Výsledky vyhľadávania - "JAMA oncology"

Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019 Autor Kocarnik, Jonathan M, Compton, Kelly, Dean, Frances E, Fu, Weijia, Gaw, Brian L, Harvey, James D, Henrikson, Hannah Jacqueline, Lu, Dan, Pennini, Alyssa, Xu, Rixing, Ababneh, Emad, Abbasi-Kangevari, Mohsen, Abbastabar, Hedayat, Abd-Elsalam, Sherief M, Abdoli, Amir, Abedi, Aidin, Abidi, Hassan, Abolhassani, Hassan, Adedeji, Isaac Akinkunmi, Adnani, Qorinah Estiningtyas Sakilah, Advani, Shailesh M, Afzal, Muhammad Sohail, Aghaali, Mohammad, Ahinkorah, Bright Opoku, Ahmad, Sajjad, Ahmad, Tauseef, Ahmadi, Ali, Ahmadi, Sepideh, Ahmed Rashid, Tarik, Ahmed Salih, Yusra, Akalu, Gizachew Taddesse, Aklilu, Addis, Akram, Tayyaba, Akunna, Chisom Joyqueenet, Al Hamad, Hanadi, Alahdab, Fares, Al-Aly, Ziyad, Ali, Saqib, Alimohamadi, Yousef, Alipour, Vahid, Aljunid, Syed Mohamed, Alkhayyat, Motasem, Almasi-Hashiani, Amir, Almasri, Nihad A, Al-Maweri, Sadeq Ali Ali, Almustanyir, Sami, Alonso, Nivaldo, Alvis-Guzman, Nelson, Amu, Hubert, Anbesu, Etsay Woldu, Ancuceanu, Robert, Ansari, Fereshteh, Ansari-Moghaddam, Alireza, Antwi, Maxwell Hubert, Anvari, Davood, Anyasodor, Anayochukwu Edward, Aqeel, Muhammad, Arabloo, Jalal, Arab-Zozani, Morteza, Aremu, Olatunde, Ariffin, Hany, Aripov, Timur, Arshad, Muhammad, Artaman, Al, Arulappan, Judie, Asemi, Zatollah, Asghari Jafarabadi, Mohammad, Ashraf, Tahira, Atorkey, Prince, Aujayeb, Avinash, Ausloos, Marcel, Awedew, Atalel Fentahun, Ayala Quintanilla, Beatriz Paulina, Ayenew, Temesgen, Azab, Mohammed A, Azadnajafabad, Sina, Azari Jafari, Amirhossein, Azarian, Ghasem, Azzam, Ahmed Y, Badiye, Ashish D, Bahadory, Saeed, Baig, Atif Amin, Baker, Jennifer L, Balakrishnan, Senthilkumar, Banach, Maciej, Bärnighausen, Till Winfried, Barone-Adesi, Francesco, Barra, Fabio, Barrow, Amadou, Behzadifar, Masoud, Belgaumi, Uzma Iqbal, Bezabhe, Woldesellassie M Mequanint, Bezabih, Yihienew Mequanint, Bhagat, Devidas S, Bhagavathula, Akshaya Srikanth, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhaskar, Sonu, Bhattacharyya, Krittika, Bhojaraja, Vijayalakshmi S

“…The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform…”
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Estimates and Projections of the Global Economic Cost of 29 Cancers in 204 Countries and Territories From 2020 to 2050 Autor Chen, Simiao, Cao, Zhong, Prettner, Klaus, Kuhn, Michael, Yang, Juntao, Jiao, Lirui, Wang, Zhuoran, Li, Weimin, Geldsetzer, Pascal, Bärnighausen, Till, Bloom, David E, Wang, Chen

