objectives of this study were to determine the prevalence of …”
Weitere Angaben

Connective Tissue and Fibroblast Senescence in Skin Aging von Wlaschek, Meinhard, Maity, Pallab, Makrantonaki, Evgenia, Scharffetter-Kochanek, Karin

“… There is increasing evidence that skin aging is significantly enforced by the accumulation of senescent dermal fibroblasts. Various stressors damaging …”
Weitere Angaben

Research Techniques Made Simple: Analysis of Collective Cell Migration Using the Wound Healing Assay von Grada, Ayman, Otero-Vinas, Marta, Prieto-Castrillo, Francisco, Obagi, Zaidal, Falanga, Vincent

“… Collective cell migration is a hallmark of wound repair, cancer invasion and metastasis, immune responses, angiogenesis, and embryonic morphogenesis. Wound …”
Weitere Angaben

Cellular Senescence and the Senescence-Associated Secretory Phenotype as Drivers of Skin Photoaging von Fitsiou, Eleni, Pulido, Tanya, Campisi, Judith, Alimirah, Fatouma, Demaria, Marco

“… Chronic exposure to UVR is known to disrupt tissue homeostasis, accelerate the onset of age-related phenotypes, and increase the risk for skin cancer-a …”
Weitere Angaben

The Burden of Atopic Dermatitis: Summary of a Report for the National Eczema Association von Drucker, Aaron M, Wang, Annie R, Li, Wen-Qing, Sevetson, Erika, Block, Julie K, Qureshi, Abrar A

“… To assess the patient-level and societal burden of atopic dermatitis, we comprehensively reviewed the literature related to quality of life, social, economic, …”
Weitere Angaben

Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations von Philippeos, Christina, Telerman, Stephanie B, Oulès, Bénédicte, Pisco, Angela O, Shaw, Tanya J, Elgueta, Raul, Lombardi, Giovanna, Driskell, Ryan R, Soldin, Mark, Lynch, Magnus D, Watt, Fiona M

“… Previous studies have shown that mouse dermis is composed of functionally distinct fibroblast lineages. To explore the extent of fibroblast heterogeneity in …”
Weitere Angaben

Augmented Intelligence Dermatology: Deep Neural Networks Empower Medical Professionals in Diagnosing Skin Cancer and Predicting Treatment Options for 134 Skin Disorders von Han, Seung Seog, Park, Ilwoo, Eun Chang, Sung, Lim, Woohyung, Kim, Myoung Shin, Park, Gyeong Hun, Chae, Je Byeong, Huh, Chang Hun, Na, Jung-Im

“… Although deep learning algorithms have demonstrated expert-level performance, previous efforts were mostly binary classifications of limited disorders. We …”
Weitere Angaben

Environmentally-Induced (Extrinsic) Skin Aging: Exposomal Factors and Underlying Mechanisms von Krutmann, Jean, Schikowski, Tamara, Morita, Akimichi, Berneburg, Mark

“… As a barrier organ, the skin is an ideal model to study environmentally-induced (extrinsic) aging. In this review, we explain the development of extrinsic skin …”
Weitere Angaben

Research Techniques Made Simple: Animal Models of Wound Healing von Grada, Ayman, Mervis, Joshua, Falanga, Vincent

“… Animal models have been developed to study the complex cellular and biochemical processes of wound repair and to evaluate the efficacy and safety of potential …”
Weitere Angaben

A MicroRNA-29 Mimic (Remlarsen) Represses Extracellular Matrix Expression and Fibroplasia in the Skin von Gallant-Behm, Corrie L, Piper, Joseph, Lynch, Joshua M, Seto, Anita G, Hong, Seok Jong, Mustoe, Thomas A, Maari, Catherine, Pestano, Linda A, Dalby, Christina M, Jackson, Aimee L, Rubin, Paul, Marshall, William S

“… MicroRNA-29 (miR-29) negatively regulates fibrosis and is downregulated in multiple fibrotic organs and tissues, including in the skin. miR-29 mimics prevent …”
Weitere Angaben

The Growing Burden of Invasive Melanoma: Projections of Incidence Rates and Numbers of New Cases in Six Susceptible Populations through 2031 von Whiteman, David C, Green, Adele C, Olsen, Catherine M

“… New melanoma therapies are being developed rapidly, complementing prevention and detection strategies for disease control. Estimating the future burden of …”
Weitere Angaben

The Genetics of Chronic Itch: Gene Expression in the Skin of Patients with Atopic Dermatitis and Psoriasis with Severe Itch von Nattkemper, Leigh A, Tey, Hong Liang, Valdes-Rodriguez, Rodrigo, Lee, Helen, Mollanazar, Nicholas K, Albornoz, Christian, Sanders, Kristen M, Yosipovitch, Gil

“… To identify itch-related mediators and receptors that are differentially expressed in pruritic skin, we used RNA sequencing to analyze the complete …”
Weitere Angaben

Inflammaging and the Skin von Pilkington, Suzanne M, Bulfone-Paus, Silvia, Griffiths, Christopher E M, Watson, Rachel E B

“… As global life expectancy continues to rise, we are challenged with maintaining health into old age. One strategy is to target the chronic low-level …”
Weitere Angaben

A Critical Role of the IL-1β-IL-1R Signaling Pathway in Skin Inflammation and Psoriasis Pathogenesis von Cai, Yihua, Xue, Feng, Quan, Chen, Qu, Minye, Liu, Na, Zhang, Yuan, Fleming, Chris, Hu, Xiaoling, Zhang, Huang-Ge, Weichselbaum, Ralph, Fu, Yang-Xin, Tieri, David, Rouchka, Eric C, Zheng, Jie, Yan, Jun

“… The IL-1 signaling pathway has been shown to play a critical role in the pathogenesis of chronic, autoinflammatory skin diseases such as psoriasis. However, …”
Weitere Angaben

Artificial Intelligence in Dermatology: A Primer von Young, Albert T, Xiong, Mulin, Pfau, Jacob, Keiser, Michael J, Wei, Maria L

“… Artificial intelligence is becoming increasingly important in dermatology, with studies reporting accuracy matching or exceeding dermatologists for the …”
Weitere Angaben

IL-4Rα Blockade by Dupilumab Decreases Staphylococcus aureus Colonization and Increases Microbial Diversity in Atopic Dermatitis von Callewaert, Chris, Nakatsuji, Teruaki, Knight, Rob, Kosciolek, Tomasz, Vrbanac, Alison, Kotol, Paul, Ardeleanu, Marius, Hultsch, Thomas, Guttman-Yassky, Emma, Bissonnette, Robert, Silverberg, Jonathan I, Krueger, James, Menter, Alan, Graham, Neil M H, Pirozzi, Gianluca, Hamilton, Jennifer D, Gallo, Richard L

“… Dupilumab is a fully human antibody to interleukin-4 receptor α that improves the signs and symptoms of moderate to severe atopic dermatitis (AD). To determine …”
Weitere Angaben