Výsledky vyhľadávania - "Jonkers, Jos"

Understanding and overcoming resistance to PARP inhibitors in cancer therapy Autor Dias, Mariana Paes, Moser, Sarah C, Ganesan, Shridar, Jonkers, Jos

“…Developing novel targeted anticancer therapies is a major goal of current research. The use of poly(ADP-ribose) polymerase (PARP) inhibitors in patients with…”
Získať plný text

Genetically engineered mouse models in oncology research and cancer medicine Autor Kersten, Kelly, de Visser, Karin E, van Miltenburg, Martine H, Jonkers, Jos

“…Genetically engineered mouse models (GEMMs) have contributed significantly to the field of cancer research. In contrast to cancer cell inoculation models,…”
Získať plný text

Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response Autor Salvagno, Camilla, Ciampricotti, Metamia, Tuit, Sander, Hau, Cheei-Sing, van Weverwijk, Antoinette, Coffelt, Seth B., Kersten, Kelly, Vrijland, Kim, Kos, Kevin, Ulas, Thomas, Song, Ji-Ying, Ooi, Chia-Huey, Rüttinger, Dominik, Cassier, Philippe A., Jonkers, Jos, Schultze, Joachim L., Ries, Carola H., de Visser, Karin E.

“…Recent studies have revealed a role for macrophages and neutrophils in limiting chemotherapy efficacy; however, the mechanisms underlying the therapeutic…”
Získať plný text

EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation Autor Rondinelli, Beatrice, Gogola, Ewa, Yücel, Hatice, Duarte, Alexandra A., van de Ven, Marieke, van der Sluijs, Roxanne, Konstantinopoulos, Panagiotis A., Jonkers, Jos, Ceccaldi, Raphaël, Rottenberg, Sven, D’Andrea, Alan D.

“…Rondinelli et al. show that EZH2-mediated H3K27me3 at stalled replication forks recruits MUS81 nuclease to facilitate fork degradation. Loss of EZH2…”
Získať plný text

Easy quantification of template-directed CRISPR/Cas9 editing Autor Brinkman, Eva K, Kousholt, Arne N, Harmsen, Tim, Leemans, Christ, Chen, Tao, Jonkers, Jos, van Steensel, Bas

“…Abstract Template-directed CRISPR/Cas9 editing is a powerful tool for introducing subtle mutations in genomes. However, the success rate of incorporation of…”
Získať plný text

Patient-derived xenograft models: an emerging platform for translational cancer research Autor Hidalgo, Manuel, Amant, Frederic, Biankin, Andrew V, Budinská, Eva, Byrne, Annette T, Caldas, Carlos, Clarke, Robert B, de Jong, Steven, Jonkers, Jos, Mælandsmo, Gunhild Mari, Roman-Roman, Sergio, Seoane, Joan, Trusolino, Livio, Villanueva, Alberto

“…Recently, there has been an increasing interest in the development and characterization of patient-derived tumor xenograft (PDX) models for cancer research…”
Zistit podrobnosti o prístupe

Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer Autor Prekovic, Stefan, Schuurman, Karianne, Mayayo-Peralta, Isabel, Manjón, Anna G., Buijs, Mark, Yavuz, Selçuk, Wellenstein, Max D., Barrera, Alejandro, Monkhorst, Kim, Huber, Anne, Morris, Ben, Lieftink, Cor, Chalkiadakis, Theofilos, Alkan, Ferhat, Silva, Joana, Győrffy, Balázs, Hoekman, Liesbeth, van den Broek, Bram, Teunissen, Hans, Debets, Donna O., Severson, Tesa, Jonkers, Jos, Reddy, Timothy, de Visser, Karin E., Faller, William, Beijersbergen, Roderick, Altelaar, Maarten, de Wit, Elzo, Medema, Rene, Zwart, Wilbert

“…The glucocorticoid receptor (GR) regulates gene expression, governing aspects of homeostasis, but is also involved in cancer. Pharmacological GR activation is…”
Získať plný text

Replication fork stability confers chemoresistance in BRCA-deficient cells Autor Ray Chaudhuri, Arnab, Callen, Elsa, Ding, Xia, Gogola, Ewa, Duarte, Alexandra A., Lee, Ji-Eun, Wong, Nancy, Lafarga, Vanessa, Calvo, Jennifer A., Panzarino, Nicholas J., John, Sam, Day, Amanda, Crespo, Anna Vidal, Shen, Binghui, Starnes, Linda M., Ruiter, Julian R. de, Daniel, Jeremy A., Konstantinopoulos, Panagiotis A., Cortez, David, Cantor, Sharon B., Fernandez-Capetillo, Oscar, Ge, Kai, Jonkers, Jos, Rottenberg, Sven, Sharan, Shyam K., Nussenzweig, André

