Search Results - "JACC. Basic to translational science"

Mechanisms of Cardiovascular Benefits of Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors: A State-of-the-Art Review by Lopaschuk, Gary D, Verma, Subodh

“…Recent clinical trials have shown that sodium glucose co-transport 2 (SGLT2) inhibitors have dramatic beneficial cardiovascular outcomes. These include a…”
Get full text

Limitations of Animal Studies for Predicting Toxicity in Clinical Trials: Is it Time to Rethink Our Current Approach? by Van Norman, Gail A

“…Animal testing is used in pharmaceutical and industrial research to predict human toxicity, and yet analysis suggests that animal models are poor predictors of…”
Get full text

Fibroblasts in the Infarcted, Remodeling, and Failing Heart by Humeres, Claudio, Frangogiannis, Nikolaos G.

“…•Cardiac fibroblasts become activated following injury and participate in repair and remodeling of the heart.•The authors discuss the phenotypic alterations…”
Get full text

First-in-Man Study of a Cardiac Extracellular Matrix Hydrogel in Early and Late Myocardial Infarction Patients by Traverse, Jay H., Henry, Timothy D., Dib, Nabil, Patel, Amit N., Pepine, Carl, Schaer, Gary L., DeQuach, Jessica A., Kinsey, Adam M., Chamberlin, Paul, Christman, Karen L.

“…[Display omitted] •A first-in-man clinical trial was completed with VentriGel, an extracellular matrix hydrogel derived from decellularized porcine myocardium,…”
Get full text

The GLP-1 Analogs Liraglutide and Semaglutide Reduce Atherosclerosis in ApoE−/− and LDLr−/− Mice by a Mechanism That Includes Inflammatory Pathways by Rakipovski, Günaj, Rolin, Bidda, Nøhr, Jane, Klewe, Ib, Frederiksen, Klaus S., Augustin, Robert, Hecksher-Sørensen, Jacob, Ingvorsen, Camilla, Polex-Wolf, Joseph, Knudsen, Lotte Bjerre

“…[Display omitted] •The GLP-1RAs liraglutide and semaglutide reduce cardiovascular risk in type 2 diabetes patients.•In ApoE−/− mice and LDLr−/− mice,…”
Get full text

COVID-19 for the cardiologist: basic virology, epidemiology, cardiac manifestations, and potential therapeutic strategies by Atri, Deepak, Siddiqi, Hasan K., Lang, Joshua P., Nauffal, Victor, Morrow, David A., Bohula, Erin A.

“…Coronavirus disease-2019 (COVID-19), a contagious disease caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has reached pandemic status…”
Get full text

SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis by Bailey, Adam L., Dmytrenko, Oleksandr, Greenberg, Lina, Bredemeyer, Andrea L., Ma, Pan, Liu, Jing, Penna, Vinay, Winkler, Emma S., Sviben, Sanja, Brooks, Erin, Nair, Ajith P., Heck, Kent A., Rali, Aniket S., Simpson, Leo, Saririan, Mehrdad, Hobohm, Dan, Stump, W. Tom, Fitzpatrick, James A., Xie, Xuping, Zhang, Xianwen, Shi, Pei-Yong, Hinson, J. Travis, Gi, Weng-Tein, Schmidt, Constanze, Leuschner, Florian, Lin, Chieh-Yu, Diamond, Michael S., Greenberg, Michael J., Lavine, Kory J.

“…[Display omitted] •SARS-CoV-2 directly infects cardiomyocytes in patients with COVID-19 myocarditis and does not infect cardiac macrophages, fibroblasts, or…”
Get full text

Iron Overload via Heme Degradation in the Endoplasmic Reticulum Triggers Ferroptosis in Myocardial Ischemia-Reperfusion Injury by Miyamoto, Hiroko Deguchi, Ikeda, Masataka, Ide, Tomomi, Tadokoro, Tomonori, Furusawa, Shun, Abe, Ko, Ishimaru, Kosei, Enzan, Nobuyuki, Sada, Masashi, Yamamoto, Taishi, Matsushima, Shouji, Koumura, Tomoko, Yamada, Ken-ichi, Imai, Hirotaka, Tsutsui, Hiroyuki

“…[Display omitted] •It remains unknown how ferroptosis, triggered by excessive lipid peroxides via iron overload, is induced in I/R injury.•GPx4, an endogenous…”
Get full text

Empagliflozin Increases Cardiac Energy Production in Diabetes: Novel Translational Insights Into the Heart Failure Benefits of SGLT2 Inhibitors by Verma, Subodh, Rawat, Sonia, Ho, Kim L, Wagg, Cory S, Zhang, Liyan, Teoh, Hwee, Dyck, John E, Uddin, Golam M, Oudit, Gavin Y, Mayoux, Eric, Lehrke, Michael, Marx, Nikolaus, Lopaschuk, Gary D

“…SGLT2 inhibitors have profound benefits on reducing heart failure and cardiovascular mortality in individuals with type 2 diabetes, although the mechanism(s)…”
Get full text

