Suchergebnisse - "Jaiswal, Siddhartha"

Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease von Jaiswal, Siddhartha, Libby, Peter

“… Ageing and inflammation strongly drive the risk of cardiovascular disease. Work over the past decade has uncovered a common condition characterized by the …”
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Clonal hematopoiesis in human aging and disease von Jaiswal, Siddhartha, Ebert, Benjamin L

“… As people age, their tissues accumulate an increasing number of somatic mutations. Although most of these mutations are of little or no functional consequence, …”
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Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes von Steensma, David P, Bejar, Rafael, Jaiswal, Siddhartha, Lindsley, R Coleman, Sekeres, Mikkael A, Hasserjian, Robert P, Ebert, Benjamin L

“… Recent genetic analyses of large populations have revealed that somatic mutations in hematopoietic cells leading to clonal expansion are commonly acquired …”
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Author Correction: Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease von Jaiswal, Siddhartha, Libby, Peter

“… An amendment to this paper has been published and can be accessed via a link at the top of the paper …”
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Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease von Jaiswal, Siddhartha, Natarajan, Pradeep, Silver, Alexander J, Gibson, Christopher J, Bick, Alexander G, Shvartz, Eugenia, McConkey, Marie, Gupta, Namrata, Gabriel, Stacey, Ardissino, Diego, Baber, Usman, Mehran, Roxana, Fuster, Valentin, Danesh, John, Frossard, Philippe, Saleheen, Danish, Melander, Olle, Sukhova, Galina K, Neuberg, Donna, Libby, Peter, Kathiresan, Sekar, Ebert, Benjamin L

“… The development of clonal hematopoiesis with increasing age was associated with nearly a doubling in the risk of coronary heart disease, along with an increase …”
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Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes von Jaiswal, Siddhartha, Fontanillas, Pierre, Flannick, Jason, Manning, Alisa, Grauman, Peter V, Mar, Brenton G, Lindsley, R. Coleman, Mermel, Craig H, Burtt, Noel, Chavez, Alejandro, Higgins, John M, Moltchanov, Vladislav, Kuo, Frank C, Kluk, Michael J, Henderson, Brian, Kinnunen, Leena, Koistinen, Heikki A, Ladenvall, Claes, Getz, Gad, Correa, Adolfo, Banahan, Benjamin F, Gabriel, Stacey, Kathiresan, Sekar, Stringham, Heather M, McCarthy, Mark I, Boehnke, Michael, Tuomilehto, Jaakko, Haiman, Christopher, Groop, Leif, Atzmon, Gil, Wilson, James G, Neuberg, Donna, Altshuler, David, Ebert, Benjamin L

“… About 10% of people older than 70 years of age carry one or more mutations in their hematopoietic cells, and these persons have a higher relative risk of a …”
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Genomic profiling for clinical decision making in myeloid neoplasms and acute leukemia von Duncavage, Eric J, Bagg, Adam, Hasserjian, Robert P, DiNardo, Courtney D, Godley, Lucy A, Iacobucci, Ilaria, Jaiswal, Siddhartha, Malcovati, Luca, Vannucchi, Alessandro M, Patel, Keyur P, Arber, Daniel A, Arcila, Maria E, Bejar, Rafael, Berliner, Nancy, Borowitz, Michael J, Branford, Susan, Brown, Anna L, Cargo, Catherine A, Döhner, Hartmut, Falini, Brunangelo, Garcia-Manero, Guillermo, Haferlach, Torsten, Hellström-Lindberg, Eva, Kim, Annette S, Klco, Jeffery M, Komrokji, Rami, Lee-Cheun Loh, Mignon, Loghavi, Sanam, Mullighan, Charles G, Ogawa, Seishi, Orazi, Attilio, Papaemmanuil, Elli, Reiter, Andreas, Ross, David M, Savona, Michael, Shimamura, Akiko, Skoda, Radek C, Solé, Francesc, Stone, Richard M, Tefferi, Ayalew, Walter, Matthew J, Wu, David, Ebert, Benjamin L, Cazzola, Mario