“…Cells deficient in the Brca1 and Brca2 genes have reduced capacity to repair DNA double-strand breaks by homologous recombination and consequently are…”
Získať plný text

The Tandem Duplicator Phenotype Is a Prevalent Genome-Wide Cancer Configuration Driven by Distinct Gene Mutations Autor Menghi, Francesca, Barthel, Floris P, Yadav, Vinod, Tang, Ming, Ji, Bo, Tang, Zhonghui, Carter, Gregory W, Ruan, Yijun, Scully, Ralph, Verhaak, Roel G W, Jonkers, Jos, Liu, Edison T

“…The tandem duplicator phenotype (TDP) is a genome-wide instability configuration primarily observed in breast, ovarian, and endometrial carcinomas. Here, we…”
Zistit podrobnosti o prístupe

Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways Autor Boelens, Mirjam C, Wu, Tony J, Nabet, Barzin Y, Xu, Bihui, Qiu, Yu, Yoon, Taewon, Azzam, Diana J, Twyman-Saint Victor, Christina, Wiemann, Brianne Z, Ishwaran, Hemant, Ter Brugge, Petra J, Jonkers, Jos, Slingerland, Joyce, Minn, Andy J

“…Stromal communication with cancer cells can influence treatment response. We show that stromal and breast cancer (BrCa) cells utilize paracrine and juxtacrine…”
Zistit podrobnosti o prístupe

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality Autor Gogola, Ewa, Duarte, Alexandra A, de Ruiter, Julian R, Wiegant, Wouter W, Schmid, Jonas A, de Bruijn, Roebi, James, Dominic I, Guerrero Llobet, Sergi, Vis, Daniel J, Annunziato, Stefano, van den Broek, Bram, Barazas, Marco, Kersbergen, Ariena, van de Ven, Marieke, Tarsounas, Madalena, Ogilvie, Donald J, van Vugt, Marcel, Wessels, Lodewyk F A, Bartkova, Jirina, Gromova, Irina, Andújar-Sánchez, Miguel, Bartek, Jiri, Lopes, Massimo, van Attikum, Haico, Borst, Piet, Jonkers, Jos, Rottenberg, Sven

“…Inhibitors of poly(ADP-ribose) (PAR) polymerase (PARPi) have recently entered the clinic for the treatment of homologous recombination (HR)-deficient cancers…”
Zistit podrobnosti o prístupe

REV7 counteracts DNA double-strand break resection and affects PARP inhibition Autor Xu, Guotai, Chapman, J. Ross, Brandsma, Inger, Yuan, Jingsong, Mistrik, Martin, Bouwman, Peter, Bartkova, Jirina, Gogola, Ewa, Warmerdam, Daniël, Barazas, Marco, Jaspers, Janneke E., Watanabe, Kenji, Pieterse, Mark, Kersbergen, Ariena, Sol, Wendy, Celie, Patrick H. N., Schouten, Philip C., van den Broek, Bram, Salman, Ahmed, Nieuwland, Marja, de Rink, Iris, de Ronde, Jorma, Jalink, Kees, Boulton, Simon J., Chen, Junjie, van Gent, Dik C., Bartek, Jiri, Jonkers, Jos, Borst, Piet, Rottenberg, Sven

“…Loss of REV7 is shown to regulate end resection of double-stranded DNA breaks in BRCA1-deficient cells, leading to PARP inhibitor resistance and restoration of…”
Získať plný text

CD26-negative and CD26-positive tissue-resident fibroblasts contribute to functionally distinct CAF subpopulations in breast cancer Autor Houthuijzen, Julia M., de Bruijn, Roebi, van der Burg, Eline, Drenth, Anne Paulien, Wientjens, Ellen, Filipovic, Tamara, Bullock, Esme, Brambillasca, Chiara S., Pulver, Emilia M., Nieuwland, Marja, de Rink, Iris, van Diepen, Frank, Klarenbeek, Sjoerd, Kerkhoven, Ron, Brunton, Valerie G., Scheele, Colinda L.G.J., Boelens, Mirjam C., Jonkers, Jos