“…Cancers are a leading cause of mortality, accounting for nearly 10 million annual deaths worldwide, or 1 in 6 deaths. Cancers also negatively affect countries'…”
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Sentinel Lymph Node Biopsy vs No Axillary Surgery in Patients With Small Breast Cancer and Negative Results on Ultrasonography of Axillary Lymph Nodes: The SOUND Randomized Clinical Trial Autor Gentilini, Oreste Davide, Botteri, Edoardo, Sangalli, Claudia, Galimberti, Viviana, Porpiglia, Mauro, Agresti, Roberto, Luini, Alberto, Viale, Giuseppe, Cassano, Enrico, Peradze, Nickolas, Toesca, Antonio, Massari, Giulia, Sacchini, Virgilio, Munzone, Elisabetta, Leonardi, Maria Cristina, Cattadori, Francesca, Di Micco, Rosa, Esposito, Emanuela, Sgarella, Adele, Cattaneo, Silvia, Busani, Massimo, Dessena, Massimo, Bianchi, Anna, Cretella, Elisabetta, Ripoll Orts, Francisco, Mueller, Michael, Tinterri, Corrado, Chahuan Manzur, Badir Jorge, Benedetto, Chiara, Veronesi, Paolo

“…Sentinel lymph node biopsy (SLNB) is the standard of care for axillary node staging of patients with early breast cancer (BC), but its necessity can be…”
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Efficacy and Safety of Nivolumab Plus Ipilimumab in Patients With Advanced Hepatocellular Carcinoma Previously Treated With Sorafenib: The CheckMate 040 Randomized Clinical Trial Autor Yau, Thomas, Kang, Yoon-Koo, Kim, Tae-You, El-Khoueiry, Anthony B, Santoro, Armando, Sangro, Bruno, Melero, Ignacio, Kudo, Masatoshi, Hou, Ming-Mo, Matilla, Ana, Tovoli, Francesco, Knox, Jennifer J, Ruth He, Aiwu, El-Rayes, Bassel F, Acosta-Rivera, Mirelis, Lim, Ho-Yeong, Neely, Jaclyn, Shen, Yun, Wisniewski, Tami, Anderson, Jeffrey, Hsu, Chiun

“…Most patients with hepatocellular carcinoma (HCC) are diagnosed with advanced disease not eligible for potentially curative therapies; therefore, new treatment…”
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Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study Autor Fitzmaurice, Christina, Abate, Degu, Abbasi, Naghmeh, Abbastabar, Hedayat, Abd-Allah, Foad, Abdel-Rahman, Omar, Abdelalim, Ahmed, Abdoli, Amir, Abdollahpour, Ibrahim, Abdulle, Abdishakur S M, Abebe, Nebiyu Dereje, Abraha, Haftom Niguse, Abu-Raddad, Laith Jamal, Abualhasan, Ahmed, Adedeji, Isaac Akinkunmi, Advani, Shailesh M, Afarideh, Mohsen, Afshari, Mahdi, Aghaali, Mohammad, Agius, Dominic, Agrawal, Sutapa, Ahmadi, Ayat, Ahmadian, Elham, Ahmadpour, Ehsan, Ahmed, Muktar Beshir, Akbari, Mohammad Esmaeil, Akinyemiju, Tomi, Al-Aly, Ziyad, AlAbdulKader, Assim M, Alahdab, Fares, Alam, Tahiya, Alamene, Genet Melak, Alemnew, Birhan Tamene T, Alene, Kefyalew Addis, Alinia, Cyrus, Alipour, Vahid, Aljunid, Syed Mohamed, Bakeshei, Fatemeh Allah, Almadi, Majid Abdulrahman Hamad, Almasi-Hashiani, Amir, Alsharif, Ubai, Alsowaidi, Shirina, Alvis-Guzman, Nelson, Amini, Erfan, Amini, Saeed, Amoako, Yaw Ampem, Anbari, Zohreh, Anber, Nahla Hamed, Andrei, Catalina Liliana, Anjomshoa, Mina, Ansari, Fereshteh, Ansariadi, Ansariadi, Appiah, Seth Christopher Yaw, Arab-Zozani, Morteza, Arabloo, Jalal, Arefi, Zohreh, Aremu, Olatunde, Areri, Habtamu Abera, Artaman, Al, Asayesh, Hamid, Asfaw, Ephrem Tsegay, Ashagre, Alebachew Fasil, Assadi, Reza, Ataeinia, Bahar, Atalay, Hagos Tasew, Ataro, Zerihun, Atique, Suleman, Ausloos, Marcel, Avila-Burgos, Leticia, Avokpaho, Euripide F G A, Awasthi, Ashish, Awoke, Nefsu, Ayala Quintanilla, Beatriz Paulina, Ayanore, Martin Amogre, Ayele, Henok Tadesse, Babaee, Ebrahim, Bacha, Umar, Badawi, Alaa, Bagherzadeh, Mojtaba, Bagli, Eleni, Balakrishnan, Senthilkumar, Balouchi, Abbas, Bärnighausen, Till Winfried, Battista, Robert J, Behzadifar, Masoud, Behzadifar, Meysam, Bekele, Bayu Begashaw, Belay, Yared Belete, Belayneh, Yaschilal Muche, Berfield, Kathleen Kim Sachiko, Berhane, Adugnaw, Bernabe, Eduardo, Beuran, Mircea, Bhakta, Nickhill, Bhattacharyya, Krittika, Biadgo, Belete, Bijani, Ali, Bin Sayeed, Muhammad Shahdaat, Birungi, Charles, Bisignano, Catherine