“… Myeloid neoplasms and acute leukemias derive from the clonal expansion of hematopoietic cells driven by somatic gene mutations. Although assessment of …”
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TET2-mutant clonal hematopoiesis and risk of gout von Agrawal, Mridul, Niroula, Abhishek, Cunin, Pierre, McConkey, Marie, Shkolnik, Veronica, Kim, Peter G, Wong, Waihay J, Weeks, Lachelle D, Lin, Amy E, Miller, Peter G, Gibson, Christopher J, Sekar, Aswin, Schaefer, Inga-Marie, Neuberg, Donna, Stone, Richard M, Bick, Alexander G, Uddin, Md Mesbah, Griffin, Gabriel K, Jaiswal, Siddhartha, Natarajan, Pradeep, Nigrovic, Peter A, Rao, Deepak A, Ebert, Benjamin L

“… Gout is a common inflammatory arthritis caused by precipitation of monosodium urate (MSU) crystals in individuals with hyperuricemia. Acute flares are …”
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Clonal Hematopoiesis of Indeterminate Potential Predicts Adverse Outcomes in Patients With Atherosclerotic Cardiovascular Disease von Gumuser, Esra D, Schuermans, Art, Cho, So Mi Jemma, Sporn, Zachary A, Uddin, Md Mesbah, Paruchuri, Kaavya, Nakao, Tetsushi, Yu, Zhi, Haidermota, Sara, Hornsby, Whitney, Weeks, Lachelle D, Niroula, Abhishek, Jaiswal, Siddhartha, Libby, Peter, Ebert, Benjamin L, Bick, Alexander G, Natarajan, Pradeep, Honigberg, Michael C

“… Clonal hematopoiesis of indeterminate potential (CHIP)-the age-related clonal expansion of blood stem cells with leukemia-associated mutations-is a novel …”
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PPM1D -truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells von Kahn, Josephine D, Miller, Peter G, Silver, Alexander J, Sellar, Rob S, Bhatt, Shruti, Gibson, Christopher, McConkey, Marie, Adams, Dylan, Mar, Brenton, Mertins, Philipp, Fereshetian, Shaunt, Krug, Karsten, Zhu, Haoling, Letai, Anthony, Carr, Steven A, Doench, John, Jaiswal, Siddhartha, Ebert, Benjamin L

“… Truncating mutations in the terminal exon of protein phosphatase Mg2 /Mn2 1D ( ) have been identified in clonal hematopoiesis and myeloid neoplasms, with a …”
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Clonal Hematopoiesis: Somatic Mutations in Blood Cells and Atherosclerosis von Natarajan, Pradeep, Jaiswal, Siddhartha, Kathiresan, Sekar

“… The most important prognostic factor for atherosclerotic cardiovascular disease is age, independent of all other recognized risk factors. Recently, exome …”
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Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis von Kim, Peter Geon, Niroula, Abhishek, Shkolnik, Veronica, McConkey, Marie, Lin, Amy E, Słabicki, Mikołaj, Kemp, John P, Bick, Alexander, Gibson, Christopher J, Griffin, Gabriel, Sekar, Aswin, Brooks, Daniel J, Wong, Waihay J, Cohen, Drew N, Uddin, Md Mesbah, Shin, Wesley J, Pirruccello, James, Tsai, Jonathan M, Agrawal, Mridul, Kiel, Douglas P, Bouxsein, Mary L, Richards, J Brent, Evans, David M, Wein, Marc N, Charles, Julia F, Jaiswal, Siddhartha, Natarajan, Pradeep, Ebert, Benjamin L

“… Osteoporosis is caused by an imbalance of osteoclasts and osteoblasts, occurring in close proximity to hematopoietic cells in the bone marrow. Recurrent …”
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Clonal haematopoiesis of indeterminate potential predicts incident cardiac arrhythmias von Schuermans, Art, Vlasschaert, Caitlyn, Nauffal, Victor, Cho, So Mi Jemma, Uddin, Md Mesbah, Nakao, Tetsushi, Niroula, Abhishek, Klarqvist, Marcus D R, Weeks, Lachelle D, Lin, Amy E, Saadatagah, Seyedmohammad, Lannery, Kim, Wong, Megan, Hornsby, Whitney, Lubitz, Steven A, Ballantyne, Christie, Jaiswal, Siddhartha, Libby, Peter, Ebert, Benjamin L, Bick, Alexander G, Ellinor, Patrick T, Natarajan, Pradeep, Honigberg, Michael C