“…Cancer-associated fibroblasts (CAFs) are abundantly present in the microenvironment of virtually all tumors and strongly impact tumor progression. Despite…”
Získať plný text

Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer Autor Ter Brugge, Petra, Kristel, Petra, van der Burg, Eline, Boon, Ute, de Maaker, Michiel, Lips, Esther, Mulder, Lennart, de Ruiter, Julian, Moutinho, Catia, Gevensleben, Heidrun, Marangoni, Elisabetta, Majewski, Ian, Józwiak, Katarzyna, Kloosterman, Wigard, van Roosmalen, Markus, Duran, Karen, Hogervorst, Frans, Turner, Nick, Esteller, Manel, Cuppen, Edwin, Wesseling, Jelle, Jonkers, Jos

“…Although BRCA1-deficient tumors are extremely sensitive to DNA-damaging drugs and poly(ADP-ribose) polymerase (PARP) inhibitors, recurrences do occur and,…”
Zistit podrobnosti o prístupe

MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling Autor Zimmerli, Dario, Brambillasca, Chiara S., Talens, Francien, Bhin, Jinhyuk, Linstra, Renske, Romanens, Lou, Bhattacharya, Arkajyoti, Joosten, Stacey E. P., Da Silva, Ana Moises, Padrao, Nuno, Wellenstein, Max D., Kersten, Kelly, de Boo, Mart, Roorda, Maurits, Henneman, Linda, de Bruijn, Roebi, Annunziato, Stefano, van der Burg, Eline, Drenth, Anne Paulien, Lutz, Catrin, Endres, Theresa, van de Ven, Marieke, Eilers, Martin, Wessels, Lodewyk, de Visser, Karin E., Zwart, Wilbert, Fehrmann, Rudolf S. N., van Vugt, Marcel A. T. M., Jonkers, Jos

“…The limited efficacy of immune checkpoint inhibitor treatment in triple-negative breast cancer (TNBC) patients is attributed to sparse or unresponsive…”
Získať plný text

How do real tumors become resistant to cisplatin? Autor Borst, Piet, Rottenberg, Sven, Jonkers, Jos

“…Lab research on cultured tumor cells selected for resistance to platinum compounds has turned up a diverse array of resistance mechanisms. In contrast, we…”
Získať plný text

Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer Autor Annunziato, Stefano, de Ruiter, Julian R., Henneman, Linda, Brambillasca, Chiara S., Lutz, Catrin, Vaillant, François, Ferrante, Federica, Drenth, Anne Paulien, van der Burg, Eline, Siteur, Bjørn, van Gerwen, Bas, de Bruijn, Roebi, van Miltenburg, Martine H., Huijbers, Ivo J., van de Ven, Marieke, Visvader, Jane E., Lindeman, Geoffrey J., Wessels, Lodewyk F. A., Jonkers, Jos

“…BRCA1 -mutated breast cancer is primarily driven by DNA copy-number alterations (CNAs) containing large numbers of candidate driver genes. Validation of these…”
Získať plný text

Targeting homologous recombination repair defects in cancer Autor Evers, Bastiaan, Helleday, Thomas, Jonkers, Jos

“…DNA repair is essential for cells to maintain genome stability in an environment that constantly produces DNA damage. There is a growing appreciation that…”
Získať plný text

CopywriteR: DNA copy number detection from off-target sequence data Autor Kuilman, Thomas, Velds, Arno, Kemper, Kristel, Ranzani, Marco, Bombardelli, Lorenzo, Hoogstraat, Marlous, Nevedomskaya, Ekaterina, Xu, Guotai, de Ruiter, Julian, Lolkema, Martijn P, Ylstra, Bauke, Jonkers, Jos, Rottenberg, Sven, Wessels, Lodewyk F, Adams, David J, Peeper, Daniel S, Krijgsman, Oscar

“…Current methods for detection of copy number variants (CNV) and aberrations (CNA) from targeted sequencing data are based on the depth of coverage of captured…”
Získať plný text

The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity Autor Becker, Jordan R., Cuella-Martin, Raquel, Barazas, Marco, Liu, Rui, Oliveira, Catarina, Oliver, Antony W., Bilham, Kirstin, Holt, Abbey B., Blackford, Andrew N., Heierhorst, Jörg, Jonkers, Jos, Rottenberg, Sven, Chapman, J. Ross

“…53BP1 controls a specialized non-homologous end joining (NHEJ) pathway that is essential for adaptive immunity, yet oncogenic in BRCA1 mutant cancers…”
Získať plný text