“…Cancer and other noncommunicable diseases (NCDs) are now widely recognized as a threat to global development. The latest United Nations high-level meeting on…”
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Efficacy and Safety of Pembrolizumab or Pembrolizumab Plus Chemotherapy vs Chemotherapy Alone for Patients With First-line, Advanced Gastric Cancer: The KEYNOTE-062 Phase 3 Randomized Clinical Trial Autor Shitara, Kohei, Van Cutsem, Eric, Bang, Yung-Jue, Fuchs, Charles, Wyrwicz, Lucjan, Lee, Keun-Wook, Kudaba, Iveta, Garrido, Marcelo, Chung, Hyun Cheol, Lee, Jeeyun, Castro, Hugo Raul, Mansoor, Wasat, Braghiroli, Maria Ignez, Karaseva, Nina, Caglevic, Christian, Villanueva, Luis, Goekkurt, Eray, Satake, Hironaga, Enzinger, Peter, Alsina, Maria, Benson, Al, Chao, Joseph, Ko, Andrew H, Wainberg, Zev A, Kher, Uma, Shah, Sukrut, Kang, S Peter, Tabernero, Josep

“…Safe and effective therapies for untreated, advanced gastric/gastroesophageal junction (G/GEJ) cancer remain an unmet need. To evaluate the antitumor activity…”
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Effect of Nivolumab vs Bevacizumab in Patients With Recurrent Glioblastoma: The CheckMate 143 Phase 3 Randomized Clinical Trial Autor Reardon, David A, Brandes, Alba A, Omuro, Antonio, Mulholland, Paul, Lim, Michael, Wick, Antje, Baehring, Joachim, Ahluwalia, Manmeet S, Roth, Patrick, Bähr, Oliver, Phuphanich, Surasak, Sepulveda, Juan Manuel, De Souza, Paul, Sahebjam, Solmaz, Carleton, Michael, Tatsuoka, Kay, Taitt, Corina, Zwirtes, Ricardo, Sampson, John, Weller, Michael

“…Clinical outcomes for glioblastoma remain poor. Treatment with immune checkpoint blockade has shown benefits in many cancer types. To our knowledge, data from…”
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Update of Incidence, Prevalence, Survival, and Initial Treatment in Patients With Non-Small Cell Lung Cancer in the US Autor Ganti, Apar Kishor, Klein, Alyssa B, Cotarla, Ion, Seal, Brian, Chou, Engels

“…Updated estimates of non-small cell lung cancer (NSCLC) in the US are needed. To calculate the most recent epidemiologic estimates of NSCLC in the US. This…”
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SARS-CoV-2 Transmission in Patients With Cancer at a Tertiary Care Hospital in Wuhan, China Autor Yu, Jing, Ouyang, Wen, Chua, Melvin L K, Xie, Conghua

