Suchergebnisse - "Jensen, Michael D"

Metabolic changes in aging humans: current evidence and therapeutic strategies von Palmer, Allyson K., Jensen, Michael D.

“… Aging and metabolism are inextricably linked, and many age-related changes in body composition, including increased central adiposity and sarcopenia, have …”
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Role of body fat distribution and the metabolic complications of obesity von Jensen, Michael D

“… An upper body/visceral fat distribution in obesity is closely linked with metabolic complications, whereas increased lower body fat is independently predictive …”
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Mechanisms and metabolic implications of regional differences among fat depots von Tchkonia, Tamara, Thomou, Thomas, Zhu, Yi, Karagiannides, Iordanes, Pothoulakis, Charalabos, Jensen, Michael D, Kirkland, James L

“… Fat distribution is closely linked to metabolic disease risk. Distribution varies with sex, genetic background, disease state, certain drugs and hormones, …”
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How to Measure Adipose Tissue Insulin Sensitivity von Søndergaard, Esben, Espinosa De Ycaza, Ana Elena, Morgan-Bathke, Maria, Jensen, Michael D.

“… Context and Objective:Adipose tissue insulin resistance may cause hepatic and skeletal muscle insulin resistance by releasing excess free fatty acids (FFAs) …”
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JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age von Xu, Ming, Tchkonia, Tamara, Ding, Husheng, Ogrodnik, Mikolaj, Lubbers, Ellen R, Pirtskhalava, Tamar, White, Thomas A, Johnson, Kurt O, Stout, Michael B, Mezera, Vojtech, Giorgadze, Nino, Jensen, Michael D, LeBrasseur, Nathan K, Kirkland, James L

“… Chronic, low grade, sterile inflammation frequently accompanies aging and age-related diseases. Cellular senescence is associated with the production of …”
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Targeting senescent cells alleviates obesity‐induced metabolic dysfunction von Palmer, Allyson K., Xu, Ming, Zhu, Yi, Pirtskhalava, Tamar, Weivoda, Megan M., Hachfeld, Christine M., Prata, Larissa G., Dijk, Theo H., Verkade, Esther, Casaclang‐Verzosa, Grace, Johnson, Kurt O., Cubro, Hajrunisa, Doornebal, Ewald J., Ogrodnik, Mikolaj, Jurk, Diana, Jensen, Michael D., Chini, Eduardo N., Miller, Jordan D., Matveyenko, Aleksey, Stout, Michael B., Schafer, Marissa J., White, Thomas A., Hickson, LaTonya J., Demaria, Marco, Garovic, Vesna, Grande, Joseph, Arriaga, Edgar A., Kuipers, Folkert, Zglinicki, Thomas, LeBrasseur, Nathan K., Campisi, Judith, Tchkonia, Tamar, Kirkland, James L.

“… Adipose tissue inflammation and dysfunction are associated with obesity‐related insulin resistance and diabetes, but mechanisms underlying this relationship …”
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Normal-Weight Central Obesity: Implications for Total and Cardiovascular Mortality von Sahakyan, Karine R, Somers, Virend K, Rodriguez-Escudero, Juan P, Hodge, David O, Carter, Rickey E, Sochor, Ondrej, Coutinho, Thais, Jensen, Michael D, Roger, Véronique L, Singh, Prachi, Lopez-Jimenez, Francisco

“… The relationship between central obesity and survival in community-dwelling adults with normal body mass index (BMI) is not well-known. To examine total and …”
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Red blood cell triglycerides—a unique pool that incorporates plasma-free fatty acids and relates to metabolic health von Song, Yilin, Jensen, Michael D.

“… Most research into red blood cell (RBC) lipids focuses on membrane phospholipids and their relationships to metabolic conditions and diet. Triglycerides (TGs) …”
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The Science of Obesity Management: An Endocrine Society Scientific Statement von Bray, George A, Heisel, William E, Afshin, Ashkan, Jensen, Michael D, Dietz, William H, Long, Michael, Kushner, Robert F, Daniels, Stephen R, Wadden, Thomas A, Tsai, Adam G, Hu, Frank B, Jakicic, John M, Ryan, Donna H, Wolfe, Bruce M, Inge, Thomas H

“… Abstract The prevalence of obesity, measured by body mass index, has risen to unacceptable levels in both men and women in the United States and worldwide with …”
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Blood cadmium in Chinese adults and its relationships with diabetes and obesity von Nie, Xiaomin, Wang, Ningjian, Chen, Yi, Chen, Chi, Han, Bing, Zhu, Chunfang, Chen, Yingchao, Xia, Fangzhen, Cang, Zhen, Lu, Meng, Meng, Ying, Jiang, Boren, D. Jensen, Michael, Lu, Yingli

“… The aim of this study is to evaluate blood cadmium levels (BCLs) in Chinese adults and explore whether blood cadmium is associated with diabetes or obesity …”
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Targeting senescent cells enhances adipogenesis and metabolic function in old age von Xu, Ming, Palmer, Allyson K, Ding, Husheng, Weivoda, Megan M, Pirtskhalava, Tamar, White, Thomas A, Sepe, Anna, Johnson, Kurt O, Stout, Michael B, Giorgadze, Nino, Jensen, Michael D, LeBrasseur, Nathan K, Tchkonia, Tamar, Kirkland, James L

“… Senescent cells accumulate in fat with aging. We previously found genetic clearance of senescent cells from progeroid INK-ATTAC mice prevents lipodystrophy …”
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Fat tissue, aging, and cellular senescence von Tchkonia, Tamara, Morbeck, Dean E., Von Zglinicki, Thomas, Van Deursen, Jan, Lustgarten, Joseph, Scrable, Heidi, Khosla, Sundeep, Jensen, Michael D., Kirkland, James L.

