Search Results - "JCI insight"

Neutrophil extracellular traps in COVID-19 by Zuo, Yu, Yalavarthi, Srilakshmi, Shi, Hui, Gockman, Kelsey, Zuo, Melanie, Madison, Jacqueline A., Blair, Christopher N., Weber, Andrew, Barnes, Betsy J., Egeblad, Mikala, Woods, Robert J., Kanthi, Yogendra, Knight, Jason S.

“…In severe cases of coronavirus disease 2019 (COVID-19), viral pneumonia progresses to respiratory failure. Neutrophil extracellular traps (NETs) are…”
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Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity by Tadokoro, Tomonori, Ikeda, Masataka, Ide, Tomomi, Deguchi, Hiroko, Ikeda, Soichiro, Okabe, Kosuke, Ishikita, Akihito, Matsushima, Shouji, Koumura, Tomoko, Yamada, Ken-ichi, Imai, Hirotaka, Tsutsui, Hiroyuki

“…Doxorubicin (DOX), a chemotherapeutic agent, induces a cardiotoxicity referred to as doxorubicin-induced cardiomyopathy (DIC). This cardiotoxicity often limits…”
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COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status by Thomas, Tiffany, Stefanoni, Davide, Reisz, Julie A., Nemkov, Travis, Bertolone, Lorenzo, Francis, Richard O., Hudson, Krystalyn E., Zimring, James C., Hansen, Kirk C., Hod, Eldad A., Spitalnik, Steven L., D’Alessandro, Angelo

“…BACKGROUNDReprogramming of host metabolism supports viral pathogenesis by fueling viral proliferation, by providing, for example, free amino acids and fatty…”
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Semaglutide lowers body weight in rodents via distributed neural pathways by Gabery, Sanaz, Salinas, Casper G., Paulsen, Sarah J., Ahnfelt-Rønne, Jonas, Alanentalo, Tomas, Baquero, Arian F., Buckley, Stephen T., Farkas, Erzsébet, Fekete, Csaba, Frederiksen, Klaus S., Helms, Hans Christian C., Jeppesen, Jacob F., John, Linu M., Pyke, Charles, Nøhr, Jane, Lu, Tess T., Polex-Wolf, Joseph, Prevot, Vincent, Raun, Kirsten, Simonsen, Lotte, Sun, Gao, Szilvásy-Szabó, Anett, Willenbrock, Hanni, Secher, Anna, Knudsen, Lotte Bjerre

“…Semaglutide, a glucagon-like peptide 1 (GLP-1) analog, induces weight loss, lowers glucose levels, and reduces cardiovascular risk in patients with diabetes…”
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The laboratory tests and host immunity of COVID-19 patients with different severity of illness by Wang, Feng, Hou, Hongyan, Luo, Ying, Tang, Guoxing, Wu, Shiji, Huang, Min, Liu, Weiyong, Zhu, Yaowu, Lin, Qun, Mao, Liyan, Fang, Minghao, Zhang, Huilan, Sun, Ziyong

“…BACKGROUNDThe coronavirus disease 2019 (COVID-19), infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a severe outbreak…”
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Anti-spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection by Liu, Li, Wei, Qiang, Lin, Qingqing, Fang, Jun, Wang, Haibo, Kwok, Hauyee, Tang, Hangying, Nishiura, Kenji, Peng, Jie, Tan, Zhiwu, Wu, Tongjin, Cheung, Ka-Wai, Chan, Kwok-Hung, Alvarez, Xavier, Qin, Chuan, Lackner, Andrew, Perlman, Stanley, Yuen, Kwok-Yung, Chen, Zhiwei

“…Newly emerging viruses, such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle Eastern respiratory syndrome CoVs (MERS-CoV), and H7N9, cause…”
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Longitudinal COVID-19 profiling associates IL-1RA and IL-10 with disease severity and RANTES with mild disease by Zhao, Yan, Qin, Ling, Zhang, Ping, Li, Kang, Liang, Lianchun, Sun, Jianping, Xu, Bin, Dai, Yanchao, Li, Xuemei, Zhang, Chi, Peng, Yanchun, Feng, Yingmei, Li, Ang, Hu, Zhongjie, Xiang, Haiping, Ogg, Graham, Ho, Ling-Pei, McMichael, Andrew, Jin, Ronghua, Knight, Julian C., Dong, Tao, Zhang, Yonghong

