Suchergebnisse - "Jiang, Baishan"

USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy von Xiong, Wenjun, Gao, Xueliang, Zhang, Tiantian, Jiang, Baishan, Hu, Ming-Ming, Bu, Xia, Gao, Yang, Zhang, Lin-Zhou, Xiao, Bo-Lin, He, Chuan, Sun, Yishuang, Li, Haiou, Shi, Jie, Xiao, Xiangling, Xiang, Bolin, Xie, Conghua, Chen, Gang, Zhang, Haojian, Wei, Wenyi, Freeman, Gordon J., Shu, Hong-Bing, Wang, Haizhen, Zhang, Jinfang

“… Anti-PD-1/PD-L1 immunotherapy has achieved impressive therapeutic outcomes in patients with multiple cancer types. However, the underlined molecular …”
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Discovery and resistance mechanism of a selective CDK12 degrader von Jiang, Baishan, Gao, Yang, Che, Jianwei, Lu, Wenchao, Kaltheuner, Ines H., Dries, Ruben, Kalocsay, Marian, Berberich, Matthew J., Jiang, Jie, You, Inchul, Kwiatkowski, Nicholas, Riching, Kristin M., Daniels, Danette L., Sorger, Peter K., Geyer, Matthias, Zhang, Tinghu, Gray, Nathanael S.

“… Cyclin-dependent kinase 12 (CDK12) is an emerging therapeutic target due to its role in regulating transcription of DNA-damage response (DDR) genes. However, …”
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Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation von Olson, Calla M, Jiang, Baishan, Erb, Michael A, Liang, Yanke, Doctor, Zainab M, Zhang, Zinan, Zhang, Tinghu, Kwiatkowski, Nicholas, Boukhali, Myriam, Green, Jennifer L, Haas, Wilhelm, Nomanbhoy, Tyzoon, Fischer, Eric S, Young, Richard A, Bradner, James E, Winter, Georg E, Gray, Nathanael S

“… Cyclin-dependent kinase 9 (CDK9), an important regulator of transcriptional elongation, is a promising target for cancer therapy, particularly for cancers …”
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Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML von Brand, Matthias, Jiang, Baishan, Bauer, Sophie, Donovan, Katherine A, Liang, Yanke, Wang, Eric S, Nowak, Radosław P, Yuan, Jingting C, Zhang, Tinghu, Kwiatkowski, Nicholas, Müller, André C, Fischer, Eric S, Gray, Nathanael S, Winter, Georg E

“… The design of selective small molecules is often stymied by similar ligand binding pockets. Here, we report BSJ-03-123, a phthalimide-based degrader that …”
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INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors von Li, Qing, Jiang, Baishan, Guo, Jiaye, Shao, Hong, Del Priore, Isabella S, Chang, Qing, Kudo, Rei, Li, Zhiqiang, Razavi, Pedram, Liu, Bo, Boghossian, Andrew S, Rees, Matthew G, Ronan, Melissa M, Roth, Jennifer A, Donovan, Katherine A, Palafox, Marta, Reis-Filho, Jorge S, de Stanchina, Elisa, Fischer, Eric S, Rosen, Neal, Serra, Violeta, Koff, Andrew, Chodera, John D, Gray, Nathanael S, Chandarlapaty, Sarat

“… Cyclin-dependent kinases 4 and 6 (CDK4/6) represent a major therapeutic vulnerability for breast cancer. The kinases are clinically targeted via ATP …”
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MELK is not necessary for the proliferation of basal-like breast cancer cells von Huang, Hai-Tsang, Seo, Hyuk-Soo, Zhang, Tinghu, Wang, Yubao, Jiang, Baishan, Li, Qing, Buckley, Dennis L, Nabet, Behnam, Roberts, Justin M, Paulk, Joshiawa, Dastjerdi, Shiva, Winter, Georg E, McLauchlan, Hilary, Moran, Jennifer, Bradner, James E, Eck, Michael J, Dhe-Paganon, Sirano, Zhao, Jean J, Gray, Nathanael S

“… Thorough preclinical target validation is essential for the success of drug discovery efforts. In this study, we combined chemical and genetic perturbants, …”
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Therapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability von Ye, Minhui, Fang, Yingzhe, Chen, Lu, Song, Zemin, Bao, Qing, Wang, Fei, Huang, Hao, Xu, Jin, Wang, Ziwen, Xiao, Ruijing, Han, Meng, Gao, Song, Liu, Hudan, Jiang, Baishan, Qing, Guoliang