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Outcomes of Observation vs Stereotactic Ablative Radiation for Oligometastatic Prostate Cancer: The ORIOLE Phase 2 Randomized Clinical Trial Autor Phillips, Ryan, Shi, William Yue, Deek, Matthew, Radwan, Noura, Lim, Su Jin, Antonarakis, Emmanuel S, Rowe, Steven P, Ross, Ashley E, Gorin, Michael A, Deville, Curtiland, Greco, Stephen C, Wang, Hailun, Denmeade, Samuel R, Paller, Channing J, Dipasquale, Shirl, DeWeese, Theodore L, Song, Daniel Y, Wang, Hao, Carducci, Michael A, Pienta, Kenneth J, Pomper, Martin G, Dicker, Adam P, Eisenberger, Mario A, Alizadeh, Ash A, Diehn, Maximilian, Tran, Phuoc T

“…Complete metastatic ablation of oligometastatic prostate cancer may provide an alternative to early initiation of androgen deprivation therapy (ADT). To…”
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Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients With Newly Diagnosed and Recurrent Glioblastoma: A Phase 3 Prospective Externally Controlled Cohort Trial Autor Liau, Linda M, Ashkan, Keyoumars, Brem, Steven, Campian, Jian L, Trusheim, John E, Iwamoto, Fabio M, Tran, David D, Ansstas, George, Cobbs, Charles S, Heth, Jason A, Salacz, Michael E, D'Andre, Stacy, Aiken, Robert D, Moshel, Yaron A, Nam, Joo Y, Pillainayagam, Clement P, Wagner, Stephanie A, Walter, Kevin A, Chaudhary, Rekha, Goldlust, Samuel A, Lee, Ian Y, Bota, Daniela A, Elinzano, Heinrich, Grewal, Jai, Lillehei, Kevin, Mikkelsen, Tom, Walbert, Tobias, Abram, Steven, Brenner, Andrew J, Ewend, Matthew G, Khagi, Simon, Lovick, Darren S, Portnow, Jana, Kim, Lyndon, Loudon, William G, Martinez, Nina L, Thompson, Reid C, Avigan, David E, Fink, Karen L, Geoffroy, Francois J, Giglio, Pierre, Gligich, Oleg, Krex, Dietmar, Lindhorst, Scott M, Lutzky, Jose, Meisel, Hans-Jörg, Nadji-Ohl, Minou, Sanchin, Lhagva, Sloan, Andrew, Taylor, Lynne P, Wu, Julian K, Dunbar, Erin M, Etame, Arnold B, Kesari, Santosh, Mathieu, David, Piccioni, David E, Baskin, David S, Lacroix, Michel, May, Sven-Axel, New, Pamela Z, Pluard, Timothy J, Toms, Steven A, Tse, Victor, Peak, Scott, Villano, John L, Battiste, James D, Mulholland, Paul J, Pearlman, Michael L, Petrecca, Kevin, Schulder, Michael, Prins, Robert M, Boynton, Alton L, Bosch, Marnix L

“…Glioblastoma is the most lethal primary brain cancer. Clinical outcomes for glioblastoma remain poor, and new treatments are needed. To investigate whether…”
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Fatal Toxic Effects Associated With Immune Checkpoint Inhibitors: A Systematic Review and Meta-analysis Autor Wang, Daniel Y, Salem, Joe-Elie, Cohen, Justine V, Chandra, Sunandana, Menzer, Christian, Ye, Fei, Zhao, Shilin, Das, Satya, Beckermann, Kathryn E, Ha, Lisa, Rathmell, W Kimryn, Ancell, Kristin K, Balko, Justin M, Bowman, Caitlin, Davis, Elizabeth J, Chism, David D, Horn, Leora, Long, Georgina V, Carlino, Matteo S, Lebrun-Vignes, Benedicte, Eroglu, Zeynep, Hassel, Jessica C, Menzies, Alexander M, Sosman, Jeffrey A, Sullivan, Ryan J, Moslehi, Javid J, Johnson, Douglas B