“…Identifying immune correlates of COVID-19 disease severity is an urgent need for clinical management, vaccine evaluation, and drug development. Here, we…”
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Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist by Willard, Francis S., Douros, Jonathan D., Gabe, Maria B.N., Showalter, Aaron D., Wainscott, David B., Suter, Todd M., Capozzi, Megan E., van der Velden, Wijnand J.C., Stutsman, Cynthia, Cardona, Guemalli R., Urva, Shweta, Emmerson, Paul J., Holst, Jens J., D’Alessio, David A., Coghlan, Matthew P., Rosenkilde, Mette M., Campbell, Jonathan E., Sloop, Kyle W.

“…Tirzepatide (LY3298176) is a dual GIP and GLP-1 receptor agonist under development for the treatment of type 2 diabetes mellitus (T2DM), obesity, and…”
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An immune-based biomarker signature is associated with mortality in COVID-19 patients by Abers, Michael S., Delmonte, Ottavia M., Ricotta, Emily E., Fintzi, Jonathan, Fink, Danielle L., de Jesus, Adriana A. Almeida, Zarember, Kol A., Alehashemi, Sara, Oikonomou, Vasileios, Desai, Jigar V., Canna, Scott W., Shakoory, Bita, Dobbs, Kerry, Imberti, Luisa, Sottini, Alessandra, Quiros-Roldan, Eugenia, Castelli, Francesco, Rossi, Camillo, Brugnoni, Duilio, Biondi, Andrea, Bettini, Laura Rachele, D’Angio’, Mariella, Bonfanti, Paolo, Castagnoli, Riccardo, Montagna, Daniela, Licari, Amelia, Marseglia, Gian Luigi, Gliniewicz, Emily F., Shaw, Elana, Kahle, Dana E., Rastegar, Andre T., Stack, Michael, Myint-Hpu, Katherine, Levinson, Susan L., DiNubile, Mark J., Chertow, Daniel W., Burbelo, Peter D., Cohen, Jeffrey I., Calvo, Katherine R., Tsang, John S., Su, Helen C., Gallin, John I., Kuhns, Douglas B., Goldbach-Mansky, Raphaela, Lionakis, Michail S., Notarangelo, Luigi D.

“…Immune and inflammatory responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contribute to disease severity of coronavirus disease 2019…”
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NLRP3/caspase-1/GSDMD–mediated pyroptosis exerts a crucial role in astrocyte pathological injury in mouse model of depression by Li, Shanshan, Sun, Yiming, Song, Mengmeng, Song, Yuting, Fang, Yinquan, Zhang, Qingyu, Li, Xueting, Song, Nanshan, Ding, Jianhua, Lu, Ming, Hu, Gang

“…Emerging evidence suggests that astrocyte loss is one of the most important pathological features in the hippocampus of patients with major depressive disorder…”
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Generation and testing of clinical-grade exosomes for pancreatic cancer by Mendt, Mayela, Kamerkar, Sushrut, Sugimoto, Hikaru, McAndrews, Kathleen M., Wu, Chia-Chin, Gagea, Mihai, Yang, Sujuan, Blanko, Elena V. Rodriges, Peng, Qian, Ma, Xiaoyan, Marszalek, Joseph R., Maitra, Anirban, Yee, Cassian, Rezvani, Katayoun, Shpall, Elizabeth, LeBleu, Valerie S., Kalluri, Raghu

“…Exosomes are extracellular vesicles produced by all cells with a remarkable ability to efficiently transfer genetic material, including exogenously loaded…”
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PD-L1 expression and tumor mutational burden are independent biomarkers in most cancers by Yarchoan, Mark, Albacker, Lee A., Hopkins, Alexander C., Montesion, Meagan, Murugesan, Karthikeyan, Vithayathil, Teena T., Zaidi, Neeha, Azad, Nilofer S., Laheru, Daniel A., Frampton, Garrett M., Jaffee, Elizabeth M.