“… Tumor cells must rewire nucleotide synthesis to satisfy the demands of unbridled proliferation. Meanwhile, they exhibit augmented reactive oxygen species (ROS) …”
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Catalytic Degraders Effectively Address Kinase Site Mutations in EML4-ALK Oncogenic Fusions von Gao, Yang, Jiang, Baishan, Kim, Hellen, Berberich, Matthew J, Che, Jianwei, Donovan, Katherine A, Hatcher, John M, Huerta, Fidel, Kwiatkowski, Nicholas P, Liu, Yingpeng, Liuni, Peter P, Metivier, Rebecca J, Murali, Vineeth K, Nowak, Radosław P, Zhang, Tinghu, Fischer, Eric S, Gray, Nathanael S, Jones, Lyn H

“… Heterobifunctional degraders, known as proteolysis targeting chimeras (PROTACs), theoretically possess a catalytic mode-of-action, yet few studies have either …”
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Palmitoylation of KSHV pORF55 is required for Golgi localization and efficient progeny virion production von Zhou, Yaru, Tian, Xuezhang, Wang, Shaowei, Gao, Ming, Zhang, Chuchu, Ma, Jiali, Cheng, Xi, Bai, Lei, Qin, Hai-Bin, Luo, Min-Hua, Qin, Qingsong, Jiang, Baishan, Lan, Ke, Zhang, Junjie

“… Kaposi’s sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA virus etiologically associated with multiple malignancies. Both latency and sporadic …”
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Ligase IV inhibitor SCR7 enhances gene editing directed by CRISPR–Cas9 and ssODN in human cancer cells von Hu, Zheng, Shi, Zhaoying, Guo, Xiaogang, Jiang, Baishan, Wang, Guo, Luo, Dixian, Chen, Yonglong, Zhu, Yuan-Shan

“… Background Precise genome editing is essential for both basic and translational research. The recently developed CRISPR/Cas9 system can specifically cleave a …”
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ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1-mutant lung cancer von Deng, Jiehui, Thennavan, Aatish, Dolgalev, Igor, Chen, Ting, Li, Jie, Marzio, Antonio, Poirier, John T., Peng, David H., Bulatovic, Mirna, Mukhopadhyay, Subhadip, Silver, Heather, Papadopoulos, Eleni, Pyon, Val, Thakurdin, Cassandra, Han, Han, Li, Fei, Li, Shuai, Ding, Hailin, Hu, Hai, Pan, Yuanwang, Weerasekara, Vajira, Jiang, Baishan, Wang, Eric S., Ahearn, Ian, Philips, Mark, Papagiannakopoulos, Thales, Tsirigos, Aristotelis, Rothenberg, Eli, Gainor, Justin, Freeman, Gordon J., Rudin, Charles M., Gray, Nathanael S., Hammerman, Peter S., Pagano, Michele, Heymach, John V., Perou, Charles M., Bardeesy, Nabeel, Wong, Kwok-Kin

“… Inactivating mutations in LKB1/STK11 are present in roughly 20% of nonsmall cell lung cancers (NSCLC) and portend poor response to anti-PD-1 immunotherapy …”
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Targeting protein tyrosine phosphatases for CDK6-induced immunotherapy resistance von Gao, Xueliang, Wu, Yongxia, Chick, Joel M., Abbott, Andrea, Jiang, Baishan, Wang, David J., Comte-Walters, Susana, Johnson, Roger H., Oberholtzer, Nathaniel, Nishimura, Michael I., Gygi, Steven P., Mehta, Anand, Guttridge, Denis C., Ball, Lauren, Mehrotra, Shikhar, Sicinski, Piotr, Yu, Xue-Zhong, Wang, Haizhen

“… Elucidating the mechanisms of resistance to immunotherapy and developing strategies to improve its efficacy are challenging goals. Bioinformatics analysis …”
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Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhibition von Fassl, Anne, Brain, Christopher, Abu-Remaileh, Monther, Stukan, Iga, Butter, Deborah, Stepien, Piotr, Feit, Avery S., Bergholz, Johann, Michowski, Wojciech, Otto, Tobias, Sheng, Qing, Loo, Alice, Michael, Walter, Tiedt, Ralph, DeAngelis, Carmine, Schiff, Rachel, Jiang, Baishan, Jovanovic, Bojana, Nowak, Karolina, Ericsson, Maria, Cameron, Michael, Gray, Nathanael, Dillon, Deborah, Zhao, Jean J., Sabatini, David M., Jeselsohn, Rinath, Brown, Myles, Polyak, Kornelia, Sicinski, Piotr