Platelet and Endothelial Activation as Potential Mechanisms Behind the Thrombotic Complications of COVID-19 Patients by Canzano, Paola, Brambilla, Marta, Porro, Benedetta, Cosentino, Nicola, Tortorici, Elena, Vicini, Stefano, Poggio, Paolo, Cascella, Andrea, Pengo, Martino F., Veglia, Fabrizio, Fiorelli, Susanna, Bonomi, Alice, Cavalca, Viviana, Trabattoni, Daniela, Andreini, Daniele, Omodeo Salè, Emanuela, Parati, Gianfranco, Tremoli, Elena, Camera, Marina

“…[Display omitted] •The cytokine storm present in COVID-19 patients induces, together with the imbalance of endothelial functions, a massive cell activation…”
Get full text

Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Inflammation and Restored by Empagliflozin by Juni, Rio P., Kuster, Diederik W.D., Goebel, Max, Helmes, Michiel, Musters, René J.P., van der Velden, Jolanda, Koolwijk, Pieter, Paulus, Walter J., van Hinsbergh, Victor W.M.

“…[Display omitted] •CMECs exert a direct positive effect on cardiomyocyte contraction and relaxation, which is mainly mediated by endothelial-derived…”
Get full text

Atrial Myopathy by Shen, Mark J., Arora, Rishi, Jalife, José

“…•The authors discuss the concept of atrial myopathy; its relationship to aging, electrophysiological remodeling, and autonomic remodeling; the interplay…”
Get full text

SGLT2 Inhibitor-Induced Sympathoinhibition: A Novel Mechanism for Cardiorenal Protection by Herat, Lakshini Y, Magno, Aaron L, Rudnicka, Caroline, Hricova, Jana, Carnagarin, Revathy, Ward, Natalie C, Arcambal, Angelique, Kiuchi, Marcio G, Head, Geoff A, Schlaich, Markus P, Matthews, Vance B

“…Recent clinical trial data suggest a cardiorenal protective effect of sodium glucose cotransporter 2 (SGLT2) inhibition. We demonstrate that chemical…”
Get full text

JAK2 (V617F) -mediated clonal hematopoiesis accelerates pathological remodeling in murine heart failure by Sano, Soichi, Wang, Ying, Yura, Yoshimitsu, Sano, Miho, Oshima, Kosei, Yang, Yue, Katanasaka, Yasufumi, Min, Kyung-Duk, Matsuura, Shinobu, Ravid, Katya, Mohi, Golam, Walsh, Kenneth

Get full text

Radiation-Induced Endothelial Vascular Injury: A Review of Possible Mechanisms by Venkatesulu, Bhanu Prasad, Mahadevan, Lakshmi Shree, Aliru, Maureen L, Yang, Xi, Bodd, Monica Himaani, Singh, Pankaj K, Yusuf, Syed Wamique, Abe, Jun-Ichi, Krishnan, Sunil

“…In radiation therapy for cancer, the therapeutic ratio represents an optimal balance between tumor control and normal tissue complications. As improvements in…”
Get full text

The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury by Siripanthong, Bhurint, Asatryan, Babken, Hanff, Thomas C., Chatha, Salman R., Khanji, Mohammed Y., Ricci, Fabrizio, Muser, Daniele, Ferrari, Victor A., Nazarian, Saman, Santangeli, Pasquale, Deo, Rajat, Cooper, Leslie T., Mohiddin, Saidi A., Chahal, C. Anwar A.

“…•COVID-19 myocardial injury results from immune and hypercoagulability responses.•Long-term cardiac consequences of COVID-19 include structural and functional…”
Get full text

Targeting the Inflammasome in Cardiovascular Disease by Olsen, Maria Belland, Gregersen, Ida, Sandanger, Øystein, Yang, Kuan, Sokolova, Marina, Halvorsen, Bente E., Gullestad, Lars, Broch, Kaspar, Aukrust, Pål, Louwe, Mieke C.

“…•Development of cardiovascular disease and inflammation are heavily intertwined, and inflammasome activation is thought play an important role in this…”
Get full text

CCR2+ Monocyte-Derived Infiltrating Macrophages Are Required for Adverse Cardiac Remodeling During Pressure Overload by Patel, Bindiya, Bansal, Shyam S., Ismahil, Mohamed Ameen, Hamid, Tariq, Rokosh, Gregg, Mack, Matthias, Prabhu, Sumanth D.

“…[Display omitted] •Hypothesis: CCR2+ monocyte-derived cardiac macrophages are required for adverse LV remodeling, cardiac T-cell expansion, and the transition…”
Get full text

Artificial Intelligence Discusses the Role of Artificial Intelligence in Translational Medicine: A JACC: Basic to Translational Science Interview With ChatGPT by Mann, Douglas L

Get full text

Blockade of Fibroblast YAP Attenuates Cardiac Fibrosis and Dysfunction Through MRTF-A Inhibition by Francisco, Jamie, Zhang, Yu, Jeong, Jae Im, Mizushima, Wataru, Ikeda, Shohei, Ivessa, Andreas, Oka, Shinichi, Zhai, Peiyong, Tallquist, Michelle D., Del Re, Dominic P.

“…[Display omitted] •YAP is activated by myocardial infarction or neuroendocrine stimulation in cardiac fibroblasts.•Active YAP promotes TEA domain transcription…”
Get full text