“…PD-L1 expression and tumor mutational burden (TMB) have emerged as important biomarkers of response to immune checkpoint inhibitor (ICI) therapy. These…”
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Diabetic retinopathy: current understanding, mechanisms, and treatment strategies by Duh, Elia J., Sun, Jennifer K., Stitt, Alan W.

“…Diabetic retinopathy (DR) causes significant visual loss on a global scale. Treatments for the vision-threatening complications of diabetic macular edema (DME)…”
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The senescence-associated secretome as an indicator of age and medical risk by Schafer, Marissa J., Zhang, Xu, Kumar, Amanika, Atkinson, Elizabeth J., Zhu, Yi, Jachim, Sarah, Mazula, Daniel L., Brown, Ashley K., Berning, Michelle, Aversa, Zaira, Kotajarvi, Brian, Bruce, Charles J., Greason, Kevin L., Suri, Rakesh M., Tracy, Russell P., Cummings, Steven R., White, Thomas A., LeBrasseur, Nathan K.

“…Produced by senescent cells, the senescence-associated secretory phenotype (SASP) is a potential driver of age-related dysfunction. We tested whether…”
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TGF-β inhibition via CRISPR promotes the long-term efficacy of CAR T cells against solid tumors by Tang, Na, Cheng, Chen, Zhang, Xingying, Qiao, Miaomiao, Li, Na, Mu, Wei, Wei, Xiao-Fei, Han, Weidong, Wang, Haoyi

“…In recent years, chimeric antigen receptor-modified T cell (CAR T cell) therapy has proven to be a promising approach against cancer. Nonetheless, this…”
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Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections by Remy, Kenneth E., Mazer, Monty, Striker, David A., Ellebedy, Ali H., Walton, Andrew H., Unsinger, Jacqueline, Blood, Teresa M., Mudd, Philip A., Yi, Daehan J., Mannion, Daniel A., Osborne, Dale F., Martin, R. Scott, Anand, Nitin J., Bosanquet, James P., Blood, Jane, Drewry, Anne M., Caldwell, Charles C., Turnbull, Isaiah R., Brakenridge, Scott C., Moldwawer, Lyle L., Hotchkiss, Richard S.

“…COVID-19-associated morbidity and mortality have been attributed to a pathologic host response. Two divergent hypotheses have been proposed: hyperinflammatory…”
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The complement system in COVID-19: friend and foe? by Java, Anuja, Apicelli, Anthony J, Liszewski, M Kathryn, Coler-Reilly, Ariella, Atkinson, John P, Kim, Alfred Hj, Kulkarni, Hrishikesh S

“…Coronavirus disease 2019 (COVID-19), the disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in a global pandemic and a…”
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Necroptosis: a crucial pathogenic mediator of human disease by Choi, Mary E., Price, David R., Ryter, Stefan W., Choi, Augustine M. K.

“…Necroptosis is a genetically regulated form of necrotic cell death that has emerged as an important pathway in human disease. The necroptosis pathway is…”
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Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin by Jiang, Yanyun, Tsoi, Lam C., Billi, Allison C., Ward, Nicole L., Harms, Paul W., Zeng, Chang, Maverakis, Emanual, Kahlenberg, J. Michelle, Gudjonsson, Johann E.

“…The skin serves as the primary interface between our body and the external environment and acts as a barrier against entry of physical agents, chemicals, and…”
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Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer by Karki, Rajendra, Sharma, Bhesh Raj, Lee, Ein, Banoth, Balaji, Malireddi, R.K. Subbarao, Samir, Parimal, Tuladhar, Shraddha, Mummareddy, Harisankeerth, Burton, Amanda R., Vogel, Peter, Kanneganti, Thirumala-Devi

“…Interferon regulatory factor 1 (IRF1) regulates diverse biological functions, including modulation of cellular responses involved in tumorigenesis. Genetic…”
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