“… This study presents strategies to render triple-negative breast cancers sensitive to CDK4/6 inhibitors. Inhibitors of cyclin-dependent kinases CDK4 and CDK6 …”
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Development of Oral, Potent, and Selective CK1α Degraders for AML Therapy von Huang, Lu, Chen, Lu, Chen, Lu, Peng, Bo, Zhou, Lixin, Sun, Yanli, Shi, Taiting, Lu, Jiayi, Lin, Weiye, Liu, Yuhang, Cao, Linhui, Li, Lanlan, Han, Qiangqiang, Chen, Xi, Yang, Ping, Zhang, Shuo, Wang, Zhe, Yang, Jing, Guo, Zhixiang, Jiang, Baishan, Lu, Wenchao

“… Molecular glue degraders (MGDs) are proximity-inducing agents that mediate the cooperative interaction between a target protein and an E3 ligase, introducing …”
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ELISA detection of semicarbazide based on a fast sample pretreatment method von Fang, Zhiyuan, Jiang, Baishan, Wu, Wei, Xiang, Zhicheng, Ouyang, Chuanyan, Huang, Tulong, Chen, Junhua, Zeng, Lingwen

“… A direct ELISA was established for the fast detection of semicarbazide (SEM) using a novel biotin derivative. Without a tedious extraction procedure, as low as …”
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Harmine Induces Adipocyte Thermogenesis through RAC1-MEK-ERK-CHD4 Axis von Nie, Tao, Hui, Xiaoyan, Mao, Liufeng, Nie, Baoming, Li, Kuai, Sun, Wei, Gao, Xuefei, Tang, Xiaofeng, Xu, Yong, Jiang, Baishan, Tu, Zhengcao, Li, Peng, Ding, Ke, Han, Weiping, Zhang, Shaoping, Xu, Aimin, Ding, Sheng, Liu, Pentao, Patterson, Adam, Cooper, Garth, Wu, Donghai

“… Harmine is a natural compound possessing insulin-sensitizing effect in db/db diabetic mice. However its effect on adipose tissue browning is unknown. Here we …”
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Development of Dual and Selective Degraders of Cyclin‐Dependent Kinases 4 and 6 von Jiang, Baishan, Wang, Eric S., Donovan, Katherine A., Liang, Yanke, Fischer, Eric S., Zhang, Tinghu, Gray, Nathanael S.

“… Cyclin‐dependent kinases 4 and 6 (CDK4/6) are key regulators of the cell cycle, and there are FDA‐approved CDK4/6 inhibitors for treating patients with …”
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Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development von Donovan, Katherine A, Ferguson, Fleur M, Bushman, Jonathan W, Eleuteri, Nicholas A, Bhunia, Debabrata, Ryu, SeongShick, Tan, Li, Shi, Kun, Yue, Hong, Liu, Xiaoxi, Dobrovolsky, Dennis, Jiang, Baishan, Wang, Jinhua, Hao, Mingfeng, You, Inchul, Teng, Mingxing, Liang, Yanke, Hatcher, John, Li, Zhengnian, Manz, Theresa D, Groendyke, Brian, Hu, Wanyi, Nam, Yunju, Sengupta, Sandip, Cho, Hanna, Shin, Injae, Agius, Michael P, Ghobrial, Irene M, Ma, Michelle W, Che, Jianwei, Buhrlage, Sara J, Sim, Taebo, Gray, Nathanael S, Fischer, Eric S

“… Targeted protein degradation (TPD) refers to the use of small molecules to induce ubiquitin-dependent degradation of proteins. TPD is of interest in drug …”
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Selective and Potent Molecular Glue Degraders for NIMA‐Related Kinase 7 von Chen, Lu, Huang, Lu, Wen, Wuqiang, Zeng, Pingping, Wu, Yuanyuan, Han, Qiangqiang, Chen, Xi, Guo, Zhixiang, Yu, Haijun, Lu, Wenchao, Jiang, Baishan

“… Molecular glue degraders (MGDs) represent a promising strategy for targeted protein degradation within cells. While chemoproteomics has unveiled hundreds of …”
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PROTAC-mediated CDK degradation differentially impacts cancer cell cycles due to heterogeneity in kinase dependencies von Kumarasamy, Vishnu, Gao, Zhe, Zhao, Bosheng, Jiang, Baishan, Rubin, Seth M, Burgess, Kevin, Witkiewicz, Agnieszka K, Knudsen, Erik S

“… Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibition yields differential cellular responses in multiple tumor models due to redundancy in cell cycle. We …”
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