Výsledky vyhľadávania - "Jansen, Gerrit"

The role of alternative splicing in cancer: From oncogenesis to drug resistance Autor Sciarrillo, Rocco, Wojtuszkiewicz, Anna, Assaraf, Yehuda G., Jansen, Gerrit, Kaspers, Gertjan J.L., Giovannetti, Elisa, Cloos, Jacqueline

“…Alternative splicing is a tightly regulated process whereby non-coding sequences of pre-mRNA are removed and protein-coding segments are assembled in diverse…”
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Positioning of proteasome inhibitors in therapy of solid malignancies Autor Roeten, Margot S. F., Cloos, Jacqueline, Jansen, Gerrit

“…Targeting of the protein degradation pathway, in particular, the ubiquitin-proteasome system, has emerged as an attractive novel cancer chemotherapeutic…”
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Mortality in septic patients treated with vitamin C: a systematic meta-analysis Autor Scholz, Sean S., Borgstedt, Rainer, Ebeling, Nicole, Menzel, Leoni C., Jansen, Gerrit, Rehberg, Sebastian

“…Background Supplementation of vitamin C in septic patients remains controversial despite eight large clinical trials published only in 2020. We aimed to…”
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Advancements in Public First Responder Programs for Out-of-Hospital Cardiac Arrest: An Updated Literature Review Autor Kern, Michael, Jansen, Gerrit, Strickmann, Bernd, Kerner, Thoralf

“…Out-of-hospital cardiac arrest (OHCA) is a leading cause of death worldwide, with a low survival rate of around 7% globally. Key factors for improving survival…”
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Folate receptors and transporters: biological role and diagnostic/therapeutic targets in cancer and other diseases Autor Frigerio, Barbara, Bizzoni, Claudia, Jansen, Gerrit, Leamon, Christopher P., Peters, Godefridus J., Low, Philip S., Matherly, Larry H., Figini, Mariangela

“…Folate receptors and transporters and one-carbon metabolism continue to be important areas of study given their essential roles in an assortment of diseases…”
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Molecular basis of resistance to proteasome inhibitors in hematological malignancies Autor Niewerth, Denise, Jansen, Gerrit, Assaraf, Yehuda G., Zweegman, Sonja, Kaspers, Gertjan J.L., Cloos, Jacqueline

“…Over the past decade, the proteasome inhibitor bortezomib (Velcade) has not only gained a cornerstone position in the treatment of hematological malignancies,…”
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Bortezomib resistance in multiple myeloma is associated with increased serine synthesis Autor Zaal, Esther A., Wu, Wei, Jansen, Gerrit, Zweegman, Sonja, Cloos, Jacqueline, Berkers, Celia R.

“…Background The proteasome inhibitor bortezomib (BTZ) is successfully applied in the treatment of multiple myeloma, but its efficacy is restricted by the…”
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Proteasome inhibitors as experimental therapeutics of autoimmune diseases Autor Verbrugge, Sue Ellen, Scheper, Rik J, Lems, Willem F, de Gruijl, Tanja D, Jansen, Gerrit

“…Current treatment strategies for rheumatoid arthritis (RA) consisting of disease-modifying anti-rheumatic drugs or biological agents are not always effective,…”
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Lysosomal sequestration of sunitinib: a novel mechanism of drug resistance Autor Gotink, Kristy J, Broxterman, Henk J, Labots, Mariette, de Haas, Richard R, Dekker, Henk, Honeywell, Richard J, Rudek, Michelle A, Beerepoot, Laurens V, Musters, René J, Jansen, Gerrit, Griffioen, Arjan W, Assaraf, Yehuda G, Pili, Roberto, Peters, Godefridus J, Verheul, Henk M W

“…Resistance to antiangiogenic tyrosine kinase inhibitors such as sunitinib is an important clinical problem, but its underlying mechanisms are largely unknown…”
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Computational comparison of common event-based differential splicing tools: practical considerations for laboratory researchers Autor Muller, Ittai B., Meijers, Stijn, Kampstra, Peter, van Dijk, Steven, van Elswijk, Michel, Lin, Marry, Wojtuszkiewicz, Anna M., Jansen, Gerrit, de Jonge, Robert, Cloos, Jacqueline

“…Background Computational tools analyzing RNA-sequencing data have boosted alternative splicing research by identifying and assessing differentially spliced…”
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First in man study of [18F]fluoro-PEG-folate PET: a novel macrophage imaging technique to visualize rheumatoid arthritis Autor Verweij, Nicki J. F., Yaqub, Maqsood, Bruijnen, Stefan T. G., Pieplenbosch, S., ter Wee, Marieke M., Jansen, Gerrit, Chen, Qingshou, Low, Philip S., Windhorst, Albert D., Lammertsma, Adriaan A., Hoekstra, Otto S., Voskuyl, Alexandre E., van der Laken, Conny J.