“… Clonal haematopoiesis of indeterminate potential (CHIP), the age-related expansion of blood cells with preleukemic mutations, is associated with …”
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Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47 von Chao, Mark P, Jaiswal, Siddhartha, Weissman-Tsukamoto, Rachel, Alizadeh, Ash A, Gentles, Andrew J, Volkmer, Jens, Weiskopf, Kipp, Willingham, Stephen B, Raveh, Tal, Park, Christopher Y, Majeti, Ravindra, Weissman, Irving L

“… Under normal physiological conditions, cellular homeostasis is partly regulated by a balance of pro- and anti-phagocytic signals. CD47, which prevents cancer …”
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CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells von Majeti, Ravindra, Chao, Mark P, Alizadeh, Ash A, Pang, Wendy W, Jaiswal, Siddhartha, Gibbs, Jr, Kenneth D, van Rooijen, Nico, Weissman, Irving L

“… Acute myeloid leukemia (AML) is organized as a cellular hierarchy initiated and maintained by a subset of self-renewing leukemia stem cells (LSC). We …”
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Genetic modification of inflammation- and clonal hematopoiesis–associated cardiovascular risk von Yu, Zhi, Fidler, Trevor P., Ruan, Yunfeng, Vlasschaert, Caitlyn, Nakao, Tetsushi, Uddin, Md Mesbah, Mack, Taralynn, Niroula, Abhishek, Heimlich, J. Brett, Zekavat, Seyedeh M., Gibson, Christopher J., Griffin, Gabriel K., Wang, Yuxuan, Peloso, Gina M., Heard-Costa, Nancy, Levy, Daniel, Vasan, Ramachandran S., Aguet, François, Ardlie, Kristin G., Taylor, Kent D., Rich, Stephen S., Rotter, Jerome I., Libby, Peter, Jaiswal, Siddhartha, Ebert, Benjamin L., Bick, Alexander G., Tall, Alan R., Natarajan, Pradeep

“… Clonal hematopoiesis of indeterminate potential (CHIP) is associated with an increased risk of cardiovascular diseases (CVDs), putatively via inflammasome …”
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CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis von Jaiswal, Siddhartha, Jamieson, Catriona H M, Pang, Wendy W, Park, Christopher Y, Chao, Mark P, Majeti, Ravindra, Traver, David, van Rooijen, Nico, Weissman, Irving L

“… Macrophages clear pathogens and damaged or aged cells from the blood stream via phagocytosis. Cell-surface CD47 interacts with its receptor on macrophages, …”
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Increased local DNA methylation disorder in AMLs with DNMT3A-destabilizing variants and its clinical implication von Lee, Dohoon, Koo, Bonil, Kim, Seokhyeon, Byun, Jamin, Hong, Junshik, Shin, Dong-Yeop, Sun, Choong-Hyun, Kim, Jaesung, Song, Ji-Joon, Jaiswal, Siddhartha, Yoon, Sung-Soo, Kim, Sun, Koh, Youngil

“… The mechanistic link between the complex mutational landscape of de novo methyltransferase DNMT3A and the pathology of acute myeloid leukemia (AML) has not …”
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Clonal hematopoiesis and nonhematologic disorders von Jaiswal, Siddhartha

“… Clonal expansions of mutated hematopoietic cells, termed clonal hematopoiesis, are common in aging humans. One expected consequence of mutation-associated …”
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Clonal hematopoiesis: elements associated with clonal expansion and diseases von Ryu, Gangpyo, Koh, Youngil, Jaiswal, Siddhartha, Yoon, Sung-soo

“… Clonal hematopoiesis (CH), characterized by the expansion of hematopoietic stem and progenitor cells harboring somatic mutations, has emerged as a significant …”
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