“… Summary Fat tissue, frequently the largest organ in humans, is at the nexus of mechanisms involved in longevity and age‐related metabolic dysfunction. Fat …”
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The famine exposure in early life and metabolic syndrome in adulthood von Wang, Ningjian, Wang, Xiaojin, Li, Qin, Han, Bing, Chen, Yi, Zhu, Chunfang, Chen, Yingchao, Lin, Dongping, Wang, Bingshun, Jensen, Michael D., Lu, Yingli

“… Epidemiologic studies have revealed that early-life conditions influence later risk of chronic diseases. We aimed to explore whether exposure to Chinese famine …”
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Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis von Buchwald, Henry, Estok, Rhonda, Fahrbach, Kyle, Banel, Deirdre, Jensen, Michael D, Pories, Walter J, Bantle, John P, Sledge, Isabella

“… The prevalence of obesity-induced type 2 diabetes mellitus is increasing worldwide. The objective of this review and meta-analysis is to determine the impact …”
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Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue von Schafer, Marissa J, White, Thomas A, Evans, Glenda, Tonne, Jason M, Verzosa, Grace C, Stout, Michael B, Mazula, Daniel L, Palmer, Allyson K, Baker, Darren J, Jensen, Michael D, Torbenson, Michael S, Miller, Jordan D, Ikeda, Yasuhiro, Tchkonia, Tamara, van Deursen, Jan M, Kirkland, James L, LeBrasseur, Nathan K

“… Considerable evidence implicates cellular senescence in the biology of aging and chronic disease. Diet and exercise are determinants of healthy aging; however, …”
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Normal weight obesity: a risk factor for cardiometabolic dysregulation and cardiovascular mortality von Romero-Corral, Abel, Somers, Virend K, Sierra-Johnson, Justo, Korenfeld, Yoel, Boarin, Simona, Korinek, Josef, Jensen, Michael D, Parati, Gianfranco, Lopez-Jimenez, Francisco

“… We hypothesized that subjects with a normal body mass index (BMI), but high body fat (BF) content [normal weight obesity (NWO)], have a higher prevalence of …”
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Exposure to severe famine in the prenatal or postnatal period and the development of diabetes in adulthood: an observational study von Wang, Ningjian, Cheng, Jing, Han, Bing, Li, Qin, Chen, Yi, Xia, Fangzhen, Jiang, Boren, Jensen, Michael D., Lu, Yingli

“… Aims/hypothesis Limited studies have compared the effect of prenatal or postnatal exposure to different severities of famine on the risk of developing …”
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Regional differences in cellular mechanisms of adipose tissue gain with overfeeding von Tchoukalova, Yourka D, Votruba, Susanne B, Tchkonia, Tamara, Giorgadze, Nino, Kirkland, James L, Jensen, Michael D

“… Body fat distribution is an important predictor of the metabolic consequences of obesity, but the cellular mechanisms regulating regional fat accumulation are …”
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Percutaneous Gastrostomy Device for the Treatment of Class II and Class III Obesity: Results of a Randomized Controlled Trial von Thompson, Christopher C, Abu Dayyeh, Barham K, Kushner, Robert, Sullivan, Shelby, Schorr, Alan B, Amaro, Anastassia, Apovian, Caroline M, Fullum, Terrence, Zarrinpar, Amir, Jensen, Michael D, Stein, Adam C, Edmundowicz, Steven, Kahaleh, Michel, Ryou, Marvin, Bohning, Matthew J, Ginsberg, Gregory, Huang, Christopher, Tran, Daniel D, Glaser, Joseph P, Martin, John A, Jaffe, David L, Farraye, Francis A, Ho, Samuel B, Kumar, Nitin, Harakal, Donna, Young, Meredith, Thomas, Catherine E, Shukla, Alpana P, Ryan, Michele B, Haas, Miki, Goldsmith, Heidi, McCrea, Jennifer, Aronne, Louis J

“… The AspireAssist System (AspireAssist) is an endoscopic weight loss device that is comprised of an endoscopically placed percutaneous gastrostomy tube and an …”
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Exposure to Famine in Early Life and Nonalcoholic Fatty Liver Disease in Adulthood von Wang, Ningjian, Chen, Yi, Ning, Zhiyuan, Li, Qin, Han, Bing, Zhu, Chunfang, Chen, Yingchao, Xia, Fangzhen, Jiang, Boren, Wang, Bingshun, Wang, Xiaojin, Jensen, Michael D, Lu, Yingli

“… Epidemiologic studies have indicated that early life nutrition influences later risk of obesity, type 2 diabetes, and metabolic syndrome. Nonalcoholic fatty …”
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