Search Results - "Jacobs, Heinz"

Mutating for Good: DNA Damage Responses During Somatic Hypermutation by Pilzecker, Bas, Jacobs, Heinz

“…Somatic hypermutation (SHM) of immunoglobulin ( ) genes plays a key role in antibody mediated immunity. SHM in B cells provides the molecular basis for…”
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Investigating the characteristics of residential end uses of water: A worldwide review by Mazzoni, Filippo, Alvisi, Stefano, Blokker, Mirjam, Buchberger, Steven G., Castelletti, Andrea, Cominola, Andrea, Gross, Marie-Philine, Jacobs, Heinz E., Mayer, Peter, Steffelbauer, David B., Stewart, Rodney A., Stillwell, Ashlynn S., Tzatchkov, Velitchko, Yamanaka, Victor-Hugo Alcocer, Franchini, Marco

“…•We systematically review 114 studies on the residential end uses of water.•We develop a multi-level analysis to compare the outcomes available in the…”
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Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity by Vujanovic, Marko, Krietsch, Jana, Raso, Maria Chiara, Terraneo, Nastassja, Zellweger, Ralph, Schmid, Jonas A, Taglialatela, Angelo, Huang, Jen-Wei, Holland, Cory L, Zwicky, Katharina, Herrador, Raquel, Jacobs, Heinz, Cortez, David, Ciccia, Alberto, Penengo, Lorenza, Lopes, Massimo

“…DNA damage tolerance during eukaryotic replication is orchestrated by PCNA ubiquitination. While monoubiquitination activates mutagenic translesion synthesis,…”
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Intermittent water supply : a South African perspective by Loubser, Carlo, Chimbanga, Bubala Mwiinga, Jacobs, Heinz Erasmus

“…The prevalence of intermittent water supply in South Africa was investigated in this research study. Data on intermittent water supply in South Africa was…”
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DNA damage tolerance in hematopoietic stem and progenitor cells in mice by Pilzecker, Bas, Buoninfante, Olimpia Alessandra, van den Berk, Paul, Lancini, Cesare, Song, Ji-Ying, Citterio, Elisabetta, Jacobs, Heinz

“…DNA damage tolerance (DDT) enables bypassing of DNA lesions during replication, thereby preventing fork stalling, replication stress, and secondary DNA damage…”
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Drinking Water Temperature around the Globe: Understanding, Policies, Challenges and Opportunities by Agudelo-Vera, Claudia, Avvedimento, Stefania, Boxall, Joby, Creaco, Enrico, de Kater, Henk, Di Nardo, Armando, Djukic, Aleksandar, Douterelo, Isabel, Fish, Katherine E., Iglesias Rey, Pedro L., Jacimovic, Nenad, Jacobs, Heinz E., Kapelan, Zoran, Martinez Solano, Javier, Montoya Pachongo, Carolina, Piller, Olivier, Quintiliani, Claudia, Ručka, Jan, Tuhovčák, Ladislav, Blokker, Mirjam

“…Water temperature is often monitored at water sources and treatment works; however, there is limited monitoring of the water temperature in the drinking water…”
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Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis by Wilting, Roel H, Yanover, Eva, Heideman, Marinus R, Jacobs, Heinz, Horner, James, van der Torre, Jaco, DePinho, Ronald A, Dannenberg, Jan-Hermen

“…Histone deacetylases (HDACs) counterbalance acetylation of lysine residues, a protein modification involved in numerous biological processes. Here, Hdac1 and…”
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Tumor-educated Tregs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node niche by Kos, Kevin, Aslam, Muhammad A., van de Ven, Rieneke, Wellenstein, Max D., Pieters, Wietske, van Weverwijk, Antoinette, Duits, Danique E.M., van Pul, Kim, Hau, Cheei-Sing, Vrijland, Kim, Kaldenbach, Daphne, Raeven, Elisabeth A.M., Quezada, Sergio A., Beyaert, Rudi, Jacobs, Heinz, de Gruijl, Tanja D., de Visser, Karin E.

“…Breast cancer is accompanied by systemic immunosuppression, which facilitates metastasis formation, but how this shapes organotropism of metastasis is poorly…”
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Molecular dependencies and genomic consequences of a global DNA damage tolerance defect by de Groot, Daniel, Spanjaard, Aldo, Shah, Ronak, Kreft, Maaike, Morris, Ben, Lieftink, Cor, Catsman, Joyce J. I., Ormel, Shirley, Ayidah, Matilda, Pilzecker, Bas, Buoninfante, Olimpia Alessandra, van den Berk, Paul C. M., Beijersbergen, Roderick L., Jacobs, Heinz