“…Immune checkpoint inhibitors (ICIs) are now a mainstay of cancer treatment. Although rare, fulminant and fatal toxic effects may complicate these otherwise…”
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Final Overall Survival Efficacy Results of Ivosidenib for Patients With Advanced Cholangiocarcinoma With IDH1 Mutation: The Phase 3 Randomized Clinical ClarIDHy Trial Autor Zhu, Andrew X, Macarulla, Teresa, Javle, Milind M, Kelley, R Kate, Lubner, Sam J, Adeva, Jorge, Cleary, James M, Catenacci, Daniel V T, Borad, Mitesh J, Bridgewater, John A, Harris, William P, Murphy, Adrian G, Oh, Do-Youn, Whisenant, Jonathan R, Lowery, Maeve A, Goyal, Lipika, Shroff, Rachna T, El-Khoueiry, Anthony B, Chamberlain, Christina X, Aguado-Fraile, Elia, Choe, Sung, Wu, Bin, Liu, Hua, Gliser, Camelia, Pandya, Shuchi S, Valle, Juan W, Abou-Alfa, Ghassan K

“…Isocitrate dehydrogenase 1 (IDH1) variations occur in up to approximately 20% of patients with intrahepatic cholangiocarcinoma. In the ClarIDHy trial,…”
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The Effect of Abemaciclib Plus Fulvestrant on Overall Survival in Hormone Receptor-Positive, ERBB2-Negative Breast Cancer That Progressed on Endocrine Therapy-MONARCH 2: A Randomized Clinical Trial Autor Sledge, Jr, George W, Toi, Masakazu, Neven, Patrick, Sohn, Joohyuk, Inoue, Kenichi, Pivot, Xavier, Burdaeva, Olga, Okera, Meena, Masuda, Norikazu, Kaufman, Peter A, Koh, Han, Grischke, Eva-Maria, Conte, PierFranco, Lu, Yi, Barriga, Susana, Hurt, Karla, Frenzel, Martin, Johnston, Stephen, Llombart-Cussac, Antonio

“…Statistically significant overall survival (OS) benefits of CDK4 and CDK6 inhibitors in combination with fulvestrant for hormone receptor (HR)-positive, ERBB2…”
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Effect of Pembrolizumab After Stereotactic Body Radiotherapy vs Pembrolizumab Alone on Tumor Response in Patients With Advanced Non-Small Cell Lung Cancer: Results of the PEMBRO-RT Phase 2 Randomized Clinical Trial Autor Theelen, Willemijn S M E, Peulen, Heike M U, Lalezari, Ferry, van der Noort, Vincent, de Vries, Jeltje F, Aerts, Joachim G J V, Dumoulin, Daphne W, Bahce, Idris, Niemeijer, Anna-Larissa N, de Langen, Adrianus J, Monkhorst, Kim, Baas, Paul

“…Many patients with advanced non-small cell lung cancer (NSCLC) receiving immunotherapy show primary resistance. High-dose radiotherapy can lead to increased…”
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Proton FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases: The FAST-01 Nonrandomized Trial Autor Mascia, Anthony E, Daugherty, Emily C, Zhang, Yongbin, Lee, Eunsin, Xiao, Zhiyan, Sertorio, Mathieu, Woo, Jennifer, Backus, Lori R, McDonald, Julie M, McCann, Claire, Russell, Kenneth, Levine, Lisa, Sharma, Ricky A, Khuntia, Dee, Bradley, Jeffrey D, Simone, 2nd, Charles B, Perentesis, John P, Breneman, John C

“…To our knowledge, there have been no clinical trials of ultra-high-dose-rate radiotherapy delivered at more than 40 Gy/sec, known as FLASH therapy, nor…”
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Effect of Pembrolizumab Plus Neoadjuvant Chemotherapy on Pathologic Complete Response in Women With Early-Stage Breast Cancer: An Analysis of the Ongoing Phase 2 Adaptively Randomized I-SPY2 Trial Autor Nanda, Rita, Liu, Minetta C, Yau, Christina, Shatsky, Rebecca, Pusztai, Lajos, Wallace, Anne, Chien, A Jo, Forero-Torres, Andres, Ellis, Erin, Han, Heather, Clark, Amy, Albain, Kathy, Boughey, Judy C, Jaskowiak, Nora T, Elias, Anthony, Isaacs, Claudine, Kemmer, Kathleen, Helsten, Teresa, Majure, Melanie, Stringer-Reasor, Erica, Parker, Catherine, Lee, Marie C, Haddad, Tufia, Cohen, Ronald N, Asare, Smita, Wilson, Amy, Hirst, Gillian L, Singhrao, Ruby, Steeg, Katherine, Asare, Adam, Matthews, Jeffrey B, Berry, Scott, Sanil, Ashish, Schwab, Richard, Symmans, W Fraser, van 't Veer, Laura, Yee, Douglas, DeMichele, Angela, Hylton, Nola M, Melisko, Michelle, Perlmutter, Jane, Rugo, Hope S, Berry, Donald A, Esserman, Laura J