“…Non-invasive imaging of arthritis activity in rheumatoid arthritis (RA) patients using macrophage PET holds promise for early diagnosis and therapeutic…”
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Positioning of aminopeptidase inhibitors in next generation cancer therapy Autor Hitzerd, Sarina M, Verbrugge, Sue Ellen, Ossenkoppele, Gert, Jansen, Gerrit, Peters, Godefridus J

“…Aminopeptidases represent a class of (zinc) metalloenzymes that catalyze the cleavage of amino acids nearby the N-terminus of polypeptides, resulting in…”
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High immunoproteasome and low constitutive proteasome subunit levels correlate with sensitivity to bortezomib-containing chemotherapy: update from the Children’s Oncology Group AALL1231 trial Autor Roeten, Margot S. F., Van Meerloo, Johan, Van Dijk, Suzanne N., Kwidama, Zinia, Jenkins, Gaye, Teachey, David T., Devidas, Meenakshi, Loh, Mignon L., Kaspers, Gertjan J. L., Zweegman, Sonja, Jansen, Gerrit, Horton, Terzah M., Cloos, Jacqueline

“…Not available.Not available…”
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The role of l-leucovorin uptake and metabolism in the modulation of 5-fluorouracil efficacy and antifolate toxicity Autor Peters, Godefridus J., Kathmann, Ietje, Giovannetti, Elisa, Smid, Kees, Assaraf, Yehuda G., Jansen, Gerrit

“…L-Leucovorin (l-LV; 5-formyltetrahydrofolate, folinic acid) is a precursor for 5,10-methylenetetrahydrofolate (5,10-CH -THF), which is important for the…”
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Prediction of peri-operative mortality in care of preterm children in non-cardiac surgery Autor Jansen, Gerrit, Irmscher, Linda, Jagoda, Sunil, Hinkelbein, Jochen, May, Theodor W., Popp, Jakob, Rehberg, Sebastian

“…Background The aim of this study was to develop a risk calculation model for peri-operative 30-day-mortality in preterm infants in non-cardiac surgery. Methods…”
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Depletion of activated macrophages with a folate receptor-beta-specific antibody improves symptoms in mouse models of rheumatoid arthritis Autor Hu, Yingwen, Wang, Bingbing, Shen, Jiayin, Low, Stewart A., Putt, Karson S., Niessen, Hans W. M., Matteson, Eric L., Murphy, Linda, Ruppert, Clemens, Jansen, Gerrit, Oliver, Stephen J., Feng, Yang, Dimitrov, Dimiter S., Nickerson-Nutter, Cheryl, Low, Philip S.

“…Objectives Most therapies for autoimmune and inflammatory diseases either neutralize or suppress production of inflammatory cytokines produced by activated…”
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Folate Receptor Beta for Macrophage Imaging in Rheumatoid Arthritis Autor Steinz, Maarten M., Ezdoglian, Aiarpi, Khodadust, Fatemeh, Molthoff, Carla F. M., Srinivasarao, Madduri, Low, Philip S., Zwezerijnen, Gerben J. C., Yaqub, Maqsood, Beaino, Wissam, Windhorst, Albert D., Tas, Sander W., Jansen, Gerrit, van der Laken, Conny J.

“…Non-invasive imaging modalities constitute an increasingly important tool in diagnostic and therapy response monitoring of patients with autoimmune diseases,…”
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Prehospital analgesia for trauma-related pain by paramedics: a comparative retrospective observational study of paracetamol, nalbuphine plus paracetamol, and piritramide Autor Lohmann, Jonas, Deicke, Martin, Deslandes, Marvin, Grannemann, Julia Johanna, Kolaparambil Varghese, Lydia Johnson, Hinkelbein, Jochen, Hoyer, Annika, Kalmbach, Matthias, Plappert, Thomas, Strickmann, Bernd, Vaseekaran, Mathini, Vollmer, Tobias, Jansen, Gerrit

“…Background In this retrospective observational study, we compared the efficacy and safety of paracetamol compared with those of nalbuphine plus paracetamol and…”
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Effectiveness and safety of prehospital analgesia with nalbuphine and paracetamol versus morphine by paramedics - an observational study Autor Deslandes, Marvin, Deicke, Martin, Grannemann, Julia Johanna, Hinkelbein, Jochen, Hoyer, Annika, Kalmbach, Matthias, Kobiella, André, Strickmann, Bernd, Plappert, Thomas, Jansen, Gerrit

“…Background Despite the development of various analgesic concepts, prehospital oligoanalgesia remains very common. The present work examines prehospital…”
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Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1 Autor Fang, Jing, Rhyasen, Garrett, Bolanos, Lyndsey, Rasch, Christopher, Varney, Melinda, Wunderlich, Mark, Goyama, Susumu, Jansen, Gerrit, Cloos, Jacqueline, Rigolino, Carmela, Cortelezzi, Agostino, Mulloy, James C, Oliva, Esther N, Cuzzola, Maria, Starczynowski, Daniel T

“…Bortezomib (Velcade) is used widely for the treatment of various human cancers; however, its mechanisms of action are not fully understood, particularly in…”
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