“…Background DNA damage tolerance (DDT) enables replication to continue in the presence of fork stalling lesions. In mammalian cells, DDT is regulated by two…”
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Cholesterol biosynthesis as a drug-induced vulnerability in diffuse large B cell lymphoma insensitive to EZH2 inhibition by Niccolai, Rachele, Göbel, Camiel, Ndoj, Klevis, Kreft, Maaike, Kuiken, Hendrik J., Lieftink, Cor, Morris, Ben, Yska, Sietse D., Hendrix, Sebastian, van den Broek, Bram, Pappalardo, Vincent, Kersten, Marie José, Beijersbergen, Roderick L., Zelcer, Noam, van Leeuwen, Fred, Jacobs, Heinz

“…•GCB-DLBCL insensitive to EZH2 inhibition become dependent on cholesterol synthesis.•This dependency relates to altered LDLR subcellular localization and LDL…”
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Defining domestic water consumption based on personal water use activities by Crouch, Melissa Lauren, Heinz Erasmus Jacobs, Vanessa L. Speight

“…As the world increasingly faces water shortages, it is critical to develop realistic estimates of water consumption based on water-use activities rather than…”
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DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age by Urbanus, Jos, Cosgrove, Jason, Beltman, Joost B., Elhanati, Yuval, Moral, Rafael A., Conrad, Cecile, van Heijst, Jeroen W., Tubeuf, Emilie, Velds, Arno, Kok, Lianne, Merle, Candice, Magnusson, Jens P., Guyonnet, Léa, Frisén, Jonas, Fre, Silvia, Walczak, Aleksandra M., Mora, Thierry, Jacobs, Heinz, Schumacher, Ton N., Perié, Leïla

“…Ageing is associated with changes in the cellular composition of the immune system. During ageing, hematopoietic stem and progenitor cells (HSPCs) that produce…”
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Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells by Lancini, Cesare, van den Berk, Paul C M, Vissers, Joseph H A, Gargiulo, Gaetano, Song, Ji-Ying, Hulsman, Danielle, Serresi, Michela, Tanger, Ellen, Blom, Marleen, Vens, Conchita, van Lohuizen, Maarten, Jacobs, Heinz, Citterio, Elisabetta

“…Histone ubiquitination at DNA breaks is required for activation of the DNA damage response (DDR) and DNA repair. How the dynamic removal of this modification…”
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Sin3a-associated Hdac1 and Hdac2 are essential for hematopoietic stem cell homeostasis and contribute differentially to hematopoiesis by Heideman, M. R., Lancini, C., Proost, N., Yanover, E., Jacobs, H., Dannenberg, J.-H.

“…Class I histone deacetylases are critical regulators of gene transcription by erasing lysine acetylation. Targeting histone deacetylases using relative…”
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Supplementary household water sources to augment potable municipal supply in South Africa by Du Plessis, Kobus, Nel, Nicole, Jacobs, Heinz, Loubser, Carlo

“…This paper addresses on-site supplementary household water sources with a focus on groundwater abstraction, rainwater harvesting and greywater reuse as…”
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PCNA Ubiquitination Is Important, But Not Essential for Translesion DNA Synthesis in Mammalian Cells by Hendel, Ayal, Krijger, Peter H. L., Diamant, Noam, Goren, Zohar, Langerak, Petra, Kim, Jungmin, Reißner, Thomas, Lee, Kyoo-young, Geacintov, Nicholas E., Carell, Thomas, Myung, Kyungjae, Tateishi, Satoshi, D'Andrea, Alan, Jacobs, Heinz, Livneh, Zvi

“…Translesion DNA synthesis (TLS) is a DNA damage tolerance mechanism in which specialized low-fidelity DNA polymerases bypass replication-blocking lesions, and…”
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Garden footprint area and water use of gated communities in South Africa by du Plessis, Jacques L, Knox, Ashley J, Jacobs, Heinz E

“…Gated community homes in South Africa are popular amongst property buyers in urban environments such as cities and metropoles due to the increased security and…”
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Analysis of water use by gated communities in South Africa by Du Plessis, Jacques, Jacobs, Heinz

“…Gated communities (hereafter GCs) are popular in many countries, including South Africa, because added security and lifestyle improvements are offered relative…”
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Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation by Spanjaard, Aldo, Stratigopoulou, Maria, de Groot, Daniël, Aslam, Muhammad, van den Berk, Paul C. M., Stappenbelt, Chantal, Ayidah, Matilda, Catsman, Joyce J. I., Pardieck, Iris N., Kreft, Maaike, Arens, Ramon, Guikema, Jeroen E. J., Jacobs, Heinz

“…The development and differentiation of B cells is intimately linked to cell proliferation and the generation of diverse immunoglobulin gene ( Ig ) repertoires…”
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Gemcitabine as chemotherapy of head and neck cancer in Fanconi anemia patients by van Harten, Anne M., Shah, Ronak, de Boer, D. Vicky, Buijze, Marijke, Kreft, Maaike, Song, Ji-Ying, Zürcher, Lisa M., Jacobs, Heinz, Brakenhoff, Ruud H.

“…Fanconi anemia (FA) is a rare hereditary disease resulting from an inactivating mutation in the FA/BRCA pathway, critical for the effective repair of DNA…”
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