“…Approximately 25% of patients with early-stage breast cancer who receive (neo)adjuvant chemotherapy experience a recurrence within 5 years. Improvements in…”
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Durvalumab With or Without Tremelimumab vs Standard Chemotherapy in First-line Treatment of Metastatic Non-Small Cell Lung Cancer: The MYSTIC Phase 3 Randomized Clinical Trial Autor Rizvi, Naiyer A, Cho, Byoung Chul, Reinmuth, Niels, Lee, Ki Hyeong, Luft, Alexander, Ahn, Myung-Ju, van den Heuvel, Michel M, Cobo, Manuel, Vicente, David, Smolin, Alexey, Moiseyenko, Vladimir, Antonia, Scott J, Le Moulec, Sylvestre, Robinet, Gilles, Natale, Ronald, Schneider, Jeffrey, Shepherd, Frances A, Geater, Sarayut Lucien, Garon, Edward B, Kim, Edward S, Goldberg, Sarah B, Nakagawa, Kazuhiko, Raja, Rajiv, Higgs, Brandon W, Boothman, Anne-Marie, Zhao, Luping, Scheuring, Urban, Stockman, Paul K, Chand, Vikram K, Peters, Solange

“…Checkpoint inhibitors targeting programmed cell death 1 or its ligand (PD-L1) as monotherapies or in combination with anti-cytotoxic T-lymphocyte-associated…”
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Safety and Efficacy of Pembrolizumab Monotherapy in Patients With Previously Treated Advanced Gastric and Gastroesophageal Junction Cancer: Phase 2 Clinical KEYNOTE-059 Trial Autor Fuchs, Charles S, Doi, Toshihiko, Jang, Raymond W, Muro, Kei, Satoh, Taroh, Machado, Manuela, Sun, Weijing, Jalal, Shadia I, Shah, Manish A, Metges, Jean-Phillipe, Garrido, Marcelo, Golan, Talia, Mandala, Mario, Wainberg, Zev A, Catenacci, Daniel V, Ohtsu, Atsushi, Shitara, Kohei, Geva, Ravit, Bleeker, Jonathan, Ko, Andrew H, Ku, Geoffrey, Philip, Philip, Enzinger, Peter C, Bang, Yung-Jue, Levitan, Diane, Wang, Jiangdian, Rosales, Minori, Dalal, Rita P, Yoon, Harry H

“…Therapeutic options are needed for patients with advanced gastric cancer whose disease has progressed after 2 or more lines of therapy. To evaluate the safety…”
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Geriatric Assessment-Driven Intervention (GAIN) on Chemotherapy-Related Toxic Effects in Older Adults With Cancer: A Randomized Clinical Trial Autor Li, Daneng, Sun, Can-Lan, Kim, Heeyoung, Soto-Perez-de-Celis, Enrique, Chung, Vincent, Koczywas, Marianna, Fakih, Marwan, Chao, Joseph, Cabrera Chien, Leana, Charles, Kemeberly, Hughes, Simone Fernandes Dos Santos, Katheria, Vani, Trent, Monica, Roberts, Elsa, Jayani, Reena, Moreno, Jeanine, Kelly, Cynthia, Sedrak, Mina S, Dale, William

“…Although geriatric assessment-driven intervention improves patient-centered outcomes, its influence on chemotherapy-related toxic effects remains unknown. To…”
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